CASC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CASC3
Entrez Gene ID	22794
Full Name	cancer susceptibility 3
Synonyms	BTZ,MLN51
General protein information	Preferred Names cancer susceptibility 3 Names protein CASC3 MLN 51 barentsz cancer susceptibility candidate 3 cancer susceptibility candidate gene 3 protein metastatic lymph node 51 metastatic lymph node gene 51 protein protein barentsz
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.1
Summary	The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008].
Disorder MIM:	606504

mRNA and Protein(s)

mRNA	Protein	Name
XM_005257163.1	XP_005257220.1	protein CASC3 isoform X1
XM_005257163.2	XP_005257220.1	protein CASC3 isoform X1
NM_007359.5	NP_031385.2	protein CASC3
NM_007359.4	NP_031385.2	protein CASC3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CASC3	XP_511470.3
Bos taurus (cattle)	CASC3	NP_001091538.1
Homo sapiens (human)	CASC3	NP_031385.2
Mus musculus (house mouse)	Casc3	NP_619601.2
Rattus norvegicus (Norway rat)	Casc3	NP_671485.1
	CASC3	XP_001096548.1
Gallus gallus (chicken)	CASC3	XP_423806.4
Canis lupus familiaris (dog)	CASC3	XP_537649.2
Xenopus tropicalis (tropical clawed frog)	casc3	NP_001012670.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure of a human catalytic step I spliceosome.
Zhan X, Yan C, Zhang X, Lei J, Shi Y
Science (New York, N.Y.)(2018 Jan)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
Mao H, Brown HE, Silver DL
RNA (New York, N.Y.)23(1)23-31(2017 01)

Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3.
Xu L, Dai W, Li J, He L, Wang F, Xia Y, Chen K, Li S, Liu T, Lu J, Zhou Y, Wang Y, Guo C
Oncotarget7(18)26027-41(2016 May)

EJC core component MLN51 interacts with eIF3 and activates translation.
Chazal PE, Daguenet E, Wendling C, Ulryck N, Tomasetto C, Sargueil B, Le Hir H
Proceedings of the National Academy of Sciences of the United States of America110(15)5903-8(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MLN51, alone or as part of the EJC, interacts directly with the pivotal eukaryotic translation initiation factor eIF3
Title: EJC core component MLN51 interacts with eIF3 and activates translation.

MLN51 is a key factor in fibroblast-like synoviocyte hyperplasia of rheumatoid arthritis patients.
Title: Metastatic lymph node 51 and fibroblast-like synoviocyte hyperproliferation in rheumatoid arthritis pathogenesis.

MLN51 is recruited into cytoplasmic aggregates known as stress granules (SGs) together with the SG-resident proteins.
Title: The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.

crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic
Title: Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.

data demonstrate that metastatic lymph node(MLN)51 protein associates with exon junction complex in the nucleus and remains stably associated with messenger RNA in the cytoplasm
Title: Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.

The following CASC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30961	NM_007359.5 Latest version!	Homo sapiens CASC3 exon junction complex subunit (CASC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu30961	XM_005257163.2 Latest version!	Homo sapiens CASC3 exon junction complex subunit (CASC3), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu30961	XM_005257163.1	Homo sapiens cancer susceptibility candidate 3 (CASC3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu30961	NM_007359.4	Homo sapiens cancer susceptibility 3 (CASC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CASC3 ( NM_007359.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_031385.2 Homo sapiens CASC3 exon junction complex subunit (CASC3), mRNA.

Price & Availability↑

CloneID	OHu30961
Clone ID Related Accession (Same CDS sequence)	XM_005257163.1 , XM_005257163.2 , NM_007359.5 , NM_007359.4
Accession Version	NM_007359.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2112bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	protein CASC3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X80199.2. On Nov 23, 2018 this sequence version replaced NM_007359.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050526.1, X80199.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264645.12/ ENSP00000264645.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGACC GGCGGCGGCA GCGCGCTTCG CAAGACACCG AGGACGAGGA ATCTGGTGCT 
TCGGGCTCCG ACAGCGGCGG CTCCCCGTTG CGGGGAGGCG GGAGCTGCAG CGGTAGCGCC 
GGAGGCGGCG GCAGCGGCTC TCTGCCTTCA CAGCGCGGAG GCCGAACCGG GGCCCTTCAT 
CTGCGGCGGG TGGAGAGCGG GGGCGCCAAG AGTGCTGAGG AGTCGGAGTG TGAGAGTGAA 
GATGGCATTG AAGGTGATGC TGTTCTCTCG GATTATGAAA GTGCAGAAGA CTCGGAAGGT 
GAAGAAGGTG AATACAGTGA AGAGGAAAAC TCCAAAGTGG AGCTGAAATC AGAAGCTAAT 
GATGCTGTTA ATTCTTCAAC AAAAGAAGAG AAGGGAGAAG AAAAGCCTGA CACCAAAAGC 
ACTGTGACTG GAGAGAGGCA AAGTGGGGAC GGACAGGAGA GCACAGAGCC TGTGGAGAAC 
AAAGTGGGTA AAAAGGGCCC TAAGCATTTG GATGATGATG AAGATCGGAA GAATCCAGCA 
TACATACCTC GGAAAGGGCT CTTCTTTGAG CATGATCTTC GAGGGCAAAC TCAGGAGGAG 
GAAGTCAGAC CCAAGGGGCG TCAGCGAAAG CTATGGAAGG ATGAGGGTCG CTGGGAGCAT 
GACAAGTTCC GGGAAGATGA GCAGGCCCCA AAGTCCCGAC AGGAGCTCAT TGCTCTTTAT 
GGTTATGACA TTCGCTCAGC TCATAATCCT GATGACATCA AACCTCGAAG AATCCGGAAA 
CCCCGATATG GGAGTCCTCC ACAAAGAGAT CCAAACTGGA ACGGTGAGCG GCTAAACAAG 
TCTCATCGCC ACCAGGGTCT TGGGGGCACC CTACCACCAA GGACATTTAT TAACAGGAAT 
GCTGCAGGTA CCGGCCGTAT GTCTGCACCC AGGAATTATT CTCGATCTGG GGGCTTCAAG 
GAAGGTCGTG CTGGTTTTAG GCCTGTGGAA GCTGGTGGGC AGCATGGTGG CCGGTCTGGT 
GAGACTGTTA AGCATGAGAT TAGTTACCGG TCACGGCGCC TAGAGCAGAC TTCTGTGAGG 
GATCCATCTC CAGAAGCAGA TGCTCCAGTG CTTGGCAGTC CTGAGAAGGA AGAGGCAGCC 
TCAGAGCCAC CAGCTGCTGC TCCTGATGCT GCACCACCAC CCCCTGATAG GCCCATTGAG 
AAGAAATCCT ATTCCCGGGC AAGAAGAACT CGAACCAAAG TTGGAGATGC AGTCAAGCTT 
GCAGAGGAGG TGCCCCCTCC TCCTGAAGGA CTGATTCCAG CACCTCCAGT CCCAGAAACC 
ACCCCAACTC CACCTACTAA GACTGGGACC TGGGAAGCTC CGGTGGATTC TAGTACAAGT 
GGACTTGAGC AAGATGTGGC ACAACTAAAT ATAGCAGAAC AGAATTGGAG TCCGGGGCAG 
CCTTCTTTCC TGCAACCACG GGAACTTCGA GGTATGCCCA ACCATATACA CATGGGAGCA 
GGACCTCCAC CTCAGTTTAA CCGGATGGAA GAAATGGGTG TCCAGGGTGG TCGAGCCAAA 
CGCTATTCAT CCCAGCGGCA AAGACCTGTG CCAGAGCCCC CCGCCCCTCC AGTGCATATC 
AGTATCATGG AGGGACATTA CTATGATCCA CTGCAGTTCC AGGGACCAAT CTATACCCAT 
GGTGACAGCC CTGCCCCGCT GCCTCCACAG GGCATGCTTG TGCAGCCAGG AATGAACCTT 
CCCCACCCAG GTTTACATCC CCACCAGACA CCAGCTCCTC TGCCCAATCC AGGCCTCTAT 
CCCCCACCAG TGTCCATGTC TCCAGGACAG CCACCACCTC AGCAGTTGCT TGCTCCTACT 
TACTTTTCTG CTCCAGGCGT CATGAACTTT GGTAATCCCA GTTACCCTTA TGCTCCAGGG 
GCACTGCCTC CCCCACCACC GCCTCATCTG TATCCTAATA CACAGGCCCC ATCACAGGTA 
TATGGAGGAG TGACCTACTA TAACCCCGCC CAGCAGCAGG TGCAGCCAAA GCCCTCCCCA 
CCCCGGAGGA CTCCCCAGCC AGTCACCATC AAGCCCCCTC CACCTGAGGT TGTAAGCAGG 
GGTTCCAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031385.2
CDS	13..2124
Translation	MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS

Target ORF information:

RefSeq Version	NM_007359.5
Organism	Homo sapiens(human)
Definition	Homo sapiens CASC3 exon junction complex subunit (CASC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007359.5

ORF Insert Sequence:

ATGGCGGACC GGCGGCGGCA GCGCGCTTCG CAAGACACCG AGGACGAGGA ATCTGGTGCT 
TCGGGCTCCG ACAGCGGCGG CTCCCCGTTG CGGGGAGGCG GGAGCTGCAG CGGTAGCGCC 
GGAGGCGGCG GCAGCGGCTC TCTGCCTTCA CAGCGCGGAG GCCGAACCGG GGCCCTTCAT 
CTGCGGCGGG TGGAGAGCGG GGGCGCCAAG AGTGCTGAGG AGTCGGAGTG TGAGAGTGAA 
GATGGCATTG AAGGTGATGC TGTTCTCTCG GATTATGAAA GTGCAGAAGA CTCGGAAGGT 
GAAGAAGGTG AATACAGTGA AGAGGAAAAC TCCAAAGTGG AGCTGAAATC AGAAGCTAAT 
GATGCTGTTA ATTCTTCAAC AAAAGAAGAG AAGGGAGAAG AAAAGCCTGA CACCAAAAGC 
ACTGTGACTG GAGAGAGGCA AAGTGGGGAC GGACAGGAGA GCACAGAGCC TGTGGAGAAC 
AAAGTGGGTA AAAAGGGCCC TAAGCATTTG GATGATGATG AAGATCGGAA GAATCCAGCA 
TACATACCTC GGAAAGGGCT CTTCTTTGAG CATGATCTTC GAGGGCAAAC TCAGGAGGAG 
GAAGTCAGAC CCAAGGGGCG TCAGCGAAAG CTATGGAAGG ATGAGGGTCG CTGGGAGCAT 
GACAAGTTCC GGGAAGATGA GCAGGCCCCA AAGTCCCGAC AGGAGCTCAT TGCTCTTTAT 
GGTTATGACA TTCGCTCAGC TCATAATCCT GATGACATCA AACCTCGAAG AATCCGGAAA 
CCCCGATATG GGAGTCCTCC ACAAAGAGAT CCAAACTGGA ACGGTGAGCG GCTAAACAAG 
TCTCATCGCC ACCAGGGTCT TGGGGGCACC CTACCACCAA GGACATTTAT TAACAGGAAT 
GCTGCAGGTA CCGGCCGTAT GTCTGCACCC AGGAATTATT CTCGATCTGG GGGCTTCAAG 
GAAGGTCGTG CTGGTTTTAG GCCTGTGGAA GCTGGTGGGC AGCATGGTGG CCGGTCTGGT 
GAGACTGTTA AGCATGAGAT TAGTTACCGG TCACGGCGCC TAGAGCAGAC TTCTGTGAGG 
GATCCATCTC CAGAAGCAGA TGCTCCAGTG CTTGGCAGTC CTGAGAAGGA AGAGGCAGCC 
TCAGAGCCAC CAGCTGCTGC TCCTGATGCT GCACCACCAC CCCCTGATAG GCCCATTGAG 
AAGAAATCCT ATTCCCGGGC AAGAAGAACT CGAACCAAAG TTGGAGATGC AGTCAAGCTT 
GCAGAGGAGG TGCCCCCTCC TCCTGAAGGA CTGATTCCAG CACCTCCAGT CCCAGAAACC 
ACCCCAACTC CACCTACTAA GACTGGGACC TGGGAAGCTC CGGTGGATTC TAGTACAAGT 
GGACTTGAGC AAGATGTGGC ACAACTAAAT ATAGCAGAAC AGAATTGGAG TCCGGGGCAG 
CCTTCTTTCC TGCAACCACG GGAACTTCGA GGTATGCCCA ACCATATACA CATGGGAGCA 
GGACCTCCAC CTCAGTTTAA CCGGATGGAA GAAATGGGTG TCCAGGGTGG TCGAGCCAAA 
CGCTATTCAT CCCAGCGGCA AAGACCTGTG CCAGAGCCCC CCGCCCCTCC AGTGCATATC 
AGTATCATGG AGGGACATTA CTATGATCCA CTGCAGTTCC AGGGACCAAT CTATACCCAT 
GGTGACAGCC CTGCCCCGCT GCCTCCACAG GGCATGCTTG TGCAGCCAGG AATGAACCTT 
CCCCACCCAG GTTTACATCC CCACCAGACA CCAGCTCCTC TGCCCAATCC AGGCCTCTAT 
CCCCCACCAG TGTCCATGTC TCCAGGACAG CCACCACCTC AGCAGTTGCT TGCTCCTACT 
TACTTTTCTG CTCCAGGCGT CATGAACTTT GGTAATCCCA GTTACCCTTA TGCTCCAGGG 
GCACTGCCTC CCCCACCACC GCCTCATCTG TATCCTAATA CACAGGCCCC ATCACAGGTA 
TATGGAGGAG TGACCTACTA TAACCCCGCC CAGCAGCAGG TGCAGCCAAA GCCCTCCCCA 
CCCCGGAGGA CTCCCCAGCC AGTCACCATC AAGCCCCCTC CACCTGAGGT TGTAAGCAGG 
GGTTCCAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASC3 ( NM_007359.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_031385.2 Homo sapiens cancer susceptibility 3 (CASC3), mRNA.

Price & Availability↑

CloneID	OHu30961
Clone ID Related Accession (Same CDS sequence)	XM_005257163.1 , XM_005257163.2 , NM_007359.5 , NM_007359.4
Accession Version	NM_007359.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2112bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-16
Organism	Homo sapiens(human)
Product	protein CASC3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB082647.1, X80199.2 and CA427444.1. On May 26, 2006 this sequence version replaced NM_007359.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050526.1, X80199.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACC GGCGGCGGCA GCGCGCTTCG CAAGACACCG AGGACGAGGA ATCTGGTGCT 
TCGGGCTCCG ACAGCGGCGG CTCCCCGTTG CGGGGAGGCG GGAGCTGCAG CGGTAGCGCC 
GGAGGCGGCG GCAGCGGCTC TCTGCCTTCA CAGCGCGGAG GCCGAACCGG GGCCCTTCAT 
CTGCGGCGGG TGGAGAGCGG GGGCGCCAAG AGTGCTGAGG AGTCGGAGTG TGAGAGTGAA 
GATGGCATTG AAGGTGATGC TGTTCTCTCG GATTATGAAA GTGCAGAAGA CTCGGAAGGT 
GAAGAAGGTG AATACAGTGA AGAGGAAAAC TCCAAAGTGG AGCTGAAATC AGAAGCTAAT 
GATGCTGTTA ATTCTTCAAC AAAAGAAGAG AAGGGAGAAG AAAAGCCTGA CACCAAAAGC 
ACTGTGACTG GAGAGAGGCA AAGTGGGGAC GGACAGGAGA GCACAGAGCC TGTGGAGAAC 
AAAGTGGGTA AAAAGGGCCC TAAGCATTTG GATGATGATG AAGATCGGAA GAATCCAGCA 
TACATACCTC GGAAAGGGCT CTTCTTTGAG CATGATCTTC GAGGGCAAAC TCAGGAGGAG 
GAAGTCAGAC CCAAGGGGCG TCAGCGAAAG CTATGGAAGG ATGAGGGTCG CTGGGAGCAT 
GACAAGTTCC GGGAAGATGA GCAGGCCCCA AAGTCCCGAC AGGAGCTCAT TGCTCTTTAT 
GGTTATGACA TTCGCTCAGC TCATAATCCT GATGACATCA AACCTCGAAG AATCCGGAAA 
CCCCGATATG GGAGTCCTCC ACAAAGAGAT CCAAACTGGA ACGGTGAGCG GCTAAACAAG 
TCTCATCGCC ACCAGGGTCT TGGGGGCACC CTACCACCAA GGACATTTAT TAACAGGAAT 
GCTGCAGGTA CCGGCCGTAT GTCTGCACCC AGGAATTATT CTCGATCTGG GGGCTTCAAG 
GAAGGTCGTG CTGGTTTTAG GCCTGTGGAA GCTGGTGGGC AGCATGGTGG CCGGTCTGGT 
GAGACTGTTA AGCATGAGAT TAGTTACCGG TCACGGCGCC TAGAGCAGAC TTCTGTGAGG 
GATCCATCTC CAGAAGCAGA TGCTCCAGTG CTTGGCAGTC CTGAGAAGGA AGAGGCAGCC 
TCAGAGCCAC CAGCTGCTGC TCCTGATGCT GCACCACCAC CCCCTGATAG GCCCATTGAG 
AAGAAATCCT ATTCCCGGGC AAGAAGAACT CGAACCAAAG TTGGAGATGC AGTCAAGCTT 
GCAGAGGAGG TGCCCCCTCC TCCTGAAGGA CTGATTCCAG CACCTCCAGT CCCAGAAACC 
ACCCCAACTC CACCTACTAA GACTGGGACC TGGGAAGCTC CGGTGGATTC TAGTACAAGT 
GGACTTGAGC AAGATGTGGC ACAACTAAAT ATAGCAGAAC AGAATTGGAG TCCGGGGCAG 
CCTTCTTTCC TGCAACCACG GGAACTTCGA GGTATGCCCA ACCATATACA CATGGGAGCA 
GGACCTCCAC CTCAGTTTAA CCGGATGGAA GAAATGGGTG TCCAGGGTGG TCGAGCCAAA 
CGCTATTCAT CCCAGCGGCA AAGACCTGTG CCAGAGCCCC CCGCCCCTCC AGTGCATATC 
AGTATCATGG AGGGACATTA CTATGATCCA CTGCAGTTCC AGGGACCAAT CTATACCCAT 
GGTGACAGCC CTGCCCCGCT GCCTCCACAG GGCATGCTTG TGCAGCCAGG AATGAACCTT 
CCCCACCCAG GTTTACATCC CCACCAGACA CCAGCTCCTC TGCCCAATCC AGGCCTCTAT 
CCCCCACCAG TGTCCATGTC TCCAGGACAG CCACCACCTC AGCAGTTGCT TGCTCCTACT 
TACTTTTCTG CTCCAGGCGT CATGAACTTT GGTAATCCCA GTTACCCTTA TGCTCCAGGG 
GCACTGCCTC CCCCACCACC GCCTCATCTG TATCCTAATA CACAGGCCCC ATCACAGGTA 
TATGGAGGAG TGACCTACTA TAACCCCGCC CAGCAGCAGG TGCAGCCAAA GCCCTCCCCA 
CCCCGGAGGA CTCCCCAGCC AGTCACCATC AAGCCCCCTC CACCTGAGGT TGTAAGCAGG 
GGTTCCAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031385.2
CDS	296..2407
Translation	MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS

Target ORF information:

RefSeq Version	NM_007359.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer susceptibility 3 (CASC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007359.4

ORF Insert Sequence:

ATGGCGGACC GGCGGCGGCA GCGCGCTTCG CAAGACACCG AGGACGAGGA ATCTGGTGCT 
TCGGGCTCCG ACAGCGGCGG CTCCCCGTTG CGGGGAGGCG GGAGCTGCAG CGGTAGCGCC 
GGAGGCGGCG GCAGCGGCTC TCTGCCTTCA CAGCGCGGAG GCCGAACCGG GGCCCTTCAT 
CTGCGGCGGG TGGAGAGCGG GGGCGCCAAG AGTGCTGAGG AGTCGGAGTG TGAGAGTGAA 
GATGGCATTG AAGGTGATGC TGTTCTCTCG GATTATGAAA GTGCAGAAGA CTCGGAAGGT 
GAAGAAGGTG AATACAGTGA AGAGGAAAAC TCCAAAGTGG AGCTGAAATC AGAAGCTAAT 
GATGCTGTTA ATTCTTCAAC AAAAGAAGAG AAGGGAGAAG AAAAGCCTGA CACCAAAAGC 
ACTGTGACTG GAGAGAGGCA AAGTGGGGAC GGACAGGAGA GCACAGAGCC TGTGGAGAAC 
AAAGTGGGTA AAAAGGGCCC TAAGCATTTG GATGATGATG AAGATCGGAA GAATCCAGCA 
TACATACCTC GGAAAGGGCT CTTCTTTGAG CATGATCTTC GAGGGCAAAC TCAGGAGGAG 
GAAGTCAGAC CCAAGGGGCG TCAGCGAAAG CTATGGAAGG ATGAGGGTCG CTGGGAGCAT 
GACAAGTTCC GGGAAGATGA GCAGGCCCCA AAGTCCCGAC AGGAGCTCAT TGCTCTTTAT 
GGTTATGACA TTCGCTCAGC TCATAATCCT GATGACATCA AACCTCGAAG AATCCGGAAA 
CCCCGATATG GGAGTCCTCC ACAAAGAGAT CCAAACTGGA ACGGTGAGCG GCTAAACAAG 
TCTCATCGCC ACCAGGGTCT TGGGGGCACC CTACCACCAA GGACATTTAT TAACAGGAAT 
GCTGCAGGTA CCGGCCGTAT GTCTGCACCC AGGAATTATT CTCGATCTGG GGGCTTCAAG 
GAAGGTCGTG CTGGTTTTAG GCCTGTGGAA GCTGGTGGGC AGCATGGTGG CCGGTCTGGT 
GAGACTGTTA AGCATGAGAT TAGTTACCGG TCACGGCGCC TAGAGCAGAC TTCTGTGAGG 
GATCCATCTC CAGAAGCAGA TGCTCCAGTG CTTGGCAGTC CTGAGAAGGA AGAGGCAGCC 
TCAGAGCCAC CAGCTGCTGC TCCTGATGCT GCACCACCAC CCCCTGATAG GCCCATTGAG 
AAGAAATCCT ATTCCCGGGC AAGAAGAACT CGAACCAAAG TTGGAGATGC AGTCAAGCTT 
GCAGAGGAGG TGCCCCCTCC TCCTGAAGGA CTGATTCCAG CACCTCCAGT CCCAGAAACC 
ACCCCAACTC CACCTACTAA GACTGGGACC TGGGAAGCTC CGGTGGATTC TAGTACAAGT 
GGACTTGAGC AAGATGTGGC ACAACTAAAT ATAGCAGAAC AGAATTGGAG TCCGGGGCAG 
CCTTCTTTCC TGCAACCACG GGAACTTCGA GGTATGCCCA ACCATATACA CATGGGAGCA 
GGACCTCCAC CTCAGTTTAA CCGGATGGAA GAAATGGGTG TCCAGGGTGG TCGAGCCAAA 
CGCTATTCAT CCCAGCGGCA AAGACCTGTG CCAGAGCCCC CCGCCCCTCC AGTGCATATC 
AGTATCATGG AGGGACATTA CTATGATCCA CTGCAGTTCC AGGGACCAAT CTATACCCAT 
GGTGACAGCC CTGCCCCGCT GCCTCCACAG GGCATGCTTG TGCAGCCAGG AATGAACCTT 
CCCCACCCAG GTTTACATCC CCACCAGACA CCAGCTCCTC TGCCCAATCC AGGCCTCTAT 
CCCCCACCAG TGTCCATGTC TCCAGGACAG CCACCACCTC AGCAGTTGCT TGCTCCTACT 
TACTTTTCTG CTCCAGGCGT CATGAACTTT GGTAATCCCA GTTACCCTTA TGCTCCAGGG 
GCACTGCCTC CCCCACCACC GCCTCATCTG TATCCTAATA CACAGGCCCC ATCACAGGTA 
TATGGAGGAG TGACCTACTA TAACCCCGCC CAGCAGCAGG TGCAGCCAAA GCCCTCCCCA 
CCCCGGAGGA CTCCCCAGCC AGTCACCATC AAGCCCCCTC CACCTGAGGT TGTAAGCAGG 
GGTTCCAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASC3 ( XM_005257163.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005257220.1 Homo sapiens cancer susceptibility candidate 3 (CASC3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30961
Clone ID Related Accession (Same CDS sequence)	XM_005257163.1 , XM_005257163.2 , NM_007359.5 , NM_007359.4
Accession Version	XM_005257163.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2112bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein CASC3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGACC GGCGGCGGCA GCGCGCTTCG CAAGACACCG AGGACGAGGA ATCTGGTGCT 
TCGGGCTCCG ACAGCGGCGG CTCCCCGTTG CGGGGAGGCG GGAGCTGCAG CGGTAGCGCC 
GGAGGCGGCG GCAGCGGCTC TCTGCCTTCA CAGCGCGGAG GCCGAACCGG GGCCCTTCAT 
CTGCGGCGGG TGGAGAGCGG GGGCGCCAAG AGTGCTGAGG AGTCGGAGTG TGAGAGTGAA 
GATGGCATTG AAGGTGATGC TGTTCTCTCG GATTATGAAA GTGCAGAAGA CTCGGAAGGT 
GAAGAAGGTG AATACAGTGA AGAGGAAAAC TCCAAAGTGG AGCTGAAATC AGAAGCTAAT 
GATGCTGTTA ATTCTTCAAC AAAAGAAGAG AAGGGAGAAG AAAAGCCTGA CACCAAAAGC 
ACTGTGACTG GAGAGAGGCA AAGTGGGGAC GGACAGGAGA GCACAGAGCC TGTGGAGAAC 
AAAGTGGGTA AAAAGGGCCC TAAGCATTTG GATGATGATG AAGATCGGAA GAATCCAGCA 
TACATACCTC GGAAAGGGCT CTTCTTTGAG CATGATCTTC GAGGGCAAAC TCAGGAGGAG 
GAAGTCAGAC CCAAGGGGCG TCAGCGAAAG CTATGGAAGG ATGAGGGTCG CTGGGAGCAT 
GACAAGTTCC GGGAAGATGA GCAGGCCCCA AAGTCCCGAC AGGAGCTCAT TGCTCTTTAT 
GGTTATGACA TTCGCTCAGC TCATAATCCT GATGACATCA AACCTCGAAG AATCCGGAAA 
CCCCGATATG GGAGTCCTCC ACAAAGAGAT CCAAACTGGA ACGGTGAGCG GCTAAACAAG 
TCTCATCGCC ACCAGGGTCT TGGGGGCACC CTACCACCAA GGACATTTAT TAACAGGAAT 
GCTGCAGGTA CCGGCCGTAT GTCTGCACCC AGGAATTATT CTCGATCTGG GGGCTTCAAG 
GAAGGTCGTG CTGGTTTTAG GCCTGTGGAA GCTGGTGGGC AGCATGGTGG CCGGTCTGGT 
GAGACTGTTA AGCATGAGAT TAGTTACCGG TCACGGCGCC TAGAGCAGAC TTCTGTGAGG 
GATCCATCTC CAGAAGCAGA TGCTCCAGTG CTTGGCAGTC CTGAGAAGGA AGAGGCAGCC 
TCAGAGCCAC CAGCTGCTGC TCCTGATGCT GCACCACCAC CCCCTGATAG GCCCATTGAG 
AAGAAATCCT ATTCCCGGGC AAGAAGAACT CGAACCAAAG TTGGAGATGC AGTCAAGCTT 
GCAGAGGAGG TGCCCCCTCC TCCTGAAGGA CTGATTCCAG CACCTCCAGT CCCAGAAACC 
ACCCCAACTC CACCTACTAA GACTGGGACC TGGGAAGCTC CGGTGGATTC TAGTACAAGT 
GGACTTGAGC AAGATGTGGC ACAACTAAAT ATAGCAGAAC AGAATTGGAG TCCGGGGCAG 
CCTTCTTTCC TGCAACCACG GGAACTTCGA GGTATGCCCA ACCATATACA CATGGGAGCA 
GGACCTCCAC CTCAGTTTAA CCGGATGGAA GAAATGGGTG TCCAGGGTGG TCGAGCCAAA 
CGCTATTCAT CCCAGCGGCA AAGACCTGTG CCAGAGCCCC CCGCCCCTCC AGTGCATATC 
AGTATCATGG AGGGACATTA CTATGATCCA CTGCAGTTCC AGGGACCAAT CTATACCCAT 
GGTGACAGCC CTGCCCCGCT GCCTCCACAG GGCATGCTTG TGCAGCCAGG AATGAACCTT 
CCCCACCCAG GTTTACATCC CCACCAGACA CCAGCTCCTC TGCCCAATCC AGGCCTCTAT 
CCCCCACCAG TGTCCATGTC TCCAGGACAG CCACCACCTC AGCAGTTGCT TGCTCCTACT 
TACTTTTCTG CTCCAGGCGT CATGAACTTT GGTAATCCCA GTTACCCTTA TGCTCCAGGG 
GCACTGCCTC CCCCACCACC GCCTCATCTG TATCCTAATA CACAGGCCCC ATCACAGGTA 
TATGGAGGAG TGACCTACTA TAACCCCGCC CAGCAGCAGG TGCAGCCAAA GCCCTCCCCA 
CCCCGGAGGA CTCCCCAGCC AGTCACCATC AAGCCCCCTC CACCTGAGGT TGTAAGCAGG 
GGTTCCAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005257220.1
CDS	74..2185
Translation	MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS

Target ORF information:

RefSeq Version	XM_005257163.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer susceptibility candidate 3 (CASC3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005257163.1

ORF Insert Sequence:

ATGGCGGACC GGCGGCGGCA GCGCGCTTCG CAAGACACCG AGGACGAGGA ATCTGGTGCT 
TCGGGCTCCG ACAGCGGCGG CTCCCCGTTG CGGGGAGGCG GGAGCTGCAG CGGTAGCGCC 
GGAGGCGGCG GCAGCGGCTC TCTGCCTTCA CAGCGCGGAG GCCGAACCGG GGCCCTTCAT 
CTGCGGCGGG TGGAGAGCGG GGGCGCCAAG AGTGCTGAGG AGTCGGAGTG TGAGAGTGAA 
GATGGCATTG AAGGTGATGC TGTTCTCTCG GATTATGAAA GTGCAGAAGA CTCGGAAGGT 
GAAGAAGGTG AATACAGTGA AGAGGAAAAC TCCAAAGTGG AGCTGAAATC AGAAGCTAAT 
GATGCTGTTA ATTCTTCAAC AAAAGAAGAG AAGGGAGAAG AAAAGCCTGA CACCAAAAGC 
ACTGTGACTG GAGAGAGGCA AAGTGGGGAC GGACAGGAGA GCACAGAGCC TGTGGAGAAC 
AAAGTGGGTA AAAAGGGCCC TAAGCATTTG GATGATGATG AAGATCGGAA GAATCCAGCA 
TACATACCTC GGAAAGGGCT CTTCTTTGAG CATGATCTTC GAGGGCAAAC TCAGGAGGAG 
GAAGTCAGAC CCAAGGGGCG TCAGCGAAAG CTATGGAAGG ATGAGGGTCG CTGGGAGCAT 
GACAAGTTCC GGGAAGATGA GCAGGCCCCA AAGTCCCGAC AGGAGCTCAT TGCTCTTTAT 
GGTTATGACA TTCGCTCAGC TCATAATCCT GATGACATCA AACCTCGAAG AATCCGGAAA 
CCCCGATATG GGAGTCCTCC ACAAAGAGAT CCAAACTGGA ACGGTGAGCG GCTAAACAAG 
TCTCATCGCC ACCAGGGTCT TGGGGGCACC CTACCACCAA GGACATTTAT TAACAGGAAT 
GCTGCAGGTA CCGGCCGTAT GTCTGCACCC AGGAATTATT CTCGATCTGG GGGCTTCAAG 
GAAGGTCGTG CTGGTTTTAG GCCTGTGGAA GCTGGTGGGC AGCATGGTGG CCGGTCTGGT 
GAGACTGTTA AGCATGAGAT TAGTTACCGG TCACGGCGCC TAGAGCAGAC TTCTGTGAGG 
GATCCATCTC CAGAAGCAGA TGCTCCAGTG CTTGGCAGTC CTGAGAAGGA AGAGGCAGCC 
TCAGAGCCAC CAGCTGCTGC TCCTGATGCT GCACCACCAC CCCCTGATAG GCCCATTGAG 
AAGAAATCCT ATTCCCGGGC AAGAAGAACT CGAACCAAAG TTGGAGATGC AGTCAAGCTT 
GCAGAGGAGG TGCCCCCTCC TCCTGAAGGA CTGATTCCAG CACCTCCAGT CCCAGAAACC 
ACCCCAACTC CACCTACTAA GACTGGGACC TGGGAAGCTC CGGTGGATTC TAGTACAAGT 
GGACTTGAGC AAGATGTGGC ACAACTAAAT ATAGCAGAAC AGAATTGGAG TCCGGGGCAG 
CCTTCTTTCC TGCAACCACG GGAACTTCGA GGTATGCCCA ACCATATACA CATGGGAGCA 
GGACCTCCAC CTCAGTTTAA CCGGATGGAA GAAATGGGTG TCCAGGGTGG TCGAGCCAAA 
CGCTATTCAT CCCAGCGGCA AAGACCTGTG CCAGAGCCCC CCGCCCCTCC AGTGCATATC 
AGTATCATGG AGGGACATTA CTATGATCCA CTGCAGTTCC AGGGACCAAT CTATACCCAT 
GGTGACAGCC CTGCCCCGCT GCCTCCACAG GGCATGCTTG TGCAGCCAGG AATGAACCTT 
CCCCACCCAG GTTTACATCC CCACCAGACA CCAGCTCCTC TGCCCAATCC AGGCCTCTAT 
CCCCCACCAG TGTCCATGTC TCCAGGACAG CCACCACCTC AGCAGTTGCT TGCTCCTACT 
TACTTTTCTG CTCCAGGCGT CATGAACTTT GGTAATCCCA GTTACCCTTA TGCTCCAGGG 
GCACTGCCTC CCCCACCACC GCCTCATCTG TATCCTAATA CACAGGCCCC ATCACAGGTA 
TATGGAGGAG TGACCTACTA TAACCCCGCC CAGCAGCAGG TGCAGCCAAA GCCCTCCCCA 
CCCCGGAGGA CTCCCCAGCC AGTCACCATC AAGCCCCCTC CACCTGAGGT TGTAAGCAGG 
GGTTCCAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASC3 ( XM_005257163.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005257220.1 Homo sapiens CASC3 exon junction complex subunit (CASC3), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu30961
Clone ID Related Accession (Same CDS sequence)	XM_005257163.1 , XM_005257163.2 , NM_007359.5 , NM_007359.4
Accession Version	XM_005257163.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2112bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein CASC3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005257163.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGACC GGCGGCGGCA GCGCGCTTCG CAAGACACCG AGGACGAGGA ATCTGGTGCT 
TCGGGCTCCG ACAGCGGCGG CTCCCCGTTG CGGGGAGGCG GGAGCTGCAG CGGTAGCGCC 
GGAGGCGGCG GCAGCGGCTC TCTGCCTTCA CAGCGCGGAG GCCGAACCGG GGCCCTTCAT 
CTGCGGCGGG TGGAGAGCGG GGGCGCCAAG AGTGCTGAGG AGTCGGAGTG TGAGAGTGAA 
GATGGCATTG AAGGTGATGC TGTTCTCTCG GATTATGAAA GTGCAGAAGA CTCGGAAGGT 
GAAGAAGGTG AATACAGTGA AGAGGAAAAC TCCAAAGTGG AGCTGAAATC AGAAGCTAAT 
GATGCTGTTA ATTCTTCAAC AAAAGAAGAG AAGGGAGAAG AAAAGCCTGA CACCAAAAGC 
ACTGTGACTG GAGAGAGGCA AAGTGGGGAC GGACAGGAGA GCACAGAGCC TGTGGAGAAC 
AAAGTGGGTA AAAAGGGCCC TAAGCATTTG GATGATGATG AAGATCGGAA GAATCCAGCA 
TACATACCTC GGAAAGGGCT CTTCTTTGAG CATGATCTTC GAGGGCAAAC TCAGGAGGAG 
GAAGTCAGAC CCAAGGGGCG TCAGCGAAAG CTATGGAAGG ATGAGGGTCG CTGGGAGCAT 
GACAAGTTCC GGGAAGATGA GCAGGCCCCA AAGTCCCGAC AGGAGCTCAT TGCTCTTTAT 
GGTTATGACA TTCGCTCAGC TCATAATCCT GATGACATCA AACCTCGAAG AATCCGGAAA 
CCCCGATATG GGAGTCCTCC ACAAAGAGAT CCAAACTGGA ACGGTGAGCG GCTAAACAAG 
TCTCATCGCC ACCAGGGTCT TGGGGGCACC CTACCACCAA GGACATTTAT TAACAGGAAT 
GCTGCAGGTA CCGGCCGTAT GTCTGCACCC AGGAATTATT CTCGATCTGG GGGCTTCAAG 
GAAGGTCGTG CTGGTTTTAG GCCTGTGGAA GCTGGTGGGC AGCATGGTGG CCGGTCTGGT 
GAGACTGTTA AGCATGAGAT TAGTTACCGG TCACGGCGCC TAGAGCAGAC TTCTGTGAGG 
GATCCATCTC CAGAAGCAGA TGCTCCAGTG CTTGGCAGTC CTGAGAAGGA AGAGGCAGCC 
TCAGAGCCAC CAGCTGCTGC TCCTGATGCT GCACCACCAC CCCCTGATAG GCCCATTGAG 
AAGAAATCCT ATTCCCGGGC AAGAAGAACT CGAACCAAAG TTGGAGATGC AGTCAAGCTT 
GCAGAGGAGG TGCCCCCTCC TCCTGAAGGA CTGATTCCAG CACCTCCAGT CCCAGAAACC 
ACCCCAACTC CACCTACTAA GACTGGGACC TGGGAAGCTC CGGTGGATTC TAGTACAAGT 
GGACTTGAGC AAGATGTGGC ACAACTAAAT ATAGCAGAAC AGAATTGGAG TCCGGGGCAG 
CCTTCTTTCC TGCAACCACG GGAACTTCGA GGTATGCCCA ACCATATACA CATGGGAGCA 
GGACCTCCAC CTCAGTTTAA CCGGATGGAA GAAATGGGTG TCCAGGGTGG TCGAGCCAAA 
CGCTATTCAT CCCAGCGGCA AAGACCTGTG CCAGAGCCCC CCGCCCCTCC AGTGCATATC 
AGTATCATGG AGGGACATTA CTATGATCCA CTGCAGTTCC AGGGACCAAT CTATACCCAT 
GGTGACAGCC CTGCCCCGCT GCCTCCACAG GGCATGCTTG TGCAGCCAGG AATGAACCTT 
CCCCACCCAG GTTTACATCC CCACCAGACA CCAGCTCCTC TGCCCAATCC AGGCCTCTAT 
CCCCCACCAG TGTCCATGTC TCCAGGACAG CCACCACCTC AGCAGTTGCT TGCTCCTACT 
TACTTTTCTG CTCCAGGCGT CATGAACTTT GGTAATCCCA GTTACCCTTA TGCTCCAGGG 
GCACTGCCTC CCCCACCACC GCCTCATCTG TATCCTAATA CACAGGCCCC ATCACAGGTA 
TATGGAGGAG TGACCTACTA TAACCCCGCC CAGCAGCAGG TGCAGCCAAA GCCCTCCCCA 
CCCCGGAGGA CTCCCCAGCC AGTCACCATC AAGCCCCCTC CACCTGAGGT TGTAAGCAGG 
GGTTCCAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005257220.1
CDS	44..2155
Translation	MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS

Target ORF information:

RefSeq Version	XM_005257163.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CASC3 exon junction complex subunit (CASC3), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005257163.2

ORF Insert Sequence:

ATGGCGGACC GGCGGCGGCA GCGCGCTTCG CAAGACACCG AGGACGAGGA ATCTGGTGCT 
TCGGGCTCCG ACAGCGGCGG CTCCCCGTTG CGGGGAGGCG GGAGCTGCAG CGGTAGCGCC 
GGAGGCGGCG GCAGCGGCTC TCTGCCTTCA CAGCGCGGAG GCCGAACCGG GGCCCTTCAT 
CTGCGGCGGG TGGAGAGCGG GGGCGCCAAG AGTGCTGAGG AGTCGGAGTG TGAGAGTGAA 
GATGGCATTG AAGGTGATGC TGTTCTCTCG GATTATGAAA GTGCAGAAGA CTCGGAAGGT 
GAAGAAGGTG AATACAGTGA AGAGGAAAAC TCCAAAGTGG AGCTGAAATC AGAAGCTAAT 
GATGCTGTTA ATTCTTCAAC AAAAGAAGAG AAGGGAGAAG AAAAGCCTGA CACCAAAAGC 
ACTGTGACTG GAGAGAGGCA AAGTGGGGAC GGACAGGAGA GCACAGAGCC TGTGGAGAAC 
AAAGTGGGTA AAAAGGGCCC TAAGCATTTG GATGATGATG AAGATCGGAA GAATCCAGCA 
TACATACCTC GGAAAGGGCT CTTCTTTGAG CATGATCTTC GAGGGCAAAC TCAGGAGGAG 
GAAGTCAGAC CCAAGGGGCG TCAGCGAAAG CTATGGAAGG ATGAGGGTCG CTGGGAGCAT 
GACAAGTTCC GGGAAGATGA GCAGGCCCCA AAGTCCCGAC AGGAGCTCAT TGCTCTTTAT 
GGTTATGACA TTCGCTCAGC TCATAATCCT GATGACATCA AACCTCGAAG AATCCGGAAA 
CCCCGATATG GGAGTCCTCC ACAAAGAGAT CCAAACTGGA ACGGTGAGCG GCTAAACAAG 
TCTCATCGCC ACCAGGGTCT TGGGGGCACC CTACCACCAA GGACATTTAT TAACAGGAAT 
GCTGCAGGTA CCGGCCGTAT GTCTGCACCC AGGAATTATT CTCGATCTGG GGGCTTCAAG 
GAAGGTCGTG CTGGTTTTAG GCCTGTGGAA GCTGGTGGGC AGCATGGTGG CCGGTCTGGT 
GAGACTGTTA AGCATGAGAT TAGTTACCGG TCACGGCGCC TAGAGCAGAC TTCTGTGAGG 
GATCCATCTC CAGAAGCAGA TGCTCCAGTG CTTGGCAGTC CTGAGAAGGA AGAGGCAGCC 
TCAGAGCCAC CAGCTGCTGC TCCTGATGCT GCACCACCAC CCCCTGATAG GCCCATTGAG 
AAGAAATCCT ATTCCCGGGC AAGAAGAACT CGAACCAAAG TTGGAGATGC AGTCAAGCTT 
GCAGAGGAGG TGCCCCCTCC TCCTGAAGGA CTGATTCCAG CACCTCCAGT CCCAGAAACC 
ACCCCAACTC CACCTACTAA GACTGGGACC TGGGAAGCTC CGGTGGATTC TAGTACAAGT 
GGACTTGAGC AAGATGTGGC ACAACTAAAT ATAGCAGAAC AGAATTGGAG TCCGGGGCAG 
CCTTCTTTCC TGCAACCACG GGAACTTCGA GGTATGCCCA ACCATATACA CATGGGAGCA 
GGACCTCCAC CTCAGTTTAA CCGGATGGAA GAAATGGGTG TCCAGGGTGG TCGAGCCAAA 
CGCTATTCAT CCCAGCGGCA AAGACCTGTG CCAGAGCCCC CCGCCCCTCC AGTGCATATC 
AGTATCATGG AGGGACATTA CTATGATCCA CTGCAGTTCC AGGGACCAAT CTATACCCAT 
GGTGACAGCC CTGCCCCGCT GCCTCCACAG GGCATGCTTG TGCAGCCAGG AATGAACCTT 
CCCCACCCAG GTTTACATCC CCACCAGACA CCAGCTCCTC TGCCCAATCC AGGCCTCTAT 
CCCCCACCAG TGTCCATGTC TCCAGGACAG CCACCACCTC AGCAGTTGCT TGCTCCTACT 
TACTTTTCTG CTCCAGGCGT CATGAACTTT GGTAATCCCA GTTACCCTTA TGCTCCAGGG 
GCACTGCCTC CCCCACCACC GCCTCATCTG TATCCTAATA CACAGGCCCC ATCACAGGTA 
TATGGAGGAG TGACCTACTA TAACCCCGCC CAGCAGCAGG TGCAGCCAAA GCCCTCCCCA 
CCCCGGAGGA CTCCCCAGCC AGTCACCATC AAGCCCCCTC CACCTGAGGT TGTAAGCAGG 
GGTTCCAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of a human catalytic step I spliceosome.
Science (New York, N.Y.)(2018 Jan)
Zhan X,Yan C,Zhang X,Lei J,Shi Y

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
RNA (New York, N.Y.)23(1)23-31(2017 01)
Mao H,Brown HE,Silver DL

Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3.
Oncotarget7(18)26027-41(2016 May)
Xu L,Dai W,Li J,He L,Wang F,Xia Y,Chen K,Li S,Liu T,Lu J,Zhou Y,Wang Y,Guo C

EJC core component MLN51 interacts with eIF3 and activates translation.
Proceedings of the National Academy of Sciences of the United States of America110(15)5903-8(2013 Apr)
Chazal PE,Daguenet E,Wendling C,Ulryck N,Tomasetto C,Sargueil B,Le Hir H

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CASC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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