Nppc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nppc
Entrez Gene ID	18159
Full Name	natriuretic peptide type C
Synonyms	CNP,lbab
General protein information	Preferred Names natriuretic peptide type C Names C-type natriuretic peptide natriuretic peptide precursor C natriuretic peptide precursor type C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 C5\|1 43.98 cM
Summary	This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010933.5	NP_035063.1	C-type natriuretic peptide preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NPPC	XP_852684.1
Rattus norvegicus (Norway rat)	Nppc	NP_446202.1
Pan troglodytes (chimpanzee)	NPPC	XP_001141992.1
Xenopus tropicalis (tropical clawed frog)	nppc	NP_001106395.1
	NPPC	XP_001108190.2
Homo sapiens (human)	NPPC	NP_077720.1
Bos taurus (cattle)	NPPC	NP_776550.1
Danio rerio (zebrafish)	LOC100536373	XP_003201196.1
Mus musculus (house mouse)	Nppc	NP_035063.1
Danio rerio (zebrafish)	si:ch211-126j24.3	NP_001103410.1

Gene Ontology
Bibliography

Related articles in PubMed

Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.
Blaser MC, Wei K, Adams RL, Zhou YQ, Caruso LL, Mirzaei Z, Lam A, Tam RK, Zhang H, Heximer SP, Henkelman M, Simmons CA
Circulation research(2017 Dec)

A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice.
Jiao Y, Yan J, Jiao F, Yang H, Donahue LR, Li X, Roe BA, Stuart J, Gu W
BMC genetics816(2007 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2)
Title: Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals.

CNP activates bone turnover and remodeling in vivo and possibly accelerates fracture healing in a mouse model.
Title: Increased Bone Turnover and Possible Accelerated Fracture Healing in a Murine Model With an Increased Circulating C-Type Natriuretic Peptide.

The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP)--are summarized in the review.
Title: [C-TYPE NATRIURETIC PEP- TIDE: WHAT, WHERE AND WHAT FOR IS THIS?].

CNP/NPR-C pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders
Title: Endothelial C-type natriuretic peptide maintains vascular homeostasis.

Connexin mimetics directed against connexin-43 (Cx43 CMP) overcame NPPC-mediated meiotic arrest in both isolated cumulus oocyte complexes and antral follicles.
Title: Prophase I arrest of mouse oocytes mediated by natriuretic peptide precursor C requires GJA1 (connexin-43) and GJA4 (connexin-37) gap junctions in the antral follicle and cumulus-oocyte complex.

The following Nppc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nppc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16182	NM_010933.5 Latest version!	Mus musculus natriuretic peptide type C (Nppc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nppc ( NM_010933.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035063.1 Mus musculus natriuretic peptide type C (Nppc), mRNA.

Price & Availability↑

CloneID	OMu16182
Clone ID Related Accession (Same CDS sequence)	NM_010933.5
Accession Version	NM_010933.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Mus musculus(house mouse)
Product	C-type natriuretic peptide preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY718381.1, AK036176.1 and AC158132.6. On Apr 2, 2011 this sequence version replaced NM_010933.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036176.1, AK020093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

ATGCACCTCT CCCAGCTGAT CGCCTGCGCC CTGCTGCTCG CGCTACTCTC GCTCCGGCCC 
TCTGAAGCCA AGCCCGGGAC ACCACCGAAG GTCCCGAGAA CCCCGCCAGG GGAGGAGCTG 
GCGGATTCCC AGGCAGCTGG TGGCAATCAG AAAAAGGGTG ACAAGACTCC AGGCAGCGGG 
GGAGCCAATC TCAAGGGAGA CCGATCGCGA CTGCTCCGGG ACCTGCGTGT GGACACCAAG 
TCCCGGGCTG CTTGGGCCCG CCTTCTGCAC GAGCACCCCA ACGCGCGCAA ATACAAAGGC 
GGCAACAAGA AGGGCTTGTC CAAAGGCTGC TTTGGCCTCA AGCTGGACCG GATCGGCTCC 
ATGAGCGGTC TGGGATGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035063.1
CDS	136..516
Translation	MHLSQLIACALLLALLSLRPSEAKPGTPPKVPRTPPGEELADSQAAGGNQKKGDKTPGSGGANLKGDRSRLLRDLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC

Target ORF information:

RefSeq Version	NM_010933.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus natriuretic peptide type C (Nppc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010933.5

ORF Insert Sequence:

ATGCACCTCT CCCAGCTGAT CGCCTGCGCC CTGCTGCTCG CGCTACTCTC GCTCCGGCCC 
TCTGAAGCCA AGCCCGGGAC ACCACCGAAG GTCCCGAGAA CCCCGCCAGG GGAGGAGCTG 
GCGGATTCCC AGGCAGCTGG TGGCAATCAG AAAAAGGGTG ACAAGACTCC AGGCAGCGGG 
GGAGCCAATC TCAAGGGAGA CCGATCGCGA CTGCTCCGGG ACCTGCGTGT GGACACCAAG 
TCCCGGGCTG CTTGGGCCCG CCTTCTGCAC GAGCACCCCA ACGCGCGCAA ATACAAAGGC 
GGCAACAAGA AGGGCTTGTC CAAAGGCTGC TTTGGCCTCA AGCTGGACCG GATCGGCTCC 
ATGAGCGGTC TGGGATGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.
Circulation research(2017 Dec)
Blaser MC,Wei K,Adams RL,Zhou YQ,Caruso LL,Mirzaei Z,Lam A,Tam RK,Zhang H,Heximer SP,Henkelman M,Simmons CA

A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice.
BMC genetics816(2007 Apr)
Jiao Y,Yan J,Jiao F,Yang H,Donahue LR,Li X,Roe BA,Stuart J,Gu W

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Nppc cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報