Nppc cDNA ORF clone, Rattus norvegicus(Norway rat)

Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
Lu J, Pan SS
The journal of physiological sciences : JPS67(4)475-487(2017 Jul)

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Buttgereit J, Shanks J, Li D, Hao G, Athwal A, Langenickel TH, Wright H, da Costa Goncalves AC, Monti J, Plehm R, Popova E, Qadri F, Lapidus I, Ryan B, ?zcelik C, Paterson DJ, Bader M, Herring N
Cardiovascular research112(3)637-644(2016 Dec)

Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism.
Dickey DM, Edmund AB, Otto NM, Chaffee TS, Robinson JW, Potter LR
The Journal of biological chemistry291(21)11385-93(2016 May)

C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation.
Title: C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.

The CNP/NPR-B pathway is upregulated in the rectum of depressed rats and may be one mechanism for depression-associated digestive disorders. Xiaoyaosan antagonizes this pathway at least partially.
Title: CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan.

Study findings suggest that CNP could ameliorate ischemia-reperfusion-induced acute kidney injury through inhibition of apoptotic and oxidative stress pathways, possibly through natriuretic peptide receptor-B-cGMP signaling
Title: C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats.

A significant direct relationship was determined between plasma CNP levels and prolonged intervals of mesenteric ischaemia.
Title: Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia.

These preliminary data give new insights into the relationship between natriuretic peptide signaling and sKATP in the myocardium.
Title: Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes.