Nnmt cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nnmt
Entrez Gene ID	18113
Full Name	nicotinamide N-methyltransferase
General protein information	Preferred Names nicotinamide N-methyltransferase Names nicotinamide N-methyltransferase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 A5.3\|9 26.45 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001311062.1	NP_001297991.1	nicotinamide N-methyltransferase isoform 2
XM_006510077.4	XP_006510140.1	nicotinamide N-methyltransferase isoform X2
NM_010924.3	NP_035054.1	nicotinamide N-methyltransferase isoform 1
XM_011242417.1	XP_011240719.1	nicotinamide N-methyltransferase isoform X1
XM_011242417.2	XP_011240719.1	nicotinamide N-methyltransferase isoform X1
XM_006510077.3	XP_006510140.1	nicotinamide N-methyltransferase isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NNMT	XP_001150091.1
Xenopus tropicalis (tropical clawed frog)	nnmt	XP_002942948.2
Canis lupus familiaris (dog)	NNMT	XP_546514.2
Mus musculus (house mouse)	Nnmt	NP_035054.1
	NNMT	XP_001086727.1
Rattus norvegicus (Norway rat)	Nnmt	NP_001100289.1
Xenopus tropicalis (tropical clawed frog)	inmt	NP_001128277.1
Xenopus tropicalis (tropical clawed frog)	nnmt	XP_002942950.2
Xenopus tropicalis (tropical clawed frog)	LOC100496871	XP_002942952.2
Xenopus tropicalis (tropical clawed frog)	LOC100127789	XP_004916158.1
Homo sapiens (human)	NNMT	NP_006160.1
Xenopus tropicalis (tropical clawed frog)	inmt	XP_002942951.2

Gene Ontology
Bibliography

Related articles in PubMed

Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
Swaminathan S, Birudukota S, Thakur MK, Parveen R, Kandan S, Juluri S, Shaik S, Anand NN, Burri RR, Kristam R, Hallur MS, Rajagopal S, Schreuder H, Langer T, Rudolph C, Ruf S, Dhakshinamoorthy S, Gosu R, Kannt A
Biochemical and biophysical research communications491(2)416-422(2017 09)

Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex.
Fame RM, Dehay C, Kennedy H, Macklis JD
Cerebral cortex (New York, N.Y. : 1991)27(3)1817-1830(2017 Mar)

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB
Nature508(7495)258-62(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide have been presented.
Title: Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.

NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 signalling, and is a unique and attractive target for treating obesity and type 2 diabetes
Title: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Brain NNMT expression was not altered in hyperhomocysteinemia.
Title: Hyperhomocysteinemia does not affect global DNA methylation and nicotinamide N-methyltransferase expression in mice.

Adipose tissue is a source of nicotinamide N-methyltransferase and homocysteine.
Title: Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.

the progression of vascular inflammation and atherosclerosis was associated with the upregulation of hepatic nicotinamide N-methyltransferase activity and subsequent increase in endogenous MNA plasma levels
Title: Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis.

The following Nnmt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nnmt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22097	NM_010924.3 Latest version!	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu68323	NM_001311062.1 Latest version!	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu22097	XM_011242417.2 Latest version!	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu42053	XM_006510077.4 Latest version!	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu22097	XM_011242417.1	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu42053	XM_006510077.3	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nnmt ( NM_010924.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035054.1 Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22097
Clone ID Related Accession (Same CDS sequence)	NM_010924.3 , XM_011242417.1 , XM_011242417.2
Accession Version	NM_010924.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	nicotinamide N-methyltransferase isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113548.22, CF732455.1, BC028757.1 and AK006371.1. On Jul 22, 2015 this sequence version replaced NM_010924.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U86105.1, BC028757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGAATGAAGG GACCTGAGAA GGAGGAGAAG TTGAGGCGTG CAATCAAGCA GGTACTAAAG 
TGTGATGTGA CCCAGAGCCA GCCTCTGGGT GGGGTCTCTC TGCCTCCTGC TGACTGCTTG 
CTCAGCACGC TGTGCCTGGA TGCTGCCTGC CCTGACCTCC CGGCCTATCG CACTGCCCTC 
AGGAACCTGG GCAGTCTGCT CAAGCCAGGA GGCTTCCTGG TGATGGTAGA TGCCCTGAAG 
AGTAGCTACT ACATGATTGG GGAGCAGAAG TTTTCCAGCC TTCCCCTGGG ATGGGAGACT 
GTTCGAGATG CTGTGGAAGA GGCCGGTTAC ACCATTGAGC AGTTTGAGGT GATTTCTCAA 
AATTACTCTT CTACCACATC CAATAATGAA GGACTCTTCT CCCTAGTGGG GCGAAAGCCA 
GGCAGATCTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035054.1
CDS	166..960
Translation	MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSLPPADCLLSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLFSLVGRKPGRSE

Target ORF information:

RefSeq Version	NM_010924.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010924.3

ORF Insert Sequence:

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGAATGAAGG GACCTGAGAA GGAGGAGAAG TTGAGGCGTG CAATCAAGCA GGTACTAAAG 
TGTGATGTGA CCCAGAGCCA GCCTCTGGGT GGGGTCTCTC TGCCTCCTGC TGACTGCTTG 
CTCAGCACGC TGTGCCTGGA TGCTGCCTGC CCTGACCTCC CGGCCTATCG CACTGCCCTC 
AGGAACCTGG GCAGTCTGCT CAAGCCAGGA GGCTTCCTGG TGATGGTAGA TGCCCTGAAG 
AGTAGCTACT ACATGATTGG GGAGCAGAAG TTTTCCAGCC TTCCCCTGGG ATGGGAGACT 
GTTCGAGATG CTGTGGAAGA GGCCGGTTAC ACCATTGAGC AGTTTGAGGT GATTTCTCAA 
AATTACTCTT CTACCACATC CAATAATGAA GGACTCTTCT CCCTAGTGGG GCGAAAGCCA 
GGCAGATCTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nnmt ( XM_011242417.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011240719.1 Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu22097
Clone ID Related Accession (Same CDS sequence)	NM_010924.3 , XM_011242417.1 , XM_011242417.2
Accession Version	XM_011242417.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	nicotinamide N-methyltransferase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGAATGAAGG GACCTGAGAA GGAGGAGAAG TTGAGGCGTG CAATCAAGCA GGTACTAAAG 
TGTGATGTGA CCCAGAGCCA GCCTCTGGGT GGGGTCTCTC TGCCTCCTGC TGACTGCTTG 
CTCAGCACGC TGTGCCTGGA TGCTGCCTGC CCTGACCTCC CGGCCTATCG CACTGCCCTC 
AGGAACCTGG GCAGTCTGCT CAAGCCAGGA GGCTTCCTGG TGATGGTAGA TGCCCTGAAG 
AGTAGCTACT ACATGATTGG GGAGCAGAAG TTTTCCAGCC TTCCCCTGGG ATGGGAGACT 
GTTCGAGATG CTGTGGAAGA GGCCGGTTAC ACCATTGAGC AGTTTGAGGT GATTTCTCAA 
AATTACTCTT CTACCACATC CAATAATGAA GGACTCTTCT CCCTAGTGGG GCGAAAGCCA 
GGCAGATCTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011240719.1
CDS	226..1020
Translation	MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSLPPADCLLSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLFSLVGRKPGRSE

Target ORF information:

RefSeq Version	XM_011242417.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011242417.1

ORF Insert Sequence:

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGAATGAAGG GACCTGAGAA GGAGGAGAAG TTGAGGCGTG CAATCAAGCA GGTACTAAAG 
TGTGATGTGA CCCAGAGCCA GCCTCTGGGT GGGGTCTCTC TGCCTCCTGC TGACTGCTTG 
CTCAGCACGC TGTGCCTGGA TGCTGCCTGC CCTGACCTCC CGGCCTATCG CACTGCCCTC 
AGGAACCTGG GCAGTCTGCT CAAGCCAGGA GGCTTCCTGG TGATGGTAGA TGCCCTGAAG 
AGTAGCTACT ACATGATTGG GGAGCAGAAG TTTTCCAGCC TTCCCCTGGG ATGGGAGACT 
GTTCGAGATG CTGTGGAAGA GGCCGGTTAC ACCATTGAGC AGTTTGAGGT GATTTCTCAA 
AATTACTCTT CTACCACATC CAATAATGAA GGACTCTTCT CCCTAGTGGG GCGAAAGCCA 
GGCAGATCTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nnmt ( NM_001311062.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001297991.1 Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu68323
Clone ID Related Accession (Same CDS sequence)	NM_001311062.1
Accession Version	NM_001311062.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	nicotinamide N-methyltransferase isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113548.22 and AA152901.1. On Jul 22, 2015 this sequence version replaced XM_006510078.2. Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region that result in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a novel C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U89377.1, CD240988.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGAATGAAGG GACCTGAGAA GGAGGAGAAG TTGAGGCGTG CAATCAAGCA GGAACCTGGG 
CAGTCTGCTC AAGCCAGGAG GCTTCCTGGT GATGGTAGAT GCCCTGAAGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297991.1
CDS	166..639
Translation	MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQEPGQSAQARRLPGDGRCPEE

Target ORF information:

RefSeq Version	NM_001311062.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311062.1

ORF Insert Sequence:

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGAATGAAGG GACCTGAGAA GGAGGAGAAG TTGAGGCGTG CAATCAAGCA GGAACCTGGG 
CAGTCTGCTC AAGCCAGGAG GCTTCCTGGT GATGGTAGAT GCCCTGAAGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nnmt ( XM_006510077.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006510140.1 Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu42053
Clone ID Related Accession (Same CDS sequence)	XM_006510077.4 , XM_006510077.3
Accession Version	XM_006510077.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	nicotinamide N-methyltransferase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006510077.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGGTGCACGA CTTACTCGAC AAAACAAATC ATGGACTCGG CACATAAATG CATCTTTAGA 
GGTCTCCACA AGAAGAAAAC AAAAACGAGT TGTTTTCCCT GGTGGTACAG CCGCCACTCG 
GCACCGAAGC ATGGAGAAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006510140.1
CDS	1080..1583
Translation	MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGNRCTTYSTKQIMDSAHKCIFRGLHKKKTKTSCFPWWYSRHSAPKHGET

Target ORF information:

RefSeq Version	XM_006510077.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006510077.3

ORF Insert Sequence:

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGGTGCACGA CTTACTCGAC AAAACAAATC ATGGACTCGG CACATAAATG CATCTTTAGA 
GGTCTCCACA AGAAGAAAAC AAAAACGAGT TGTTTTCCCT GGTGGTACAG CCGCCACTCG 
GCACCGAAGC ATGGAGAAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nnmt ( XM_011242417.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011240719.1 Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu22097
Clone ID Related Accession (Same CDS sequence)	NM_010924.3 , XM_011242417.1 , XM_011242417.2
Accession Version	XM_011242417.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	nicotinamide N-methyltransferase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011242417.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGAATGAAGG GACCTGAGAA GGAGGAGAAG TTGAGGCGTG CAATCAAGCA GGTACTAAAG 
TGTGATGTGA CCCAGAGCCA GCCTCTGGGT GGGGTCTCTC TGCCTCCTGC TGACTGCTTG 
CTCAGCACGC TGTGCCTGGA TGCTGCCTGC CCTGACCTCC CGGCCTATCG CACTGCCCTC 
AGGAACCTGG GCAGTCTGCT CAAGCCAGGA GGCTTCCTGG TGATGGTAGA TGCCCTGAAG 
AGTAGCTACT ACATGATTGG GGAGCAGAAG TTTTCCAGCC TTCCCCTGGG ATGGGAGACT 
GTTCGAGATG CTGTGGAAGA GGCCGGTTAC ACCATTGAGC AGTTTGAGGT GATTTCTCAA 
AATTACTCTT CTACCACATC CAATAATGAA GGACTCTTCT CCCTAGTGGG GCGAAAGCCA 
GGCAGATCTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011240719.1
CDS	246..1040
Translation	MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSLPPADCLLSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLFSLVGRKPGRSE

Target ORF information:

RefSeq Version	XM_011242417.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011242417.2

ORF Insert Sequence:

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGAATGAAGG GACCTGAGAA GGAGGAGAAG TTGAGGCGTG CAATCAAGCA GGTACTAAAG 
TGTGATGTGA CCCAGAGCCA GCCTCTGGGT GGGGTCTCTC TGCCTCCTGC TGACTGCTTG 
CTCAGCACGC TGTGCCTGGA TGCTGCCTGC CCTGACCTCC CGGCCTATCG CACTGCCCTC 
AGGAACCTGG GCAGTCTGCT CAAGCCAGGA GGCTTCCTGG TGATGGTAGA TGCCCTGAAG 
AGTAGCTACT ACATGATTGG GGAGCAGAAG TTTTCCAGCC TTCCCCTGGG ATGGGAGACT 
GTTCGAGATG CTGTGGAAGA GGCCGGTTAC ACCATTGAGC AGTTTGAGGT GATTTCTCAA 
AATTACTCTT CTACCACATC CAATAATGAA GGACTCTTCT CCCTAGTGGG GCGAAAGCCA 
GGCAGATCTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nnmt ( XM_006510077.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006510140.1 Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X2, mRNA.

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CloneID	OMu42053
Clone ID Related Accession (Same CDS sequence)	XM_006510077.4 , XM_006510077.3
Accession Version	XM_006510077.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	nicotinamide N-methyltransferase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006510077.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGGTGCACGA CTTACTCGAC AAAACAAATC ATGGACTCGG CACATAAATG CATCTTTAGA 
GGTCTCCACA AGAAGAAAAC AAAAACGAGT TGTTTTCCCT GGTGGTACAG CCGCCACTCG 
GCACCGAAGC ATGGAGAAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006510140.1
CDS	1081..1584
Translation	MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGNRCTTYSTKQIMDSAHKCIFRGLHKKKTKTSCFPWWYSRHSAPKHGET

Target ORF information:

RefSeq Version	XM_006510077.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006510077.4

ORF Insert Sequence:

ATGGAATCTG GCTTCACCTC CAAGGACACT TATCTAAGTC ATTTTAATCC TCGGGATTAC 
TTGGAAAAAT ATTACAGCTT TGGGTCCAGA CACTGTGCAG AAAACGAGAT CCTCAGACAT 
CTGCTGAAAA ATCTTTTTAA GATATTCTGC CTGGGTGCTG TAAAAGGAGA ACTCCTGATT 
GACATTGGCT CTGGCCCCAC CATCTATCAG CTTCTCTCTG CCTGTGAGTC CTTCACGGAG 
ATCATTGTCT CTGACTACAC AGACCAGAAC CTCTGGGAGC TGCAGAAATG GCTGAAGAAG 
GAACCAGGAG CCTTTGACTG GTCCCCAGTG GTCACCTATG TGTGTGATCT TGAAGGCAAC 
AGGTGCACGA CTTACTCGAC AAAACAAATC ATGGACTCGG CACATAAATG CATCTTTAGA 
GGTCTCCACA AGAAGAAAAC AAAAACGAGT TGTTTTCCCT GGTGGTACAG CCGCCACTCG 
GCACCGAAGC ATGGAGAAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
Biochemical and biophysical research communications491(2)416-422(2017 09)
Swaminathan S,Birudukota S,Thakur MK,Parveen R,Kandan S,Juluri S,Shaik S,Anand NN,Burri RR,Kristam R,Hallur MS,Rajagopal S,Schreuder H,Langer T,Rudolph C,Ruf S,Dhakshinamoorthy S,Gosu R,Kannt A

Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex.
Cerebral cortex (New York, N.Y. : 1991)27(3)1817-1830(2017 Mar)
Fame RM,Dehay C,Kennedy H,Macklis JD

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Nature508(7495)258-62(2014 Apr)
Kraus D,Yang Q,Kong D,Banks AS,Zhang L,Rodgers JT,Pirinen E,Pulinilkunnil TC,Gong F,Wang YC,Cen Y,Sauve AA,Asara JM,Peroni OD,Monia BP,Bhanot S,Alhonen L,Puigserver P,Kahn BB

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Nnmt cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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