Mx2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mx2
Entrez Gene ID	17858
Full Name	MX dynamin-like GTPase 2
Synonyms	AI528743,Mx-2
General protein information	Preferred Names MX dynamin-like GTPase 2 Names interferon-induced GTP-binding protein Mx2 myxovirus (influenza virus) resistance 2 myxovirus resistance protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 C4\|16 57.51 cM
Summary	This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to vesicular stomatitis virus, a member of the rhabdovirus family, but not to influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a frameshift that inactivates this gene product. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013606.1	NP_038634.1	interferon-induced GTP-binding protein Mx2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.
N?rnberger C, Zimmermann V, Gerhardt M, Staeheli P
Journal of virology90(23)10682-10692(2016 Dec)

Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid.
Kong J, Xu B, Wei W, Wang X, Xie W, Yu XF
Protein & cell5(12)954-7(2014 Dec)

The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling.
Budry L, Balsalobre A, Gauthier Y, Khetchoumian K, L'honor? A, Vallette S, Brue T, Figarella-Branger D, Meij B, Drouin J
Genes & development26(20)2299-310(2012 Oct)

Impact of lactobacilli on orally acquired listeriosis.
Archambaud C, Nahori MA, Soubigou G, B?cavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)

Functional diversity of Mx proteins: variations on a theme of host resistance to infection.
Lee SH, Vidal SM
Genome research12(4)527-30(2002 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized.
Title: Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid.

The following Mx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09673	NM_013606.1 Latest version!	Mus musculus MX dynamin-like GTPase 2 (Mx2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mx2 ( NM_013606.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038634.1 Mus musculus MX dynamin-like GTPase 2 (Mx2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu09673
Clone ID Related Accession (Same CDS sequence)	NM_013606.1
Accession Version	NM_013606.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	interferon-induced GTP-binding protein Mx2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB029920.1. On Jul 25, 2007 this sequence version replaced XR_035745.1. Transcript Variant: This variant (1) encodes the functional protein. This variant is not expressed in the mouse reference genome strain. Sequence Note: This RefSeq record was created to represent the transcript and the full-length, functional protein that is expressed in several strains. It does not contain a one nucleotide insertion that causes a frameshift in the CDS of several strains, including the strain of the reference genome, C57BL/6J. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KX774217.1, BC007127.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849380, SAMN00849385 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 2460745, 10233954 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTCTTA GCACAGAAGA AAACACAGGC GTTGATTCAG TCAACTTACC CAGTGGAGAG 
ACGGGCCTAG GAGAGAAAGA CCAGGAGTCT GTGAACAATC TCTGCAGTCA GTATGAGGAG 
AAGGTGCGGC CCTGCATTGA CCTCATCGAC TCCCTGCGGG CTCTGGGTGT GGAGCAGGAC 
CTGGCCCTGC CTGCCATCGC TGTCATTGGG GACCAGAGTT CAGGGAAGAG CTCTGTGCTG 
GAAGCACTGT CTGGAGTGGC CCTCCCCAGA GGCAGTGGTA TTGTCACCAG ATGCCCTCTG 
GTGCTGAAAT TGAGGAAGCT GAATGAGGGA GAGGAGTGGA GAGGCAAAGT CTCCTATGAT 
GACATCGAAG TGGAGCTCTC TGATCCTTCA GAGGTGGAAG AGGCCATCAA CAAGGGTCAG 
AACTTCATTG CTGGGGTAGG TCTGGGGATC AGTGATAAGC TCATTAGCCT GGATGTCAGC 
TCCCCAAATG TCCCAGACCT GACTCTCATT GACCTGCCTG GAATTACCAG GGTGGCTGTA 
GGCAACCAGC CTGCAGACAT AGGACGCCAG ATCAAGAGAC TCATCAAGAC ATACATCCAA 
AAACAGGAGA CCATCAACCT GGTGGTGGTC CCCAGCAATG TGGACATTGC CACCACAGAG 
GCTCTGAGCA TGGCTCAGGA GGTGGACCCT GAAGGGGATA GGACCATAGG GATCTTGACC 
AAGCCCGATC TGGTGGACAG AGGTACTGAA GACAAGGTCG TGGATGTGGT GCGGAACCTG 
GTGTACCATC TGAAGAAGGG CTACATGATA GTCAAGTGCA GAGGCCAGCA GGACATCCAA 
GAGCAGCTGA GCCTGACTGA GGCTCTTCAG AATGAGCAAA TCTTCTTCAA GGAACACCCT 
CATTTCAGAG TTCTTCTGGA GGATGGGAAG GCCACAGTGC CCTGCCTGGC AGAGAGACTG 
ACCGCAGAGC TCATCTTACA CATCTGTAAA TCTCTTCCTC TGCTAGAAAA TCAAATAAAG 
GAAAGTCACC AGAGTGCAAG TGAGGAGCTG CAGAAGTACG GTATGGACAT ACCAGAAGAT 
GACAGTGAAA AAACGTTCTT CCTGATTGAA AAAATCAATG CTTTTAACCA GGACATCACT 
GCCCTAGTAC AAGGGGAAGA GAATGTGGCA GAGGGAGAAT GTCGCCTATT CACCAGGCTC 
CGAAAAGAGT TCTTGTCCTG GAGTAAGGAG ATCGAAAAGA ATTTCGCAAA AGGTTATGCT 
GTTTTATATA ATGAAGTCTG GGCATTTGAA AAGCAGTACC GTGGACGAGA ATTGCCAGGG 
TTTGTGAATT ACAAAACATT TGAGAACATT ATAAGAAGAC AAATCAAAAC CCTGGAAGAA 
CCAGCTATAG AAATGCTGCA CACGGTCACT GAAATTGTAC GAGCTGCCTT TACAAGTGTT 
TCTGAGAAAA ATTTTTCTGA GTTTTATAAC CTCCACAGAA CTACCAAGTC CAAACTTGAA 
GACATCAGAT TAGAACAAGA AAAGGAAGCA GAGATGTCAA TCCGACTCCA CTTCAAGATG 
GAACAAATTA TCTACTGCCA GGACCAGATT TACAGAGGAG CCTTGCAGAA GGTCAGAGAG 
GAGGAAGCTG AGGAGGAGAA GAAGACAAAG CATGGCACTT CCAGTTCCTC TCAGTCCCAA 
GATTTACAGA CCTCATCCAT GGCTGAGATC TTCCAGCATC TGAATGCCTA CCGCCAAGAG 
GCTCACAACC GCATCTCCAG CCACGTTCCC TTGATCATCC AGTATTTCAT CCTGAAAATG 
TTTGCTGAGC GGCTGCAGAA GGGCATGCTC CAGCTCCTGC AGGACAAGGA TTCCTGCAGC 
TGGCTCCTGA AGGAGCAGAG TGACACAAGC GAGAAGAGGA AGTTCCTGAA GGAGAGGCTG 
GCAAGGCTGG CCCAGGCTCG GCGCCGGCTA GCCAAATTCC CTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038634.1
CDS	120..2087
Translation	MVLSTEENTGVDSVNLPSGETGLGEKDQESVNNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLRKLNEGEEWRGKVSYDDIEVELSDPSEVEEAINKGQNFIAGVGLGISDKLISLDVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDRGTEDKVVDVVRNLVYHLKKGYMIVKCRGQQDIQEQLSLTEALQNEQIFFKEHPHFRVLLEDGKATVPCLAERLTAELILHICKSLPLLENQIKESHQSASEELQKYGMDIPEDDSEKTFFLIEKINAFNQDITALVQGEENVAEGECRLFTRLRKEFLSWSKEIEKNFAKGYAVLYNEVWAFEKQYRGRELPGFVNYKTFENIIRRQIKTLEEPAIEMLHTVTEIVRAAFTSVSEKNFSEFYNLHRTTKSKLEDIRLEQEKEAEMSIRLHFKMEQIIYCQDQIYRGALQKVREEEAEEEKKTKHGTSSSSQSQDLQTSSMAEIFQHLNAYRQEAHNRISSHVPLIIQYFILKMFAERLQKGMLQLLQDKDSCSWLLKEQSDTSEKRKFLKERLARLAQARRRLAKFPG

Target ORF information:

RefSeq Version	NM_013606.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MX dynamin-like GTPase 2 (Mx2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013606.1

ORF Insert Sequence:

ATGGTTCTTA GCACAGAAGA AAACACAGGC GTTGATTCAG TCAACTTACC CAGTGGAGAG 
ACGGGCCTAG GAGAGAAAGA CCAGGAGTCT GTGAACAATC TCTGCAGTCA GTATGAGGAG 
AAGGTGCGGC CCTGCATTGA CCTCATCGAC TCCCTGCGGG CTCTGGGTGT GGAGCAGGAC 
CTGGCCCTGC CTGCCATCGC TGTCATTGGG GACCAGAGTT CAGGGAAGAG CTCTGTGCTG 
GAAGCACTGT CTGGAGTGGC CCTCCCCAGA GGCAGTGGTA TTGTCACCAG ATGCCCTCTG 
GTGCTGAAAT TGAGGAAGCT GAATGAGGGA GAGGAGTGGA GAGGCAAAGT CTCCTATGAT 
GACATCGAAG TGGAGCTCTC TGATCCTTCA GAGGTGGAAG AGGCCATCAA CAAGGGTCAG 
AACTTCATTG CTGGGGTAGG TCTGGGGATC AGTGATAAGC TCATTAGCCT GGATGTCAGC 
TCCCCAAATG TCCCAGACCT GACTCTCATT GACCTGCCTG GAATTACCAG GGTGGCTGTA 
GGCAACCAGC CTGCAGACAT AGGACGCCAG ATCAAGAGAC TCATCAAGAC ATACATCCAA 
AAACAGGAGA CCATCAACCT GGTGGTGGTC CCCAGCAATG TGGACATTGC CACCACAGAG 
GCTCTGAGCA TGGCTCAGGA GGTGGACCCT GAAGGGGATA GGACCATAGG GATCTTGACC 
AAGCCCGATC TGGTGGACAG AGGTACTGAA GACAAGGTCG TGGATGTGGT GCGGAACCTG 
GTGTACCATC TGAAGAAGGG CTACATGATA GTCAAGTGCA GAGGCCAGCA GGACATCCAA 
GAGCAGCTGA GCCTGACTGA GGCTCTTCAG AATGAGCAAA TCTTCTTCAA GGAACACCCT 
CATTTCAGAG TTCTTCTGGA GGATGGGAAG GCCACAGTGC CCTGCCTGGC AGAGAGACTG 
ACCGCAGAGC TCATCTTACA CATCTGTAAA TCTCTTCCTC TGCTAGAAAA TCAAATAAAG 
GAAAGTCACC AGAGTGCAAG TGAGGAGCTG CAGAAGTACG GTATGGACAT ACCAGAAGAT 
GACAGTGAAA AAACGTTCTT CCTGATTGAA AAAATCAATG CTTTTAACCA GGACATCACT 
GCCCTAGTAC AAGGGGAAGA GAATGTGGCA GAGGGAGAAT GTCGCCTATT CACCAGGCTC 
CGAAAAGAGT TCTTGTCCTG GAGTAAGGAG ATCGAAAAGA ATTTCGCAAA AGGTTATGCT 
GTTTTATATA ATGAAGTCTG GGCATTTGAA AAGCAGTACC GTGGACGAGA ATTGCCAGGG 
TTTGTGAATT ACAAAACATT TGAGAACATT ATAAGAAGAC AAATCAAAAC CCTGGAAGAA 
CCAGCTATAG AAATGCTGCA CACGGTCACT GAAATTGTAC GAGCTGCCTT TACAAGTGTT 
TCTGAGAAAA ATTTTTCTGA GTTTTATAAC CTCCACAGAA CTACCAAGTC CAAACTTGAA 
GACATCAGAT TAGAACAAGA AAAGGAAGCA GAGATGTCAA TCCGACTCCA CTTCAAGATG 
GAACAAATTA TCTACTGCCA GGACCAGATT TACAGAGGAG CCTTGCAGAA GGTCAGAGAG 
GAGGAAGCTG AGGAGGAGAA GAAGACAAAG CATGGCACTT CCAGTTCCTC TCAGTCCCAA 
GATTTACAGA CCTCATCCAT GGCTGAGATC TTCCAGCATC TGAATGCCTA CCGCCAAGAG 
GCTCACAACC GCATCTCCAG CCACGTTCCC TTGATCATCC AGTATTTCAT CCTGAAAATG 
TTTGCTGAGC GGCTGCAGAA GGGCATGCTC CAGCTCCTGC AGGACAAGGA TTCCTGCAGC 
TGGCTCCTGA AGGAGCAGAG TGACACAAGC GAGAAGAGGA AGTTCCTGAA GGAGAGGCTG 
GCAAGGCTGG CCCAGGCTCG GCGCCGGCTA GCCAAATTCC CTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.
Journal of virology90(23)10682-10692(2016 Dec)
N?rnberger C,Zimmermann V,Gerhardt M,Staeheli P

Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid.
Protein & cell5(12)954-7(2014 Dec)
Kong J,Xu B,Wei W,Wang X,Xie W,Yu XF

The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling.
Genes & development26(20)2299-310(2012 Oct)
Budry L,Balsalobre A,Gauthier Y,Khetchoumian K,L'honor? A,Vallette S,Brue T,Figarella-Branger D,Meij B,Drouin J

Impact of lactobacilli on orally acquired listeriosis.
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)
Archambaud C,Nahori MA,Soubigou G,B?cavin C,Laval L,Lechat P,Smokvina T,Langella P,Lecuit M,Cossart P

Functional diversity of Mx proteins: variations on a theme of host resistance to infection.
Genome research12(4)527-30(2002 Apr)
Lee SH,Vidal SM

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Mx2 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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