Mx1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mx1
Entrez Gene ID	17857
Full Name	MX dynamin-like GTPase 1
Synonyms	AI893580,Mx,Mx-1
General protein information	Preferred Names MX dynamin-like GTPase 1 Names interferon-induced GTP-binding protein Mx1 myxoma resistance protein 1 myxovirus (influenza virus) resistance 1 myxovirus (influenza) resistance 1 polypeptide
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 C4\|16 57.46 cM
Summary	This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010846.1	NP_034976.1	interferon-induced GTP-binding protein Mx1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Bayesian Diallel Analysis Reveals?
Maurizio PL, Ferris MT, Keele GR, Miller DR, Shaw GD, Whitmore AC, West A, Morrison CR, Noll KE, Plante KS, Cockrell AS, Threadgill DW, Pardo-Manuel de Villena F, Baric RS, Heise MT, Valdar W
G3 (Bethesda, Md.)(2017 Nov)

Improvement influenza HA2 DNA vaccine cellular and humoral immune responses with Mx bio adjuvant.
Soleimani S, Shahsavandi S, Maddadgar O
Biologicals : journal of the International Association of Biological Standardization466-10(2017 Mar)

Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.
N?rnberger C, Zimmermann V, Gerhardt M, Staeheli P
Journal of virology90(23)10682-10692(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that Mx protein as host defense peptide can be potentiated for improving influenza vaccine efficacy.
Title: Improvement influenza HA2 DNA vaccine cellular and humoral immune responses with Mx bio adjuvant.

the enhanced influenza virus susceptibility of CAST/EiJ mice can be explained by minor alterations in the MX1 restriction factor that negatively affect its enzymatic activity and reduce its half-life
Title: Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.

Our studies emphasize therefore that proper controls are crucial when modeling gene deletion using the Mx1-Cre transgene.
Title: Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis.

In Mx1-intact mice with weakened resistance due to deficiencies in Mavs and Tlr7, an elevated respiratory bacterial burden was found.
Title: Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.

Mouse Mx1 was shown to be essential for interferon type I-dependent protective immunity against primary influenza. (Review)
Title: Host genetics of severe influenza: from mouse Mx1 to human IRF7.

The following Mx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18500	NM_010846.1 Latest version!	Mus musculus MX dynamin-like GTPase 1 (Mx1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mx1 ( NM_010846.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034976.1 Mus musculus MX dynamin-like GTPase 1 (Mx1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18500
Clone ID Related Accession (Same CDS sequence)	NM_010846.1
Accession Version	NM_010846.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	interferon-induced GTP-binding protein Mx1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M12279.1. On Jul 25, 2007 this sequence version replaced XR_035486.1. Transcript Variant: This variant (1) represents the protein-coding allele found in the A2G strain. Sequence Note: This RefSeq record was created to represent the transcript and the full-length, functional protein that is expressed in wild mouse strains. It does not contain the deletion of exons that results in a shortened CDS found in several inbred laboratory strains, including the strain of the reference genome, C57BL/6J. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M12279.1, BC011113.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849380, SAMN01164135 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 2903437 ##RefSeq-Attributes-END##

ATGGATTCTG TGAATAATCT GTGCAGGCAC TATGAGGAGA AGGTGCGGCC CTGTATTGAC 
CTCATCGACA CCCTGAGGGC TCTGGGTGTG GAGCAGGACC TGGCCCTGCC TGCCATCGCT 
GTCATTGGGG ACCAGAGTTC AGGGAAGAGC TCTGTTCTGG AAGCACTGTC TGGAGTGGCC 
CTCCCCAGAG GCAGTGGTAT TGTCACCAGA TGCCCTCTGG TGCTGAAATT GAGGAAGCTG 
AAAGAAGGAG AGGAGTGGAG AGGCAAAGTC TCCTATGATG ACATCGAAGT GGAGCTCTCT 
GATCCTTCAG AGGTGGAAGA GGCCATTAAC AAGGGTCAGA ACTTCATTGC TGGGGTAGGC 
CTGGGGATCA GTGATAAGCT CATTAGCCTG GATGTCAGCT CCCCAAATGT CCCAGACCTG 
ACTCTCATTG ACCTGCCTGG AATTACCAGG GTGGCTGTAG GCAACCAGCC TGCAGACATA 
GGACGCCAGA TCAAGAGACT TATCAAGACA TACATCCAAA AACAAGAGAC CATCAACCTG 
GTGGTAGTCC CCAGCAATGT GGACATTGCT ACCACAGAGG CTCTGAGCAT GGCTCAGGAG 
GTGGACCCTG AAGGGGATAG GACCATAGGG GTCTTGACCA AGCCTGATCT GGTGGACAGA 
GGTGCTGAAG GCAAGGTCTT GGATGTGATG CGGAACCTGG TGTATCCTCT GAAGAAGGGC 
TACATGATAG TCAAGTGCAG AGGTCAGCAG GACATCCAAG AGCAGCTGAG CCTGACTGAG 
GCTTTTCAGA AAGAGCAAGT CTTCTTCAAG GATCACTCAT ACTTCAGCAT TCTTCTGGAA 
GATGGGAAGG CCACAGTGCC CTGCCTGGCA GAGAGACTGA CTGAGGAGCT CACCTCCCAC 
ATCTGTAAAT CACTGCCACT ATTGGAAGAT CAAATAAATA GCAGTCATCA GAGTGCAAGC 
GAGGAGCTGC AGAAGTACGG TGCAGACATA CCAGAAGATG ACAGAACGAG GATGTCCTTT 
CTGGTGAATA AAATCAGTGC CTTCAATAGG AATATCATGA ATTTGATACA AGCACAGGAA 
ACCGTATCAG AGGGAGACAG CCGGTTGTTT ACCAAACTGC GAAATGAGTT TCTTGCTTGG 
GATGATCATA TTGAGGAATA TTTTAAAAAA GATTCTCCTG AGGTACAAAG CAAGATGAAA 
GAATTTGAAA ATCAGTATCG TGGCCGGGAG CTGCCAGGGT TTGTGGACTA CAAGGCATTT 
GAGAGCATCA TCAAAAAGCG AGTCAAAGCC CTGGAAGAGT CTGCTGTGAA CATGCTGCGC 
AGGGTCACTA AGATGGTCCA AACTGCCTTC GTAAAGATTT TATCAAATGA TTTTGGTGAT 
TTTTTAAACC TCTGCTGTAC TGCTAAGTCC AAAATTAAAG AAATAAGATT AAACCAAGAA 
AAGGAAGCTG AAAACCTGAT CCGACTTCAC TTCCAGATGG AACAGATTGT CTACTGCCAG 
GACCAGGTTT ACAAGGAAAC CTTGAAGACG ATCAGAGAGA AGGAAGCTGA GAAAGAGAAG 
ACCAAGGCAT TAATAAACCC TGCTACCTTT CAAAATAACT CTCAGTTTCC TCAAAAGGGG 
TTGACTACCA CTGAGATGAC CCAGCACCTG AAAGCCTACT ACCAGGAGTG CAGACGGAAT 
ATTGGGAGAC AGATCCCTCT GATTATCCAG TACTTCATCC TGAAAACATT TGGGGAGGAA 
ATAGAGAAAA TGATGCTTCA GCTTTTACAG GACACCAGTA AGTGCAGCTG GTTCCTGGAG 
GAGCAGAGTG ACACCAGAGA GAAGAAGAAG TTCCTGAAAA GGCGGCTTTT AAGGCTGGAT 
GAGGCTCGGC AGAAGCTTGC CAAATTCTCC GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034976.1
CDS	214..2109
Translation	MDSVNNLCRHYEEKVRPCIDLIDTLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLRKLKEGEEWRGKVSYDDIEVELSDPSEVEEAINKGQNFIAGVGLGISDKLISLDVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVVPSNVDIATTEALSMAQEVDPEGDRTIGVLTKPDLVDRGAEGKVLDVMRNLVYPLKKGYMIVKCRGQQDIQEQLSLTEAFQKEQVFFKDHSYFSILLEDGKATVPCLAERLTEELTSHICKSLPLLEDQINSSHQSASEELQKYGADIPEDDRTRMSFLVNKISAFNRNIMNLIQAQETVSEGDSRLFTKLRNEFLAWDDHIEEYFKKDSPEVQSKMKEFENQYRGRELPGFVDYKAFESIIKKRVKALEESAVNMLRRVTKMVQTAFVKILSNDFGDFLNLCCTAKSKIKEIRLNQEKEAENLIRLHFQMEQIVYCQDQVYKETLKTIREKEAEKEKTKALINPATFQNNSQFPQKGLTTTEMTQHLKAYYQECRRNIGRQIPLIIQYFILKTFGEEIEKMMLQLLQDTSKCSWFLEEQSDTREKKKFLKRRLLRLDEARQKLAKFSD

Target ORF information:

RefSeq Version	NM_010846.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MX dynamin-like GTPase 1 (Mx1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010846.1

ORF Insert Sequence:

ATGGATTCTG TGAATAATCT GTGCAGGCAC TATGAGGAGA AGGTGCGGCC CTGTATTGAC 
CTCATCGACA CCCTGAGGGC TCTGGGTGTG GAGCAGGACC TGGCCCTGCC TGCCATCGCT 
GTCATTGGGG ACCAGAGTTC AGGGAAGAGC TCTGTTCTGG AAGCACTGTC TGGAGTGGCC 
CTCCCCAGAG GCAGTGGTAT TGTCACCAGA TGCCCTCTGG TGCTGAAATT GAGGAAGCTG 
AAAGAAGGAG AGGAGTGGAG AGGCAAAGTC TCCTATGATG ACATCGAAGT GGAGCTCTCT 
GATCCTTCAG AGGTGGAAGA GGCCATTAAC AAGGGTCAGA ACTTCATTGC TGGGGTAGGC 
CTGGGGATCA GTGATAAGCT CATTAGCCTG GATGTCAGCT CCCCAAATGT CCCAGACCTG 
ACTCTCATTG ACCTGCCTGG AATTACCAGG GTGGCTGTAG GCAACCAGCC TGCAGACATA 
GGACGCCAGA TCAAGAGACT TATCAAGACA TACATCCAAA AACAAGAGAC CATCAACCTG 
GTGGTAGTCC CCAGCAATGT GGACATTGCT ACCACAGAGG CTCTGAGCAT GGCTCAGGAG 
GTGGACCCTG AAGGGGATAG GACCATAGGG GTCTTGACCA AGCCTGATCT GGTGGACAGA 
GGTGCTGAAG GCAAGGTCTT GGATGTGATG CGGAACCTGG TGTATCCTCT GAAGAAGGGC 
TACATGATAG TCAAGTGCAG AGGTCAGCAG GACATCCAAG AGCAGCTGAG CCTGACTGAG 
GCTTTTCAGA AAGAGCAAGT CTTCTTCAAG GATCACTCAT ACTTCAGCAT TCTTCTGGAA 
GATGGGAAGG CCACAGTGCC CTGCCTGGCA GAGAGACTGA CTGAGGAGCT CACCTCCCAC 
ATCTGTAAAT CACTGCCACT ATTGGAAGAT CAAATAAATA GCAGTCATCA GAGTGCAAGC 
GAGGAGCTGC AGAAGTACGG TGCAGACATA CCAGAAGATG ACAGAACGAG GATGTCCTTT 
CTGGTGAATA AAATCAGTGC CTTCAATAGG AATATCATGA ATTTGATACA AGCACAGGAA 
ACCGTATCAG AGGGAGACAG CCGGTTGTTT ACCAAACTGC GAAATGAGTT TCTTGCTTGG 
GATGATCATA TTGAGGAATA TTTTAAAAAA GATTCTCCTG AGGTACAAAG CAAGATGAAA 
GAATTTGAAA ATCAGTATCG TGGCCGGGAG CTGCCAGGGT TTGTGGACTA CAAGGCATTT 
GAGAGCATCA TCAAAAAGCG AGTCAAAGCC CTGGAAGAGT CTGCTGTGAA CATGCTGCGC 
AGGGTCACTA AGATGGTCCA AACTGCCTTC GTAAAGATTT TATCAAATGA TTTTGGTGAT 
TTTTTAAACC TCTGCTGTAC TGCTAAGTCC AAAATTAAAG AAATAAGATT AAACCAAGAA 
AAGGAAGCTG AAAACCTGAT CCGACTTCAC TTCCAGATGG AACAGATTGT CTACTGCCAG 
GACCAGGTTT ACAAGGAAAC CTTGAAGACG ATCAGAGAGA AGGAAGCTGA GAAAGAGAAG 
ACCAAGGCAT TAATAAACCC TGCTACCTTT CAAAATAACT CTCAGTTTCC TCAAAAGGGG 
TTGACTACCA CTGAGATGAC CCAGCACCTG AAAGCCTACT ACCAGGAGTG CAGACGGAAT 
ATTGGGAGAC AGATCCCTCT GATTATCCAG TACTTCATCC TGAAAACATT TGGGGAGGAA 
ATAGAGAAAA TGATGCTTCA GCTTTTACAG GACACCAGTA AGTGCAGCTG GTTCCTGGAG 
GAGCAGAGTG ACACCAGAGA GAAGAAGAAG TTCCTGAAAA GGCGGCTTTT AAGGCTGGAT 
GAGGCTCGGC AGAAGCTTGC CAAATTCTCC GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bayesian Diallel Analysis Reveals?
G3 (Bethesda, Md.)(2017 Nov)
Maurizio PL,Ferris MT,Keele GR,Miller DR,Shaw GD,Whitmore AC,West A,Morrison CR,Noll KE,Plante KS,Cockrell AS,Threadgill DW,Pardo-Manuel de Villena F,Baric RS,Heise MT,Valdar W

Improvement influenza HA2 DNA vaccine cellular and humoral immune responses with Mx bio adjuvant.
Biologicals : journal of the International Association of Biological Standardization466-10(2017 Mar)
Soleimani S,Shahsavandi S,Maddadgar O

Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.
Journal of virology90(23)10682-10692(2016 Dec)
N?rnberger C,Zimmermann V,Gerhardt M,Staeheli P

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Mx1 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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