Matn1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Matn1
Entrez Gene ID	17180
Full Name	matrilin 1, cartilage matrix protein
Synonyms	CMP,Crtm,Mat1,matrilin-1
General protein information	Preferred Names matrilin 1, cartilage matrix protein Names cartilage matrix protein matrilin 1, cartilage matrix protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D2.2\|4 64.09 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010769.2	NP_034899.2	cartilage matrix protein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MATN1	XP_001147912.2
Xenopus tropicalis (tropical clawed frog)	matn1	NP_001025613.1
Mus musculus (house mouse)	Matn1	NP_034899.2
Rattus norvegicus (Norway rat)	Matn1	NP_001006980.1
Gallus gallus (chicken)	MATN1	NP_001025546.2
Homo sapiens (human)	MATN1	NP_002370.1
	MATN1	XP_001094970.1
Canis lupus familiaris (dog)	MATN1	XP_005617979.1
Bos taurus (cattle)	MATN1	NP_001137338.1
Danio rerio (zebrafish)	matn1	NP_001093210.1

Gene Ontology
Bibliography

Related articles in PubMed

Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development.
Metwalli KA, Do MA, Nguyen K, Mallick S, Kin K, Farokhnia N, Jun G, Fakhouri WD
Journal of dental research97(2)226-236(2018 Feb)

Generation and characterization of mice with mesenchyme-specific deletion of the entire ESET histone methyltransferase protein.
Yang L, Gee AO, Zielinska-Kwiatkowska A, Chansky HA
Genesis (New York, N.Y. : 2000)(2017 Dec)

Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs.
Decker RS, Um HB, Dyment NA, Cottingham N, Usami Y, Enomoto-Iwamoto M, Kronenberg MS, Maye P, Rowe DW, Koyama E, Pacifici M
Developmental biology426(1)56-68(2017 06)

Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop.
Kamper M, Paulsson M, Zaucke F
Cell and tissue research367(2)359-367(2017 Feb)

Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice.
Chen Y, Cossman J, Jayasuriya CT, Li X, Guan Y, Fonseca V, Yang K, Charbonneau C, Yu H, Kanbe K, Ma P, Darling E, Chen Q
PloS one11(6)e0156676(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results provide evidence that Matn1 plays a protective role in cartilage degeneration under altered mechanical environment.
Title: Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice.

Matrilin-1 is an inhibitor of neovascularization
Title: Matrilin-1 is an inhibitor of neovascularization.

Secretion of matrilin 3 V194D mutant protein is not dependent on hetero-oligomerization with matrilin 1.
Title: Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation.

Transgenic mice expressing mutant (D469Delta) cartilage oligomeric matrix protein showed a slight gender specific growth retardation and both, tibial growth plate and sternum abnormalities.
Title: Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations.

Data show that the cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita.
Title: The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita.

The following Matn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Matn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21429	NM_010769.2 Latest version!	Mus musculus matrilin 1, cartilage matrix protein (Matn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$293.30 $419.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Matn1 ( NM_010769.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034899.2 Mus musculus matrilin 1, cartilage matrix protein (Matn1), mRNA.

Price & Availability↑

CloneID	OMu21429
Clone ID Related Accession (Same CDS sequence)	NM_010769.2
Accession Version	NM_010769.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	cartilage matrix protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK014342.1, BC047140.1 and AV020141.1. On Apr 2, 2008 this sequence version replaced NM_010769.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014342.1, BC047140.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGTCA CCTCTGGTCC AGCCTTTGCT CTCTGTAGCC TGCTGCTCCT GCTGCTGCTG 
CTGCTACAGG TCCCTGATAG CCTCAGTCTT GTCCCCCAGC CCAGAGGGCA CCTCTGCCGG 
ACACGACCCA CGGACCTGGT GTTTGTTGTC GATAGCTCTC GAAGTGTGAG ACCCGTGGAG 
TTTGAGAAGG TGAAGGTATT CCTGTCTCAG GTCATTGAGT CACTGGATGT GGGGCCCAAT 
GCCACGAGGG TGGGCTTGGT CAACTACGCC AGCACTGTGA AACCAGAGTT CCCGCTCCGG 
GCCCATGGCT CCAAGGCCTC GCTGCTGCAA GCTGTGCGCC GCATCCAGCC GCTGTCCACG 
GGTACCATGA CTGGCCTGGC TCTGCAATTC GCCATCACCA AGGCCTTGAG TGATGCTGAG 
GGTGGACGCG CCAGATCCCC CGACATCAGC AAGGTTGTCA TCGTGGTGAC TGATGGGAGG 
CCCCAGGACA GCGTGCGGGA CGTGTCTGAG CGCGCGAGGG CCAGTGGCAT TGAGCTGTTC 
GCCATCGGCG TGGGCCGCGT GGACAAGGCT ACGCTGCGAC AGATCGCTAG CGAGCCGCAG 
GACGAGCACG TGGATTACGT GGAGAGCTAC AATGTCATCG AGAAGCTGGC CAAGAAGTTC 
CAAGAGGCCT TCTGCGTGGT GTCCGACCTG TGTGCCACAG GGGACCATGA TTGTGAGCAG 
CTGTGCGTTA GTTCTCCTGG CTCCTACACC TGTGCCTGCC ATGAGGGCTT CACCCTGAAC 
AGCGATGGCA AGACCTGCAA TGTCTGCCGT GGGGGTGGAA GCGGCTCAGC CACCGACCTG 
GTCTTCCTCA TCGACGGATC CAAGAGCGTG CGGCCTGAGA ACTTTGAGCT GGTGAAGAAG 
TTCATCAACC AGATTGTGGA CACGTTAGAT GTGTCGGACA GGCTAGCCCA GGTGGGGCTG 
GTGCAGTACT CCAGCTCCAT TCGCCAGGAG TTCCCACTCG GCCGCTTCCA CACCAAGAAG 
GACATTAAGG CCGCGGTGCG GAACATGTCC TACATGGAGA AAGGCACCAT GACTGGCGCC 
GCCTTGAAGT ATCTCATAGA TAATTCTTTC ACTGTGTCCA GCGGGGCAAG GCCTGGAGCC 
CAGAAGGTGG GCATCGTCTT CACCGATGGC CGGAGCCAGG ACTACATTAA TGACGCTGCC 
AGGAAGGCCA AGGACCTTGG CTTTAAGATG TTTGCGGTGG GCGTGGGCAA TGCTGTGGAG 
GAAGAGCTGA GGGAGATCGC TTCCGAGCCC GTGGCAGACC ACTACTTTTA CACAGCTGAC 
TTCAAGACCA TCAACCAGAT TGGCAAGAAG CTGCAGAAAC AAATCTGTGT GGAGGAAGAC 
CCCTGTGCTT GTGAGTCCAT ACTGAAATTT GAGGCCAAGG TGGAGGGTCT GCTGCAGGCC 
CTGACCAGGA AGCTGGAAGC TGTGAGCGGG CGGCTGGCTG TCCTGGAGAA CAGAATCATC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034899.2
CDS	40..1542
Translation	MKVTSGPAFALCSLLLLLLLLLQVPDSLSLVPQPRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGLVNYASTVKPEFPLRAHGSKASLLQAVRRIQPLSTGTMTGLALQFAITKALSDAEGGRARSPDISKVVIVVTDGRPQDSVRDVSERARASGIELFAIGVGRVDKATLRQIASEPQDEHVDYVESYNVIEKLAKKFQEAFCVVSDLCATGDHDCEQLCVSSPGSYTCACHEGFTLNSDGKTCNVCRGGGSGSATDLVFLIDGSKSVRPENFELVKKFINQIVDTLDVSDRLAQVGLVQYSSSIRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAARKAKDLGFKMFAVGVGNAVEEELREIASEPVADHYFYTADFKTINQIGKKLQKQICVEEDPCACESILKFEAKVEGLLQALTRKLEAVSGRLAVLENRII

Target ORF information:

RefSeq Version	NM_010769.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrilin 1, cartilage matrix protein (Matn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010769.2

ORF Insert Sequence:

ATGAAGGTCA CCTCTGGTCC AGCCTTTGCT CTCTGTAGCC TGCTGCTCCT GCTGCTGCTG 
CTGCTACAGG TCCCTGATAG CCTCAGTCTT GTCCCCCAGC CCAGAGGGCA CCTCTGCCGG 
ACACGACCCA CGGACCTGGT GTTTGTTGTC GATAGCTCTC GAAGTGTGAG ACCCGTGGAG 
TTTGAGAAGG TGAAGGTATT CCTGTCTCAG GTCATTGAGT CACTGGATGT GGGGCCCAAT 
GCCACGAGGG TGGGCTTGGT CAACTACGCC AGCACTGTGA AACCAGAGTT CCCGCTCCGG 
GCCCATGGCT CCAAGGCCTC GCTGCTGCAA GCTGTGCGCC GCATCCAGCC GCTGTCCACG 
GGTACCATGA CTGGCCTGGC TCTGCAATTC GCCATCACCA AGGCCTTGAG TGATGCTGAG 
GGTGGACGCG CCAGATCCCC CGACATCAGC AAGGTTGTCA TCGTGGTGAC TGATGGGAGG 
CCCCAGGACA GCGTGCGGGA CGTGTCTGAG CGCGCGAGGG CCAGTGGCAT TGAGCTGTTC 
GCCATCGGCG TGGGCCGCGT GGACAAGGCT ACGCTGCGAC AGATCGCTAG CGAGCCGCAG 
GACGAGCACG TGGATTACGT GGAGAGCTAC AATGTCATCG AGAAGCTGGC CAAGAAGTTC 
CAAGAGGCCT TCTGCGTGGT GTCCGACCTG TGTGCCACAG GGGACCATGA TTGTGAGCAG 
CTGTGCGTTA GTTCTCCTGG CTCCTACACC TGTGCCTGCC ATGAGGGCTT CACCCTGAAC 
AGCGATGGCA AGACCTGCAA TGTCTGCCGT GGGGGTGGAA GCGGCTCAGC CACCGACCTG 
GTCTTCCTCA TCGACGGATC CAAGAGCGTG CGGCCTGAGA ACTTTGAGCT GGTGAAGAAG 
TTCATCAACC AGATTGTGGA CACGTTAGAT GTGTCGGACA GGCTAGCCCA GGTGGGGCTG 
GTGCAGTACT CCAGCTCCAT TCGCCAGGAG TTCCCACTCG GCCGCTTCCA CACCAAGAAG 
GACATTAAGG CCGCGGTGCG GAACATGTCC TACATGGAGA AAGGCACCAT GACTGGCGCC 
GCCTTGAAGT ATCTCATAGA TAATTCTTTC ACTGTGTCCA GCGGGGCAAG GCCTGGAGCC 
CAGAAGGTGG GCATCGTCTT CACCGATGGC CGGAGCCAGG ACTACATTAA TGACGCTGCC 
AGGAAGGCCA AGGACCTTGG CTTTAAGATG TTTGCGGTGG GCGTGGGCAA TGCTGTGGAG 
GAAGAGCTGA GGGAGATCGC TTCCGAGCCC GTGGCAGACC ACTACTTTTA CACAGCTGAC 
TTCAAGACCA TCAACCAGAT TGGCAAGAAG CTGCAGAAAC AAATCTGTGT GGAGGAAGAC 
CCCTGTGCTT GTGAGTCCAT ACTGAAATTT GAGGCCAAGG TGGAGGGTCT GCTGCAGGCC 
CTGACCAGGA AGCTGGAAGC TGTGAGCGGG CGGCTGGCTG TCCTGGAGAA CAGAATCATC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development.
Journal of dental research97(2)226-236(2018 Feb)
Metwalli KA,Do MA,Nguyen K,Mallick S,Kin K,Farokhnia N,Jun G,Fakhouri WD

Generation and characterization of mice with mesenchyme-specific deletion of the entire ESET histone methyltransferase protein.
Genesis (New York, N.Y. : 2000)(2017 Dec)
Yang L,Gee AO,Zielinska-Kwiatkowska A,Chansky HA

Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs.
Developmental biology426(1)56-68(2017 06)
Decker RS,Um HB,Dyment NA,Cottingham N,Usami Y,Enomoto-Iwamoto M,Kronenberg MS,Maye P,Rowe DW,Koyama E,Pacifici M

Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop.
Cell and tissue research367(2)359-367(2017 Feb)
Kamper M,Paulsson M,Zaucke F

Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice.
PloS one11(6)e0156676(2016)
Chen Y,Cossman J,Jayasuriya CT,Li X,Guan Y,Fonseca V,Yang K,Charbonneau C,Yu H,Kanbe K,Ma P,Darling E,Chen Q

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Matn1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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