MATN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MATN1
Entrez Gene ID	4146
Full Name	matrilin 1, cartilage matrix protein
Synonyms	CMP,CRTM
General protein information	Preferred Names matrilin 1, cartilage matrix protein Names cartilage matrix protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p35.2
Summary	This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias. [provided by RefSeq, Jul 2008].
Disorder MIM:	115437

mRNA and Protein(s)

mRNA	Protein	Name
NM_002379.3	NP_002370.1	cartilage matrix protein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MATN1	XP_001147912.2
Xenopus tropicalis (tropical clawed frog)	matn1	NP_001025613.1
Mus musculus (house mouse)	Matn1	NP_034899.2
Rattus norvegicus (Norway rat)	Matn1	NP_001006980.1
Gallus gallus (chicken)	MATN1	NP_001025546.2
Homo sapiens (human)	MATN1	NP_002370.1
	MATN1	XP_001094970.1
Canis lupus familiaris (dog)	MATN1	XP_005617979.1
Bos taurus (cattle)	MATN1	NP_001137338.1
Danio rerio (zebrafish)	matn1	NP_001093210.1

Gene Ontology
Bibliography

Related articles in PubMed

Matrilin-1 is an inhibitor of neovascularization.
Foradori MJ, Chen Q, Fernandez CA, Harper J, Li X, Tsang PC, Langer R, Moses MA
The Journal of biological chemistry289(20)14301-9(2014 May)

The association of rs1149048 polymorphism in matrilin-1(MATN1) gene with adolescent idiopathic scoliosis susceptibility: a meta-analysis.
Zhang H, Zhao S, Zhao Z, Tang L, Guo Q, Liu S, Chen L
Molecular biology reports41(4)2543-9(2014)

Single-nucleotide polymorphism in Turkish patients with adolescent idiopathic scoliosis: curve progression is not related with MATN-1, LCT C/T-13910, and VDR BsmI.
Yilmaz H, Zateri C, Uludag A, Bakar C, Kosar S, Ozdemir O
Journal of orthopaedic research : official publication of the Orthopaedic Research Society30(9)1459-63(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Matrilin-1 is an inhibitor of neovascularization
Title: Matrilin-1 is an inhibitor of neovascularization.

this meta-analysis found an overall significant association of rs1149048 polymorphism with risk of AIS, especially in Asian population.
Title: The association of rs1149048 polymorphism in matrilin-1(MATN1) gene with adolescent idiopathic scoliosis susceptibility: a meta-analysis.

no significant difference in single nucleotide polymorphism between adolescent idiopathic scoliosis cases and controls
Title: Single-nucleotide polymorphism in Turkish patients with adolescent idiopathic scoliosis: curve progression is not related with MATN-1, LCT C/T-13910, and VDR BsmI.

The A allele of single nucleotide polymorphism rs1065755 in the MATN1 gene is associated with adolescent idiopathic scoliosis.
Title: Associations between matrilin-1 gene polymorphisms and adolescent idiopathic scoliosis curve patterns in a Korean population.

we concluded that MATN1 SNP is not associated with either adolescent idiopathic scoliosis predisposition or curve severity in Japanese.
Title: Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population.

The following MATN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MATN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18688	NM_002379.3 Latest version!	Homo sapiens matrilin 1 (MATN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MATN1 ( NM_002379.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002370.1 Homo sapiens matrilin 1 (MATN1), mRNA.

Price & Availability↑

CloneID	OHu18688
Clone ID Related Accession (Same CDS sequence)	NM_002379.3
Accession Version	NM_002379.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	cartilage matrix protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312949.1 and AL137857.29. This sequence is a reference standard in the RefSeqGene project. On Sep 26, 2008 this sequence version replaced NM_002379.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312949.1, AK075519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465420 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373765.5/ ENSP00000362870.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGGTCC TCTCTGGCAC TAGCCTCATG CTCTGCAGCC TGCTGCTGCT GCTCCAGGCC 
CTGTGCAGCC CTGGCCTCGC CCCCCAGTCC AGAGGCCATC TCTGCCGGAC GCGGCCCACA 
GACCTGGTGT TTGTTGTCGA CAGCTCTCGC AGCGTTCGGC CTGTTGAATT TGAGAAAGTG 
AAGGTATTCC TGTCCCAGGT CATCGAGTCG CTGGACGTGG GGCCCAATGC CACCCGGGTG 
GGCATGGTCA ACTATGCCAG CACCGTGAAG CAGGAGTTCT CGCTGCGGGC TCATGTCTCC 
AAGGCCGCAC TGCTGCAGGC TGTGCGCCGT ATCCAGCCGC TGTCCACAGG CACCATGACC 
GGCCTGGCCA TCCAGTTCGC TATCACCAAA GCCTTCGGCG ATGCAGAGGG TGGTCGTTCC 
AGGTCCCCTG ACATCAGCAA GGTGGTCATC GTGGTGACAG ACGGGAGGCC CCAGGACAGC 
GTGCAGGACG TGTCTGCGCG GGCCCGGGCC AGCGGCGTCG AGCTGTTCGC CATCGGAGTG 
GGCAGCGTGG ACAAGGCCAC GCTGCGGCAG ATCGCCAGCG AGCCGCAGGA CGAACACGTC 
GATTACGTGG AGAGCTACAG CGTCATCGAG AAGCTGTCCA GGAAGTTCCA GGAGGCCTTC 
TGCGTGGTGT CAGACCTGTG CGCCACAGGG GACCATGACT GTGAGCAGGT GTGCATCAGC 
TCCCCCGGTT CCTACACCTG CGCCTGCCAC GAGGGCTTCA CTCTGAACAG CGACGGCAAG 
ACCTGCAATG TCTGCAGTGG TGGTGGTGGC AGCTCGGCCA CTGACCTGGT CTTCCTCATT 
GACGGATCCA AGAGTGTGAG GCCAGAGAAC TTTGAGCTGG TGAAGAAGTT CATCAGTCAG 
ATCGTGGATA CGCTGGACGT GTCAGACAAG CTGGCCCAGG TGGGGCTGGT GCAGTACTCA 
AGCTCTGTGC GCCAGGAGTT CCCCCTGGGT CGCTTCCACA CCAAGAAGGA CATCAAGGCG 
GCTGTGCGGA ATATGTCCTA CATGGAGAAG GGCACAATGA CTGGGGCTGC TCTCAAGTAC 
CTCATTGACA ATTCCTTCAC TGTGTCCAGT GGGGCTAGGC CCGGGGCCCA GAAGGTGGGC 
ATTGTCTTCA CTGATGGCCG GAGCCAGGAC TACATTAATG ATGCTGCCAA GAAGGCCAAA 
GACCTCGGCT TTAAGATGTT TGCTGTGGGT GTGGGCAATG CCGTGGAGGA TGAGCTGAGG 
GAAATAGCCT CAGAGCCTGT GGCAGAGCAC TACTTCTACA CGGCTGACTT CAAGACCATC 
AACCAGATAG GCAAGAAGTT GCAGAAGAAG ATCTGTGTGG AGGAAGACCC GTGTGCCTGC 
GAGTCCCTGG TGAAATTCCA AGCCAAAGTG GAGGGGCTGC TGCAGGCCCT GACCAGGAAA 
CTGGAAGCTG TGAGTAAGCG GCTGGCCATC CTGGAGAACA CAGTTGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002370.1
CDS	35..1525
Translation	MRVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILENTVV

Target ORF information:

RefSeq Version	NM_002379.3
Organism	Homo sapiens(human)
Definition	Homo sapiens matrilin 1 (MATN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002379.3

ORF Insert Sequence:

ATGAGGGTCC TCTCTGGCAC TAGCCTCATG CTCTGCAGCC TGCTGCTGCT GCTCCAGGCC 
CTGTGCAGCC CTGGCCTCGC CCCCCAGTCC AGAGGCCATC TCTGCCGGAC GCGGCCCACA 
GACCTGGTGT TTGTTGTCGA CAGCTCTCGC AGCGTTCGGC CTGTTGAATT TGAGAAAGTG 
AAGGTATTCC TGTCCCAGGT CATCGAGTCG CTGGACGTGG GGCCCAATGC CACCCGGGTG 
GGCATGGTCA ACTATGCCAG CACCGTGAAG CAGGAGTTCT CGCTGCGGGC TCATGTCTCC 
AAGGCCGCAC TGCTGCAGGC TGTGCGCCGT ATCCAGCCGC TGTCCACAGG CACCATGACC 
GGCCTGGCCA TCCAGTTCGC TATCACCAAA GCCTTCGGCG ATGCAGAGGG TGGTCGTTCC 
AGGTCCCCTG ACATCAGCAA GGTGGTCATC GTGGTGACAG ACGGGAGGCC CCAGGACAGC 
GTGCAGGACG TGTCTGCGCG GGCCCGGGCC AGCGGCGTCG AGCTGTTCGC CATCGGAGTG 
GGCAGCGTGG ACAAGGCCAC GCTGCGGCAG ATCGCCAGCG AGCCGCAGGA CGAACACGTC 
GATTACGTGG AGAGCTACAG CGTCATCGAG AAGCTGTCCA GGAAGTTCCA GGAGGCCTTC 
TGCGTGGTGT CAGACCTGTG CGCCACAGGG GACCATGACT GTGAGCAGGT GTGCATCAGC 
TCCCCCGGTT CCTACACCTG CGCCTGCCAC GAGGGCTTCA CTCTGAACAG CGACGGCAAG 
ACCTGCAATG TCTGCAGTGG TGGTGGTGGC AGCTCGGCCA CTGACCTGGT CTTCCTCATT 
GACGGATCCA AGAGTGTGAG GCCAGAGAAC TTTGAGCTGG TGAAGAAGTT CATCAGTCAG 
ATCGTGGATA CGCTGGACGT GTCAGACAAG CTGGCCCAGG TGGGGCTGGT GCAGTACTCA 
AGCTCTGTGC GCCAGGAGTT CCCCCTGGGT CGCTTCCACA CCAAGAAGGA CATCAAGGCG 
GCTGTGCGGA ATATGTCCTA CATGGAGAAG GGCACAATGA CTGGGGCTGC TCTCAAGTAC 
CTCATTGACA ATTCCTTCAC TGTGTCCAGT GGGGCTAGGC CCGGGGCCCA GAAGGTGGGC 
ATTGTCTTCA CTGATGGCCG GAGCCAGGAC TACATTAATG ATGCTGCCAA GAAGGCCAAA 
GACCTCGGCT TTAAGATGTT TGCTGTGGGT GTGGGCAATG CCGTGGAGGA TGAGCTGAGG 
GAAATAGCCT CAGAGCCTGT GGCAGAGCAC TACTTCTACA CGGCTGACTT CAAGACCATC 
AACCAGATAG GCAAGAAGTT GCAGAAGAAG ATCTGTGTGG AGGAAGACCC GTGTGCCTGC 
GAGTCCCTGG TGAAATTCCA AGCCAAAGTG GAGGGGCTGC TGCAGGCCCT GACCAGGAAA 
CTGGAAGCTG TGAGTAAGCG GCTGGCCATC CTGGAGAACA CAGTTGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Matrilin-1 is an inhibitor of neovascularization.
The Journal of biological chemistry289(20)14301-9(2014 May)
Foradori MJ,Chen Q,Fernandez CA,Harper J,Li X,Tsang PC,Langer R,Moses MA

The association of rs1149048 polymorphism in matrilin-1(MATN1) gene with adolescent idiopathic scoliosis susceptibility: a meta-analysis.
Molecular biology reports41(4)2543-9(2014)
Zhang H,Zhao S,Zhao Z,Tang L,Guo Q,Liu S,Chen L

Single-nucleotide polymorphism in Turkish patients with adolescent idiopathic scoliosis: curve progression is not related with MATN-1, LCT C/T-13910, and VDR BsmI.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society30(9)1459-63(2012 Sep)
Yilmaz H,Zateri C,Uludag A,Bakar C,Kosar S,Ozdemir O

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MATN1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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