Mal cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mal
Entrez Gene ID	17153
Full Name	myelin and lymphocyte protein, T cell differentiation protein
Synonyms	Mpv17,Vip17
General protein information	Preferred Names myelin and lymphocyte protein, T cell differentiation protein Names myelin and lymphocyte protein T-lymphocyte maturation-associated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 F1
Summary	This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001171187.1	NP_001164658.1	myelin and lymphocyte protein isoform 2
NM_010762.5	NP_034892.1	myelin and lymphocyte protein isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAL	XP_003949891.1
	MAL	XP_001095645.2
Canis lupus familiaris (dog)	MAL	NP_001003253.1
Mus musculus (house mouse)	Mal	NP_034892.1
Danio rerio (zebrafish)	zgc:153665	NP_001070931.1
Bos taurus (cattle)	MAL	NP_001068896.1
Gallus gallus (chicken)	MAL	NP_001186320.1
Danio rerio (zebrafish)	zgc:158773	NP_001075880.1
Xenopus tropicalis (tropical clawed frog)	mal	NP_001006929.1
Rattus norvegicus (Norway rat)	Mal	NP_036930.1
Danio rerio (zebrafish)	mal	NP_001017686.1
Homo sapiens (human)	MAL	NP_002362.1

Gene Ontology
Bibliography

Related articles in PubMed

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Kennedy AJ, Rahn EJ, Paulukaitis BS, Savell KE, Kordasiewicz HB, Wang J, Lewis JW, Posey J, Strange SK, Guzman-Karlsson MC, Phillips SE, Decker K, Motley ST, Swayze EE, Ecker DJ, Michael TP, Day JJ, Sweatt JD
Cell reports16(10)2666-2685(2016 09)

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells.
Wankel B, Ouyang J, Guo X, Hadjiolova K, Miller J, Liao Y, Tham DK, Romih R, Andrade LR, Gumper I, Simon JP, Sachdeva R, Tolmachova T, Seabra MC, Fukuda M, Schaeren-Wiemers N, Hong WJ, Sabatini DD, Wu XR, Kong X, Kreibich G, Rindler MJ, Sun TT
Molecular biology of the cell27(10)1621-34(2016 05)

Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination.
Linden JR, Ma Y, Zhao B, Harris JM, Rumah KR, Schaeren-Wiemers N, Vartanian T
mBio6(3)e02513(2015 Jun)

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ?-Toxin.
Rumah KR, Ma Y, Linden JR, Oo ML, Anrather J, Schaeren-Wiemers N, Alonso MA, Fischetti VA, McClain MS, Vartanian T
PLoS pathogens11(5)e1004896(2015 May)

MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells.
Schmid D, Zeis T, Sobrio M, Schaeren-Wiemers N
ASN neuro6(5)(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression of the developmentally regulated proteolipid MAL is required for the cytotoxic effect of Clostridium perfringens Epsilon Toxin.
Title: Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination.

MAL overexpression leads to reduced expression of Mpz and p75NTR, despite functional pathways and normal expression of genes important for Schwann cell differentiation.
Title: MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells.

VIP17/MAL overexpression results in abnormal cilium and cyst development, in vitro and in vivo, and in VIP17/MAL-overexpressing mice that develop cysts secondary to a ciliary defect.
Title: VIP17/MAL expression modulates epithelial cyst formation and ciliogenesis.

the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
Title: MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.

Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
Title: Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.

The following Mal gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mal cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11825	NM_001171187.1 Latest version!	Mus musculus myelin and lymphocyte protein, T cell differentiation protein (Mal), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu06819	NM_010762.5 Latest version!	Mus musculus myelin and lymphocyte protein, T cell differentiation protein (Mal), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mal ( NM_001171187.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001164658.1 Mus musculus myelin and lymphocyte protein, T cell differentiation protein (Mal), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu11825
Clone ID Related Accession (Same CDS sequence)	NM_001171187.1
Accession Version	NM_001171187.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	myelin and lymphocyte protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK158653.1, AK019046.1 and BY626921.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY708507.1, AK019046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCGG CAGCGGCTTC GGGTGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTCCCTG ACTTGCTCTT CGTTTGTGAG TTTGATGCAG CCTACCACTG TGTGGCTGCC 
CTATTTTACC TCAGTGCCTC AGTTCTGGAA GCCCTGGCCA CCATCTCAAT GTTTGATGGC 
TTTACTTACA AGCATTACCA TGAAAACATC GCCGCAGTGG TGTTTGCCTA CGTGGTCACT 
CTGATCTACG TGGTCCATGC TGTGTTTTCC TTAATCAGAT GGAAGTCTTC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001164658.1
CDS	563..856
Translation	MAPAAASGGSTLPSGFSVFTTFPDLLFVCEFDAAYHCVAALFYLSASVLEALATISMFDGFTYKHYHENIAAVVFAYVVTLIYVVHAVFSLIRWKSS

Target ORF information:

RefSeq Version	NM_001171187.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus myelin and lymphocyte protein, T cell differentiation protein (Mal), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171187.1

ORF Insert Sequence:

ATGGCTCCGG CAGCGGCTTC GGGTGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTCCCTG ACTTGCTCTT CGTTTGTGAG TTTGATGCAG CCTACCACTG TGTGGCTGCC 
CTATTTTACC TCAGTGCCTC AGTTCTGGAA GCCCTGGCCA CCATCTCAAT GTTTGATGGC 
TTTACTTACA AGCATTACCA TGAAAACATC GCCGCAGTGG TGTTTGCCTA CGTGGTCACT 
CTGATCTACG TGGTCCATGC TGTGTTTTCC TTAATCAGAT GGAAGTCTTC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mal ( NM_010762.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034892.1 Mus musculus myelin and lymphocyte protein, T cell differentiation protein (Mal), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu06819
Clone ID Related Accession (Same CDS sequence)	NM_010762.5
Accession Version	NM_010762.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	myelin and lymphocyte protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK158653.1 and BY626921.1. On Jan 15, 2010 this sequence version replaced NM_010762.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006826.1, AK158653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCGG CAGCGGCTTC GGGTGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTCCCTG ACTTGCTCTT CGTTTGTGAG TTTGTCTTTG GAGGCCTGGT GTGGATCCTG 
ATTGCCTCCT CCCTGGTACC CTTGCCCCTG GCCCAGGGCT GGGTGATGTT TGTGTCTGTG 
TTCTGCTTTG TGGCCACCAC TTCCCTGATG ATCTTGTACA TAATTGGTAC TCATGGCGGT 
GAGACTTCCT GGATCACACT GGATGCAGCC TACCACTGTG TGGCTGCCCT ATTTTACCTC 
AGTGCCTCAG TTCTGGAAGC CCTGGCCACC ATCTCAATGT TTGATGGCTT TACTTACAAG 
CATTACCATG AAAACATCGC CGCAGTGGTG TTTGCCTACG TGGTCACTCT GATCTACGTG 
GTCCATGCTG TGTTTTCCTT AATCAGATGG AAGTCTTCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034892.1
CDS	563..1024
Translation	MAPAAASGGSTLPSGFSVFTTFPDLLFVCEFVFGGLVWILIASSLVPLPLAQGWVMFVSVFCFVATTSLMILYIIGTHGGETSWITLDAAYHCVAALFYLSASVLEALATISMFDGFTYKHYHENIAAVVFAYVVTLIYVVHAVFSLIRWKSS

Target ORF information:

RefSeq Version	NM_010762.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus myelin and lymphocyte protein, T cell differentiation protein (Mal), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010762.5

ORF Insert Sequence:

ATGGCTCCGG CAGCGGCTTC GGGTGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTCCCTG ACTTGCTCTT CGTTTGTGAG TTTGTCTTTG GAGGCCTGGT GTGGATCCTG 
ATTGCCTCCT CCCTGGTACC CTTGCCCCTG GCCCAGGGCT GGGTGATGTT TGTGTCTGTG 
TTCTGCTTTG TGGCCACCAC TTCCCTGATG ATCTTGTACA TAATTGGTAC TCATGGCGGT 
GAGACTTCCT GGATCACACT GGATGCAGCC TACCACTGTG TGGCTGCCCT ATTTTACCTC 
AGTGCCTCAG TTCTGGAAGC CCTGGCCACC ATCTCAATGT TTGATGGCTT TACTTACAAG 
CATTACCATG AAAACATCGC CGCAGTGGTG TTTGCCTACG TGGTCACTCT GATCTACGTG 
GTCCATGCTG TGTTTTCCTT AATCAGATGG AAGTCTTCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Cell reports16(10)2666-2685(2016 09)
Kennedy AJ,Rahn EJ,Paulukaitis BS,Savell KE,Kordasiewicz HB,Wang J,Lewis JW,Posey J,Strange SK,Guzman-Karlsson MC,Phillips SE,Decker K,Motley ST,Swayze EE,Ecker DJ,Michael TP,Day JJ,Sweatt JD

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells.
Molecular biology of the cell27(10)1621-34(2016 05)
Wankel B,Ouyang J,Guo X,Hadjiolova K,Miller J,Liao Y,Tham DK,Romih R,Andrade LR,Gumper I,Simon JP,Sachdeva R,Tolmachova T,Seabra MC,Fukuda M,Schaeren-Wiemers N,Hong WJ,Sabatini DD,Wu XR,Kong X,Kreibich G,Rindler MJ,Sun TT

Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination.
mBio6(3)e02513(2015 Jun)
Linden JR,Ma Y,Zhao B,Harris JM,Rumah KR,Schaeren-Wiemers N,Vartanian T

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ?-Toxin.
PLoS pathogens11(5)e1004896(2015 May)
Rumah KR,Ma Y,Linden JR,Oo ML,Anrather J,Schaeren-Wiemers N,Alonso MA,Fischetti VA,McClain MS,Vartanian T

MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells.
ASN neuro6(5)(2014)
Schmid D,Zeis T,Sobrio M,Schaeren-Wiemers N

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Mal cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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