MAL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAL
Entrez Gene ID	4118
Full Name	mal, T cell differentiation protein
General protein information	Preferred Names mal, T cell differentiation protein Names myelin and lymphocyte protein MyD88-adapter-like T-lymphocyte maturation-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q11.1
Summary	The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012].
Disorder MIM:	188860

mRNA and Protein(s)

mRNA	Protein	Name
NM_002371.3	NP_002362.1	myelin and lymphocyte protein isoform a
NM_022440.2	NP_071885.1	myelin and lymphocyte protein isoform d
NM_022439.2	NP_071884.1	myelin and lymphocyte protein isoform c
NM_002371.4	NP_002362.1	myelin and lymphocyte protein isoform a
NM_022438.2	NP_071883.1	myelin and lymphocyte protein isoform b

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAL	XP_003949891.1
	MAL	XP_001095645.2
Canis lupus familiaris (dog)	MAL	NP_001003253.1
Mus musculus (house mouse)	Mal	NP_034892.1
Danio rerio (zebrafish)	zgc:153665	NP_001070931.1
Bos taurus (cattle)	MAL	NP_001068896.1
Gallus gallus (chicken)	MAL	NP_001186320.1
Danio rerio (zebrafish)	zgc:158773	NP_001075880.1
Xenopus tropicalis (tropical clawed frog)	mal	NP_001006929.1
Rattus norvegicus (Norway rat)	Mal	NP_036930.1
Danio rerio (zebrafish)	mal	NP_001017686.1
Homo sapiens (human)	MAL	NP_002362.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.
Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B
Nature structural & molecular biology24(9)743-751(2017 Sep)

MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis.
Zanotti L, Romani C, Tassone L, Todeschini P, Tassi RA, Bandiera E, Damia G, Ricci F, Ardighieri L, Calza S, Marchini S, Beltrame L, Tognon G, D'Incalci M, Pecorelli S, Sartori E, Odicino F, Ravaggi A, Bignotti E
BMC cancer17(1)366(2017 May)

MAL and TMEM220 are novel DNA methylation markers in human gastric cancer.
Choi B, Han TS, Min J, Hur K, Lee SM, Lee HJ, Kim YJ, Yang HK
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals22(1)35-44(2017 Feb)

Reconstructing the TIR Side of the Myddosome: a Paradigm for TIR-TIR Interactions.
Vyncke L, Bovijn C, Pauwels E, Van Acker T, Ruyssinck E, Burg E, Tavernier J, Peelman F
Structure (London, England : 1993)24(3)437-47(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here the authors show that MAL TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 TIR domains and induce formation of MyD88 assemblies.
Title: Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer.
Title: MAL and TMEM220 are novel DNA methylation markers in human gastric cancer.

Results show that MAl protein binds to and regulates MYD88.
Title: Reconstructing the TIR Side of the Myddosome: a Paradigm for TIR-TIR Interactions.

This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas
Title: Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis.

Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
Title: DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer.

The following MAL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15962	NM_022440.2 Latest version!	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant d, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15983	NM_002371.4 Latest version!	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15772	NM_022439.2 Latest version!	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant c, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu16029	NM_022438.2 Latest version!	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu15983	NM_002371.3	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAL ( NM_022440.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071885.1 Homo sapiens mal, T cell differentiation protein (MAL), transcript variant d, mRNA.

Price & Availability↑

CloneID	OHu15962
Clone ID Related Accession (Same CDS sequence)	NM_022440.2
Accession Version	NM_022440.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 168bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	myelin and lymphocyte protein isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76681.1 and BC000458.2. On May 9, 2012 this sequence version replaced NM_022440.1. Transcript Variant: This variant (d) is missing alternatively spliced exons 2 and 3, resulting in the shortest isoform (d). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X76681.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGTGTTCT CCTACATAGC CACTCTGCTC 
TACGTGGTCC ATGCGGTGTT CTCTTTAATC AGATGGAAGT CTTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071885.1
CDS	139..306
Translation	MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFVFSYIATLLYVVHAVFSLIRWKSS

Target ORF information:

RefSeq Version	NM_022440.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant d, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022440.2

ORF Insert Sequence:

1
61
121

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGTGTTCT CCTACATAGC CACTCTGCTC 
TACGTGGTCC ATGCGGTGTT CTCTTTAATC AGATGGAAGT CTTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAL ( NM_002371.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002362.1 Homo sapiens mal, T cell differentiation protein (MAL), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu15983
Clone ID Related Accession (Same CDS sequence)	NM_002371.3 , NM_002371.4
Accession Version	NM_002371.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-12
Organism	Homo sapiens(human)
Product	myelin and lymphocyte protein isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76678.1 and BC000458.2. On May 9, 2012 this sequence version replaced NM_002371.2. Transcript Variant: This variant (a) includes both alternatively spliced exons 2 and 3, resulting in the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000458.2, SRR1803612.189995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG 
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG 
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA 
GAGACTTCCT GGGTCACCTT GGACGCAGCC TACCACTGCA CCGCTGCCCT CTTTTACCTC 
AGCGCCTCAG TCCTGGAGGC CCTGGCCACC ATCACGATGC AAGACGGCTT CACCTACAGG 
CACTACCATG AAAACATTGC TGCCGTGGTG TTCTCCTACA TAGCCACTCT GCTCTACGTG 
GTCCATGCGG TGTTCTCTTT AATCAGATGG AAGTCTTCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002362.1
CDS	139..600
Translation	MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVASSLVPWPLVQGWVMFVSVFCFVATTTLIILYIIGAHGGETSWVTLDAAYHCTAALFYLSASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS

Target ORF information:

RefSeq Version	NM_002371.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002371.3

ORF Insert Sequence:

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG 
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG 
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA 
GAGACTTCCT GGGTCACCTT GGACGCAGCC TACCACTGCA CCGCTGCCCT CTTTTACCTC 
AGCGCCTCAG TCCTGGAGGC CCTGGCCACC ATCACGATGC AAGACGGCTT CACCTACAGG 
CACTACCATG AAAACATTGC TGCCGTGGTG TTCTCCTACA TAGCCACTCT GCTCTACGTG 
GTCCATGCGG TGTTCTCTTT AATCAGATGG AAGTCTTCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAL ( NM_002371.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002362.1 Homo sapiens mal, T cell differentiation protein (MAL), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu15983
Clone ID Related Accession (Same CDS sequence)	NM_002371.3 , NM_002371.4
Accession Version	NM_002371.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	myelin and lymphocyte protein isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76678.1 and BC000458.2. On Nov 22, 2018 this sequence version replaced NM_002371.3. Transcript Variant: This variant (a) includes both alternatively spliced exons 2 and 3, resulting in the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000458.2, SRR1660807.103390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309988.9/ ENSP00000310880.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG 
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG 
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA 
GAGACTTCCT GGGTCACCTT GGACGCAGCC TACCACTGCA CCGCTGCCCT CTTTTACCTC 
AGCGCCTCAG TCCTGGAGGC CCTGGCCACC ATCACGATGC AAGACGGCTT CACCTACAGG 
CACTACCATG AAAACATTGC TGCCGTGGTG TTCTCCTACA TAGCCACTCT GCTCTACGTG 
GTCCATGCGG TGTTCTCTTT AATCAGATGG AAGTCTTCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002362.1
CDS	86..547
Translation	MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVASSLVPWPLVQGWVMFVSVFCFVATTTLIILYIIGAHGGETSWVTLDAAYHCTAALFYLSASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS

Target ORF information:

RefSeq Version	NM_002371.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002371.4

ORF Insert Sequence:

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG 
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG 
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA 
GAGACTTCCT GGGTCACCTT GGACGCAGCC TACCACTGCA CCGCTGCCCT CTTTTACCTC 
AGCGCCTCAG TCCTGGAGGC CCTGGCCACC ATCACGATGC AAGACGGCTT CACCTACAGG 
CACTACCATG AAAACATTGC TGCCGTGGTG TTCTCCTACA TAGCCACTCT GCTCTACGTG 
GTCCATGCGG TGTTCTCTTT AATCAGATGG AAGTCTTCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAL ( NM_022439.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071884.1 Homo sapiens mal, T cell differentiation protein (MAL), transcript variant c, mRNA.

Price & Availability↑

CloneID	OHu15772
Clone ID Related Accession (Same CDS sequence)	NM_022439.2
Accession Version	NM_022439.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	myelin and lymphocyte protein isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76680.1 and BC000458.2. On May 9, 2012 this sequence version replaced NM_022439.1. Transcript Variant: This variant (c) is missing alternatively spliced exon 2 but includes exon 3, resulting in isoform c which is shorter than the predominant isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX457478.2, X76680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145313, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGACGCAG CCTACCACTG CACCGCTGCC 
CTCTTTTACC TCAGCGCCTC AGTCCTGGAG GCCCTGGCCA CCATCACGAT GCAAGACGGC 
TTCACCTACA GGCACTACCA TGAAAACATT GCTGCCGTGG TGTTCTCCTA CATAGCCACT 
CTGCTCTACG TGGTCCATGC GGTGTTCTCT TTAATCAGAT GGAAGTCTTC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071884.1
CDS	139..432
Translation	MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFDAAYHCTAALFYLSASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS

Target ORF information:

RefSeq Version	NM_022439.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant c, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022439.2

ORF Insert Sequence:

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGACGCAG CCTACCACTG CACCGCTGCC 
CTCTTTTACC TCAGCGCCTC AGTCCTGGAG GCCCTGGCCA CCATCACGAT GCAAGACGGC 
TTCACCTACA GGCACTACCA TGAAAACATT GCTGCCGTGG TGTTCTCCTA CATAGCCACT 
CTGCTCTACG TGGTCCATGC GGTGTTCTCT TTAATCAGAT GGAAGTCTTC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAL ( NM_022438.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071883.1 Homo sapiens mal, T cell differentiation protein (MAL), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu16029
Clone ID Related Accession (Same CDS sequence)	NM_022438.2
Accession Version	NM_022438.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	myelin and lymphocyte protein isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76679.1 and BC000458.2. On May 9, 2012 this sequence version replaced NM_022438.1. Transcript Variant: This variant (b) includes alternatively spliced exon 2 but is missing exon 3, resulting in isoform b which is shorter than the predominant isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X76679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG 
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG 
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA 
GAGACTTCCT GGGTCACCTT GGTGTTCTCC TACATAGCCA CTCTGCTCTA CGTGGTCCAT 
GCGGTGTTCT CTTTAATCAG ATGGAAGTCT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071883.1
CDS	139..474
Translation	MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVASSLVPWPLVQGWVMFVSVFCFVATTTLIILYIIGAHGGETSWVTLVFSYIATLLYVVHAVFSLIRWKSS

Target ORF information:

RefSeq Version	NM_022438.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mal, T cell differentiation protein (MAL), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022438.2

ORF Insert Sequence:

ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG 
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG 
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA 
GAGACTTCCT GGGTCACCTT GGTGTTCTCC TACATAGCCA CTCTGCTCTA CGTGGTCCAT 
GCGGTGTTCT CTTTAATCAG ATGGAAGTCT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.
Nature structural & molecular biology24(9)743-751(2017 Sep)
Ve T,Vajjhala PR,Hedger A,Croll T,DiMaio F,Horsefield S,Yu X,Lavrencic P,Hassan Z,Morgan GP,Mansell A,Mobli M,O'Carroll A,Chauvin B,Gambin Y,Sierecki E,Landsberg MJ,Stacey KJ,Egelman EH,Kobe B

MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis.
BMC cancer17(1)366(2017 May)
Zanotti L,Romani C,Tassone L,Todeschini P,Tassi RA,Bandiera E,Damia G,Ricci F,Ardighieri L,Calza S,Marchini S,Beltrame L,Tognon G,D'Incalci M,Pecorelli S,Sartori E,Odicino F,Ravaggi A,Bignotti E

MAL and TMEM220 are novel DNA methylation markers in human gastric cancer.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals22(1)35-44(2017 Feb)
Choi B,Han TS,Min J,Hur K,Lee SM,Lee HJ,Kim YJ,Yang HK

Reconstructing the TIR Side of the Myddosome: a Paradigm for TIR-TIR Interactions.
Structure (London, England : 1993)24(3)437-47(2016 Mar)
Vyncke L,Bovijn C,Pauwels E,Van Acker T,Ruyssinck E,Burg E,Tavernier J,Peelman F

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MAL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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