Ltk cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ltk
Entrez Gene ID	17005
Full Name	leukocyte tyrosine kinase
General protein information	Preferred Names leukocyte tyrosine kinase Names leukocyte tyrosine kinase receptor leukocyte receptor tyrosine kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 E5\|2 59.97 cM
Summary	The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_203345.2	NP_976220.2	leukocyte tyrosine kinase receptor isoform D precursor
NM_008523.2	NP_032549.2	leukocyte tyrosine kinase receptor isoform A
NM_206941.1	NP_996824.1	leukocyte tyrosine kinase receptor isoform B
NM_206942.2	NP_996825.2	leukocyte tyrosine kinase receptor isoform C precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ltk	NP_001101233.2
Homo sapiens (human)	LTK	NP_002335.2
Pan troglodytes (chimpanzee)	LTK	XP_001149706.1
	LTK	XP_001099288.2
Mus musculus (house mouse)	Ltk	NP_976220.2

Gene Ontology
Bibliography

Related articles in PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.
Norden DM, Trojanowski PJ, Walker FR, Godbout JP
Neurobiology of aging4422-41(2016 08)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.
Weiss JB, Xue C, Benice T, Xue L, Morris SW, Raber J
Pharmacology, biochemistry, and behavior100(3)566-74(2012 Jan)

Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.
Li J, Niu XL, Madamanchi NR
The Journal of biological chemistry283(49)34260-72(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In hippocampus, Ltk and Alk (anaplastic lymphoma kinase) are expressed throughout dentate gyrus, CA1, and CA3. Data suggest genetic interactions between Ltk and Alk in neurogenesis and behavioral measures (i.e., activity, anxiety, spatial memory).
Title: Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.

LAR regulates Fyn/JAK2/STAT3 and Fyn/p38 MAPK pathways involved in ROS-induced apoptosis
Title: Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.

polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
Title: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.

Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants.
Title: The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator.

The following Ltk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ltk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13371	NM_008523.2 Latest version!	Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu09701	NM_206941.1 Latest version!	Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$377.30 $539.00
OMu09635	NM_203345.2 Latest version!	Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$524.30 $749.00
OMu09704	NM_206942.2 Latest version!	Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ltk ( NM_008523.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032549.2 Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13371
Clone ID Related Accession (Same CDS sequence)	NM_008523.2
Accession Version	NM_008523.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1731bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	leukocyte tyrosine kinase receptor isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC047138.1. On Apr 1, 2004 this sequence version replaced NM_008523.1. Transcript Variant: This variant (1) is lacking several exons from the 5' end, and an internal coding exon compared to transcript variant 4. This results in a shorter isoform (A), which has a different N-terminus, is missing a 61 aa segment compared to isoform D, and that is localized in the endoplasmic reticulum. This variant is specifically expressed in the lymphocytes and initiates translation from a non-AUG (CUG) start codon. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047138.1, X52621.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 1662793, 8380920 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGGAGACCC GCGCGGCGGC GCCGGGCAGC GGCGGGAGAG GAGGCGCGGC AGGCGGTGAT 
ACTTCTGAGT CTGACCTCCT CTGGGCTGAT GGGGAAGATG GCACATCCTT TGTCCACCCC 
AGTGGTGAGC TCTACCTACA GCCTCTGGCA GTCACAGAGG GCCATGGGGA GGTGGAGATC 
CGAAAGCATC CCAACTGCAG TCACTGCCCT TTCAAAGACT GCCAGTGGCA GGCAGAGCTC 
TGGACGGCCG AATGCACGTG CCCAGAGGGC ACGGAGCTAG CTGTGGATAA TGTCACTTGC 
ATGGACCTGC CAACCACCGC AAGCCCTCTG ATCCTGATGG GAGCTGTAGT GGCAGCCTTG 
GCACTGAGTC TCCTAATGAT GTGTGCAGTC CTGATTCTAG TGAACCAGAA GTGTCAGGGC 
CTGTGGGGGA CCAGGCTGCC AGGCCCTGAG CTTGAGCTAA GCAAGCTTCG ATCCTCTGCC 
ATCAGGACAG CACCCAACCC TTACTATTGT CAGGTGGGAC TCAGTCCTGC CCAGCCCTGG 
CCTTTGCCCC CAGGGCTCAC TGAGGTTTCA CCAGCCAATG TCACTCTACT CAGAGCCCTT 
GGCCATGGTG CCTTTGGGGA AGTGTACGAG GGACTAGTGA CTGGTCTTCC TGGGGACTCC 
AGTCCTCTTC CAGTGGCTAT TAAGACTCTG CCAGAGCTCT GCTCCCATCA GGATGAGCTG 
GATTTTCTCA TGGAGGCTCT GATCATCAGC AAGTTCAGCC ATCAGAACAT TGTACGCTGT 
GTGGGGCTCA GCTTTCGGTC TGCCCCGCGC CTCATTCTGC TGGAGCTGAT GTCTGGTGGG 
GACATGAAGA GCTTTTTGAG GCACAGCAGA CCACACCCAG GACAACTGGC ACCTCTGACC 
ATGCAGGACC TATTGCAGCT GGCCCAGGAT ATAGCCCAGG GCTGCCACTA CCTGGAGGAA 
AATCACTTCA TTCACAGAGA CATTGCTGCC CGTAACTGTC TGCTTAGCTG CAGTGGAGCC 
AGCCGAGTGG CCAAGATTGG AGATTTTGGA ATGGCAAGAG ATATCTACCA GGCCAGTTAT 
TATCGCAAGG GTGGCCGGAC CTTGCTCCCA GTCAAGTGGA TGCCGCCAGA AGCTCTCCTG 
GAGGGCCTTT TCACATCCAA GACAGACTCC TGGTCTTTTG GGGTCCTGCT CTGGGAGATC 
TTCTCACTGG GGTATATGCC CTACCCTGGA CATACCAACC AGGAGGTTCT AGACTTCATT 
GCCACAGGGA ACAGGATGGA CCCTCCTAGG AACTGTCCTG GGCCAGTGTA CCGAATCATG 
ACCCAGTGTT GGCAGCATCA GCCGGAGCTC CGCCCTGACT TTGGCAGCAT CTTGGAACGG 
ATTCAGTACT GCACTCAGGA CCCTGATGTG CTGAACTCAC CCCTGCCCGT GGAACCTGGG 
CCCATTCTAG AGGAGGAAGA GGCCTCCAGG CTGGGAAACA GGTCACTGGA GGGTCTTAGA 
TCCCCAAAGC CCCTAGAGCT GAGTTCTCAG AACTTGAAGA GCTGGGGAGG AGGCCTTCTT 
GGCTCTTGGC TGCCCTCTGG CCTCAAGACC CTCAAACCCA GGTGCCTCCA ACCTCAGAAC 
ATTTGGAACC CCACCTATGG CTCCTGGACC CCAAGGGGCC CCCAGGGTGA AGATACAGGC 
ATTGAACACT GCAATGGCTC CTCCTCAAGT TCCATTCCAG GCATCCAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032549.2
CDS	228..1958
Translation	LETRAAAPGSGGRGGAAGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNPTYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ

Target ORF information:

RefSeq Version	NM_008523.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008523.2

ORF Insert Sequence:

CTGGAGACCC GCGCGGCGGC GCCGGGCAGC GGCGGGAGAG GAGGCGCGGC AGGCGGTGAT 
ACTTCTGAGT CTGACCTCCT CTGGGCTGAT GGGGAAGATG GCACATCCTT TGTCCACCCC 
AGTGGTGAGC TCTACCTACA GCCTCTGGCA GTCACAGAGG GCCATGGGGA GGTGGAGATC 
CGAAAGCATC CCAACTGCAG TCACTGCCCT TTCAAAGACT GCCAGTGGCA GGCAGAGCTC 
TGGACGGCCG AATGCACGTG CCCAGAGGGC ACGGAGCTAG CTGTGGATAA TGTCACTTGC 
ATGGACCTGC CAACCACCGC AAGCCCTCTG ATCCTGATGG GAGCTGTAGT GGCAGCCTTG 
GCACTGAGTC TCCTAATGAT GTGTGCAGTC CTGATTCTAG TGAACCAGAA GTGTCAGGGC 
CTGTGGGGGA CCAGGCTGCC AGGCCCTGAG CTTGAGCTAA GCAAGCTTCG ATCCTCTGCC 
ATCAGGACAG CACCCAACCC TTACTATTGT CAGGTGGGAC TCAGTCCTGC CCAGCCCTGG 
CCTTTGCCCC CAGGGCTCAC TGAGGTTTCA CCAGCCAATG TCACTCTACT CAGAGCCCTT 
GGCCATGGTG CCTTTGGGGA AGTGTACGAG GGACTAGTGA CTGGTCTTCC TGGGGACTCC 
AGTCCTCTTC CAGTGGCTAT TAAGACTCTG CCAGAGCTCT GCTCCCATCA GGATGAGCTG 
GATTTTCTCA TGGAGGCTCT GATCATCAGC AAGTTCAGCC ATCAGAACAT TGTACGCTGT 
GTGGGGCTCA GCTTTCGGTC TGCCCCGCGC CTCATTCTGC TGGAGCTGAT GTCTGGTGGG 
GACATGAAGA GCTTTTTGAG GCACAGCAGA CCACACCCAG GACAACTGGC ACCTCTGACC 
ATGCAGGACC TATTGCAGCT GGCCCAGGAT ATAGCCCAGG GCTGCCACTA CCTGGAGGAA 
AATCACTTCA TTCACAGAGA CATTGCTGCC CGTAACTGTC TGCTTAGCTG CAGTGGAGCC 
AGCCGAGTGG CCAAGATTGG AGATTTTGGA ATGGCAAGAG ATATCTACCA GGCCAGTTAT 
TATCGCAAGG GTGGCCGGAC CTTGCTCCCA GTCAAGTGGA TGCCGCCAGA AGCTCTCCTG 
GAGGGCCTTT TCACATCCAA GACAGACTCC TGGTCTTTTG GGGTCCTGCT CTGGGAGATC 
TTCTCACTGG GGTATATGCC CTACCCTGGA CATACCAACC AGGAGGTTCT AGACTTCATT 
GCCACAGGGA ACAGGATGGA CCCTCCTAGG AACTGTCCTG GGCCAGTGTA CCGAATCATG 
ACCCAGTGTT GGCAGCATCA GCCGGAGCTC CGCCCTGACT TTGGCAGCAT CTTGGAACGG 
ATTCAGTACT GCACTCAGGA CCCTGATGTG CTGAACTCAC CCCTGCCCGT GGAACCTGGG 
CCCATTCTAG AGGAGGAAGA GGCCTCCAGG CTGGGAAACA GGTCACTGGA GGGTCTTAGA 
TCCCCAAAGC CCCTAGAGCT GAGTTCTCAG AACTTGAAGA GCTGGGGAGG AGGCCTTCTT 
GGCTCTTGGC TGCCCTCTGG CCTCAAGACC CTCAAACCCA GGTGCCTCCA ACCTCAGAAC 
ATTTGGAACC CCACCTATGG CTCCTGGACC CCAAGGGGCC CCCAGGGTGA AGATACAGGC 
ATTGAACACT GCAATGGCTC CTCCTCAAGT TCCATTCCAG GCATCCAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ltk ( NM_206941.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_996824.1 Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu09701
Clone ID Related Accession (Same CDS sequence)	NM_206941.1
Accession Version	NM_206941.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1914bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	leukocyte tyrosine kinase receptor isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC047138.1 and M90470.1. Transcript Variant: This variant (2) is missing several exons from the 5' end, and has a different 5' end exon compared to transcript variant 4. This results in a shorter isoform (B) with a different N-terminus compared to isoform D. This variant is specifically expressed in the brain and initiates translation from a non-AUG (CUG) start codon. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 1662793, 8380920 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGGAGACCC GCGCGGCGGC GCCGGGCAGC GGCGGGAGAG GAGGCGCGGC AGGTGGAGGG 
AGCGGCTGGA CGTCGCGAGC CCACTCTCCG CAGGCCGGAC GCTCGCCGCG GGAAGGGGCC 
GAGGGCGGCG AGGGCTGCGC GGAGGCCTGG GCTGCGCTCC GCTGGGCTGC GGCGGGAGGC 
TTCGGGGGCG GCGGCGGGGC CTGCGCGGCG GGCGGCGGTG GCGGCGGCTA CCGGGGCGGT 
GATACTTCTG AGTCTGACCT CCTCTGGGCT GATGGGGAAG ATGGCACATC CTTTGTCCAC 
CCCAGTGGTG AGCTCTACCT ACAGCCTCTG GCAGTCACAG AGGGCCATGG GGAGGTGGAG 
ATCCGAAAGC ATCCCAACTG CAGTCACTGC CCTTTCAAAG ACTGCCAGTG GCAGGCAGAG 
CTCTGGACGG CCGAATGCAC GTGCCCAGAG GGCACGGAGC TAGCTGTGGA TAATGTCACT 
TGCATGGACC TGCCAACCAC CGCAAGCCCT CTGATCCTGA TGGGAGCTGT AGTGGCAGCC 
TTGGCACTGA GTCTCCTAAT GATGTGTGCA GTCCTGATTC TAGTGAACCA GAAGTGTCAG 
GGCCTGTGGG GGACCAGGCT GCCAGGCCCT GAGCTTGAGC TAAGCAAGCT TCGATCCTCT 
GCCATCAGGA CAGCACCCAA CCCTTACTAT TGTCAGGTGG GACTCAGTCC TGCCCAGCCC 
TGGCCTTTGC CCCCAGGGCT CACTGAGGTT TCACCAGCCA ATGTCACTCT ACTCAGAGCC 
CTTGGCCATG GTGCCTTTGG GGAAGTGTAC GAGGGACTAG TGACTGGTCT TCCTGGGGAC 
TCCAGTCCTC TTCCAGTGGC TATTAAGACT CTGCCAGAGC TCTGCTCCCA TCAGGATGAG 
CTGGATTTTC TCATGGAGGC TCTGATCATC AGCAAGTTCA GCCATCAGAA CATTGTACGC 
TGTGTGGGGC TCAGCTTTCG GTCTGCCCCG CGCCTCATTC TGCTGGAGCT GATGTCTGGT 
GGGGACATGA AGAGCTTTTT GAGGCACAGC AGACCACACC CAGGACAACT GGCACCTCTG 
ACCATGCAGG ACCTATTGCA GCTGGCCCAG GATATAGCCC AGGGCTGCCA CTACCTGGAG 
GAAAATCACT TCATTCACAG AGACATTGCT GCCCGTAACT GTCTGCTTAG CTGCAGTGGA 
GCCAGCCGAG TGGCCAAGAT TGGAGATTTT GGAATGGCAA GAGATATCTA CCAGGCCAGT 
TATTATCGCA AGGGTGGCCG GACCTTGCTC CCAGTCAAGT GGATGCCGCC AGAAGCTCTC 
CTGGAGGGCC TTTTCACATC CAAGACAGAC TCCTGGTCTT TTGGGGTCCT GCTCTGGGAG 
ATCTTCTCAC TGGGGTATAT GCCCTACCCT GGACATACCA ACCAGGAGGT TCTAGACTTC 
ATTGCCACAG GGAACAGGAT GGACCCTCCT AGGAACTGTC CTGGGCCAGT GTACCGAATC 
ATGACCCAGT GTTGGCAGCA TCAGCCGGAG CTCCGCCCTG ACTTTGGCAG CATCTTGGAA 
CGGATTCAGT ACTGCACTCA GGACCCTGAT GTGCTGAACT CACCCCTGCC CGTGGAACCT 
GGGCCCATTC TAGAGGAGGA AGAGGCCTCC AGGCTGGGAA ACAGGTCACT GGAGGGTCTT 
AGATCCCCAA AGCCCCTAGA GCTGAGTTCT CAGAACTTGA AGAGCTGGGG AGGAGGCCTT 
CTTGGCTCTT GGCTGCCCTC TGGCCTCAAG ACCCTCAAAC CCAGGTGCCT CCAACCTCAG 
AACATTTGGA ACCCCACCTA TGGCTCCTGG ACCCCAAGGG GCCCCCAGGG TGAAGATACA 
GGCATTGAAC ACTGCAATGG CTCCTCCTCA AGTTCCATTC CAGGCATCCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996824.1
CDS	228..2141
Translation	LETRAAAPGSGGRGGAAGGGSGWTSRAHSPQAGRSPREGAEGGEGCAEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNPTYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ

Target ORF information:

RefSeq Version	NM_206941.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206941.1

ORF Insert Sequence:

CTGGAGACCC GCGCGGCGGC GCCGGGCAGC GGCGGGAGAG GAGGCGCGGC AGGTGGAGGG 
AGCGGCTGGA CGTCGCGAGC CCACTCTCCG CAGGCCGGAC GCTCGCCGCG GGAAGGGGCC 
GAGGGCGGCG AGGGCTGCGC GGAGGCCTGG GCTGCGCTCC GCTGGGCTGC GGCGGGAGGC 
TTCGGGGGCG GCGGCGGGGC CTGCGCGGCG GGCGGCGGTG GCGGCGGCTA CCGGGGCGGT 
GATACTTCTG AGTCTGACCT CCTCTGGGCT GATGGGGAAG ATGGCACATC CTTTGTCCAC 
CCCAGTGGTG AGCTCTACCT ACAGCCTCTG GCAGTCACAG AGGGCCATGG GGAGGTGGAG 
ATCCGAAAGC ATCCCAACTG CAGTCACTGC CCTTTCAAAG ACTGCCAGTG GCAGGCAGAG 
CTCTGGACGG CCGAATGCAC GTGCCCAGAG GGCACGGAGC TAGCTGTGGA TAATGTCACT 
TGCATGGACC TGCCAACCAC CGCAAGCCCT CTGATCCTGA TGGGAGCTGT AGTGGCAGCC 
TTGGCACTGA GTCTCCTAAT GATGTGTGCA GTCCTGATTC TAGTGAACCA GAAGTGTCAG 
GGCCTGTGGG GGACCAGGCT GCCAGGCCCT GAGCTTGAGC TAAGCAAGCT TCGATCCTCT 
GCCATCAGGA CAGCACCCAA CCCTTACTAT TGTCAGGTGG GACTCAGTCC TGCCCAGCCC 
TGGCCTTTGC CCCCAGGGCT CACTGAGGTT TCACCAGCCA ATGTCACTCT ACTCAGAGCC 
CTTGGCCATG GTGCCTTTGG GGAAGTGTAC GAGGGACTAG TGACTGGTCT TCCTGGGGAC 
TCCAGTCCTC TTCCAGTGGC TATTAAGACT CTGCCAGAGC TCTGCTCCCA TCAGGATGAG 
CTGGATTTTC TCATGGAGGC TCTGATCATC AGCAAGTTCA GCCATCAGAA CATTGTACGC 
TGTGTGGGGC TCAGCTTTCG GTCTGCCCCG CGCCTCATTC TGCTGGAGCT GATGTCTGGT 
GGGGACATGA AGAGCTTTTT GAGGCACAGC AGACCACACC CAGGACAACT GGCACCTCTG 
ACCATGCAGG ACCTATTGCA GCTGGCCCAG GATATAGCCC AGGGCTGCCA CTACCTGGAG 
GAAAATCACT TCATTCACAG AGACATTGCT GCCCGTAACT GTCTGCTTAG CTGCAGTGGA 
GCCAGCCGAG TGGCCAAGAT TGGAGATTTT GGAATGGCAA GAGATATCTA CCAGGCCAGT 
TATTATCGCA AGGGTGGCCG GACCTTGCTC CCAGTCAAGT GGATGCCGCC AGAAGCTCTC 
CTGGAGGGCC TTTTCACATC CAAGACAGAC TCCTGGTCTT TTGGGGTCCT GCTCTGGGAG 
ATCTTCTCAC TGGGGTATAT GCCCTACCCT GGACATACCA ACCAGGAGGT TCTAGACTTC 
ATTGCCACAG GGAACAGGAT GGACCCTCCT AGGAACTGTC CTGGGCCAGT GTACCGAATC 
ATGACCCAGT GTTGGCAGCA TCAGCCGGAG CTCCGCCCTG ACTTTGGCAG CATCTTGGAA 
CGGATTCAGT ACTGCACTCA GGACCCTGAT GTGCTGAACT CACCCCTGCC CGTGGAACCT 
GGGCCCATTC TAGAGGAGGA AGAGGCCTCC AGGCTGGGAA ACAGGTCACT GGAGGGTCTT 
AGATCCCCAA AGCCCCTAGA GCTGAGTTCT CAGAACTTGA AGAGCTGGGG AGGAGGCCTT 
CTTGGCTCTT GGCTGCCCTC TGGCCTCAAG ACCCTCAAAC CCAGGTGCCT CCAACCTCAG 
AACATTTGGA ACCCCACCTA TGGCTCCTGG ACCCCAAGGG GCCCCCAGGG TGAAGATACA 
GGCATTGAAC ACTGCAATGG CTCCTCCTCA AGTTCCATTC CAGGCATCCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ltk ( NM_203345.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_976220.2 Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu09635
Clone ID Related Accession (Same CDS sequence)	NM_203345.2
Accession Version	NM_203345.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	leukocyte tyrosine kinase receptor isoform D precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M90470.1, AL844536.13 and BC047138.1. On Nov 2, 2007 this sequence version replaced NM_203345.1. Transcript Variant: This variant (4) encodes the longest isoform (D), is expressed in neuroblastoma cells, and initiates translation from the standard AUG start codon. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M90470.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTGCT CCCACCGGCT GCTGCTGTGG CTGGGAGCTG CTGGAACTAT TCTTTGCTCC 
AACTCGGAGT TCCAGACACC TTTTCTAACA CCTTCGCTTT TGCCGGTGCT GGTACTCAAT 
TCCCAGGAGC AGAAAGTCAC CCCCACACCC AGTAAATTGG AGCCAGCTTC CCTCCCAAAT 
CCTCTAGGCA CACGGGGGCC TTGGGTGTTT AACACCTGTG GCGCCAGCGG CAGGAGCGGA 
CCCACACAAA CACAGTGCGA TGGGGCATAC ACAGGAAGCA GCGTGATGGT GACAGTGGGG 
GCTGCCGGGC CGCTCAAAGG CGTGCAGCTG TGGCGGGTGC CAGACACAGG CCAGTATCTG 
ATCTCCGCCT ACGGAGCGGC GGGCGGCAAG GGCGCCCAAA ACCACCTGTC ACGGGCGCAC 
GGCATCTTCC TCTCAGCAGT CTTCTTCCTC CGTCGCGGGG AGCCGGTGTA CATCCTTGTG 
GGGCAGCAGG GCCAGGACGC CTGTCCCGGA GGGAGCCCTG AGAGCCAACT CGTCTGTCTG 
GGAGAGTCTG GGGAGCATGC AACCACCTAT GGGACCGAAA GGATCCCAGG CTGGAGACGC 
TGGGCCGGCG GGGGCGGGGG TGGCGGAGGC GCCACCTCCA TCTTCCGGCT GCGCGCGGGG 
GAGCCAGAGC CGCTGCTGGT GGCGGCGGGA GGCGGCGGGA GGTCCTACCG GAGGCGACCT 
GACCGCGGCC GGACTCAGGC CGTCCCCGAG AGGCTGGAGA CCCGCGCGGC GGCGCCGGGC 
AGCGGCGGGA GAGGAGGCGC GGCAGGTGGA GGGAGCGGCT GGACGTCGCG AGCCCACTCT 
CCGCAGGCCG GACGCTCGCC GCGGGAAGGG GCCGAGGGCG GCGAGGGCTG CGCGGAGGCC 
TGGGCTGCGC TCCGCTGGGC TGCGGCGGGA GGCTTCGGGG GCGGCGGCGG GGCCTGCGCG 
GCGGGCGGCG GTGGCGGCGG CTACCGGGGC GGTGATACTT CTGAGTCTGA CCTCCTCTGG 
GCTGATGGGG AAGATGGCAC ATCCTTTGTC CACCCCAGTG GTGAGCTCTA CCTACAGCCT 
CTGGCAGTCA CAGAGGGCCA TGGGGAGGTG GAGATCCGAA AGCATCCCAA CTGCAGTCAC 
TGCCCTTTCA AAGACTGCCA GTGGCAGGCA GAGCTCTGGA CGGCCGAATG CACGTGCCCA 
GAGGGCACGG AGCTAGCTGT GGATAATGTC ACTTGCATGG ACCTGCCAAC CACCGCAAGC 
CCTCTGATCC TGATGGGAGC TGTAGTGGCA GCCTTGGCAC TGAGTCTCCT AATGATGTGT 
GCAGTCCTGA TTCTAGTGAA CCAGAAGTGT CAGGGCCTGT GGGGGACCAG GCTGCCAGGC 
CCTGAGCTTG AGCTAAGCAA GCTTCGATCC TCTGCCATCA GGACAGCACC CAACCCTTAC 
TATTGTCAGG TGGGACTCAG TCCTGCCCAG CCCTGGCCTT TGCCCCCAGG GCTCACTGAG 
GTTTCACCAG CCAATGTCAC TCTACTCAGA GCCCTTGGCC ATGGTGCCTT TGGGGAAGTG 
TACGAGGGAC TAGTGACTGG TCTTCCTGGG GACTCCAGTC CTCTTCCAGT GGCTATTAAG 
ACTCTGCCAG AGCTCTGCTC CCATCAGGAT GAGCTGGATT TTCTCATGGA GGCTCTGATC 
ATCAGCAAGT TCAGCCATCA GAACATTGTA CGCTGTGTGG GGCTCAGCTT TCGGTCTGCC 
CCGCGCCTCA TTCTGCTGGA GCTGATGTCT GGTGGGGACA TGAAGAGCTT TTTGAGGCAC 
AGCAGACCAC ACCCAGGACA ACTGGCACCT CTGACCATGC AGGACCTATT GCAGCTGGCC 
CAGGATATAG CCCAGGGCTG CCACTACCTG GAGGAAAATC ACTTCATTCA CAGAGACATT 
GCTGCCCGTA ACTGTCTGCT TAGCTGCAGT GGAGCCAGCC GAGTGGCCAA GATTGGAGAT 
TTTGGAATGG CAAGAGATAT CTACCAGGCC AGTTATTATC GCAAGGGTGG CCGGACCTTG 
CTCCCAGTCA AGTGGATGCC GCCAGAAGCT CTCCTGGAGG GCCTTTTCAC ATCCAAGACA 
GACTCCTGGT CTTTTGGGGT CCTGCTCTGG GAGATCTTCT CACTGGGGTA TATGCCCTAC 
CCTGGACATA CCAACCAGGA GGTTCTAGAC TTCATTGCCA CAGGGAACAG GATGGACCCT 
CCTAGGAACT GTCCTGGGCC AGTGTACCGA ATCATGACCC AGTGTTGGCA GCATCAGCCG 
GAGCTCCGCC CTGACTTTGG CAGCATCTTG GAACGGATTC AGTACTGCAC TCAGGACCCT 
GATGTGCTGA ACTCACCCCT GCCCGTGGAA CCTGGGCCCA TTCTAGAGGA GGAAGAGGCC 
TCCAGGCTGG GAAACAGGTC ACTGGAGGGT CTTAGATCCC CAAAGCCCCT AGAGCTGAGT 
TCTCAGAACT TGAAGAGCTG GGGAGGAGGC CTTCTTGGCT CTTGGCTGCC CTCTGGCCTC 
AAGACCCTCA AACCCAGGTG CCTCCAACCT CAGAACATTT GGAACCCCAC CTATGGCTCC 
TGGACCCCAA GGGGCCCCCA GGGTGAAGAT ACAGGCATTG AACACTGCAA TGGCTCCTCC 
TCAAGTTCCA TTCCAGGCAT CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_976220.2
CDS	138..2804
Translation	MGCSHRLLLWLGAAGTILCSNSEFQTPFLTPSLLPVLVLNSQEQKVTPTPSKLEPASLPNPLGTRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVMVTVGAAGPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQQGQDACPGGSPESQLVCLGESGEHATTYGTERIPGWRRWAGGGGGGGGATSIFRLRAGEPEPLLVAAGGGGRSYRRRPDRGRTQAVPERLETRAAAPGSGGRGGAAGGGSGWTSRAHSPQAGRSPREGAEGGEGCAEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNPTYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ

Target ORF information:

RefSeq Version	NM_203345.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203345.2

ORF Insert Sequence:

ATGGGCTGCT CCCACCGGCT GCTGCTGTGG CTGGGAGCTG CTGGAACTAT TCTTTGCTCC 
AACTCGGAGT TCCAGACACC TTTTCTAACA CCTTCGCTTT TGCCGGTGCT GGTACTCAAT 
TCCCAGGAGC AGAAAGTCAC CCCCACACCC AGTAAATTGG AGCCAGCTTC CCTCCCAAAT 
CCTCTAGGCA CACGGGGGCC TTGGGTGTTT AACACCTGTG GCGCCAGCGG CAGGAGCGGA 
CCCACACAAA CACAGTGCGA TGGGGCATAC ACAGGAAGCA GCGTGATGGT GACAGTGGGG 
GCTGCCGGGC CGCTCAAAGG CGTGCAGCTG TGGCGGGTGC CAGACACAGG CCAGTATCTG 
ATCTCCGCCT ACGGAGCGGC GGGCGGCAAG GGCGCCCAAA ACCACCTGTC ACGGGCGCAC 
GGCATCTTCC TCTCAGCAGT CTTCTTCCTC CGTCGCGGGG AGCCGGTGTA CATCCTTGTG 
GGGCAGCAGG GCCAGGACGC CTGTCCCGGA GGGAGCCCTG AGAGCCAACT CGTCTGTCTG 
GGAGAGTCTG GGGAGCATGC AACCACCTAT GGGACCGAAA GGATCCCAGG CTGGAGACGC 
TGGGCCGGCG GGGGCGGGGG TGGCGGAGGC GCCACCTCCA TCTTCCGGCT GCGCGCGGGG 
GAGCCAGAGC CGCTGCTGGT GGCGGCGGGA GGCGGCGGGA GGTCCTACCG GAGGCGACCT 
GACCGCGGCC GGACTCAGGC CGTCCCCGAG AGGCTGGAGA CCCGCGCGGC GGCGCCGGGC 
AGCGGCGGGA GAGGAGGCGC GGCAGGTGGA GGGAGCGGCT GGACGTCGCG AGCCCACTCT 
CCGCAGGCCG GACGCTCGCC GCGGGAAGGG GCCGAGGGCG GCGAGGGCTG CGCGGAGGCC 
TGGGCTGCGC TCCGCTGGGC TGCGGCGGGA GGCTTCGGGG GCGGCGGCGG GGCCTGCGCG 
GCGGGCGGCG GTGGCGGCGG CTACCGGGGC GGTGATACTT CTGAGTCTGA CCTCCTCTGG 
GCTGATGGGG AAGATGGCAC ATCCTTTGTC CACCCCAGTG GTGAGCTCTA CCTACAGCCT 
CTGGCAGTCA CAGAGGGCCA TGGGGAGGTG GAGATCCGAA AGCATCCCAA CTGCAGTCAC 
TGCCCTTTCA AAGACTGCCA GTGGCAGGCA GAGCTCTGGA CGGCCGAATG CACGTGCCCA 
GAGGGCACGG AGCTAGCTGT GGATAATGTC ACTTGCATGG ACCTGCCAAC CACCGCAAGC 
CCTCTGATCC TGATGGGAGC TGTAGTGGCA GCCTTGGCAC TGAGTCTCCT AATGATGTGT 
GCAGTCCTGA TTCTAGTGAA CCAGAAGTGT CAGGGCCTGT GGGGGACCAG GCTGCCAGGC 
CCTGAGCTTG AGCTAAGCAA GCTTCGATCC TCTGCCATCA GGACAGCACC CAACCCTTAC 
TATTGTCAGG TGGGACTCAG TCCTGCCCAG CCCTGGCCTT TGCCCCCAGG GCTCACTGAG 
GTTTCACCAG CCAATGTCAC TCTACTCAGA GCCCTTGGCC ATGGTGCCTT TGGGGAAGTG 
TACGAGGGAC TAGTGACTGG TCTTCCTGGG GACTCCAGTC CTCTTCCAGT GGCTATTAAG 
ACTCTGCCAG AGCTCTGCTC CCATCAGGAT GAGCTGGATT TTCTCATGGA GGCTCTGATC 
ATCAGCAAGT TCAGCCATCA GAACATTGTA CGCTGTGTGG GGCTCAGCTT TCGGTCTGCC 
CCGCGCCTCA TTCTGCTGGA GCTGATGTCT GGTGGGGACA TGAAGAGCTT TTTGAGGCAC 
AGCAGACCAC ACCCAGGACA ACTGGCACCT CTGACCATGC AGGACCTATT GCAGCTGGCC 
CAGGATATAG CCCAGGGCTG CCACTACCTG GAGGAAAATC ACTTCATTCA CAGAGACATT 
GCTGCCCGTA ACTGTCTGCT TAGCTGCAGT GGAGCCAGCC GAGTGGCCAA GATTGGAGAT 
TTTGGAATGG CAAGAGATAT CTACCAGGCC AGTTATTATC GCAAGGGTGG CCGGACCTTG 
CTCCCAGTCA AGTGGATGCC GCCAGAAGCT CTCCTGGAGG GCCTTTTCAC ATCCAAGACA 
GACTCCTGGT CTTTTGGGGT CCTGCTCTGG GAGATCTTCT CACTGGGGTA TATGCCCTAC 
CCTGGACATA CCAACCAGGA GGTTCTAGAC TTCATTGCCA CAGGGAACAG GATGGACCCT 
CCTAGGAACT GTCCTGGGCC AGTGTACCGA ATCATGACCC AGTGTTGGCA GCATCAGCCG 
GAGCTCCGCC CTGACTTTGG CAGCATCTTG GAACGGATTC AGTACTGCAC TCAGGACCCT 
GATGTGCTGA ACTCACCCCT GCCCGTGGAA CCTGGGCCCA TTCTAGAGGA GGAAGAGGCC 
TCCAGGCTGG GAAACAGGTC ACTGGAGGGT CTTAGATCCC CAAAGCCCCT AGAGCTGAGT 
TCTCAGAACT TGAAGAGCTG GGGAGGAGGC CTTCTTGGCT CTTGGCTGCC CTCTGGCCTC 
AAGACCCTCA AACCCAGGTG CCTCCAACCT CAGAACATTT GGAACCCCAC CTATGGCTCC 
TGGACCCCAA GGGGCCCCCA GGGTGAAGAT ACAGGCATTG AACACTGCAA TGGCTCCTCC 
TCAAGTTCCA TTCCAGGCAT CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ltk ( NM_206942.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_996825.2 Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 3, mRNA.

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CloneID	OMu09704
Clone ID Related Accession (Same CDS sequence)	NM_206942.2
Accession Version	NM_206942.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2484bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	leukocyte tyrosine kinase receptor isoform C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M90470.1, AL844536.13 and BC047138.1. On Nov 2, 2007 this sequence version replaced NM_206942.1. Transcript Variant: This variant (3) is lacking an internal coding exon compared to transcript variant 4. This results in an isoform (C), which is missing a 61 aa segment compared to isoform D, and that is localized in the endoplasmic reticulum. This variant is expressed in neuroblastoma cells and initiates translation from the standard AUG start codon. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC141299.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTGCT CCCACCGGCT GCTGCTGTGG CTGGGAGCTG CTGGAACTAT TCTTTGCTCC 
AACTCGGAGT TCCAGACACC TTTTCTAACA CCTTCGCTTT TGCCGGTGCT GGTACTCAAT 
TCCCAGGAGC AGAAAGTCAC CCCCACACCC AGTAAATTGG AGCCAGCTTC CCTCCCAAAT 
CCTCTAGGCA CACGGGGGCC TTGGGTGTTT AACACCTGTG GCGCCAGCGG CAGGAGCGGA 
CCCACACAAA CACAGTGCGA TGGGGCATAC ACAGGAAGCA GCGTGATGGT GACAGTGGGG 
GCTGCCGGGC CGCTCAAAGG CGTGCAGCTG TGGCGGGTGC CAGACACAGG CCAGTATCTG 
ATCTCCGCCT ACGGAGCGGC GGGCGGCAAG GGCGCCCAAA ACCACCTGTC ACGGGCGCAC 
GGCATCTTCC TCTCAGCAGT CTTCTTCCTC CGTCGCGGGG AGCCGGTGTA CATCCTTGTG 
GGGCAGCAGG GCCAGGACGC CTGTCCCGGA GGGAGCCCTG AGAGCCAACT CGTCTGTCTG 
GGAGAGTCTG GGGAGCATGC AACCACCTAT GGGACCGAAA GGATCCCAGG CTGGAGACGC 
TGGGCCGGCG GGGGCGGGGG TGGCGGAGGC GCCACCTCCA TCTTCCGGCT GCGCGCGGGG 
GAGCCAGAGC CGCTGCTGGT GGCGGCGGGA GGCGGCGGGA GGTCCTACCG GAGGCGACCT 
GACCGCGGCC GGACTCAGGC CGTCCCCGAG AGGCTGGAGA CCCGCGCGGC GGCGCCGGGC 
AGCGGCGGGA GAGGAGGCGC GGCAGGCGGT GATACTTCTG AGTCTGACCT CCTCTGGGCT 
GATGGGGAAG ATGGCACATC CTTTGTCCAC CCCAGTGGTG AGCTCTACCT ACAGCCTCTG 
GCAGTCACAG AGGGCCATGG GGAGGTGGAG ATCCGAAAGC ATCCCAACTG CAGTCACTGC 
CCTTTCAAAG ACTGCCAGTG GCAGGCAGAG CTCTGGACGG CCGAATGCAC GTGCCCAGAG 
GGCACGGAGC TAGCTGTGGA TAATGTCACT TGCATGGACC TGCCAACCAC CGCAAGCCCT 
CTGATCCTGA TGGGAGCTGT AGTGGCAGCC TTGGCACTGA GTCTCCTAAT GATGTGTGCA 
GTCCTGATTC TAGTGAACCA GAAGTGTCAG GGCCTGTGGG GGACCAGGCT GCCAGGCCCT 
GAGCTTGAGC TAAGCAAGCT TCGATCCTCT GCCATCAGGA CAGCACCCAA CCCTTACTAT 
TGTCAGGTGG GACTCAGTCC TGCCCAGCCC TGGCCTTTGC CCCCAGGGCT CACTGAGGTT 
TCACCAGCCA ATGTCACTCT ACTCAGAGCC CTTGGCCATG GTGCCTTTGG GGAAGTGTAC 
GAGGGACTAG TGACTGGTCT TCCTGGGGAC TCCAGTCCTC TTCCAGTGGC TATTAAGACT 
CTGCCAGAGC TCTGCTCCCA TCAGGATGAG CTGGATTTTC TCATGGAGGC TCTGATCATC 
AGCAAGTTCA GCCATCAGAA CATTGTACGC TGTGTGGGGC TCAGCTTTCG GTCTGCCCCG 
CGCCTCATTC TGCTGGAGCT GATGTCTGGT GGGGACATGA AGAGCTTTTT GAGGCACAGC 
AGACCACACC CAGGACAACT GGCACCTCTG ACCATGCAGG ACCTATTGCA GCTGGCCCAG 
GATATAGCCC AGGGCTGCCA CTACCTGGAG GAAAATCACT TCATTCACAG AGACATTGCT 
GCCCGTAACT GTCTGCTTAG CTGCAGTGGA GCCAGCCGAG TGGCCAAGAT TGGAGATTTT 
GGAATGGCAA GAGATATCTA CCAGGCCAGT TATTATCGCA AGGGTGGCCG GACCTTGCTC 
CCAGTCAAGT GGATGCCGCC AGAAGCTCTC CTGGAGGGCC TTTTCACATC CAAGACAGAC 
TCCTGGTCTT TTGGGGTCCT GCTCTGGGAG ATCTTCTCAC TGGGGTATAT GCCCTACCCT 
GGACATACCA ACCAGGAGGT TCTAGACTTC ATTGCCACAG GGAACAGGAT GGACCCTCCT 
AGGAACTGTC CTGGGCCAGT GTACCGAATC ATGACCCAGT GTTGGCAGCA TCAGCCGGAG 
CTCCGCCCTG ACTTTGGCAG CATCTTGGAA CGGATTCAGT ACTGCACTCA GGACCCTGAT 
GTGCTGAACT CACCCCTGCC CGTGGAACCT GGGCCCATTC TAGAGGAGGA AGAGGCCTCC 
AGGCTGGGAA ACAGGTCACT GGAGGGTCTT AGATCCCCAA AGCCCCTAGA GCTGAGTTCT 
CAGAACTTGA AGAGCTGGGG AGGAGGCCTT CTTGGCTCTT GGCTGCCCTC TGGCCTCAAG 
ACCCTCAAAC CCAGGTGCCT CCAACCTCAG AACATTTGGA ACCCCACCTA TGGCTCCTGG 
ACCCCAAGGG GCCCCCAGGG TGAAGATACA GGCATTGAAC ACTGCAATGG CTCCTCCTCA 
AGTTCCATTC CAGGCATCCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996825.2
CDS	138..2621
Translation	MGCSHRLLLWLGAAGTILCSNSEFQTPFLTPSLLPVLVLNSQEQKVTPTPSKLEPASLPNPLGTRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVMVTVGAAGPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQQGQDACPGGSPESQLVCLGESGEHATTYGTERIPGWRRWAGGGGGGGGATSIFRLRAGEPEPLLVAAGGGGRSYRRRPDRGRTQAVPERLETRAAAPGSGGRGGAAGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNPTYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ

Target ORF information:

RefSeq Version	NM_206942.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206942.2

ORF Insert Sequence:

ATGGGCTGCT CCCACCGGCT GCTGCTGTGG CTGGGAGCTG CTGGAACTAT TCTTTGCTCC 
AACTCGGAGT TCCAGACACC TTTTCTAACA CCTTCGCTTT TGCCGGTGCT GGTACTCAAT 
TCCCAGGAGC AGAAAGTCAC CCCCACACCC AGTAAATTGG AGCCAGCTTC CCTCCCAAAT 
CCTCTAGGCA CACGGGGGCC TTGGGTGTTT AACACCTGTG GCGCCAGCGG CAGGAGCGGA 
CCCACACAAA CACAGTGCGA TGGGGCATAC ACAGGAAGCA GCGTGATGGT GACAGTGGGG 
GCTGCCGGGC CGCTCAAAGG CGTGCAGCTG TGGCGGGTGC CAGACACAGG CCAGTATCTG 
ATCTCCGCCT ACGGAGCGGC GGGCGGCAAG GGCGCCCAAA ACCACCTGTC ACGGGCGCAC 
GGCATCTTCC TCTCAGCAGT CTTCTTCCTC CGTCGCGGGG AGCCGGTGTA CATCCTTGTG 
GGGCAGCAGG GCCAGGACGC CTGTCCCGGA GGGAGCCCTG AGAGCCAACT CGTCTGTCTG 
GGAGAGTCTG GGGAGCATGC AACCACCTAT GGGACCGAAA GGATCCCAGG CTGGAGACGC 
TGGGCCGGCG GGGGCGGGGG TGGCGGAGGC GCCACCTCCA TCTTCCGGCT GCGCGCGGGG 
GAGCCAGAGC CGCTGCTGGT GGCGGCGGGA GGCGGCGGGA GGTCCTACCG GAGGCGACCT 
GACCGCGGCC GGACTCAGGC CGTCCCCGAG AGGCTGGAGA CCCGCGCGGC GGCGCCGGGC 
AGCGGCGGGA GAGGAGGCGC GGCAGGCGGT GATACTTCTG AGTCTGACCT CCTCTGGGCT 
GATGGGGAAG ATGGCACATC CTTTGTCCAC CCCAGTGGTG AGCTCTACCT ACAGCCTCTG 
GCAGTCACAG AGGGCCATGG GGAGGTGGAG ATCCGAAAGC ATCCCAACTG CAGTCACTGC 
CCTTTCAAAG ACTGCCAGTG GCAGGCAGAG CTCTGGACGG CCGAATGCAC GTGCCCAGAG 
GGCACGGAGC TAGCTGTGGA TAATGTCACT TGCATGGACC TGCCAACCAC CGCAAGCCCT 
CTGATCCTGA TGGGAGCTGT AGTGGCAGCC TTGGCACTGA GTCTCCTAAT GATGTGTGCA 
GTCCTGATTC TAGTGAACCA GAAGTGTCAG GGCCTGTGGG GGACCAGGCT GCCAGGCCCT 
GAGCTTGAGC TAAGCAAGCT TCGATCCTCT GCCATCAGGA CAGCACCCAA CCCTTACTAT 
TGTCAGGTGG GACTCAGTCC TGCCCAGCCC TGGCCTTTGC CCCCAGGGCT CACTGAGGTT 
TCACCAGCCA ATGTCACTCT ACTCAGAGCC CTTGGCCATG GTGCCTTTGG GGAAGTGTAC 
GAGGGACTAG TGACTGGTCT TCCTGGGGAC TCCAGTCCTC TTCCAGTGGC TATTAAGACT 
CTGCCAGAGC TCTGCTCCCA TCAGGATGAG CTGGATTTTC TCATGGAGGC TCTGATCATC 
AGCAAGTTCA GCCATCAGAA CATTGTACGC TGTGTGGGGC TCAGCTTTCG GTCTGCCCCG 
CGCCTCATTC TGCTGGAGCT GATGTCTGGT GGGGACATGA AGAGCTTTTT GAGGCACAGC 
AGACCACACC CAGGACAACT GGCACCTCTG ACCATGCAGG ACCTATTGCA GCTGGCCCAG 
GATATAGCCC AGGGCTGCCA CTACCTGGAG GAAAATCACT TCATTCACAG AGACATTGCT 
GCCCGTAACT GTCTGCTTAG CTGCAGTGGA GCCAGCCGAG TGGCCAAGAT TGGAGATTTT 
GGAATGGCAA GAGATATCTA CCAGGCCAGT TATTATCGCA AGGGTGGCCG GACCTTGCTC 
CCAGTCAAGT GGATGCCGCC AGAAGCTCTC CTGGAGGGCC TTTTCACATC CAAGACAGAC 
TCCTGGTCTT TTGGGGTCCT GCTCTGGGAG ATCTTCTCAC TGGGGTATAT GCCCTACCCT 
GGACATACCA ACCAGGAGGT TCTAGACTTC ATTGCCACAG GGAACAGGAT GGACCCTCCT 
AGGAACTGTC CTGGGCCAGT GTACCGAATC ATGACCCAGT GTTGGCAGCA TCAGCCGGAG 
CTCCGCCCTG ACTTTGGCAG CATCTTGGAA CGGATTCAGT ACTGCACTCA GGACCCTGAT 
GTGCTGAACT CACCCCTGCC CGTGGAACCT GGGCCCATTC TAGAGGAGGA AGAGGCCTCC 
AGGCTGGGAA ACAGGTCACT GGAGGGTCTT AGATCCCCAA AGCCCCTAGA GCTGAGTTCT 
CAGAACTTGA AGAGCTGGGG AGGAGGCCTT CTTGGCTCTT GGCTGCCCTC TGGCCTCAAG 
ACCCTCAAAC CCAGGTGCCT CCAACCTCAG AACATTTGGA ACCCCACCTA TGGCTCCTGG 
ACCCCAAGGG GCCCCCAGGG TGAAGATACA GGCATTGAAC ACTGCAATGG CTCCTCCTCA 
AGTTCCATTC CAGGCATCCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.
Neurobiology of aging4422-41(2016 08)
Norden DM,Trojanowski PJ,Walker FR,Godbout JP

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.
Pharmacology, biochemistry, and behavior100(3)566-74(2012 Jan)
Weiss JB,Xue C,Benice T,Xue L,Morris SW,Raber J

Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.
The Journal of biological chemistry283(49)34260-72(2008 Dec)
Li J,Niu XL,Madamanchi NR

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Ltk cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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