Ltb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ltb
Entrez Gene ID	16994
Full Name	lymphotoxin B
Synonyms	AI662801,LTbeta,Tnfc,Tnfsf3,Tnlg1c,p33
General protein information	Preferred Names lymphotoxin B Names lymphotoxin-beta LT-beta TNF-C tumor necrosis factor C tumor necrosis factor ligand 1c tumor necrosis factor ligand superfamily member 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 18.59 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008518.2	NP_032544.1	lymphotoxin-beta

Pathways from BioSystems

Homologies

Homo sapiens (human)	LTB	NP_002332.1
Pan troglodytes (chimpanzee)	LTB	NP_001070252.1
Canis lupus familiaris (dog)	LTB	NP_001028682.1
Mus musculus (house mouse)	Ltb	NP_032544.1
Rattus norvegicus (Norway rat)	Ltb	NP_997672.1
	LTB	NP_001040615.1
Bos taurus (cattle)	LTB	XP_002697417.1

Gene Ontology
Bibliography

Related articles in PubMed

Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM
Hu Z, Chen M, Zhou H, Tharakan A, Wang X, Qiu L, Liang S, Qin X, Zhang Y, Wang W, Xu Y, Ying Z
Toxicology390100-108(2017 09)

Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility.
Donaldson DS, Sehgal A, Rios D, Williams IR, Mabbott NA
PLoS pathogens12(12)e1006075(2016 Dec)

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Premzl M
Immunogenetics68(2)125-32(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TNF/Lymphotoxin alpha/beta deficiency influences PM2.5 exposure-induced response of energy metabolism through alterations in both food intake and energy expenditure.
Title: Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM

The expression of lymphotoxin (LT)-B was significantly downregulated in the absence of T cells from nude mice and was recovered after the transfusion of T cells.
Title: T lymphocytes maintain structure and function of fibroblastic reticular cells via lymphotoxin (LT)-B.

Expression of LT alpha and beta on acinar cells in mice led to chronic pancreatitis and sufficed to reproduce key features of human autoimmune pancreatitis including the development of autoimmunity and AIP associated secondary extra pancreatic pathologies.
Title: The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.

TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter.
Title: TNF-inducible expression of lymphotoxin-? in hepatic cells: an essential role for NF-?B and Ets1 transcription factors.

Lymphotoxin-beta-receptor (LTbetaR) signaling, a pathway essential for lymphoid organogenesis, abrogates tertiary lymphoid organ development in heart transplantation.
Title: Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses.

The following Ltb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ltb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16496	NM_008518.2 Latest version!	Mus musculus lymphotoxin B (Ltb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$216.30 $309.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ltb ( NM_008518.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032544.1 Mus musculus lymphotoxin B (Ltb), mRNA.

Price & Availability↑

CloneID	OMu16496
Clone ID Related Accession (Same CDS sequence)	NM_008518.2
Accession Version	NM_008518.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	lymphotoxin-beta
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR974444.18, U16985.1 and BC064062.1. On Dec 5, 2007 this sequence version replaced NM_008518.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U16985.1, BC114919.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGGACAC GGGGACTGCA GGGCCTGGGT GGGAGACCCC AGGGGAGGGG CTGCCTCTTG 
CTGGCTGTGG CAGGAGCTAC TTCCCTGGTG ACCCTGTTGT TGGCAGTGCC TATCACTGTC 
CTGGCTGTGC TGGCCTTGGT GCCGCAGGAT CAGGGACGTC GGGTTGAGAA GATCATTGGC 
TCAGGAGCAC AGGCTCAGAA AAGACTGGAT GACAGCAAAC CGTCGTGCAT CTTGCCCTCA 
CCCTCTAGCC TCTCAGAGAC TCCTGACCCC CGTCTGCATC CTCAGAGATC CAATGCTTCC 
AGGAATCTAG CCTCCACATC CCAGGGCCCT GTTGCGCAGT CCTCTCGGGA GGCATCTGCA 
TGGATGACCA TCCTGTCTCC AGCTGCGGAT TCTACACCAG ATCCAGGGGT TCAACAGCTG 
CCAAAGGGGG AACCAGAAAC TGACCTCAAC CCTGAGCTCC CTGCTGCCCA CCTCATAGGC 
GCTTGGATGA GTGGGCAAGG GCTCAGCTGG GAGGCGAGCC AAGAAGAAGC GTTTCTGAGG 
AGCGGCGCGC AGTTCTCCCC CACCCACGGG CTGGCGCTGC CACAGGACGG CGTCTATTAC 
CTCTACTGCC ACGTCGGGTA CAGGGGCAGG ACGCCCCCTG CCGGCCGAAG CCGTGCTCGC 
TCGCTCACGC TGCGCAGCGC CCTGTACCGC GCGGGGGGCG CCTACGGGCG AGGTTCCCCC 
GAGTTGCTGC TGGAGGGCGC GGAGACAGTC ACACCTGTTG TGGACCCCAT CGGGTACGGG 
TCGTTATGGT ACACGAGCGT GGGGTTCGGC GGCCTGGCGC AGCTCCGGAG CGGCGAGAGG 
GTCTACGTTA ACATCAGTCA CCCCGACATG GTGGACTACA GGAGAGGGAA GACCTTCTTC 
GGGGCGGTGA TGGTGGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032544.1
CDS	16..936
Translation	MGTRGLQGLGGRPQGRGCLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGRRVEKIIGSGAQAQKRLDDSKPSCILPSPSSLSETPDPRLHPQRSNASRNLASTSQGPVAQSSREASAWMTILSPAADSTPDPGVQQLPKGEPETDLNPELPAAHLIGAWMSGQGLSWEASQEEAFLRSGAQFSPTHGLALPQDGVYYLYCHVGYRGRTPPAGRSRARSLTLRSALYRAGGAYGRGSPELLLEGAETVTPVVDPIGYGSLWYTSVGFGGLAQLRSGERVYVNISHPDMVDYRRGKTFFGAVMVG

Target ORF information:

RefSeq Version	NM_008518.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus lymphotoxin B (Ltb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008518.2

ORF Insert Sequence:

ATGGGGACAC GGGGACTGCA GGGCCTGGGT GGGAGACCCC AGGGGAGGGG CTGCCTCTTG 
CTGGCTGTGG CAGGAGCTAC TTCCCTGGTG ACCCTGTTGT TGGCAGTGCC TATCACTGTC 
CTGGCTGTGC TGGCCTTGGT GCCGCAGGAT CAGGGACGTC GGGTTGAGAA GATCATTGGC 
TCAGGAGCAC AGGCTCAGAA AAGACTGGAT GACAGCAAAC CGTCGTGCAT CTTGCCCTCA 
CCCTCTAGCC TCTCAGAGAC TCCTGACCCC CGTCTGCATC CTCAGAGATC CAATGCTTCC 
AGGAATCTAG CCTCCACATC CCAGGGCCCT GTTGCGCAGT CCTCTCGGGA GGCATCTGCA 
TGGATGACCA TCCTGTCTCC AGCTGCGGAT TCTACACCAG ATCCAGGGGT TCAACAGCTG 
CCAAAGGGGG AACCAGAAAC TGACCTCAAC CCTGAGCTCC CTGCTGCCCA CCTCATAGGC 
GCTTGGATGA GTGGGCAAGG GCTCAGCTGG GAGGCGAGCC AAGAAGAAGC GTTTCTGAGG 
AGCGGCGCGC AGTTCTCCCC CACCCACGGG CTGGCGCTGC CACAGGACGG CGTCTATTAC 
CTCTACTGCC ACGTCGGGTA CAGGGGCAGG ACGCCCCCTG CCGGCCGAAG CCGTGCTCGC 
TCGCTCACGC TGCGCAGCGC CCTGTACCGC GCGGGGGGCG CCTACGGGCG AGGTTCCCCC 
GAGTTGCTGC TGGAGGGCGC GGAGACAGTC ACACCTGTTG TGGACCCCAT CGGGTACGGG 
TCGTTATGGT ACACGAGCGT GGGGTTCGGC GGCCTGGCGC AGCTCCGGAG CGGCGAGAGG 
GTCTACGTTA ACATCAGTCA CCCCGACATG GTGGACTACA GGAGAGGGAA GACCTTCTTC 
GGGGCGGTGA TGGTGGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM
Toxicology390100-108(2017 09)
Hu Z,Chen M,Zhou H,Tharakan A,Wang X,Qiu L,Liang S,Qin X,Zhang Y,Wang W,Xu Y,Ying Z

Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility.
PLoS pathogens12(12)e1006075(2016 Dec)
Donaldson DS,Sehgal A,Rios D,Williams IR,Mabbott NA

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Immunogenetics68(2)125-32(2016 Feb)
Premzl M

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Ltb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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