Fut2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fut2
Entrez Gene ID	14344
Full Name	fucosyltransferase 2
General protein information	Preferred Names fucosyltransferase 2 Names galactoside 2-alpha-L-fucosyltransferase 2 GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2 alpha(1,2)FT 2 secretory blood group protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 29.41 cM
Summary	This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].

mRNA and Protein(s)

mRNA	Protein	Name
XM_011250795.1	XP_011249097.1	galactoside 2-alpha-L-fucosyltransferase 2 isoform X1
NM_018876.4	NP_061364.2	galactoside 2-alpha-L-fucosyltransferase 2
XM_011250795.2	XP_011249097.1	galactoside 2-alpha-L-fucosyltransferase 2 isoform X1
NM_001271993.1	NP_001258922.1	galactoside 2-alpha-L-fucosyltransferase 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FUT2	NP_803466.1
Xenopus tropicalis (tropical clawed frog)	LOC100487812	XP_002942536.2
Xenopus tropicalis (tropical clawed frog)	LOC100497569	XP_002945019.1
Rattus norvegicus (Norway rat)	Fut2	NP_113823.1
Homo sapiens (human)	FUT2	NP_001091107.1
Pan troglodytes (chimpanzee)	FUT2	NP_001009120.1
Xenopus tropicalis (tropical clawed frog)	LOC100487974	XP_002942537.2
Mus musculus (house mouse)	Fut2	NP_061364.2
Canis lupus familiaris (dog)	LOC484398	XP_005616399.1
Xenopus tropicalis (tropical clawed frog)	LOC100493351	XP_004916333.1

Gene Ontology
Bibliography

Related articles in PubMed

Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.
Maroni L, Hohenester SD, van de Graaf SFJ, Tolenaars D, van Lienden K, Verheij J, Marzioni M, Karlsen TH, Oude Elferink RPJ, Beuers U
Hepatology (Baltimore, Md.)66(2)542-554(2017 08)

Multigenerational Influences of the
Rausch P, K?nzel S, Suwandi A, Grassl GA, Rosenstiel P, Baines JF
Frontiers in microbiology8991(2017)

Discovery of a proteinaceous cellular receptor for a norovirus.
Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW
Science (New York, N.Y.)353(6302)933-6(2016 08)

Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding.
Magalh?es A, Rossez Y, Robbe-Masselot C, Maes E, Gomes J, Shevtsova A, Bugaytsova J, Bor?n T, Reis CA
Scientific reports625575(2016 May)

Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
Pickard JM, Maurice CF, Kinnebrew MA, Abt MC, Schenten D, Golovkina TV, Bogatyrev SR, Ismagilov RF, Pamer EG, Turnbaugh PJ, Chervonsky AV
Nature514(7524)638-41(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fut2 gene expression is responsible for disease progression in mice with primary sclerosing cholangitis.
Title: Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.

We found that Fut1 mRNA and Fut4 mRNA were upregulated, while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis.
Title: Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract.

These data suggest a novel role for Fut2 as a regulator of angiogenesis.
Title: A novel role for inducible Fut2 in angiogenesis.

Fucosyltransferase Fut)-deficient (Fut1, Fut2 and Fut4) mice which lack LeX or LeY antigen are still fertile.
Title: Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system.

These results indicate that Fut2-mediated fucosylated epithelial cells (F-ECs) share M cell-related fucosylated molecules but maintain distinctive EC characteristics, Fut1 is, therefore, a reliable marker for M cells.
Title: Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.

The following Fut2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fut2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19261	NM_001271993.1 Latest version!	Mus musculus fucosyltransferase 2 (Fut2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu19261	NM_018876.4 Latest version!	Mus musculus fucosyltransferase 2 (Fut2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu19261	XM_011250795.2 Latest version!	Mus musculus fucosyltransferase 2 (Fut2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OMu19261	XM_011250795.1	Mus musculus fucosyltransferase 2 (Fut2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fut2 ( NM_018876.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061364.2 Mus musculus fucosyltransferase 2 (Fut2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19261
Clone ID Related Accession (Same CDS sequence)	XM_011250795.1 , NM_018876.4 , XM_011250795.2 , NM_001271993.1
Accession Version	NM_018876.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1044bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	galactoside 2-alpha-L-fucosyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK033586.1, BC145831.1, AK033520.1 and BQ032725.1. On Dec 20, 2012 this sequence version replaced NM_018876.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK033586.1, AK033520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAGTG CCCAGGTACC TTTCTCCTTT CCTCTGGCCC ACTTCCTCAT CTTTGTCTTT 
GTGACTTCCA CCATCATCCA CCTCCAGCAA CGAATAGTGA AGCTCCAAAC CCTGTCAGAG 
AAGGAATTAC AGGCGGTTCA AATGTCCTCA CCAAACGCGG CAAGAACAGA CATGCAGCAG 
AGTGCCAAGC TGCAGGGCAT ATTCACGATC AATTCCATCG GCCGCCTGGG GAACCAGATG 
GGCGAATATG CTACATTGTT TGCACTGGCC AGGATGAACG GTCGGCTTGC CTTCATCCCT 
GAATCCATGC ACAACGCTCT AGCGCCCATC TTCAGGATCA GTCTCCCGGT GTTACACAGC 
GACACAGCCA GAAGGATCCC GTGGCAGAAT TACCACCTCA ACGACTGGAT GGAGGAGCGT 
TACCGCCACA TCCCGGGGCA GTATGTGCGT TTCACGGGAT ACCCGTGCTC CTGGACCTTC 
TACCACCACC TGCGCCCAGA GATCCTGAAG GAGTTCACCC TGCACGACCA TGTGCGTGAG 
GAGGCCCAGG CTTTCCTGCG TGGCCTGCGG GTGAATGGGA GCCAGCCGAG TACCTTTGTG 
GGTGTCCATG TGCGCCGAGG GGACTATGTG CATGTCATGC CCAAGGTGTG GAAGGGCGTG 
GTGGCTGACC GGGGTTACCT AGAAAAGGCC CTGGACAGGT TCCGGGCACG CTATTCATCT 
CCAGTCTTCG TGGTTACAAG CAACGGTATG GCCTGGTGCC GGGAGAACAT CAACACCTCC 
CTAGGAGACG TGGTGTTTGC GGGCAATGGT ATTGAGGGCT CACCAGCCAA GGACTTCGCG 
CTCCTCACCC AGTGCAACCA CACCATCATG ACCATTGGAA CCTTTGGGAT TTGGGCTGCC 
TACCTGGCAG GTGGTGATAC CATCTACCTA GCCAACTACA CCCTTCCGGA TTCTCCGTTC 
CTCAAAATCT TTAAGCCAGC AGCAGCCTTC CTCCCCGAGT GGATGGGCAT CCCCGCAGAC 
CTGTCCCCAC TCCTTAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061364.2
CDS	200..1243
Translation	MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIPESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH

Target ORF information:

RefSeq Version	NM_018876.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus fucosyltransferase 2 (Fut2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018876.4

ORF Insert Sequence:

ATGGCGAGTG CCCAGGTACC TTTCTCCTTT CCTCTGGCCC ACTTCCTCAT CTTTGTCTTT 
GTGACTTCCA CCATCATCCA CCTCCAGCAA CGAATAGTGA AGCTCCAAAC CCTGTCAGAG 
AAGGAATTAC AGGCGGTTCA AATGTCCTCA CCAAACGCGG CAAGAACAGA CATGCAGCAG 
AGTGCCAAGC TGCAGGGCAT ATTCACGATC AATTCCATCG GCCGCCTGGG GAACCAGATG 
GGCGAATATG CTACATTGTT TGCACTGGCC AGGATGAACG GTCGGCTTGC CTTCATCCCT 
GAATCCATGC ACAACGCTCT AGCGCCCATC TTCAGGATCA GTCTCCCGGT GTTACACAGC 
GACACAGCCA GAAGGATCCC GTGGCAGAAT TACCACCTCA ACGACTGGAT GGAGGAGCGT 
TACCGCCACA TCCCGGGGCA GTATGTGCGT TTCACGGGAT ACCCGTGCTC CTGGACCTTC 
TACCACCACC TGCGCCCAGA GATCCTGAAG GAGTTCACCC TGCACGACCA TGTGCGTGAG 
GAGGCCCAGG CTTTCCTGCG TGGCCTGCGG GTGAATGGGA GCCAGCCGAG TACCTTTGTG 
GGTGTCCATG TGCGCCGAGG GGACTATGTG CATGTCATGC CCAAGGTGTG GAAGGGCGTG 
GTGGCTGACC GGGGTTACCT AGAAAAGGCC CTGGACAGGT TCCGGGCACG CTATTCATCT 
CCAGTCTTCG TGGTTACAAG CAACGGTATG GCCTGGTGCC GGGAGAACAT CAACACCTCC 
CTAGGAGACG TGGTGTTTGC GGGCAATGGT ATTGAGGGCT CACCAGCCAA GGACTTCGCG 
CTCCTCACCC AGTGCAACCA CACCATCATG ACCATTGGAA CCTTTGGGAT TTGGGCTGCC 
TACCTGGCAG GTGGTGATAC CATCTACCTA GCCAACTACA CCCTTCCGGA TTCTCCGTTC 
CTCAAAATCT TTAAGCCAGC AGCAGCCTTC CTCCCCGAGT GGATGGGCAT CCCCGCAGAC 
CTGTCCCCAC TCCTTAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fut2 ( NM_001271993.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001258922.1 Mus musculus fucosyltransferase 2 (Fut2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19261
Clone ID Related Accession (Same CDS sequence)	XM_011250795.1 , NM_018876.4 , XM_011250795.2 , NM_001271993.1
Accession Version	NM_001271993.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1044bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	galactoside 2-alpha-L-fucosyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK033586.1, BY142283.1, BC145831.1, AK033520.1 and BQ032725.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY788993.1, BY789624.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAGTG CCCAGGTACC TTTCTCCTTT CCTCTGGCCC ACTTCCTCAT CTTTGTCTTT 
GTGACTTCCA CCATCATCCA CCTCCAGCAA CGAATAGTGA AGCTCCAAAC CCTGTCAGAG 
AAGGAATTAC AGGCGGTTCA AATGTCCTCA CCAAACGCGG CAAGAACAGA CATGCAGCAG 
AGTGCCAAGC TGCAGGGCAT ATTCACGATC AATTCCATCG GCCGCCTGGG GAACCAGATG 
GGCGAATATG CTACATTGTT TGCACTGGCC AGGATGAACG GTCGGCTTGC CTTCATCCCT 
GAATCCATGC ACAACGCTCT AGCGCCCATC TTCAGGATCA GTCTCCCGGT GTTACACAGC 
GACACAGCCA GAAGGATCCC GTGGCAGAAT TACCACCTCA ACGACTGGAT GGAGGAGCGT 
TACCGCCACA TCCCGGGGCA GTATGTGCGT TTCACGGGAT ACCCGTGCTC CTGGACCTTC 
TACCACCACC TGCGCCCAGA GATCCTGAAG GAGTTCACCC TGCACGACCA TGTGCGTGAG 
GAGGCCCAGG CTTTCCTGCG TGGCCTGCGG GTGAATGGGA GCCAGCCGAG TACCTTTGTG 
GGTGTCCATG TGCGCCGAGG GGACTATGTG CATGTCATGC CCAAGGTGTG GAAGGGCGTG 
GTGGCTGACC GGGGTTACCT AGAAAAGGCC CTGGACAGGT TCCGGGCACG CTATTCATCT 
CCAGTCTTCG TGGTTACAAG CAACGGTATG GCCTGGTGCC GGGAGAACAT CAACACCTCC 
CTAGGAGACG TGGTGTTTGC GGGCAATGGT ATTGAGGGCT CACCAGCCAA GGACTTCGCG 
CTCCTCACCC AGTGCAACCA CACCATCATG ACCATTGGAA CCTTTGGGAT TTGGGCTGCC 
TACCTGGCAG GTGGTGATAC CATCTACCTA GCCAACTACA CCCTTCCGGA TTCTCCGTTC 
CTCAAAATCT TTAAGCCAGC AGCAGCCTTC CTCCCCGAGT GGATGGGCAT CCCCGCAGAC 
CTGTCCCCAC TCCTTAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258922.1
CDS	304..1347
Translation	MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIPESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH

Target ORF information:

RefSeq Version	NM_001271993.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fucosyltransferase 2 (Fut2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271993.1

ORF Insert Sequence:

ATGGCGAGTG CCCAGGTACC TTTCTCCTTT CCTCTGGCCC ACTTCCTCAT CTTTGTCTTT 
GTGACTTCCA CCATCATCCA CCTCCAGCAA CGAATAGTGA AGCTCCAAAC CCTGTCAGAG 
AAGGAATTAC AGGCGGTTCA AATGTCCTCA CCAAACGCGG CAAGAACAGA CATGCAGCAG 
AGTGCCAAGC TGCAGGGCAT ATTCACGATC AATTCCATCG GCCGCCTGGG GAACCAGATG 
GGCGAATATG CTACATTGTT TGCACTGGCC AGGATGAACG GTCGGCTTGC CTTCATCCCT 
GAATCCATGC ACAACGCTCT AGCGCCCATC TTCAGGATCA GTCTCCCGGT GTTACACAGC 
GACACAGCCA GAAGGATCCC GTGGCAGAAT TACCACCTCA ACGACTGGAT GGAGGAGCGT 
TACCGCCACA TCCCGGGGCA GTATGTGCGT TTCACGGGAT ACCCGTGCTC CTGGACCTTC 
TACCACCACC TGCGCCCAGA GATCCTGAAG GAGTTCACCC TGCACGACCA TGTGCGTGAG 
GAGGCCCAGG CTTTCCTGCG TGGCCTGCGG GTGAATGGGA GCCAGCCGAG TACCTTTGTG 
GGTGTCCATG TGCGCCGAGG GGACTATGTG CATGTCATGC CCAAGGTGTG GAAGGGCGTG 
GTGGCTGACC GGGGTTACCT AGAAAAGGCC CTGGACAGGT TCCGGGCACG CTATTCATCT 
CCAGTCTTCG TGGTTACAAG CAACGGTATG GCCTGGTGCC GGGAGAACAT CAACACCTCC 
CTAGGAGACG TGGTGTTTGC GGGCAATGGT ATTGAGGGCT CACCAGCCAA GGACTTCGCG 
CTCCTCACCC AGTGCAACCA CACCATCATG ACCATTGGAA CCTTTGGGAT TTGGGCTGCC 
TACCTGGCAG GTGGTGATAC CATCTACCTA GCCAACTACA CCCTTCCGGA TTCTCCGTTC 
CTCAAAATCT TTAAGCCAGC AGCAGCCTTC CTCCCCGAGT GGATGGGCAT CCCCGCAGAC 
CTGTCCCCAC TCCTTAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fut2 ( XM_011250795.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011249097.1 Mus musculus fucosyltransferase 2 (Fut2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19261
Clone ID Related Accession (Same CDS sequence)	XM_011250795.1 , NM_018876.4 , XM_011250795.2 , NM_001271993.1
Accession Version	XM_011250795.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1044bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	galactoside 2-alpha-L-fucosyltransferase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGAGTG CCCAGGTACC TTTCTCCTTT CCTCTGGCCC ACTTCCTCAT CTTTGTCTTT 
GTGACTTCCA CCATCATCCA CCTCCAGCAA CGAATAGTGA AGCTCCAAAC CCTGTCAGAG 
AAGGAATTAC AGGCGGTTCA AATGTCCTCA CCAAACGCGG CAAGAACAGA CATGCAGCAG 
AGTGCCAAGC TGCAGGGCAT ATTCACGATC AATTCCATCG GCCGCCTGGG GAACCAGATG 
GGCGAATATG CTACATTGTT TGCACTGGCC AGGATGAACG GTCGGCTTGC CTTCATCCCT 
GAATCCATGC ACAACGCTCT AGCGCCCATC TTCAGGATCA GTCTCCCGGT GTTACACAGC 
GACACAGCCA GAAGGATCCC GTGGCAGAAT TACCACCTCA ACGACTGGAT GGAGGAGCGT 
TACCGCCACA TCCCGGGGCA GTATGTGCGT TTCACGGGAT ACCCGTGCTC CTGGACCTTC 
TACCACCACC TGCGCCCAGA GATCCTGAAG GAGTTCACCC TGCACGACCA TGTGCGTGAG 
GAGGCCCAGG CTTTCCTGCG TGGCCTGCGG GTGAATGGGA GCCAGCCGAG TACCTTTGTG 
GGTGTCCATG TGCGCCGAGG GGACTATGTG CATGTCATGC CCAAGGTGTG GAAGGGCGTG 
GTGGCTGACC GGGGTTACCT AGAAAAGGCC CTGGACAGGT TCCGGGCACG CTATTCATCT 
CCAGTCTTCG TGGTTACAAG CAACGGTATG GCCTGGTGCC GGGAGAACAT CAACACCTCC 
CTAGGAGACG TGGTGTTTGC GGGCAATGGT ATTGAGGGCT CACCAGCCAA GGACTTCGCG 
CTCCTCACCC AGTGCAACCA CACCATCATG ACCATTGGAA CCTTTGGGAT TTGGGCTGCC 
TACCTGGCAG GTGGTGATAC CATCTACCTA GCCAACTACA CCCTTCCGGA TTCTCCGTTC 
CTCAAAATCT TTAAGCCAGC AGCAGCCTTC CTCCCCGAGT GGATGGGCAT CCCCGCAGAC 
CTGTCCCCAC TCCTTAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011249097.1
CDS	439..1482
Translation	MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIPESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH

Target ORF information:

RefSeq Version	XM_011250795.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fucosyltransferase 2 (Fut2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011250795.1

ORF Insert Sequence:

ATGGCGAGTG CCCAGGTACC TTTCTCCTTT CCTCTGGCCC ACTTCCTCAT CTTTGTCTTT 
GTGACTTCCA CCATCATCCA CCTCCAGCAA CGAATAGTGA AGCTCCAAAC CCTGTCAGAG 
AAGGAATTAC AGGCGGTTCA AATGTCCTCA CCAAACGCGG CAAGAACAGA CATGCAGCAG 
AGTGCCAAGC TGCAGGGCAT ATTCACGATC AATTCCATCG GCCGCCTGGG GAACCAGATG 
GGCGAATATG CTACATTGTT TGCACTGGCC AGGATGAACG GTCGGCTTGC CTTCATCCCT 
GAATCCATGC ACAACGCTCT AGCGCCCATC TTCAGGATCA GTCTCCCGGT GTTACACAGC 
GACACAGCCA GAAGGATCCC GTGGCAGAAT TACCACCTCA ACGACTGGAT GGAGGAGCGT 
TACCGCCACA TCCCGGGGCA GTATGTGCGT TTCACGGGAT ACCCGTGCTC CTGGACCTTC 
TACCACCACC TGCGCCCAGA GATCCTGAAG GAGTTCACCC TGCACGACCA TGTGCGTGAG 
GAGGCCCAGG CTTTCCTGCG TGGCCTGCGG GTGAATGGGA GCCAGCCGAG TACCTTTGTG 
GGTGTCCATG TGCGCCGAGG GGACTATGTG CATGTCATGC CCAAGGTGTG GAAGGGCGTG 
GTGGCTGACC GGGGTTACCT AGAAAAGGCC CTGGACAGGT TCCGGGCACG CTATTCATCT 
CCAGTCTTCG TGGTTACAAG CAACGGTATG GCCTGGTGCC GGGAGAACAT CAACACCTCC 
CTAGGAGACG TGGTGTTTGC GGGCAATGGT ATTGAGGGCT CACCAGCCAA GGACTTCGCG 
CTCCTCACCC AGTGCAACCA CACCATCATG ACCATTGGAA CCTTTGGGAT TTGGGCTGCC 
TACCTGGCAG GTGGTGATAC CATCTACCTA GCCAACTACA CCCTTCCGGA TTCTCCGTTC 
CTCAAAATCT TTAAGCCAGC AGCAGCCTTC CTCCCCGAGT GGATGGGCAT CCCCGCAGAC 
CTGTCCCCAC TCCTTAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fut2 ( XM_011250795.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011249097.1 Mus musculus fucosyltransferase 2 (Fut2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19261
Clone ID Related Accession (Same CDS sequence)	XM_011250795.1 , NM_018876.4 , XM_011250795.2 , NM_001271993.1
Accession Version	XM_011250795.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1044bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	galactoside 2-alpha-L-fucosyltransferase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011250795.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGAGTG CCCAGGTACC TTTCTCCTTT CCTCTGGCCC ACTTCCTCAT CTTTGTCTTT 
GTGACTTCCA CCATCATCCA CCTCCAGCAA CGAATAGTGA AGCTCCAAAC CCTGTCAGAG 
AAGGAATTAC AGGCGGTTCA AATGTCCTCA CCAAACGCGG CAAGAACAGA CATGCAGCAG 
AGTGCCAAGC TGCAGGGCAT ATTCACGATC AATTCCATCG GCCGCCTGGG GAACCAGATG 
GGCGAATATG CTACATTGTT TGCACTGGCC AGGATGAACG GTCGGCTTGC CTTCATCCCT 
GAATCCATGC ACAACGCTCT AGCGCCCATC TTCAGGATCA GTCTCCCGGT GTTACACAGC 
GACACAGCCA GAAGGATCCC GTGGCAGAAT TACCACCTCA ACGACTGGAT GGAGGAGCGT 
TACCGCCACA TCCCGGGGCA GTATGTGCGT TTCACGGGAT ACCCGTGCTC CTGGACCTTC 
TACCACCACC TGCGCCCAGA GATCCTGAAG GAGTTCACCC TGCACGACCA TGTGCGTGAG 
GAGGCCCAGG CTTTCCTGCG TGGCCTGCGG GTGAATGGGA GCCAGCCGAG TACCTTTGTG 
GGTGTCCATG TGCGCCGAGG GGACTATGTG CATGTCATGC CCAAGGTGTG GAAGGGCGTG 
GTGGCTGACC GGGGTTACCT AGAAAAGGCC CTGGACAGGT TCCGGGCACG CTATTCATCT 
CCAGTCTTCG TGGTTACAAG CAACGGTATG GCCTGGTGCC GGGAGAACAT CAACACCTCC 
CTAGGAGACG TGGTGTTTGC GGGCAATGGT ATTGAGGGCT CACCAGCCAA GGACTTCGCG 
CTCCTCACCC AGTGCAACCA CACCATCATG ACCATTGGAA CCTTTGGGAT TTGGGCTGCC 
TACCTGGCAG GTGGTGATAC CATCTACCTA GCCAACTACA CCCTTCCGGA TTCTCCGTTC 
CTCAAAATCT TTAAGCCAGC AGCAGCCTTC CTCCCCGAGT GGATGGGCAT CCCCGCAGAC 
CTGTCCCCAC TCCTTAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011249097.1
CDS	364..1407
Translation	MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIPESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH

Target ORF information:

RefSeq Version	XM_011250795.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fucosyltransferase 2 (Fut2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011250795.2

ORF Insert Sequence:

ATGGCGAGTG CCCAGGTACC TTTCTCCTTT CCTCTGGCCC ACTTCCTCAT CTTTGTCTTT 
GTGACTTCCA CCATCATCCA CCTCCAGCAA CGAATAGTGA AGCTCCAAAC CCTGTCAGAG 
AAGGAATTAC AGGCGGTTCA AATGTCCTCA CCAAACGCGG CAAGAACAGA CATGCAGCAG 
AGTGCCAAGC TGCAGGGCAT ATTCACGATC AATTCCATCG GCCGCCTGGG GAACCAGATG 
GGCGAATATG CTACATTGTT TGCACTGGCC AGGATGAACG GTCGGCTTGC CTTCATCCCT 
GAATCCATGC ACAACGCTCT AGCGCCCATC TTCAGGATCA GTCTCCCGGT GTTACACAGC 
GACACAGCCA GAAGGATCCC GTGGCAGAAT TACCACCTCA ACGACTGGAT GGAGGAGCGT 
TACCGCCACA TCCCGGGGCA GTATGTGCGT TTCACGGGAT ACCCGTGCTC CTGGACCTTC 
TACCACCACC TGCGCCCAGA GATCCTGAAG GAGTTCACCC TGCACGACCA TGTGCGTGAG 
GAGGCCCAGG CTTTCCTGCG TGGCCTGCGG GTGAATGGGA GCCAGCCGAG TACCTTTGTG 
GGTGTCCATG TGCGCCGAGG GGACTATGTG CATGTCATGC CCAAGGTGTG GAAGGGCGTG 
GTGGCTGACC GGGGTTACCT AGAAAAGGCC CTGGACAGGT TCCGGGCACG CTATTCATCT 
CCAGTCTTCG TGGTTACAAG CAACGGTATG GCCTGGTGCC GGGAGAACAT CAACACCTCC 
CTAGGAGACG TGGTGTTTGC GGGCAATGGT ATTGAGGGCT CACCAGCCAA GGACTTCGCG 
CTCCTCACCC AGTGCAACCA CACCATCATG ACCATTGGAA CCTTTGGGAT TTGGGCTGCC 
TACCTGGCAG GTGGTGATAC CATCTACCTA GCCAACTACA CCCTTCCGGA TTCTCCGTTC 
CTCAAAATCT TTAAGCCAGC AGCAGCCTTC CTCCCCGAGT GGATGGGCAT CCCCGCAGAC 
CTGTCCCCAC TCCTTAAGCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.
Hepatology (Baltimore, Md.)66(2)542-554(2017 08)
Maroni L,Hohenester SD,van de Graaf SFJ,Tolenaars D,van Lienden K,Verheij J,Marzioni M,Karlsen TH,Oude Elferink RPJ,Beuers U

Multigenerational Influences of the
Frontiers in microbiology8991(2017)
Rausch P,K?nzel S,Suwandi A,Grassl GA,Rosenstiel P,Baines JF

Discovery of a proteinaceous cellular receptor for a norovirus.
Science (New York, N.Y.)353(6302)933-6(2016 08)
Orchard RC,Wilen CB,Doench JG,Baldridge MT,McCune BT,Lee YC,Lee S,Pruett-Miller SM,Nelson CA,Fremont DH,Virgin HW

Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding.
Scientific reports625575(2016 May)
Magalh?es A,Rossez Y,Robbe-Masselot C,Maes E,Gomes J,Shevtsova A,Bugaytsova J,Bor?n T,Reis CA

Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
Nature514(7524)638-41(2014 Oct)
Pickard JM,Maurice CF,Kinnebrew MA,Abt MC,Schenten D,Golovkina TV,Bogatyrev SR,Ismagilov RF,Pamer EG,Turnbaugh PJ,Chervonsky AV

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Fut2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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