Fgf6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgf6
Entrez Gene ID	14177
Full Name	fibroblast growth factor 6
Synonyms	Fgf-6,HSTF-2
General protein information	Preferred Names fibroblast growth factor 6 Names fibroblast growth factor 6 HBGF-6 HST-2 heparin secretory-transforming protein 2 heparin-binding growth factor 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F3\|6 61.92 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010204.1	NP_034334.1	fibroblast growth factor 6 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FGF6	NP_001179329.1
Xenopus tropicalis (tropical clawed frog)	fgf6	NP_001136295.1
Pan troglodytes (chimpanzee)	FGF6	XP_001157123.1
	FGF6	XP_001099809.1
Mus musculus (house mouse)	Fgf6	NP_034334.1
Homo sapiens (human)	FGF6	NP_066276.2
Rattus norvegicus (Norway rat)	Fgf6	NP_571983.1
Canis lupus familiaris (dog)	FGF6	XP_543862.1
Gallus gallus (chicken)	FGF6	XP_001232071.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of FGFs during early mouse tongue development.
Du W, Prochazka J, Prochazkova M, Klein OD
Gene expression patterns : GEP20(2)81-7(2016 Mar)

Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin.
Li J, Wang Q, Cui Y, Yang X, Li Y, Zhang X, Qiu M, Zhang Z, Zhang Z
PloS one10(5)e0128006(2015)

ALK5-mediated transforming growth factor ? signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions.
Han A, Zhao H, Li J, Pelikan R, Chai Y
Molecular and cellular biology34(16)3120-31(2014 Aug)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

A local source of FGF initiates development of the unmyelinated lineage of sensory neurons.
Hadjab S, Franck MC, Wang Y, Sterzenbach U, Sharma A, Ernfors P, Lallemend F
The Journal of neuroscience : the official journal of the Society for Neuroscience33(45)17656-66(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress.
Title: Eccentric stimulation reveals an involvement of FGF6 in muscle resistance to mechanical stress.

Rescue experiments supported the idea of a specific relationship between FGF6 and Spry 2, both being known for their particular involvement in myogenesis.
Title: Sprouty gene expression is regulated by nerve and FGF6 during regeneration of mouse muscles.

Involvement of FGF6 in myogenesis. Review.
Title: FGF6 in myogenesis.

might be involved in the changes of secretory granule content of acinar cells in the sublingual gland during the late gestational and early neonatal stages
Title: Localization of FGF-6 and FGFR-4 during prenatal and early postnatal development of the mouse sublingual gland.

At high doses, FGF6 stimulates the proliferation of the myogenic stem cells, whereas at lower doses it regulates both muscle differentiation and muscle phenotype via a calcineurin-signaling pathway.
Title: FGF6 regulates muscle differentiation through a calcineurin-dependent pathway in regenerating soleus of adult mice.

The following Fgf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05738	NM_010204.1 Latest version!	Mus musculus fibroblast growth factor 6 (Fgf6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgf6 ( NM_010204.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034334.1 Mus musculus fibroblast growth factor 6 (Fgf6), mRNA.

Price & Availability↑

CloneID	OMu05738
Clone ID Related Accession (Same CDS sequence)	NM_010204.1
Accession Version	NM_010204.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	fibroblast growth factor 6 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC163683.4 and AK086530.1. On or before Aug 17, 2006 this sequence version replaced XM_001003439.1, XM_485825.4, XM_983076.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK086530.1, M92416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCTGG GACAGAGGCT GTTCATCACT ATGTCCCGGG GAGCAGGACG TGTTCAGGGC 
ACGCTGCAGG CTCTCGTCTT CTTAGGCGTC CTAGTGGGCA TGGTGGTGCC CTCACCTGCC 
GGCGCCCGCG CCAACGGCAC GCTACTGGAC TCCAGAGGCT GGGGCACCCT CTTGTCCAGG 
TCTCGAGCTG GGCTAGCTGG AGAGATTTCG GGTGTGAATT GGGAAAGCGG CTATTTGGTG 
GGCATTAAGC GACAGCGGAG ACTCTACTGC AACGTGGGCA TTGGCTTCCA CCTCCAGGTG 
CCTCCTGACG GCCGCATCAG TGGAACACAC GAGGAGAACC CCTACAGCCT GCTGGAGATC 
TCCACGGTAG AACGGGGTGT GGTGAGCCTC TTCGGGGTGA AGAGTGCTCT CTTCATTGCC 
ATGAACAGTA AAGGAAGACT GTACACAACG CCCAGCTTCC ACGACGAATG CAAGTTCCGA 
GAAACCCTCC TTCCAAACAA CTACAACGCC TACGAGTCAG ACCTGTACAG AGGGACCTAC 
ATTGCACTGA GCAAATATGG ACGGGTAAAG CGGGGCAGCA AGGTGTCCCC AATCATGACT 
GTCACTCACT TCCTCCCCAG GATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034334.1
CDS	45..671
Translation	MALGQRLFITMSRGAGRVQGTLQALVFLGVLVGMVVPSPAGARANGTLLDSRGWGTLLSRSRAGLAGEISGVNWESGYLVGIKRQRRLYCNVGIGFHLQVPPDGRISGTHEENPYSLLEISTVERGVVSLFGVKSALFIAMNSKGRLYTTPSFHDECKFRETLLPNNYNAYESDLYRGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI

Target ORF information:

RefSeq Version	NM_010204.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibroblast growth factor 6 (Fgf6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010204.1

ORF Insert Sequence:

ATGGCCCTGG GACAGAGGCT GTTCATCACT ATGTCCCGGG GAGCAGGACG TGTTCAGGGC 
ACGCTGCAGG CTCTCGTCTT CTTAGGCGTC CTAGTGGGCA TGGTGGTGCC CTCACCTGCC 
GGCGCCCGCG CCAACGGCAC GCTACTGGAC TCCAGAGGCT GGGGCACCCT CTTGTCCAGG 
TCTCGAGCTG GGCTAGCTGG AGAGATTTCG GGTGTGAATT GGGAAAGCGG CTATTTGGTG 
GGCATTAAGC GACAGCGGAG ACTCTACTGC AACGTGGGCA TTGGCTTCCA CCTCCAGGTG 
CCTCCTGACG GCCGCATCAG TGGAACACAC GAGGAGAACC CCTACAGCCT GCTGGAGATC 
TCCACGGTAG AACGGGGTGT GGTGAGCCTC TTCGGGGTGA AGAGTGCTCT CTTCATTGCC 
ATGAACAGTA AAGGAAGACT GTACACAACG CCCAGCTTCC ACGACGAATG CAAGTTCCGA 
GAAACCCTCC TTCCAAACAA CTACAACGCC TACGAGTCAG ACCTGTACAG AGGGACCTAC 
ATTGCACTGA GCAAATATGG ACGGGTAAAG CGGGGCAGCA AGGTGTCCCC AATCATGACT 
GTCACTCACT TCCTCCCCAG GATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of FGFs during early mouse tongue development.
Gene expression patterns : GEP20(2)81-7(2016 Mar)
Du W,Prochazka J,Prochazkova M,Klein OD

Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin.
PloS one10(5)e0128006(2015)
Li J,Wang Q,Cui Y,Yang X,Li Y,Zhang X,Qiu M,Zhang Z,Zhang Z

ALK5-mediated transforming growth factor ? signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions.
Molecular and cellular biology34(16)3120-31(2014 Aug)
Han A,Zhao H,Li J,Pelikan R,Chai Y

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

A local source of FGF initiates development of the unmyelinated lineage of sensory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(45)17656-66(2013 Nov)
Hadjab S,Franck MC,Wang Y,Sterzenbach U,Sharma A,Ernfors P,Lallemend F

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Fgf6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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