FGF6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGF6
Entrez Gene ID	2251
Full Name	fibroblast growth factor 6
Synonyms	HBGF-6,HST2
General protein information	Preferred Names fibroblast growth factor 6 Names fibroblast growth factor 6 FGF-6 HST-2 HSTF-2 heparin secretory-transforming protein 2 heparin-binding growth factor 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.32
Summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008].
Disorder MIM:	134921

mRNA and Protein(s)

mRNA	Protein	Name
XM_017018995.1	XP_016874484.1	fibroblast growth factor 6 isoform X1
XM_017018996.1	XP_016874485.1	fibroblast growth factor 6 isoform X2
NM_020996.2	NP_066276.2	fibroblast growth factor 6 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FGF6	NP_001179329.1
Xenopus tropicalis (tropical clawed frog)	fgf6	NP_001136295.1
Pan troglodytes (chimpanzee)	FGF6	XP_001157123.1
	FGF6	XP_001099809.1
Mus musculus (house mouse)	Fgf6	NP_034334.1
Homo sapiens (human)	FGF6	NP_066276.2
Rattus norvegicus (Norway rat)	Fgf6	NP_571983.1
Canis lupus familiaris (dog)	FGF6	XP_543862.1
Gallus gallus (chicken)	FGF6	XP_001232071.1

Gene Ontology
Bibliography

Related articles in PubMed

Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
Li L, Fridley BL, Kalari K, Niu N, Jenkins G, Batzler A, Abo RP, Schaid D, Wang L
BMC genomics1593(2014 Feb)

Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
Jia WH, Zhang B, Matsuo K, Shin A, Xiang YB, Jee SH, Kim DH, Ren Z, Cai Q, Long J, Shi J, Wen W, Yang G, Delahanty RJ, , , Ji BT, Pan ZZ, Matsuda F, Gao YT, Oh JH, Ahn YO, Park EJ, Li HL, Park JW, Jo J, Jeong JY, Hosono S, Casey G, Peters U, Shu XO, Zeng YX, Zheng W
Nature genetics45(2)191-6(2013 Feb)

Regulation of osteoblast and osteoclast functions by FGF-6.
Bosetti M, Leigheb M, Brooks RA, Boccafoschi F, Cannas MF
Journal of cellular physiology225(2)466-71(2010 Nov)

Common genetic variants associate with serum phosphorus concentration.
Kestenbaum B, Glazer NL, K?ttgen A, Felix JF, Hwang SJ, Liu Y, Lohman K, Kritchevsky SB, Hausman DB, Petersen AK, Gieger C, Ried JS, Meitinger T, Strom TM, Wichmann HE, Campbell H, Hayward C, Rudan I, de Boer IH, Psaty BM, Rice KM, Chen YD, Li M, Arking DE, Boerwinkle E, Coresh J, Yang Q, Levy D, van Rooij FJ, Dehghan A, Rivadeneira F, Uitterlinden AG, Hofman A, van Duijn CM, Shlipak MG, Kao WH, Witteman JC, Siscovick DS, Fox CS
Journal of the American Society of Nephrology : JASN21(7)1223-32(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data demonstrate that FGF-6 may be considered a regulator of bone metabolism as shown by its activity on both osteoblasts and osteoclasts.
Title: Regulation of osteoblast and osteoclast functions by FGF-6.

FGF6 exhibits antitumor activity in vitro and correlates with expression of FGF receptors in medulloblastoma cells
Title: Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant.

The following FGF6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu57753	NM_020996.2 Latest version!	Homo sapiens fibroblast growth factor 6 (FGF6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu83627	XM_017018995.1 Latest version!	Homo sapiens fibroblast growth factor 6 (FGF6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu83628	XM_017018996.1 Latest version!	Homo sapiens fibroblast growth factor 6 (FGF6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGF6 ( NM_020996.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066276.2 Homo sapiens fibroblast growth factor 6 (FGF6), mRNA.

Price & Availability↑

CloneID	OHu57753
Clone ID Related Accession (Same CDS sequence)	NM_020996.2
Accession Version	NM_020996.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	fibroblast growth factor 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63454.1 and AC008012.8. On Dec 16, 2014 this sequence version replaced NM_020996.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X63454.1, BC121097.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800, SAMN03465413 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGCCCTGG GACAGAAACT GTTCATCACT ATGTCCCGGG GAGCAGGACG TCTGCAGGGC 
ACGCTGTGGG CTCTCGTCTT CCTAGGCATC CTAGTGGGCA TGGTGGTGCC CTCGCCTGCA 
GGCACCCGTG CCAACAACAC GCTGCTGGAC TCGAGGGGCT GGGGCACCCT GCTGTCCAGG 
TCTCGCGCCG GGCTAGCTGG AGAGATTGCC GGGGTGAACT GGGAAAGTGG CTATTTGGTG 
GGGATCAAGC GGCAGCGGAG GCTCTACTGC AACGTGGGCA TCGGCTTTCA CCTCCAGGTG 
CTCCCCGACG GCCGGATCAG CGGGACCCAC GAGGAGAACC CCTACAGCCT GCTGGAAATT 
TCCACTGTGG AGCGAGGCGT GGTGAGTCTC TTTGGAGTGA GAAGTGCCCT CTTCGTTGCC 
ATGAACAGTA AAGGAAGATT GTACGCAACG CCCAGCTTCC AAGAAGAATG CAAGTTCAGA 
GAAACCCTCC TGCCCAACAA TTACAATGCC TACGAGTCAG ACTTGTACCA AGGGACCTAC 
ATTGCCCTGA GCAAATACGG ACGGGTAAAG CGGGGCAGCA AGGTGTCCCC GATCATGACT 
GTCACTCATT TCCTTCCCAG GATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066276.2
CDS	45..671
Translation	MALGQKLFITMSRGAGRLQGTLWALVFLGILVGMVVPSPAGTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFRETLLPNNYNAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI

Target ORF information:

RefSeq Version	NM_020996.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 6 (FGF6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020996.2

ORF Insert Sequence:

ATGGCCCTGG GACAGAAACT GTTCATCACT ATGTCCCGGG GAGCAGGACG TCTGCAGGGC 
ACGCTGTGGG CTCTCGTCTT CCTAGGCATC CTAGTGGGCA TGGTGGTGCC CTCGCCTGCA 
GGCACCCGTG CCAACAACAC GCTGCTGGAC TCGAGGGGCT GGGGCACCCT GCTGTCCAGG 
TCTCGCGCCG GGCTAGCTGG AGAGATTGCC GGGGTGAACT GGGAAAGTGG CTATTTGGTG 
GGGATCAAGC GGCAGCGGAG GCTCTACTGC AACGTGGGCA TCGGCTTTCA CCTCCAGGTG 
CTCCCCGACG GCCGGATCAG CGGGACCCAC GAGGAGAACC CCTACAGCCT GCTGGAAATT 
TCCACTGTGG AGCGAGGCGT GGTGAGTCTC TTTGGAGTGA GAAGTGCCCT CTTCGTTGCC 
ATGAACAGTA AAGGAAGATT GTACGCAACG CCCAGCTTCC AAGAAGAATG CAAGTTCAGA 
GAAACCCTCC TGCCCAACAA TTACAATGCC TACGAGTCAG ACTTGTACCA AGGGACCTAC 
ATTGCCCTGA GCAAATACGG ACGGGTAAAG CGGGGCAGCA AGGTGTCCCC GATCATGACT 
GTCACTCATT TCCTTCCCAG GATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF6 ( XM_017018995.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016874484.1 Homo sapiens fibroblast growth factor 6 (FGF6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu83627
Clone ID Related Accession (Same CDS sequence)	XM_017018995.1
Accession Version	XM_017018995.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	fibroblast growth factor 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCTGG GACAGAAACT GTTCATCACT ATGTCCCGGG GAGCAGGACG TCTGCAGGGC 
ACGCTGTGGG CTCTCGTCTT CCTAGGCATC CTAGTGGGCA TGGTGGTGCC CTCGCCTGCA 
GGCACCCGTG CCAACAACAC GCTGCTGGAC TCGAGGGGCT GGGGCACCCT GCTGTCCAGG 
TCTCGCGCCG GGCTAGCTGG AGAGATTGCC GGGGTGAACT GGGAAAGTGG CTATTTGGTG 
GGGATCAAGC GGCAGCGGAG GCTCTACTGC AACGTGGGCA TCGGCTTTCA CCTCCAGGTG 
CTCCCCGACG GCCGGATCAG CGGGACCCAC GAGGAGAACC CCTACAGCCT GCTGGAAATT 
TCCACTGTGG AGCGAGGCGT GGTGAGTCTC TTTGGAGTGA GAAGTGCCCT CTTCGTTGCC 
ATGAACAGTA AAGGAAGATT GTACGCAACG CTGCGGACAC CCGGTCTCCA GGGTCACACG 
TCCAGCCACA GCTGTGTGCA GCCCCGTCTC AGGGCTCCGC GACCCGAGTT CCAGTTCCTG 
GCCAACCTAC CCTCCAGCTA CTCGTCTTAC TTTGGGCAAC GTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016874484.1
CDS	230..817
Translation	MALGQKLFITMSRGAGRLQGTLWALVFLGILVGMVVPSPAGTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATLRTPGLQGHTSSHSCVQPRLRAPRPEFQFLANLPSSYSSYFGQRH

Target ORF information:

RefSeq Version	XM_017018995.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 6 (FGF6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018995.1

ORF Insert Sequence:

ATGGCCCTGG GACAGAAACT GTTCATCACT ATGTCCCGGG GAGCAGGACG TCTGCAGGGC 
ACGCTGTGGG CTCTCGTCTT CCTAGGCATC CTAGTGGGCA TGGTGGTGCC CTCGCCTGCA 
GGCACCCGTG CCAACAACAC GCTGCTGGAC TCGAGGGGCT GGGGCACCCT GCTGTCCAGG 
TCTCGCGCCG GGCTAGCTGG AGAGATTGCC GGGGTGAACT GGGAAAGTGG CTATTTGGTG 
GGGATCAAGC GGCAGCGGAG GCTCTACTGC AACGTGGGCA TCGGCTTTCA CCTCCAGGTG 
CTCCCCGACG GCCGGATCAG CGGGACCCAC GAGGAGAACC CCTACAGCCT GCTGGAAATT 
TCCACTGTGG AGCGAGGCGT GGTGAGTCTC TTTGGAGTGA GAAGTGCCCT CTTCGTTGCC 
ATGAACAGTA AAGGAAGATT GTACGCAACG CTGCGGACAC CCGGTCTCCA GGGTCACACG 
TCCAGCCACA GCTGTGTGCA GCCCCGTCTC AGGGCTCCGC GACCCGAGTT CCAGTTCCTG 
GCCAACCTAC CCTCCAGCTA CTCGTCTTAC TTTGGGCAAC GTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF6 ( XM_017018996.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016874485.1 Homo sapiens fibroblast growth factor 6 (FGF6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu83628
Clone ID Related Accession (Same CDS sequence)	XM_017018996.1
Accession Version	XM_017018996.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	fibroblast growth factor 6 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCTGG GACAGAAACT GTTCATCACT ATGTCCCGGG GAGCAGGACG TCTGCAGGGC 
ACGCTGTGGG CTCTCGTCTT CCTAGGCATC CTAGTGGGCA TGGTGGTGCC CTCGCCTGCA 
GGCACCCGTG CCAACAACAC GCTGCTGGAC TCGAGGGGCT GGGGCACCCT GCTGTCCAGG 
TCTCGCGCCG GGCTAGCTGG AGAGATTGCC GGGGTGAACT GGGAAAGTGG CTATTTGGTG 
GGGATCAAGC GGCAGCGGAG GCTCTACTGC AACGTGGGCA TCGGCTTTCA CCTCCAGGTG 
CTCCCCGACG GCCGGATCAG CGGGACCCAC GAGGAGAACC CCTACAGCCT GCTGGAAATT 
TCCACTGTGG AGCGAGGCGT GGTGAGTCTC TTTGGAGTGA GAAGTGCCCT CTTCGTTGCC 
ATGAACAGTA AAGGAAGATT GTACGCAACG AAAGGAATTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016874485.1
CDS	230..691
Translation	MALGQKLFITMSRGAGRLQGTLWALVFLGILVGMVVPSPAGTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATKGI

Target ORF information:

RefSeq Version	XM_017018996.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 6 (FGF6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018996.1

ORF Insert Sequence:

ATGGCCCTGG GACAGAAACT GTTCATCACT ATGTCCCGGG GAGCAGGACG TCTGCAGGGC 
ACGCTGTGGG CTCTCGTCTT CCTAGGCATC CTAGTGGGCA TGGTGGTGCC CTCGCCTGCA 
GGCACCCGTG CCAACAACAC GCTGCTGGAC TCGAGGGGCT GGGGCACCCT GCTGTCCAGG 
TCTCGCGCCG GGCTAGCTGG AGAGATTGCC GGGGTGAACT GGGAAAGTGG CTATTTGGTG 
GGGATCAAGC GGCAGCGGAG GCTCTACTGC AACGTGGGCA TCGGCTTTCA CCTCCAGGTG 
CTCCCCGACG GCCGGATCAG CGGGACCCAC GAGGAGAACC CCTACAGCCT GCTGGAAATT 
TCCACTGTGG AGCGAGGCGT GGTGAGTCTC TTTGGAGTGA GAAGTGCCCT CTTCGTTGCC 
ATGAACAGTA AAGGAAGATT GTACGCAACG AAAGGAATTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
BMC genomics1593(2014 Feb)
Li L,Fridley BL,Kalari K,Niu N,Jenkins G,Batzler A,Abo RP,Schaid D,Wang L

Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
Nature genetics45(2)191-6(2013 Feb)
Jia WH,Zhang B,Matsuo K,Shin A,Xiang YB,Jee SH,Kim DH,Ren Z,Cai Q,Long J,Shi J,Wen W,Yang G,Delahanty RJ,,,Ji BT,Pan ZZ,Matsuda F,Gao YT,Oh JH,Ahn YO,Park EJ,Li HL,Park JW,Jo J,Jeong JY,Hosono S,Casey G,Peters U,Shu XO,Zeng YX,Zheng W

Regulation of osteoblast and osteoclast functions by FGF-6.
Journal of cellular physiology225(2)466-71(2010 Nov)
Bosetti M,Leigheb M,Brooks RA,Boccafoschi F,Cannas MF

Common genetic variants associate with serum phosphorus concentration.
Journal of the American Society of Nephrology : JASN21(7)1223-32(2010 Jul)
Kestenbaum B,Glazer NL,K?ttgen A,Felix JF,Hwang SJ,Liu Y,Lohman K,Kritchevsky SB,Hausman DB,Petersen AK,Gieger C,Ried JS,Meitinger T,Strom TM,Wichmann HE,Campbell H,Hayward C,Rudan I,de Boer IH,Psaty BM,Rice KM,Chen YD,Li M,Arking DE,Boerwinkle E,Coresh J,Yang Q,Levy D,van Rooij FJ,Dehghan A,Rivadeneira F,Uitterlinden AG,Hofman A,van Duijn CM,Shlipak MG,Kao WH,Witteman JC,Siscovick DS,Fox CS

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FGF6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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