F3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	F3
Entrez Gene ID	14066
Full Name	coagulation factor III
Synonyms	AA409063,CD142,Cf-3,Cf3,TF
General protein information	Preferred Names coagulation factor III Names tissue factor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 G1\|3 52.94 cM
Summary	This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010171.3	NP_034301.3	tissue factor precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	f3	XP_002933837.1
Pan troglodytes (chimpanzee)	F3	XP_001156450.1
Homo sapiens (human)	F3	NP_001984.1
Canis lupus familiaris (dog)	F3	NP_001019811.1
Mus musculus (house mouse)	F3	NP_034301.3
Rattus norvegicus (Norway rat)	F3	NP_037189.2
Bos taurus (cattle)	F3	NP_776303.1
Gallus gallus (chicken)	F3	XP_426640.2
Danio rerio (zebrafish)	f3b	NP_001017728.1
Danio rerio (zebrafish)	f3a	NP_001232896.1

Gene Ontology
Bibliography

Related articles in PubMed

The Ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3.
Johnson B, Brooks BA, Heinzmann C, Diep A, Mohandas T, Sparkes RS, Reyes H, Hoffman E, Lange E, Gatti RA
Genomics17(3)592-8(1993 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Title: Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Evening primrose oil and forskolin decreased the prothrombotic effect of celecoxib initiated by a LPS challenge in mice, and this effect was, at least partly, mediated by mitigating TF expression and activity.
Title: Evening primrose oil or forskolin ameliorates celecoxib-enhanced upregulation of tissue factor expression in mice subjected to lipopolysaccharide-induced endotoxemia.

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Ticagrelor reduced TNF-alpha-induced TF expression via proteasomal degradation.
Title: Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.

Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
Title: Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

There was no significant contribution of TF on myeloid cells in multiple models of experimental ALI, leading to the conclusion that TF in myeloid cells is not a major contributor to experimental ALI.
Title: Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury.

The following F3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20384	NM_010171.3 Latest version!	Mus musculus coagulation factor III (F3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F3 ( NM_010171.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034301.3 Mus musculus coagulation factor III (F3), mRNA.

Price & Availability↑

CloneID	OMu20384
Clone ID Related Accession (Same CDS sequence)	NM_010171.3
Accession Version	NM_010171.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Mus musculus(house mouse)
Product	tissue factor precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC129311.6, AK137642.1 and C86417.1. On Mar 18, 2008 this sequence version replaced NM_010171.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024886.1, BC016397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGATCC TCGTGCGCCC GCGCCTCCTA GCGGCTCTCG CGCCCACGTT TCTCGGCTGC 
CTCCTCCTCC AGGTGACCGC GGGTGCAGGC ATTCCAGAGA AAGCGTTTAA TTTAACTTGG 
ATATCAACTG ATTTCAAGAC AATTTTGGAG TGGCAACCCA AACCCACCAA CTATACCTAC 
ACTGTACAGA TAAGTGATCG ATCTAGAAAC TGGAAAAACA AGTGCTTCTC GACCACAGAC 
ACCGAGTGCG ACCTCACAGA CGAGATCGTG AAGGATGTGA CCTGGGCCTA TGAAGCAAAG 
GTCCTCTCTG TCCCACGGAG GAACTCAGTT CATGGAGACG GAGACCAACT TGTGATTCAT 
GGGGAGGAGC CGCCATTTAC AAACGCCCCA AAGTTTTTAC CTTACCGAGA CACAAACCTT 
GGACAGCCAG TAATTCAGCA GTTTGAACAA GATGGTAGAA AACTGAACGT GGTTGTAAAA 
GACTCACTTA CATTAGTCAG AAAGAATGGT ACATTCCTCA CCCTGCGGCA AGTCTTTGGC 
AAGGACTTGG GTTATATAAT TACTTATCGG AAAGGCTCAA GCACGGGAAA GAAAACAAAC 
ATTACAAACA CCAATGAATT CTCGATTGAT GTGGAAGAAG GAGTAAGCTA CTGCTTTTTT 
GTACAAGCTA TGATTTTCTC CAGGAAAACT AACCAAAATA GCCCAGGAAG CAGTACAGTG 
TGCACCGAGC AATGGAAGAG TTTCCTGGGA GAAACACTCA TCATTGTGGG AGCAGTGGTG 
CTCCTGGCCA CCATCTTTAT CATCCTCCTG TCCATATCTC TGTGCAAGCG CAGAAAGAAC 
CGAGCGGGAC AGAAAGGGAA GAACACCCCG TCGCGCTTGG CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034301.3
CDS	179..1063
Translation	MAILVRPRLLAALAPTFLGCLLLQVTAGAGIPEKAFNLTWISTDFKTILEWQPKPTNYTYTVQISDRSRNWKNKCFSTTDTECDLTDEIVKDVTWAYEAKVLSVPRRNSVHGDGDQLVIHGEEPPFTNAPKFLPYRDTNLGQPVIQQFEQDGRKLNVVVKDSLTLVRKNGTFLTLRQVFGKDLGYIITYRKGSSTGKKTNITNTNEFSIDVEEGVSYCFFVQAMIFSRKTNQNSPGSSTVCTEQWKSFLGETLIIVGAVVLLATIFIILLSISLCKRRKNRAGQKGKNTPSRLA

Target ORF information:

RefSeq Version	NM_010171.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus coagulation factor III (F3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010171.3

ORF Insert Sequence:

ATGGCGATCC TCGTGCGCCC GCGCCTCCTA GCGGCTCTCG CGCCCACGTT TCTCGGCTGC 
CTCCTCCTCC AGGTGACCGC GGGTGCAGGC ATTCCAGAGA AAGCGTTTAA TTTAACTTGG 
ATATCAACTG ATTTCAAGAC AATTTTGGAG TGGCAACCCA AACCCACCAA CTATACCTAC 
ACTGTACAGA TAAGTGATCG ATCTAGAAAC TGGAAAAACA AGTGCTTCTC GACCACAGAC 
ACCGAGTGCG ACCTCACAGA CGAGATCGTG AAGGATGTGA CCTGGGCCTA TGAAGCAAAG 
GTCCTCTCTG TCCCACGGAG GAACTCAGTT CATGGAGACG GAGACCAACT TGTGATTCAT 
GGGGAGGAGC CGCCATTTAC AAACGCCCCA AAGTTTTTAC CTTACCGAGA CACAAACCTT 
GGACAGCCAG TAATTCAGCA GTTTGAACAA GATGGTAGAA AACTGAACGT GGTTGTAAAA 
GACTCACTTA CATTAGTCAG AAAGAATGGT ACATTCCTCA CCCTGCGGCA AGTCTTTGGC 
AAGGACTTGG GTTATATAAT TACTTATCGG AAAGGCTCAA GCACGGGAAA GAAAACAAAC 
ATTACAAACA CCAATGAATT CTCGATTGAT GTGGAAGAAG GAGTAAGCTA CTGCTTTTTT 
GTACAAGCTA TGATTTTCTC CAGGAAAACT AACCAAAATA GCCCAGGAAG CAGTACAGTG 
TGCACCGAGC AATGGAAGAG TTTCCTGGGA GAAACACTCA TCATTGTGGG AGCAGTGGTG 
CTCCTGGCCA CCATCTTTAT CATCCTCCTG TCCATATCTC TGTGCAAGCG CAGAAAGAAC 
CGAGCGGGAC AGAAAGGGAA GAACACCCCG TCGCGCTTGG CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3.
Genomics17(3)592-8(1993 Sep)
Johnson B,Brooks BA,Heinzmann C,Diep A,Mohandas T,Sparkes RS,Reyes H,Hoffman E,Lange E,Gatti RA

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F3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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