Dnase1l3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dnase1l3
Entrez Gene ID	13421
Full Name	deoxyribonuclease 1-like 3
Synonyms	DNasegamma,Dhp2,Lsd
General protein information	Preferred Names deoxyribonuclease 1-like 3 Names deoxyribonuclease gamma DNase I homolog protein DHP2 DNase I-like 3 DNase gamma LS-DNase deoxyribonuclease I-like 3 liver and spleen DNase macrophage specific DNase I
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 A1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006517921.4	XP_006517984.1	deoxyribonuclease gamma isoform X1
NM_007870.3	NP_031896.3	deoxyribonuclease gamma precursor
XM_006517921.3	XP_006517984.1	deoxyribonuclease gamma isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dnase1l3	NP_031896.3
Homo sapiens (human)	DNASE1L3	NP_004935.1
Pan troglodytes (chimpanzee)	DNASE1L3	XP_001174037.1
Canis lupus familiaris (dog)	DNASE1L3	XP_533780.1
Danio rerio (zebrafish)	dnase1l3	NP_998318.2
Rattus norvegicus (Norway rat)	Dnase1l3	NP_446359.1
Danio rerio (zebrafish)	dnase1l3l	NP_001002403.1
	DNASE1L3	XP_001097104.1
Bos taurus (cattle)	DNASE1L3	NP_001192653.1
Gallus gallus (chicken)	DNASE1L3	NP_001029987.1
Xenopus tropicalis (tropical clawed frog)	dnase1l3	NP_988919.1

Gene Ontology
Bibliography

Related articles in PubMed

Host DNases prevent vascular occlusion by neutrophil extracellular traps.
Jim?nez-Alc?zar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renn? C, Renn? T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA
Science (New York, N.Y.)358(6367)1202-1206(2017 12)

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity.
Sisirak V, Sally B, D'Agati V, Martinez-Ortiz W, ?z?akar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yal??nkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B
Cell166(1)88-101(2016 Jun)

DNase ? is the effector endonuclease for internucleosomal DNA fragmentation in necrosis.
Mizuta R, Araki S, Furukawa M, Furukawa Y, Ebara S, Shiokawa D, Hayashi K, Tanuma S, Kitamura D
PloS one8(12)e80223(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study reports that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin, followed by an systemic lupus erythematosus-like disease. Circulating DNASE1L3 is produced by dendritic cells and macrophages, and its levels inversely correlate with anti-DNA antibody response.
Title: Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity.

DNase gamma, but not CAD, is the effector endonuclease for INDF in cells undergoing necrosis.
Title: DNase ? is the effector endonuclease for internucleosomal DNA fragmentation in necrosis.

serum contains two nucleases, DNase1 and DNase1l3, which may substitute or cooperate with each other during DNA degradation, providing effective clearance after exposure or release from dying cells.
Title: Murine serum nucleases--contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3).

These results suggest that DNasegamma provides an alternative mechanism for inducing nuclear changes when the working apoptotic cascade is unsuitable for caspase-activated DNase activation.
Title: Stage-specific expression of DNasegamma during B-cell development and its role in B-cell receptor-mediated apoptosis in WEHI-231 cells.

A comparison of the expression and transport of DNAse1 from rats and DNAse1L3 from mice is reported.
Title: Comparative characterization of rat deoxyribonuclease 1 (Dnase1) and murine deoxyribonuclease 1-like 3 (Dnase1l3).

The following Dnase1l3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dnase1l3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu00942	NM_007870.3 Latest version!	Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu00942	XM_006517921.4 Latest version!	Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu00942	XM_006517921.3	Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dnase1l3 ( NM_007870.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031896.3 Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), mRNA.

Price & Availability↑

CloneID	OMu00942
Clone ID Related Accession (Same CDS sequence)	XM_006517921.4 , NM_007870.3 , XM_006517921.3
Accession Version	NM_007870.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	deoxyribonuclease gamma precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139029.10, AF047355.1 and U76110.1. On Jan 6, 2006 this sequence version replaced NM_007870.2. ##Evidence-Data-START## Transcript exon combination :: AK156109.1, AK172254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTGC ACCCAGCTTC CCCACGCCTG GCCTCCCTGC TGCTCTTCAT CCTTGCCCTC 
CATGACACCC TGGCCCTAAG GCTCTGCTCC TTCAATGTGA GGTCCTTTGG AGCGAGCAAG 
AAGGAAAACC ATGAAGCCAT GGATATCATT GTGAAGATCA TCAAACGCTG TGACCTTATA 
CTGTTGATGG AAATCAAGGA CAGCAGCAAC AACATCTGTC CCATGCTGAT GGAGAAGCTG 
AATGGAAATT CACGAAGAAG CACAACATAC AACTATGTGA TTAGTTCTCG ACTTGGAAGA 
AACACGTACA AAGAGCAGTA TGCCTTCGTC TACAAGGAGA AGCTGGTGTC TGTGAAGACA 
AAATACCACT ACCATGACTA TCAGGATGGA GACACAGACG TGTTTTCCAG GGAGCCCTTT 
GTGGTTTGGT TCCATTCCCC CTTTACTGCT GTCAAGGACT TCGTGATTGT CCCCTTGCAC 
ACAACTCCCG AGACCTCCGT TAAAGAGATA GATGAGCTGG TCGATGTCTA CACGGATGTG 
AGAAGCCAGT GGAAGACAGA GAATTTCATC TTCATGGGTG ATTTCAACGC CGGCTGTAGC 
TATGTCCCCA AGAAGGCCTG GCAGAACATT CGTTTGAGGA CGGACCCCAA GTTTGTTTGG 
CTGATTGGGG ACCAAGAGGA CACTACGGTC AAGAAGAGTA CCAGCTGTGC CTATGACAGG 
ATTGTGCTTT GTGGACAAGA GATAGTCAAC TCCGTGGTTC CCCGTTCCAG TGGCGTCTTT 
GACTTTCAGA AAGCTTATGA CTTGTCTGAG GAGGAGGCCC TGGATGTCAG TGATCACTTT 
CCAGTTGAGT TTAAGCTACA GTCTTCAAGG GCCTTCACCA ACAACAGAAA ATCTGTTTCT 
CTCAAAAAGA GAAAAAAAGG CAATCGCTCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031896.3
CDS	198..1130
Translation	MSLHPASPRLASLLLFILALHDTLALRLCSFNVRSFGASKKENHEAMDIIVKIIKRCDLILLMEIKDSSNNICPMLMEKLNGNSRRSTTYNYVISSRLGRNTYKEQYAFVYKEKLVSVKTKYHYHDYQDGDTDVFSREPFVVWFHSPFTAVKDFVIVPLHTTPETSVKEIDELVDVYTDVRSQWKTENFIFMGDFNAGCSYVPKKAWQNIRLRTDPKFVWLIGDQEDTTVKKSTSCAYDRIVLCGQEIVNSVVPRSSGVFDFQKAYDLSEEEALDVSDHFPVEFKLQSSRAFTNNRKSVSLKKRKKGNRS

Target ORF information:

RefSeq Version	NM_007870.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007870.3

ORF Insert Sequence:

ATGTCCCTGC ACCCAGCTTC CCCACGCCTG GCCTCCCTGC TGCTCTTCAT CCTTGCCCTC 
CATGACACCC TGGCCCTAAG GCTCTGCTCC TTCAATGTGA GGTCCTTTGG AGCGAGCAAG 
AAGGAAAACC ATGAAGCCAT GGATATCATT GTGAAGATCA TCAAACGCTG TGACCTTATA 
CTGTTGATGG AAATCAAGGA CAGCAGCAAC AACATCTGTC CCATGCTGAT GGAGAAGCTG 
AATGGAAATT CACGAAGAAG CACAACATAC AACTATGTGA TTAGTTCTCG ACTTGGAAGA 
AACACGTACA AAGAGCAGTA TGCCTTCGTC TACAAGGAGA AGCTGGTGTC TGTGAAGACA 
AAATACCACT ACCATGACTA TCAGGATGGA GACACAGACG TGTTTTCCAG GGAGCCCTTT 
GTGGTTTGGT TCCATTCCCC CTTTACTGCT GTCAAGGACT TCGTGATTGT CCCCTTGCAC 
ACAACTCCCG AGACCTCCGT TAAAGAGATA GATGAGCTGG TCGATGTCTA CACGGATGTG 
AGAAGCCAGT GGAAGACAGA GAATTTCATC TTCATGGGTG ATTTCAACGC CGGCTGTAGC 
TATGTCCCCA AGAAGGCCTG GCAGAACATT CGTTTGAGGA CGGACCCCAA GTTTGTTTGG 
CTGATTGGGG ACCAAGAGGA CACTACGGTC AAGAAGAGTA CCAGCTGTGC CTATGACAGG 
ATTGTGCTTT GTGGACAAGA GATAGTCAAC TCCGTGGTTC CCCGTTCCAG TGGCGTCTTT 
GACTTTCAGA AAGCTTATGA CTTGTCTGAG GAGGAGGCCC TGGATGTCAG TGATCACTTT 
CCAGTTGAGT TTAAGCTACA GTCTTCAAGG GCCTTCACCA ACAACAGAAA ATCTGTTTCT 
CTCAAAAAGA GAAAAAAAGG CAATCGCTCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dnase1l3 ( XM_006517921.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006517984.1 Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu00942
Clone ID Related Accession (Same CDS sequence)	XM_006517921.4 , NM_007870.3 , XM_006517921.3
Accession Version	XM_006517921.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	deoxyribonuclease gamma isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006517921.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTGC ACCCAGCTTC CCCACGCCTG GCCTCCCTGC TGCTCTTCAT CCTTGCCCTC 
CATGACACCC TGGCCCTAAG GCTCTGCTCC TTCAATGTGA GGTCCTTTGG AGCGAGCAAG 
AAGGAAAACC ATGAAGCCAT GGATATCATT GTGAAGATCA TCAAACGCTG TGACCTTATA 
CTGTTGATGG AAATCAAGGA CAGCAGCAAC AACATCTGTC CCATGCTGAT GGAGAAGCTG 
AATGGAAATT CACGAAGAAG CACAACATAC AACTATGTGA TTAGTTCTCG ACTTGGAAGA 
AACACGTACA AAGAGCAGTA TGCCTTCGTC TACAAGGAGA AGCTGGTGTC TGTGAAGACA 
AAATACCACT ACCATGACTA TCAGGATGGA GACACAGACG TGTTTTCCAG GGAGCCCTTT 
GTGGTTTGGT TCCATTCCCC CTTTACTGCT GTCAAGGACT TCGTGATTGT CCCCTTGCAC 
ACAACTCCCG AGACCTCCGT TAAAGAGATA GATGAGCTGG TCGATGTCTA CACGGATGTG 
AGAAGCCAGT GGAAGACAGA GAATTTCATC TTCATGGGTG ATTTCAACGC CGGCTGTAGC 
TATGTCCCCA AGAAGGCCTG GCAGAACATT CGTTTGAGGA CGGACCCCAA GTTTGTTTGG 
CTGATTGGGG ACCAAGAGGA CACTACGGTC AAGAAGAGTA CCAGCTGTGC CTATGACAGG 
ATTGTGCTTT GTGGACAAGA GATAGTCAAC TCCGTGGTTC CCCGTTCCAG TGGCGTCTTT 
GACTTTCAGA AAGCTTATGA CTTGTCTGAG GAGGAGGCCC TGGATGTCAG TGATCACTTT 
CCAGTTGAGT TTAAGCTACA GTCTTCAAGG GCCTTCACCA ACAACAGAAA ATCTGTTTCT 
CTCAAAAAGA GAAAAAAAGG CAATCGCTCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006517984.1
CDS	663..1595
Translation	MSLHPASPRLASLLLFILALHDTLALRLCSFNVRSFGASKKENHEAMDIIVKIIKRCDLILLMEIKDSSNNICPMLMEKLNGNSRRSTTYNYVISSRLGRNTYKEQYAFVYKEKLVSVKTKYHYHDYQDGDTDVFSREPFVVWFHSPFTAVKDFVIVPLHTTPETSVKEIDELVDVYTDVRSQWKTENFIFMGDFNAGCSYVPKKAWQNIRLRTDPKFVWLIGDQEDTTVKKSTSCAYDRIVLCGQEIVNSVVPRSSGVFDFQKAYDLSEEEALDVSDHFPVEFKLQSSRAFTNNRKSVSLKKRKKGNRS

Target ORF information:

RefSeq Version	XM_006517921.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006517921.3

ORF Insert Sequence:

ATGTCCCTGC ACCCAGCTTC CCCACGCCTG GCCTCCCTGC TGCTCTTCAT CCTTGCCCTC 
CATGACACCC TGGCCCTAAG GCTCTGCTCC TTCAATGTGA GGTCCTTTGG AGCGAGCAAG 
AAGGAAAACC ATGAAGCCAT GGATATCATT GTGAAGATCA TCAAACGCTG TGACCTTATA 
CTGTTGATGG AAATCAAGGA CAGCAGCAAC AACATCTGTC CCATGCTGAT GGAGAAGCTG 
AATGGAAATT CACGAAGAAG CACAACATAC AACTATGTGA TTAGTTCTCG ACTTGGAAGA 
AACACGTACA AAGAGCAGTA TGCCTTCGTC TACAAGGAGA AGCTGGTGTC TGTGAAGACA 
AAATACCACT ACCATGACTA TCAGGATGGA GACACAGACG TGTTTTCCAG GGAGCCCTTT 
GTGGTTTGGT TCCATTCCCC CTTTACTGCT GTCAAGGACT TCGTGATTGT CCCCTTGCAC 
ACAACTCCCG AGACCTCCGT TAAAGAGATA GATGAGCTGG TCGATGTCTA CACGGATGTG 
AGAAGCCAGT GGAAGACAGA GAATTTCATC TTCATGGGTG ATTTCAACGC CGGCTGTAGC 
TATGTCCCCA AGAAGGCCTG GCAGAACATT CGTTTGAGGA CGGACCCCAA GTTTGTTTGG 
CTGATTGGGG ACCAAGAGGA CACTACGGTC AAGAAGAGTA CCAGCTGTGC CTATGACAGG 
ATTGTGCTTT GTGGACAAGA GATAGTCAAC TCCGTGGTTC CCCGTTCCAG TGGCGTCTTT 
GACTTTCAGA AAGCTTATGA CTTGTCTGAG GAGGAGGCCC TGGATGTCAG TGATCACTTT 
CCAGTTGAGT TTAAGCTACA GTCTTCAAGG GCCTTCACCA ACAACAGAAA ATCTGTTTCT 
CTCAAAAAGA GAAAAAAAGG CAATCGCTCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dnase1l3 ( XM_006517921.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006517984.1 Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu00942
Clone ID Related Accession (Same CDS sequence)	XM_006517921.4 , NM_007870.3 , XM_006517921.3
Accession Version	XM_006517921.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	deoxyribonuclease gamma isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006517921.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTGC ACCCAGCTTC CCCACGCCTG GCCTCCCTGC TGCTCTTCAT CCTTGCCCTC 
CATGACACCC TGGCCCTAAG GCTCTGCTCC TTCAATGTGA GGTCCTTTGG AGCGAGCAAG 
AAGGAAAACC ATGAAGCCAT GGATATCATT GTGAAGATCA TCAAACGCTG TGACCTTATA 
CTGTTGATGG AAATCAAGGA CAGCAGCAAC AACATCTGTC CCATGCTGAT GGAGAAGCTG 
AATGGAAATT CACGAAGAAG CACAACATAC AACTATGTGA TTAGTTCTCG ACTTGGAAGA 
AACACGTACA AAGAGCAGTA TGCCTTCGTC TACAAGGAGA AGCTGGTGTC TGTGAAGACA 
AAATACCACT ACCATGACTA TCAGGATGGA GACACAGACG TGTTTTCCAG GGAGCCCTTT 
GTGGTTTGGT TCCATTCCCC CTTTACTGCT GTCAAGGACT TCGTGATTGT CCCCTTGCAC 
ACAACTCCCG AGACCTCCGT TAAAGAGATA GATGAGCTGG TCGATGTCTA CACGGATGTG 
AGAAGCCAGT GGAAGACAGA GAATTTCATC TTCATGGGTG ATTTCAACGC CGGCTGTAGC 
TATGTCCCCA AGAAGGCCTG GCAGAACATT CGTTTGAGGA CGGACCCCAA GTTTGTTTGG 
CTGATTGGGG ACCAAGAGGA CACTACGGTC AAGAAGAGTA CCAGCTGTGC CTATGACAGG 
ATTGTGCTTT GTGGACAAGA GATAGTCAAC TCCGTGGTTC CCCGTTCCAG TGGCGTCTTT 
GACTTTCAGA AAGCTTATGA CTTGTCTGAG GAGGAGGCCC TGGATGTCAG TGATCACTTT 
CCAGTTGAGT TTAAGCTACA GTCTTCAAGG GCCTTCACCA ACAACAGAAA ATCTGTTTCT 
CTCAAAAAGA GAAAAAAAGG CAATCGCTCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006517984.1
CDS	658..1590
Translation	MSLHPASPRLASLLLFILALHDTLALRLCSFNVRSFGASKKENHEAMDIIVKIIKRCDLILLMEIKDSSNNICPMLMEKLNGNSRRSTTYNYVISSRLGRNTYKEQYAFVYKEKLVSVKTKYHYHDYQDGDTDVFSREPFVVWFHSPFTAVKDFVIVPLHTTPETSVKEIDELVDVYTDVRSQWKTENFIFMGDFNAGCSYVPKKAWQNIRLRTDPKFVWLIGDQEDTTVKKSTSCAYDRIVLCGQEIVNSVVPRSSGVFDFQKAYDLSEEEALDVSDHFPVEFKLQSSRAFTNNRKSVSLKKRKKGNRS

Target ORF information:

RefSeq Version	XM_006517921.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006517921.4

ORF Insert Sequence:

ATGTCCCTGC ACCCAGCTTC CCCACGCCTG GCCTCCCTGC TGCTCTTCAT CCTTGCCCTC 
CATGACACCC TGGCCCTAAG GCTCTGCTCC TTCAATGTGA GGTCCTTTGG AGCGAGCAAG 
AAGGAAAACC ATGAAGCCAT GGATATCATT GTGAAGATCA TCAAACGCTG TGACCTTATA 
CTGTTGATGG AAATCAAGGA CAGCAGCAAC AACATCTGTC CCATGCTGAT GGAGAAGCTG 
AATGGAAATT CACGAAGAAG CACAACATAC AACTATGTGA TTAGTTCTCG ACTTGGAAGA 
AACACGTACA AAGAGCAGTA TGCCTTCGTC TACAAGGAGA AGCTGGTGTC TGTGAAGACA 
AAATACCACT ACCATGACTA TCAGGATGGA GACACAGACG TGTTTTCCAG GGAGCCCTTT 
GTGGTTTGGT TCCATTCCCC CTTTACTGCT GTCAAGGACT TCGTGATTGT CCCCTTGCAC 
ACAACTCCCG AGACCTCCGT TAAAGAGATA GATGAGCTGG TCGATGTCTA CACGGATGTG 
AGAAGCCAGT GGAAGACAGA GAATTTCATC TTCATGGGTG ATTTCAACGC CGGCTGTAGC 
TATGTCCCCA AGAAGGCCTG GCAGAACATT CGTTTGAGGA CGGACCCCAA GTTTGTTTGG 
CTGATTGGGG ACCAAGAGGA CACTACGGTC AAGAAGAGTA CCAGCTGTGC CTATGACAGG 
ATTGTGCTTT GTGGACAAGA GATAGTCAAC TCCGTGGTTC CCCGTTCCAG TGGCGTCTTT 
GACTTTCAGA AAGCTTATGA CTTGTCTGAG GAGGAGGCCC TGGATGTCAG TGATCACTTT 
CCAGTTGAGT TTAAGCTACA GTCTTCAAGG GCCTTCACCA ACAACAGAAA ATCTGTTTCT 
CTCAAAAAGA GAAAAAAAGG CAATCGCTCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Host DNases prevent vascular occlusion by neutrophil extracellular traps.
Science (New York, N.Y.)358(6367)1202-1206(2017 12)
Jim?nez-Alc?zar M,Rangaswamy C,Panda R,Bitterling J,Simsek YJ,Long AT,Bilyy R,Krenn V,Renn? C,Renn? T,Kluge S,Panzer U,Mizuta R,Mannherz HG,Kitamura D,Herrmann M,Napirei M,Fuchs TA

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity.
Cell166(1)88-101(2016 Jun)
Sisirak V,Sally B,D'Agati V,Martinez-Ortiz W,?z?akar ZB,David J,Rashidfarrokhi A,Yeste A,Panea C,Chida AS,Bogunovic M,Ivanov II,Quintana FJ,Sanz I,Elkon KB,Tekin M,Yal??nkaya F,Cardozo TJ,Clancy RM,Buyon JP,Reizis B

DNase ? is the effector endonuclease for internucleosomal DNA fragmentation in necrosis.
PloS one8(12)e80223(2013)
Mizuta R,Araki S,Furukawa M,Furukawa Y,Ebara S,Shiokawa D,Hayashi K,Tanuma S,Kitamura D

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Dnase1l3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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