DNASE1L3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNASE1L3
Entrez Gene ID	1776
Full Name	deoxyribonuclease 1 like 3
Synonyms	DHP2,DNAS1L3,LSD,SLEB16
General protein information	Preferred Names deoxyribonuclease 1 like 3 Names deoxyribonuclease gamma DNase I homolog protein 2 DNase I homolog protein DHP2 DNase I-like 3 DNase gamma LS-DNase Liver and spleen DNase deoxyribonuclease I-like 3 deoxyribonuclease I-like III
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p14.3
Summary	This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
Disorder MIM:	602244
Disorder Html:	Systemic lupus erythematosus 16, 614420 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004944.3	NP_004935.1	deoxyribonuclease gamma isoform 1 precursor
NM_004944.4	NP_004935.1	deoxyribonuclease gamma isoform 1 precursor
NM_001256560.1	NP_001243489.1	deoxyribonuclease gamma isoform 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dnase1l3	NP_031896.3
Homo sapiens (human)	DNASE1L3	NP_004935.1
Pan troglodytes (chimpanzee)	DNASE1L3	XP_001174037.1
Canis lupus familiaris (dog)	DNASE1L3	XP_533780.1
Danio rerio (zebrafish)	dnase1l3	NP_998318.2
Rattus norvegicus (Norway rat)	Dnase1l3	NP_446359.1
Danio rerio (zebrafish)	dnase1l3l	NP_001002403.1
	DNASE1L3	XP_001097104.1
Bos taurus (cattle)	DNASE1L3	NP_001192653.1
Gallus gallus (chicken)	DNASE1L3	NP_001029987.1
Xenopus tropicalis (tropical clawed frog)	dnase1l3	NP_988919.1

Gene Ontology
Bibliography

Related articles in PubMed

Host DNases prevent vascular occlusion by neutrophil extracellular traps.
Jim?nez-Alc?zar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renn? C, Renn? T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA
Science (New York, N.Y.)358(6367)1202-1206(2017 12)

Serum level of DNase1l3 in patients with dermatomyositis/polymyositis, systemic lupus erythematosus and rheumatoid arthritis, and its association with disease activity.
Zhao Q, Yang C, Wang J, Li Y, Yang P
Clinical and experimental medicine17(4)459-465(2017 Nov)

Functional Single Nucleotide Polymorphisms (SNPs) in the Genes Encoding the Human Deoxyribonuclease (DNase) Family Potentially Relevant to Autoimmunity.
Fujihara J, Ueki M, Kimura-Kataoka K, Iida R, Takeshita H, Yasuda T
Immunological investigations45(5)406-19(2016 Jul)

An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3.
Zochling J, Newell F, Charlesworth JC, Leo P, Stankovich J, Cortes A, Zhou Y, Stevens W, Sahhar J, Roddy J, Nash P, Tymms K, Rischmueller M, Lester S, Proudman S, Brown MA
Arthritis research & therapy16(5)438(2014 Oct)

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus.
Al-Mayouf SM, Sunker A, Abdwani R, Abrawi SA, Almurshedi F, Alhashmi N, Al Sonbul A, Sewairi W, Qari A, Abdallah E, Al-Owain M, Al Motywee S, Al-Rayes H, Hashem M, Khalak H, Al-Jebali L, Alkuraya FS
Nature genetics43(12)1186-8(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1, DNASE1L3, and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed.
Title: Functional Single Nucleotide Polymorphisms (SNPs) in the Genes Encoding the Human Deoxyribonuclease (DNase) Family Potentially Relevant to Autoimmunity.

Data indicate a likely functional variant influencing scleroderma susceptibility at deoxyribonuclease I-like 3 protein DNASE1L3 missense polymorphism rs35677470.
Title: An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3.

Single nucleotide polymorphisms in the DNASE1L3 is associated with autoimmune diseases.
Title: Evaluation of all non-synonymous single nucleotide polymorphisms (SNPs) in the genes encoding human deoxyribonuclease I and I-like 3 as a functional SNP potentially implicated in autoimmunity.

DNASE1L3 mutations occur in hypocomplementemic urticarial vasculitis syndrome.
Title: DNASE1L3 mutations in hypocomplementemic urticarial vasculitis syndrome.

These results suggest a cooperative activity between CAD and DNAS1L3 to accomplish internucleosomal DNA fragmentation .
Title: Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis.

The following DNASE1L3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNASE1L3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20141	NM_004944.4 Latest version!	Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu09669	NM_001256560.1 Latest version!	Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu20141	NM_004944.3	Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNASE1L3 ( NM_004944.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004935.1 Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20141
Clone ID Related Accession (Same CDS sequence)	NM_004944.3 , NM_004944.4
Accession Version	NM_004944.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	deoxyribonuclease gamma isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI521582.1, BC015831.1 and AI660448.1. This sequence is a reference standard in the RefSeqGene project. On Feb 10, 2012 this sequence version replaced NM_004944.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.355765.1, ERR279831.11340.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCACGGG AGCTGGCCCC ACTGCTGCTT CTCCTCCTCT CCATCCACAG CGCCCTGGCC 
ATGAGGATCT GCTCCTTCAA CGTCAGGTCC TTTGGGGAAA GCAAGCAGGA AGACAAGAAT 
GCCATGGATG TCATTGTGAA GGTCATCAAA CGCTGTGACA TCATACTCGT GATGGAAATC 
AAGGACAGCA ACAACAGGAT CTGCCCCATA CTGATGGAGA AGCTGAACAG AAATTCAAGG 
AGAGGCATAA CGTACAACTA TGTGATTAGC TCTCGGCTTG GAAGAAACAC ATATAAAGAA 
CAATATGCCT TTCTCTACAA GGAAAAGCTG GTGTCTGTGA AGAGGAGTTA TCACTACCAT 
GACTATCAGG ATGGAGACGC AGATGTGTTT TCCAGGGAGC CCTTTGTGGT CTGGTTCCAA 
TCTCCCCACA CTGCTGTCAA AGACTTCGTG ATTATCCCCC TGCACACCAC CCCAGAGACA 
TCCGTTAAGG AGATCGATGA GTTGGTTGAG GTCTACACGG ACGTGAAACA CCGCTGGAAG 
GCGGAGAATT TCATTTTCAT GGGTGACTTC AATGCCGGCT GCAGCTACGT CCCCAAGAAG 
GCCTGGAAGA ACATCCGCTT GAGGACTGAC CCCAGGTTTG TTTGGCTGAT CGGGGACCAA 
GAGGACACCA CGGTGAAGAA GAGCACCAAC TGTGCATATG ACAGGATTGT GCTTAGAGGA 
CAAGAAATCG TCAGTTCTGT TGTTCCCAAG TCAAACAGTG TTTTTGACTT CCAGAAAGCT 
TACAAGCTGA CTGAAGAGGA GGCCCTGGAT GTCAGCGACC ACTTTCCAGT TGAATTTAAA 
CTACAGTCTT CAAGGGCCTT CACCAACAGC AAAAAATCTG TCACTCTAAG GAAGAAAACA 
AAGAGCAAAC GCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004935.1
CDS	98..1015
Translation	MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVMEIKDSNNRICPILMEKLNRNSRRGITYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYHYHDYQDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKHRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIVLRGQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLRKKTKSKRS

Target ORF information:

RefSeq Version	NM_004944.3
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004944.3

ORF Insert Sequence:

ATGTCACGGG AGCTGGCCCC ACTGCTGCTT CTCCTCCTCT CCATCCACAG CGCCCTGGCC 
ATGAGGATCT GCTCCTTCAA CGTCAGGTCC TTTGGGGAAA GCAAGCAGGA AGACAAGAAT 
GCCATGGATG TCATTGTGAA GGTCATCAAA CGCTGTGACA TCATACTCGT GATGGAAATC 
AAGGACAGCA ACAACAGGAT CTGCCCCATA CTGATGGAGA AGCTGAACAG AAATTCAAGG 
AGAGGCATAA CGTACAACTA TGTGATTAGC TCTCGGCTTG GAAGAAACAC ATATAAAGAA 
CAATATGCCT TTCTCTACAA GGAAAAGCTG GTGTCTGTGA AGAGGAGTTA TCACTACCAT 
GACTATCAGG ATGGAGACGC AGATGTGTTT TCCAGGGAGC CCTTTGTGGT CTGGTTCCAA 
TCTCCCCACA CTGCTGTCAA AGACTTCGTG ATTATCCCCC TGCACACCAC CCCAGAGACA 
TCCGTTAAGG AGATCGATGA GTTGGTTGAG GTCTACACGG ACGTGAAACA CCGCTGGAAG 
GCGGAGAATT TCATTTTCAT GGGTGACTTC AATGCCGGCT GCAGCTACGT CCCCAAGAAG 
GCCTGGAAGA ACATCCGCTT GAGGACTGAC CCCAGGTTTG TTTGGCTGAT CGGGGACCAA 
GAGGACACCA CGGTGAAGAA GAGCACCAAC TGTGCATATG ACAGGATTGT GCTTAGAGGA 
CAAGAAATCG TCAGTTCTGT TGTTCCCAAG TCAAACAGTG TTTTTGACTT CCAGAAAGCT 
TACAAGCTGA CTGAAGAGGA GGCCCTGGAT GTCAGCGACC ACTTTCCAGT TGAATTTAAA 
CTACAGTCTT CAAGGGCCTT CACCAACAGC AAAAAATCTG TCACTCTAAG GAAGAAAACA 
AAGAGCAAAC GCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE1L3 ( NM_004944.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004935.1 Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20141
Clone ID Related Accession (Same CDS sequence)	NM_004944.3 , NM_004944.4
Accession Version	NM_004944.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	deoxyribonuclease gamma isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI521582.1, BC015831.1, AI660448.1 and AC137936.3. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_004944.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.355765.1, AF047354.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000394549.7/ ENSP00000378053.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCACGGG AGCTGGCCCC ACTGCTGCTT CTCCTCCTCT CCATCCACAG CGCCCTGGCC 
ATGAGGATCT GCTCCTTCAA CGTCAGGTCC TTTGGGGAAA GCAAGCAGGA AGACAAGAAT 
GCCATGGATG TCATTGTGAA GGTCATCAAA CGCTGTGACA TCATACTCGT GATGGAAATC 
AAGGACAGCA ACAACAGGAT CTGCCCCATA CTGATGGAGA AGCTGAACAG AAATTCAAGG 
AGAGGCATAA CGTACAACTA TGTGATTAGC TCTCGGCTTG GAAGAAACAC ATATAAAGAA 
CAATATGCCT TTCTCTACAA GGAAAAGCTG GTGTCTGTGA AGAGGAGTTA TCACTACCAT 
GACTATCAGG ATGGAGACGC AGATGTGTTT TCCAGGGAGC CCTTTGTGGT CTGGTTCCAA 
TCTCCCCACA CTGCTGTCAA AGACTTCGTG ATTATCCCCC TGCACACCAC CCCAGAGACA 
TCCGTTAAGG AGATCGATGA GTTGGTTGAG GTCTACACGG ACGTGAAACA CCGCTGGAAG 
GCGGAGAATT TCATTTTCAT GGGTGACTTC AATGCCGGCT GCAGCTACGT CCCCAAGAAG 
GCCTGGAAGA ACATCCGCTT GAGGACTGAC CCCAGGTTTG TTTGGCTGAT CGGGGACCAA 
GAGGACACCA CGGTGAAGAA GAGCACCAAC TGTGCATATG ACAGGATTGT GCTTAGAGGA 
CAAGAAATCG TCAGTTCTGT TGTTCCCAAG TCAAACAGTG TTTTTGACTT CCAGAAAGCT 
TACAAGCTGA CTGAAGAGGA GGCCCTGGAT GTCAGCGACC ACTTTCCAGT TGAATTTAAA 
CTACAGTCTT CAAGGGCCTT CACCAACAGC AAAAAATCTG TCACTCTAAG GAAGAAAACA 
AAGAGCAAAC GCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004935.1
CDS	67..984
Translation	MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVMEIKDSNNRICPILMEKLNRNSRRGITYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYHYHDYQDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKHRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIVLRGQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLRKKTKSKRS

Target ORF information:

RefSeq Version	NM_004944.4
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004944.4

ORF Insert Sequence:

ATGTCACGGG AGCTGGCCCC ACTGCTGCTT CTCCTCCTCT CCATCCACAG CGCCCTGGCC 
ATGAGGATCT GCTCCTTCAA CGTCAGGTCC TTTGGGGAAA GCAAGCAGGA AGACAAGAAT 
GCCATGGATG TCATTGTGAA GGTCATCAAA CGCTGTGACA TCATACTCGT GATGGAAATC 
AAGGACAGCA ACAACAGGAT CTGCCCCATA CTGATGGAGA AGCTGAACAG AAATTCAAGG 
AGAGGCATAA CGTACAACTA TGTGATTAGC TCTCGGCTTG GAAGAAACAC ATATAAAGAA 
CAATATGCCT TTCTCTACAA GGAAAAGCTG GTGTCTGTGA AGAGGAGTTA TCACTACCAT 
GACTATCAGG ATGGAGACGC AGATGTGTTT TCCAGGGAGC CCTTTGTGGT CTGGTTCCAA 
TCTCCCCACA CTGCTGTCAA AGACTTCGTG ATTATCCCCC TGCACACCAC CCCAGAGACA 
TCCGTTAAGG AGATCGATGA GTTGGTTGAG GTCTACACGG ACGTGAAACA CCGCTGGAAG 
GCGGAGAATT TCATTTTCAT GGGTGACTTC AATGCCGGCT GCAGCTACGT CCCCAAGAAG 
GCCTGGAAGA ACATCCGCTT GAGGACTGAC CCCAGGTTTG TTTGGCTGAT CGGGGACCAA 
GAGGACACCA CGGTGAAGAA GAGCACCAAC TGTGCATATG ACAGGATTGT GCTTAGAGGA 
CAAGAAATCG TCAGTTCTGT TGTTCCCAAG TCAAACAGTG TTTTTGACTT CCAGAAAGCT 
TACAAGCTGA CTGAAGAGGA GGCCCTGGAT GTCAGCGACC ACTTTCCAGT TGAATTTAAA 
CTACAGTCTT CAAGGGCCTT CACCAACAGC AAAAAATCTG TCACTCTAAG GAAGAAAACA 
AAGAGCAAAC GCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE1L3 ( NM_001256560.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243489.1 Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09669
Clone ID Related Accession (Same CDS sequence)	NM_001256560.1
Accession Version	NM_001256560.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	deoxyribonuclease gamma isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI521582.1, AK301263.1, DB164811.1 and AI660448.1. Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301263.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155751, SAMEA2159764 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCACGGG AGCTGGCCCC ACTGCTGCTT CTCCTCCTCT CCATCCACAG CGCCCTGGCC 
ATGAGGATCT GCTCCTTCAA CGTCAGGTCC TTTGGGGAAA GCAAGCAGGA AGACAAGAAT 
GCCATGGATG TCATTGTGAA GGTCATCAAA CGCTGTGACA TCATACTCGT GATGGAAATC 
AAGGACAGCA ACAACAGGAT CTGCCCCATA CTGATGGAGA AGCTGAACAG GGAAAAGCTG 
GTGTCTGTGA AGAGGAGTTA TCACTACCAT GACTATCAGG ATGGAGACGC AGATGTGTTT 
TCCAGGGAGC CCTTTGTGGT CTGGTTCCAA TCTCCCCACA CTGCTGTCAA AGACTTCGTG 
ATTATCCCCC TGCACACCAC CCCAGAGACA TCCGTTAAGG AGATCGATGA GTTGGTTGAG 
GTCTACACGG ACGTGAAACA CCGCTGGAAG GCGGAGAATT TCATTTTCAT GGGTGACTTC 
AATGCCGGCT GCAGCTACGT CCCCAAGAAG GCCTGGAAGA ACATCCGCTT GAGGACTGAC 
CCCAGGTTTG TTTGGCTGAT CGGGGACCAA GAGGACACCA CGGTGAAGAA GAGCACCAAC 
TGTGCATATG ACAGGATTGT GCTTAGAGGA CAAGAAATCG TCAGTTCTGT TGTTCCCAAG 
TCAAACAGTG TTTTTGACTT CCAGAAAGCT TACAAGCTGA CTGAAGAGGA GGCCCTGGAT 
GTCAGCGACC ACTTTCCAGT TGAATTTAAA CTACAGTCTT CAAGGGCCTT CACCAACAGC 
AAAAAATCTG TCACTCTAAG GAAGAAAACA AAGAGCAAAC GCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243489.1
CDS	98..925
Translation	MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVMEIKDSNNRICPILMEKLNREKLVSVKRSYHYHDYQDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKHRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIVLRGQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLRKKTKSKRS

Target ORF information:

RefSeq Version	NM_001256560.1
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 1 like 3 (DNASE1L3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256560.1

ORF Insert Sequence:

ATGTCACGGG AGCTGGCCCC ACTGCTGCTT CTCCTCCTCT CCATCCACAG CGCCCTGGCC 
ATGAGGATCT GCTCCTTCAA CGTCAGGTCC TTTGGGGAAA GCAAGCAGGA AGACAAGAAT 
GCCATGGATG TCATTGTGAA GGTCATCAAA CGCTGTGACA TCATACTCGT GATGGAAATC 
AAGGACAGCA ACAACAGGAT CTGCCCCATA CTGATGGAGA AGCTGAACAG GGAAAAGCTG 
GTGTCTGTGA AGAGGAGTTA TCACTACCAT GACTATCAGG ATGGAGACGC AGATGTGTTT 
TCCAGGGAGC CCTTTGTGGT CTGGTTCCAA TCTCCCCACA CTGCTGTCAA AGACTTCGTG 
ATTATCCCCC TGCACACCAC CCCAGAGACA TCCGTTAAGG AGATCGATGA GTTGGTTGAG 
GTCTACACGG ACGTGAAACA CCGCTGGAAG GCGGAGAATT TCATTTTCAT GGGTGACTTC 
AATGCCGGCT GCAGCTACGT CCCCAAGAAG GCCTGGAAGA ACATCCGCTT GAGGACTGAC 
CCCAGGTTTG TTTGGCTGAT CGGGGACCAA GAGGACACCA CGGTGAAGAA GAGCACCAAC 
TGTGCATATG ACAGGATTGT GCTTAGAGGA CAAGAAATCG TCAGTTCTGT TGTTCCCAAG 
TCAAACAGTG TTTTTGACTT CCAGAAAGCT TACAAGCTGA CTGAAGAGGA GGCCCTGGAT 
GTCAGCGACC ACTTTCCAGT TGAATTTAAA CTACAGTCTT CAAGGGCCTT CACCAACAGC 
AAAAAATCTG TCACTCTAAG GAAGAAAACA AAGAGCAAAC GCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Host DNases prevent vascular occlusion by neutrophil extracellular traps.
Science (New York, N.Y.)358(6367)1202-1206(2017 12)
Jim?nez-Alc?zar M,Rangaswamy C,Panda R,Bitterling J,Simsek YJ,Long AT,Bilyy R,Krenn V,Renn? C,Renn? T,Kluge S,Panzer U,Mizuta R,Mannherz HG,Kitamura D,Herrmann M,Napirei M,Fuchs TA

Serum level of DNase1l3 in patients with dermatomyositis/polymyositis, systemic lupus erythematosus and rheumatoid arthritis, and its association with disease activity.
Clinical and experimental medicine17(4)459-465(2017 Nov)
Zhao Q,Yang C,Wang J,Li Y,Yang P

Functional Single Nucleotide Polymorphisms (SNPs) in the Genes Encoding the Human Deoxyribonuclease (DNase) Family Potentially Relevant to Autoimmunity.
Immunological investigations45(5)406-19(2016 Jul)
Fujihara J,Ueki M,Kimura-Kataoka K,Iida R,Takeshita H,Yasuda T

An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3.
Arthritis research & therapy16(5)438(2014 Oct)
Zochling J,Newell F,Charlesworth JC,Leo P,Stankovich J,Cortes A,Zhou Y,Stevens W,Sahhar J,Roddy J,Nash P,Tymms K,Rischmueller M,Lester S,Proudman S,Brown MA

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus.
Nature genetics43(12)1186-8(2011 Oct)
Al-Mayouf SM,Sunker A,Abdwani R,Abrawi SA,Almurshedi F,Alhashmi N,Al Sonbul A,Sewairi W,Qari A,Abdallah E,Al-Owain M,Al Motywee S,Al-Rayes H,Hashem M,Khalak H,Al-Jebali L,Alkuraya FS

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DNASE1L3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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