Ces1g cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ces1g
Entrez Gene ID	12623
Full Name	carboxylesterase 1G
Synonyms	Ces-1,Ces1,Ses-1
General protein information	Preferred Names carboxylesterase 1G Names liver carboxylesterase 1 ES-x acyl-coenzyme A:cholesterol acyltransferase carboxylesterase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 C5\|8 45.29 cM
Summary	This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021456.4	NP_067431.2	liver carboxylesterase 1 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LOC415787	XP_004944300.1
Mus musculus (house mouse)	Ces1g	NP_067431.2

Gene Ontology
Bibliography

Related articles in PubMed

Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr
Xu J, Xu Y, Xu Y, Yin L, Zhang Y
Scientific reports7(1)17845(2017 Dec)

Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.
Li J, Wang Y, Matye DJ, Chavan H, Krishnamurthy P, Li F, Li T
The Journal of biological chemistry292(1)146-160(2017 Jan)

Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling.
Bahitham W, Watts R, Nelson R, Lian J, Lehner R
Biochimica et biophysica acta1861(5)482-90(2016 May)

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP
PLoS genetics10(10)e1004604(2014 Oct)

OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
Iusuf D, Ludwig M, Elbatsh A, van Esch A, van de Steeg E, Wagenaar E, van der Valk M, Lin F, van Tellingen O, Schinkel AH
Molecular cancer therapeutics13(2)492-503(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of CES1 is associated with the susceptibility to high cholesterol diet-induced liver injury.
Title: Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.

Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin sensitivity.
Title: Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling.

Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR-controlled lipid homeostasis
Title: Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.

Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.
Title: OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.

Ces1/Es-x participates in the regulation of chylomicron assembly and secretion.
Title: Carboxylesterase1/Esterase-x regulates chylomicron production in mice.

The following Ces1g gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ces1g cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13307	NM_021456.4 Latest version!	Mus musculus carboxylesterase 1G (Ces1g), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$335.30 $479.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ces1g ( NM_021456.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067431.2 Mus musculus carboxylesterase 1G (Ces1g), mRNA.

Price & Availability↑

CloneID	OMu13307
Clone ID Related Accession (Same CDS sequence)	NM_021456.4
Accession Version	NM_021456.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1698bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	liver carboxylesterase 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI316467.1 and AK136588.1. On Jun 13, 2010 this sequence version replaced NM_021456.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136588.1, Y12887.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGCTCT GTGCTTTGAG TCTGATCTCT CTCACTGCTT GCTTGAGTCT GGGACACCCA 
TCCTTACCGC CTGTGGTACA CACCGTTCAT GGCAAAGTCC TGGGGAAGTA TGTCACCTTA 
GAAGGATTCT CACAGCCTGT GGCCGTCTTC CTGGGAGTCC CCTTTGCCAA GCCCCCTCTT 
GGATCTCTGA GGTTTGCTCC ACCAGAGCCT GCAGAGCCCT GGAGCTTCGT GAAGCACACC 
ACTTCCTACC CTCCTTTGTG CTACCAAAAC CCAGAGGCAG CATTGAGGCT CGCTGAGCTC 
TTCACCAACC AAAGGAAGAT CATTCCCCAC AAATTTTCTG AGGACTGTCT CTACCTCAAC 
ATTTATACTC CTGCTGACTT AACACAGAAC AGCAGGTTGC CCGTGATGGT GTGGATACAT 
GGAGGTGGAC TTGTGATAGA TGGAGCATCA ACCTATGATG GAGTGCCCCT CGCTGTCCAT 
GAAAATGTGG TTGTAGTGGT CATTCAGTAT CGCCTGGGCA TCTGGGGATT CTTCAGCACA 
GAGGATGAAC ACAGCCGGGG GAACTGGGGT CACTTGGACC AGGTGGCTGC ACTACATTGG 
GTCCAAGACA ACATTGCCAA CTTTGGGGGC AACCCAGGAT CTGTGACTAT CTTCGGCGAG 
TCAGCAGGAG GTGAAAGTGT CTCTGTTCTT GTGTTAAGCC CACTGGCCAA GAACCTCTTC 
CACAGGGCCA TCGCTCAGAG TAGTGTCATT TTCAATCCTT GCCTTTTTGG GAGAGCTGCC 
AGACCCTTGG CTAAGAAAAT TGCTGCTCTT GCTGGCTGTA AAACCACCAC CTCCGCTGCC 
ATGGTTCACT GCCTGCGCCA GAAGACTGAA GATGAGCTCT TGGAGGTCTC ACTGAAAATG 
AAATTTGGGA CTGTTGATTT TCTTGGAGAC CCCAGAGAGA GCTATCCCTT CCTCCCTACT 
GTGATTGATG GAGTGTTGCT GCCAAAGGCA CCAGAAGAGA TTCTGGCTGA GAAGAGTTTC 
AACACTGTCC CCTACATGGT GGGCATCAAC AAGCATGAGT TTGGCTGGAT CATTCCAATG 
TTTTTGGACT TCCCACTCTC TGAAAGAAAA CTGGACCAGA AGACAGCTGC ATCCATCCTG 
TGGCAGGCCT ACCCAATTCT TAACATCTCT GAAAAGCTGA TTCCAGCAGC TATTGAAAAG 
TATTTAGGAG GGACAGAAGA CCCTGCCACA ATGACAGACC TGTTCCTGGA CTTGATTGGA 
GACATTATGT TCGGTGTCCC ATCTGTAATC GTGTCCCGTA GTCACAGAGA TGCTGGAGCC 
CCAACCTACA TGTATGAATA TCAGTATCGC CCAAGTTTTG TATCAGACGA TAGACCCCAG 
GAATTGTTAG GAGACCACGC TGATGAACTC TTTTCTGTAT GGGGAGCCCC GTTTTTAAAA 
GAGGGTGCTT CAGAAGAAGA GATCAACCTC AGCAAGATGG TGATGAAATT CTGGGCCAAC 
TTTGCTCGGA ATGGGAACCC TAATGGTGAA GGGCTGCCTC ATTGGCCAGA ATATGACCAG 
AAGGAAGGAT ACCTTCAGAT TGGAGTCCCA GCACAGGCAG CCCATAGGCT GAAAGACAAG 
GAAGTGGACT TTTGGACTGA GCTCAGAGCC AAGGAAACAG CAGAGAGGTC ATCCCATAGG 
GAACATGTTG AACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067431.2
CDS	56..1753
Translation	MWLCALSLISLTACLSLGHPSLPPVVHTVHGKVLGKYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVIDGASTYDGVPLAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLFGRAARPLAKKIAALAGCKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDPRESYPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMFLDFPLSERKLDQKTAASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMFGVPSVIVSRSHRDAGAPTYMYEYQYRPSFVSDDRPQELLGDHADELFSVWGAPFLKEGASEEEINLSKMVMKFWANFARNGNPNGEGLPHWPEYDQKEGYLQIGVPAQAAHRLKDKEVDFWTELRAKETAERSSHREHVEL

Target ORF information:

RefSeq Version	NM_021456.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus carboxylesterase 1G (Ces1g), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021456.4

ORF Insert Sequence:

ATGTGGCTCT GTGCTTTGAG TCTGATCTCT CTCACTGCTT GCTTGAGTCT GGGACACCCA 
TCCTTACCGC CTGTGGTACA CACCGTTCAT GGCAAAGTCC TGGGGAAGTA TGTCACCTTA 
GAAGGATTCT CACAGCCTGT GGCCGTCTTC CTGGGAGTCC CCTTTGCCAA GCCCCCTCTT 
GGATCTCTGA GGTTTGCTCC ACCAGAGCCT GCAGAGCCCT GGAGCTTCGT GAAGCACACC 
ACTTCCTACC CTCCTTTGTG CTACCAAAAC CCAGAGGCAG CATTGAGGCT CGCTGAGCTC 
TTCACCAACC AAAGGAAGAT CATTCCCCAC AAATTTTCTG AGGACTGTCT CTACCTCAAC 
ATTTATACTC CTGCTGACTT AACACAGAAC AGCAGGTTGC CCGTGATGGT GTGGATACAT 
GGAGGTGGAC TTGTGATAGA TGGAGCATCA ACCTATGATG GAGTGCCCCT CGCTGTCCAT 
GAAAATGTGG TTGTAGTGGT CATTCAGTAT CGCCTGGGCA TCTGGGGATT CTTCAGCACA 
GAGGATGAAC ACAGCCGGGG GAACTGGGGT CACTTGGACC AGGTGGCTGC ACTACATTGG 
GTCCAAGACA ACATTGCCAA CTTTGGGGGC AACCCAGGAT CTGTGACTAT CTTCGGCGAG 
TCAGCAGGAG GTGAAAGTGT CTCTGTTCTT GTGTTAAGCC CACTGGCCAA GAACCTCTTC 
CACAGGGCCA TCGCTCAGAG TAGTGTCATT TTCAATCCTT GCCTTTTTGG GAGAGCTGCC 
AGACCCTTGG CTAAGAAAAT TGCTGCTCTT GCTGGCTGTA AAACCACCAC CTCCGCTGCC 
ATGGTTCACT GCCTGCGCCA GAAGACTGAA GATGAGCTCT TGGAGGTCTC ACTGAAAATG 
AAATTTGGGA CTGTTGATTT TCTTGGAGAC CCCAGAGAGA GCTATCCCTT CCTCCCTACT 
GTGATTGATG GAGTGTTGCT GCCAAAGGCA CCAGAAGAGA TTCTGGCTGA GAAGAGTTTC 
AACACTGTCC CCTACATGGT GGGCATCAAC AAGCATGAGT TTGGCTGGAT CATTCCAATG 
TTTTTGGACT TCCCACTCTC TGAAAGAAAA CTGGACCAGA AGACAGCTGC ATCCATCCTG 
TGGCAGGCCT ACCCAATTCT TAACATCTCT GAAAAGCTGA TTCCAGCAGC TATTGAAAAG 
TATTTAGGAG GGACAGAAGA CCCTGCCACA ATGACAGACC TGTTCCTGGA CTTGATTGGA 
GACATTATGT TCGGTGTCCC ATCTGTAATC GTGTCCCGTA GTCACAGAGA TGCTGGAGCC 
CCAACCTACA TGTATGAATA TCAGTATCGC CCAAGTTTTG TATCAGACGA TAGACCCCAG 
GAATTGTTAG GAGACCACGC TGATGAACTC TTTTCTGTAT GGGGAGCCCC GTTTTTAAAA 
GAGGGTGCTT CAGAAGAAGA GATCAACCTC AGCAAGATGG TGATGAAATT CTGGGCCAAC 
TTTGCTCGGA ATGGGAACCC TAATGGTGAA GGGCTGCCTC ATTGGCCAGA ATATGACCAG 
AAGGAAGGAT ACCTTCAGAT TGGAGTCCCA GCACAGGCAG CCCATAGGCT GAAAGACAAG 
GAAGTGGACT TTTGGACTGA GCTCAGAGCC AAGGAAACAG CAGAGAGGTC ATCCCATAGG 
GAACATGTTG AACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr
Scientific reports7(1)17845(2017 Dec)
Xu J,Xu Y,Xu Y,Yin L,Zhang Y

Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.
The Journal of biological chemistry292(1)146-160(2017 Jan)
Li J,Wang Y,Matye DJ,Chavan H,Krishnamurthy P,Li F,Li T

Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling.
Biochimica et biophysica acta1861(5)482-90(2016 May)
Bahitham W,Watts R,Nelson R,Lian J,Lehner R

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
PLoS genetics10(10)e1004604(2014 Oct)
Hoffmann AD,Yang XH,Burnicka-Turek O,Bosman JD,Ren X,Steimle JD,Vokes SA,McMahon AP,Kalinichenko VV,Moskowitz IP

OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
Molecular cancer therapeutics13(2)492-503(2014 Feb)
Iusuf D,Ludwig M,Elbatsh A,van Esch A,van de Steeg E,Wagenaar E,van der Valk M,Lin F,van Tellingen O,Schinkel AH

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Ces1g cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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