Cdx4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdx4
Entrez Gene ID	12592
Full Name	caudal type homeobox 4
Synonyms	Cdx-3,Cdx-4,Cdx3
General protein information	Preferred Names caudal type homeobox 4 Names homeobox protein CDX-4 caudal type homeo box 4 caudal-type homeobox protein 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X D\|X 46.06 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007674.3	NP_031700.1	homeobox protein CDX-4

Pathways from BioSystems

Homologies

	CDX4	XP_001095271.1
Canis lupus familiaris (dog)	CDX4	XP_549080.1
Homo sapiens (human)	CDX4	NP_005184.1
Pan troglodytes (chimpanzee)	CDX4	XP_529040.3
Bos taurus (cattle)	CDX4	XP_003588202.1
Mus musculus (house mouse)	Cdx4	NP_031700.1
Rattus norvegicus (Norway rat)	Cdx4	NP_001100412.1

Gene Ontology
Bibliography

Related articles in PubMed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2252-2266(2017 06)

Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.
Neijts R, Amin S, van Rooijen C, Deschamps J
Developmental biology422(2)146-154(2017 02)

Essential roles for Cdx in murine primitive hematopoiesis.
Brooke-Bisschop T, Savory JGA, Foley T, Ringuette R, Lohnes D
Developmental biology422(2)115-124(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a molecular mechanisms through which increased expression of HoxA10 increases Cdx4 expression by direct CDX4 activation and by Fgf2-induced beta-catenin activity. This results in Cdx4-induced HoxA10-expression, creating a positive feedback mechanism
Title: ?-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells.

Compound mutants carrying one active Cdx2 allele in the Cdx4-null background (Cdx2/4), transgenic embryos precociously expressing Hox13 genes and a novel Wnt3a hypomorph mutant all manifest a comparable phenotype with similar uro-rectal defects
Title: Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.

Data suggest that cdx proteins affect cardiogenesis by regulating the formation of cardiogenic mesoderm.
Title: Interactions between Cdx genes and retinoic acid modulate early cardiogenesis.

positive feedback relationship between HoxA10 and Cdx4, which potentially amplified the contribution of either transcription factor to the pathogenesis of AML.
Title: HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells.

Cdx4 expression is significantly down regulated in Cdx2(-/-) mutants suggesting previously unrecognized cross-regulatory interactions.
Title: Cdx4 is a Cdx2 target gene.

The following Cdx4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdx4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00576	NM_007674.3 Latest version!	Mus musculus caudal type homeobox 4 (Cdx4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdx4 ( NM_007674.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031700.1 Mus musculus caudal type homeobox 4 (Cdx4), mRNA.

Price & Availability↑

CloneID	OMu00576
Clone ID Related Accession (Same CDS sequence)	NM_007674.3
Accession Version	NM_007674.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	homeobox protein CDX-4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL669964.18. On Apr 27, 2007 this sequence version replaced NM_007674.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L08061.1, BC119158.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849379, SAMN00849386 [ECO:0000350] ##Evidence-Data-END##

ATGTATGGAA GCTGCCTTTT AGAAAAAGAA GCGGGCATGT ACCCAGGCAC TCTCAGGAGC 
CCTGGAGGAA GCAGTACAGC CGGAGTGGGC ACCTCTGGGG GCAGTGGTAG TCCTCTGCCT 
GCCTCCAACT TTACTGCAGC CCCAGTTTAC CCACACTACG TGGGTTACCC TCATATGTCC 
AACATGGATC CTCACGGGCC TTCGCTGGGA GCCTGGAGCT CACCCTACAG TCCGCCCCGG 
GAAGACTGGA GTACATACCC TGGGCCGCCC AGTACAATGG GCACAGTGCC CATGAATGAC 
ATGACCTCCC CAGTTTTCGG ATCCCCAGAC TACAGCACTC TGGGCCCCAC CAGCGGTGCA 
AGCAACGGCG GTAGCTTGCC AGACGCGGCC AGCGAGTCAC TGGTTTCTCT TGACTCCGGC 
ACCTCAGGCG CCACTTCTCC CAGCAGGAGC CGTCACAGCC CCTACGCATG GATGCGCAAA 
ACTGTGCAGG TGACGGGGAA AACCAGGACA AAAGAAAAGT ATCGTGTGGT CTACACAGAT 
CATCAACGGC TGGAGCTGGA AAAGGAATTT CACTGCAATA GATACATCAC CATCAGGAGG 
AAGTCAGAGC TGGCAGTTAA CCTGGGCCTT TCTGAGAGAC AGGTGAAAAT CTGGTTTCAG 
AATCGCAGAG CCAAGGAGAG GAAGATGATA AAAAAGAAAA TCTCCCAGTT TGAGAACACT 
GGAGGTTCCG TGCAAAGTGA CTCTGGCTCC ATCAGCCCCG GAGAACTGCC TAACGCTTTC 
TTCACCACTC CATCTGCTGT CCGTGGATTT CAGCCAATCG AGATACAGCA GGTCATAGTT 
TCTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031700.1
CDS	163..1011
Translation	MYGSCLLEKEAGMYPGTLRSPGGSSTAGVGTSGGSGSPLPASNFTAAPVYPHYVGYPHMSNMDPHGPSLGAWSSPYSPPREDWSTYPGPPSTMGTVPMNDMTSPVFGSPDYSTLGPTSGASNGGSLPDAASESLVSLDSGTSGATSPSRSRHSPYAWMRKTVQVTGKTRTKEKYRVVYTDHQRLELEKEFHCNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKMIKKKISQFENTGGSVQSDSGSISPGELPNAFFTTPSAVRGFQPIEIQQVIVSE

Target ORF information:

RefSeq Version	NM_007674.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus caudal type homeobox 4 (Cdx4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007674.3

ORF Insert Sequence:

ATGTATGGAA GCTGCCTTTT AGAAAAAGAA GCGGGCATGT ACCCAGGCAC TCTCAGGAGC 
CCTGGAGGAA GCAGTACAGC CGGAGTGGGC ACCTCTGGGG GCAGTGGTAG TCCTCTGCCT 
GCCTCCAACT TTACTGCAGC CCCAGTTTAC CCACACTACG TGGGTTACCC TCATATGTCC 
AACATGGATC CTCACGGGCC TTCGCTGGGA GCCTGGAGCT CACCCTACAG TCCGCCCCGG 
GAAGACTGGA GTACATACCC TGGGCCGCCC AGTACAATGG GCACAGTGCC CATGAATGAC 
ATGACCTCCC CAGTTTTCGG ATCCCCAGAC TACAGCACTC TGGGCCCCAC CAGCGGTGCA 
AGCAACGGCG GTAGCTTGCC AGACGCGGCC AGCGAGTCAC TGGTTTCTCT TGACTCCGGC 
ACCTCAGGCG CCACTTCTCC CAGCAGGAGC CGTCACAGCC CCTACGCATG GATGCGCAAA 
ACTGTGCAGG TGACGGGGAA AACCAGGACA AAAGAAAAGT ATCGTGTGGT CTACACAGAT 
CATCAACGGC TGGAGCTGGA AAAGGAATTT CACTGCAATA GATACATCAC CATCAGGAGG 
AAGTCAGAGC TGGCAGTTAA CCTGGGCCTT TCTGAGAGAC AGGTGAAAAT CTGGTTTCAG 
AATCGCAGAG CCAAGGAGAG GAAGATGATA AAAAAGAAAA TCTCCCAGTT TGAGAACACT 
GGAGGTTCCG TGCAAAGTGA CTCTGGCTCC ATCAGCCCCG GAGAACTGCC TAACGCTTTC 
TTCACCACTC CATCTGCTGT CCGTGGATTT CAGCCAATCG AGATACAGCA GGTCATAGTT 
TCTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2252-2266(2017 06)
Naruse C,Shibata S,Tamura M,Kawaguchi T,Abe K,Sugihara K,Kato T,Nishiuchi T,Wakana S,Ikawa M,Asano M

Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.
Developmental biology422(2)146-154(2017 02)
Neijts R,Amin S,van Rooijen C,Deschamps J

Essential roles for Cdx in murine primitive hematopoiesis.
Developmental biology422(2)115-124(2017 02)
Brooke-Bisschop T,Savory JGA,Foley T,Ringuette R,Lohnes D

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Cdx4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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