Cdk7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdk7
Entrez Gene ID	12572
Full Name	cyclin-dependent kinase 7
Synonyms	AI323415,AI528512,C230069N13,Cdkn7,Crk4
General protein information	Preferred Names cyclin-dependent kinase 7 Names cyclin-dependent kinase 7 39 kDa protein kinase CAK CDK-activating kinase CR4 protein kinase CRK4 PK (CDC2-related-kinase-4 protein kinase) P39 Mo15 TFIIH basal transcription factor complex kinase subunit cell division protein kinase 7 cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) protein-tyrosine kinase MPK-7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 D1\|13 53.23 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009874.3	NP_034004.2	cyclin-dependent kinase 7

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CDK7	XP_001160482.1
Canis lupus familiaris (dog)	CDK7	XP_850424.1
Bos taurus (cattle)	CDK7	NP_001069183.1
Gallus gallus (chicken)	CDK7	XP_001234587.2
Magnaporthe oryzae (rice blast fungus)	MGG_13401	XP_003711393.1
	CDK7	XP_001092242.1
Danio rerio (zebrafish)	cdk7	NP_998126.2
Drosophila melanogaster (fruit fly)	Cdk7	NP_511044.1
Homo sapiens (human)	CDK7	NP_001790.1
Mus musculus (house mouse)	Cdk7	NP_034004.2
Schizosaccharomyces pombe (fission yeast)	mcs6	NP_596349.1
Neurospora crassa	NCU03659	XP_960739.1
Rattus norvegicus (Norway rat)	Cdk7	XP_006231929.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002646	XP_312281.3
Caenorhabditis elegans (roundworm)	cdk-7	NP_490952.2
Saccharomyces cerevisiae (baker's yeast)	KIN28	NP_010175.1
Kluyveromyces lactis	KLLA0E14785g	XP_454616.1
Eremothecium gossypii	AGOS_ADL283W	NP_983813.1
Arabidopsis thaliana (thale cress)	CAK4	NP_176847.1
Xenopus tropicalis (tropical clawed frog)	cdk7	NP_001017219.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Wang H, Jo YJ, Sun TY, Namgoong S, Cui XS, Oh JS, Kim NH
Biochimica et biophysica acta1863(12)2993-3000(2016 12)

CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.
Abdullah AI, Zhang H, Nie Y, Tang W, Sun T
Stem cell reports7(1)69-79(2016 07)

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
Kwiatkowski N, Zhang T, Rahl PB, Abraham BJ, Reddy J, Ficarro SB, Dastur A, Amzallag A, Ramaswamy S, Tesar B, Jenkins CE, Hannett NM, McMillin D, Sanda T, Sim T, Kim ND, Look T, Mitsiades CS, Weng AP, Brown JR, Benes CH, Marto JA, Young RA, Gray NS
Nature511(7511)616-20(2014 Jul)

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
Ganuza M, S?iz-Ladera C, Ca?amero M, G?mez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamar?a D, Barbacid M
The EMBO journal31(11)2498-510(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Title: Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.

the cyclin-dependent kinase CDK7 is regulated by miR-210 and is necessary for normal NP cell-cycle progression. Our findings demonstrate that miRNAs are essential for normal NP proliferation and cell-cycle progress during neocortical development
Title: CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.

Whereas Cdk7 was completely dispensable for global transcription, it was essential for the cell cycle via phosphorylation of Cdk1 and Cdk2. In vivo, Cdk7 was indispensable for cell proliferation except during the first stages of embryonic development.
Title: Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.

investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Title: Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.

Inhibition of SF-1-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1.
Title: SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.

The following Cdk7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdk7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05028	NM_009874.3 Latest version!	Mus musculus cyclin-dependent kinase 7 (Cdk7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdk7 ( NM_009874.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034004.2 Mus musculus cyclin-dependent kinase 7 (Cdk7), mRNA.

Price & Availability↑

CloneID	OMu05028
Clone ID Related Accession (Same CDS sequence)	NM_009874.3
Accession Version	NM_009874.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	cyclin-dependent kinase 7
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ111227.1, BC068160.1, AC165159.2 and AW120870.1. On Nov 15, 2007 this sequence version replaced NM_009874.2. Sequence Note: Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145759.1, AK168286.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTGG ACGTGAAGTC TCGAGCGAAG CGCTATGAGA AACTGGACTT CCTCGGAGAG 
GGACAGTTTG CGACGGTCTA TAAGGCCAGG GACAAGAACA CCAACCAAAT CGTCGCCATT 
AAGAAAATCA AACTTGGACA CAGGTCAGAA GCTAAGGATG GAATAAATAG AACAGCCTTA 
AGGGAGATAA AGCTCTTACA GGAACTAAGT CATCCAAATA TAATTGGTCT CCTTGATGCA 
TTTGGACATA AGTCTAACAT TAGCCTTGTC TTTGATTTTA TGGAAACTGA CCTCGAGGTT 
ATTATAAAGG ATAACAGCCT TGTGCTGACA CCATCCCACA TTAAAGCCTA CATGTTGATG 
ACTCTTCAGG GCTTAGAATA TTTACATCAG CATTGGATTC TACACAGGGA TCTGAAACCA 
AACAACTTGT TGTTAGATGA GAATGGAGTT CTGAAACTGG CAGATTTTGG CCTGGCCAAA 
TCATTTGGGA GCCCCAATAG GGCTTACACA CATCAAGTTG TGACCAGATG GTACCGGGCT 
CCTGAGTTAT TGTTTGGAGC TAGGATGTAT GGTGTGGGAG TAGACATGTG GGCTGTTGGT 
TGTATATTAG CAGAATTGCT TCTAAGGGTT CCATTTTTGC CTGGAGATTC AGATCTTGAT 
CAGCTAACAA GGATATTTGA AACTCTGGGT ACACCAACTG AAGAGCAGTG GCCTGACATG 
TGTAGTCTTC CCGATTATGT GACATTTAAG AGTTTCCCTG GGGTCCCACT GCAGCACATC 
TTCATCGCGG CTGGGGACGA CCTGCTGGAG CTCATCCAAG GCCTGTTCTT ATTTAACCCG 
TGTACGCGGA CCACAGCCTC ACAGGCATTG AAGACCAAGT ACTTCAGTAA CCGCCCCGGG 
CCAACACCTG GATGCCAGCT CCCGCGACCA AACTGTCCGG TGGAGGCATT AAAGGAACCG 
GCGAATCCAA CCGTGGCAAC AAAGCGGAAA AGAGCAGAGG CCTTAGAACA AGGAATATTG 
CCCAAGAAGC TCATTTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034004.2
CDS	104..1144
Translation	MAVDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGVPLQHIFIAAGDDLLELIQGLFLFNPCTRTTASQALKTKYFSNRPGPTPGCQLPRPNCPVEALKEPANPTVATKRKRAEALEQGILPKKLIF

Target ORF information:

RefSeq Version	NM_009874.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin-dependent kinase 7 (Cdk7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009874.3

ORF Insert Sequence:

ATGGCTGTGG ACGTGAAGTC TCGAGCGAAG CGCTATGAGA AACTGGACTT CCTCGGAGAG 
GGACAGTTTG CGACGGTCTA TAAGGCCAGG GACAAGAACA CCAACCAAAT CGTCGCCATT 
AAGAAAATCA AACTTGGACA CAGGTCAGAA GCTAAGGATG GAATAAATAG AACAGCCTTA 
AGGGAGATAA AGCTCTTACA GGAACTAAGT CATCCAAATA TAATTGGTCT CCTTGATGCA 
TTTGGACATA AGTCTAACAT TAGCCTTGTC TTTGATTTTA TGGAAACTGA CCTCGAGGTT 
ATTATAAAGG ATAACAGCCT TGTGCTGACA CCATCCCACA TTAAAGCCTA CATGTTGATG 
ACTCTTCAGG GCTTAGAATA TTTACATCAG CATTGGATTC TACACAGGGA TCTGAAACCA 
AACAACTTGT TGTTAGATGA GAATGGAGTT CTGAAACTGG CAGATTTTGG CCTGGCCAAA 
TCATTTGGGA GCCCCAATAG GGCTTACACA CATCAAGTTG TGACCAGATG GTACCGGGCT 
CCTGAGTTAT TGTTTGGAGC TAGGATGTAT GGTGTGGGAG TAGACATGTG GGCTGTTGGT 
TGTATATTAG CAGAATTGCT TCTAAGGGTT CCATTTTTGC CTGGAGATTC AGATCTTGAT 
CAGCTAACAA GGATATTTGA AACTCTGGGT ACACCAACTG AAGAGCAGTG GCCTGACATG 
TGTAGTCTTC CCGATTATGT GACATTTAAG AGTTTCCCTG GGGTCCCACT GCAGCACATC 
TTCATCGCGG CTGGGGACGA CCTGCTGGAG CTCATCCAAG GCCTGTTCTT ATTTAACCCG 
TGTACGCGGA CCACAGCCTC ACAGGCATTG AAGACCAAGT ACTTCAGTAA CCGCCCCGGG 
CCAACACCTG GATGCCAGCT CCCGCGACCA AACTGTCCGG TGGAGGCATT AAAGGAACCG 
GCGAATCCAA CCGTGGCAAC AAAGCGGAAA AGAGCAGAGG CCTTAGAACA AGGAATATTG 
CCCAAGAAGC TCATTTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Biochimica et biophysica acta1863(12)2993-3000(2016 12)
Wang H,Jo YJ,Sun TY,Namgoong S,Cui XS,Oh JS,Kim NH

CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.
Stem cell reports7(1)69-79(2016 07)
Abdullah AI,Zhang H,Nie Y,Tang W,Sun T

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
Nature511(7511)616-20(2014 Jul)
Kwiatkowski N,Zhang T,Rahl PB,Abraham BJ,Reddy J,Ficarro SB,Dastur A,Amzallag A,Ramaswamy S,Tesar B,Jenkins CE,Hannett NM,McMillin D,Sanda T,Sim T,Kim ND,Look T,Mitsiades CS,Weng AP,Brown JR,Benes CH,Marto JA,Young RA,Gray NS

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
The EMBO journal31(11)2498-510(2012 May)
Ganuza M,S?iz-Ladera C,Ca?amero M,G?mez G,Schneider R,Blasco MA,Pisano D,Paramio JM,Santamar?a D,Barbacid M

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Cdk7 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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