Casp3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casp3
Entrez Gene ID	12367
Full Name	caspase 3
Synonyms	A830040C14Rik,AC-3,CASP-3,CC3,CPP-32,CPP32,Caspase-3,Lice,SCA-1,Yama,mldy
General protein information	Preferred Names caspase 3 Names caspase-3 SREBP cleavage activity 1 apopain caspase 3, apoptosis related cysteine protease cysteine protease CPP32 protein Yama
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 B1.1\|8 26.39 cM
Summary	This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017312543.2	XP_017168032.1	caspase-3 isoform X1
XM_030243266.1	XP_030099126.1	caspase-3 isoform X1
NM_009810.3	NP_033940.1	caspase-3
NM_001284409.1	NP_001271338.1	caspase-3
XM_017312543.1	XP_017168032.1	caspase-3 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CASP3	NP_004337.2
Canis lupus familiaris (dog)	CASP3	NP_001003042.1
Rattus norvegicus (Norway rat)	Casp3	NP_037054.1
Gallus gallus (chicken)	CASP3	NP_990056.1
	CASP3	XP_001083044.1
Anopheles gambiae (African malaria mosquito)	CASPS8	XP_318945.3
Xenopus tropicalis (tropical clawed frog)	casp3	NP_001120900.1
Pan troglodytes (chimpanzee)	CASP3	NP_001012435.1
Bos taurus (cattle)	CASP3	NP_001071308.1
Mus musculus (house mouse)	Casp3	NP_001271338.1

Gene Ontology
Bibliography

Related articles in PubMed

Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouse.
Stottmann RW, Moran JL, Turbe-Doan A, Driver E, Kelley M, Beier DR
Genetics188(3)615-24(2011 Jul)

Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice.
Parker A, Hardisty-Hughes RE, Wisby L, Joyce S, Brown SD
Mammalian genome : official journal of the International Mammalian Genome Society21(11-12)565-76(2010 Dec)

Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.
Li Z, Jo J, Jia JM, Lo SC, Whitcomb DJ, Jiao S, Cho K, Sheng M
Cell141(5)859-71(2010 May)

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells.
Miura M, Chen XD, Allen MR, Bi Y, Gronthos S, Seo BM, Lakhani S, Flavell RA, Feng XH, Robey PG, Young M, Shi S
The Journal of clinical investigation114(12)1704-13(2004 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings suggest that caspase-3 activation can trigger necrosis by cleaving GSDME and offer new insights into cancer chemotherapy
Title: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

This provides new insight into the immune phenotype, mechanisms, and signaling pathways that operate in microglial neurotoxic activation in amyotrophic lateral sclerosis.
Title: Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.

report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation
Title: Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.

These results indicate that the caspase-3/p120 RasGAP stress-sensing module impacts on carcinogen-induced liver cancer incidence but not sufficiently so as to affect overall survival.
Title: The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice.

ULK1 is a novel substrate of Caspase-3 and upregulation of ULK1 drives autophagy initiation in leukemia cells.
Title: Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner.

The following Casp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20031	NM_001284409.1 Latest version!	Mus musculus caspase 3 (Casp3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu20031	NM_009810.3 Latest version!	Mus musculus caspase 3 (Casp3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu20031	XM_017312543.2 Latest version!	Mus musculus caspase 3 (Casp3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu20031	XM_030243266.1 Latest version!	Mus musculus caspase 3 (Casp3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu20031	XM_017312543.1	Mus musculus caspase 3 (Casp3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casp3 ( NM_009810.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033940.1 Mus musculus caspase 3 (Casp3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu20031
Clone ID Related Accession (Same CDS sequence)	XM_017312543.2 , XM_030243266.1 , NM_009810.3 , NM_001284409.1 , XM_017312543.1
Accession Version	NM_009810.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Mus musculus(house mouse)
Product	caspase-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC119267.8. On Oct 18, 2013 this sequence version replaced NM_009810.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.61883.1, U49929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033940.1
CDS	222..1055
Translation	MENNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSHGDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH

Target ORF information:

RefSeq Version	NM_009810.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 3 (Casp3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009810.3

ORF Insert Sequence:

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp3 ( NM_001284409.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001271338.1 Mus musculus caspase 3 (Casp3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20031
Clone ID Related Accession (Same CDS sequence)	XM_017312543.2 , XM_030243266.1 , NM_009810.3 , NM_001284409.1 , XM_017312543.1
Accession Version	NM_001284409.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Mus musculus(house mouse)
Product	caspase-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC119267.8. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146226.1, BC038825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001271338.1
CDS	227..1060
Translation	MENNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSHGDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH

Target ORF information:

RefSeq Version	NM_001284409.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 3 (Casp3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001284409.1

ORF Insert Sequence:

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp3 ( XM_017312543.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168032.1 Mus musculus caspase 3 (Casp3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu20031
Clone ID Related Accession (Same CDS sequence)	XM_017312543.2 , XM_030243266.1 , NM_009810.3 , NM_001284409.1 , XM_017312543.1
Accession Version	XM_017312543.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	caspase-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017312543.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168032.1
CDS	171..1004
Translation	MENNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSHGDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH

Target ORF information:

RefSeq Version	XM_017312543.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 3 (Casp3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017312543.2

ORF Insert Sequence:

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp3 ( XM_030243266.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030099126.1 Mus musculus caspase 3 (Casp3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu20031
Clone ID Related Accession (Same CDS sequence)	XM_017312543.2 , XM_030243266.1 , NM_009810.3 , NM_001284409.1 , XM_017312543.1
Accession Version	XM_030243266.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	caspase-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030099126.1
CDS	133..966
Translation	MENNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSHGDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH

Target ORF information:

RefSeq Version	XM_030243266.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 3 (Casp3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030243266.1

ORF Insert Sequence:

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp3 ( XM_017312543.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168032.1 Mus musculus caspase 3 (Casp3), transcript variant X1, mRNA.

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CloneID	OMu20031
Clone ID Related Accession (Same CDS sequence)	XM_017312543.2 , XM_030243266.1 , NM_009810.3 , NM_001284409.1 , XM_017312543.1
Accession Version	XM_017312543.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	caspase-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168032.1
CDS	52..885
Translation	MENNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSHGDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH

Target ORF information:

RefSeq Version	XM_017312543.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 3 (Casp3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017312543.1

ORF Insert Sequence:

ATGGAGAACA ACAAAACCTC AGTGGATTCA AAATCCATTA ATAATTTTGA AGTAAAGACC 
ATACATGGGA GCAAGTCAGT GGACTCTGGG ATCTATCTGG ACAGTAGTTA CAAAATGGAT 
TATCCTGAAA TGGGCATATG CATAATAATT AATAATAAGA ACTTCCATAA GAGCACTGGA 
ATGTCATCTC GCTCTGGTAC GGATGTGGAC GCAGCCAACC TCAGAGAGAC ATTCATGGGC 
CTGAAATACC AAGTCAGGAA TAAAAATGAT CTTACTCGTG AAGACATTTT GGAATTAATG 
GATAGTGTTT CTAAGGAAGA TCATAGCAAA AGGAGCAGCT TTGTGTGTGT GATTCTAAGC 
CATGGTGATG AAGGGGTCAT TTATGGGACA AATGGGCCTG TTGAACTGAA AAAGTTGACT 
AGCTTCTTCA GAGGCGACTA CTGCCGGAGT CTGACTGGAA AGCCGAAACT CTTCATCATT 
CAGGCCTGCC GGGGTACGGA GCTGGACTGT GGCATTGAGA CAGACAGTGG GACTGATGAG 
GAGATGGCTT GCCAGAAGAT ACCGGTGGAG GCTGACTTCC TGTATGCTTA CTCTACAGCA 
CCTGGTTACT ATTCCTGGAG AAATTCAAAG GACGGGTCGT GGTTCATCCA GTCCCTTTGC 
AGCATGCTGA AGCTGTACGC GCACAAGCTA GAATTTATGC ACATTCTCAC TCGCGTTAAC 
AGGAAGGTGG CAACGGAATT CGAGTCCTTC TCCCTGGACT CCACTTTCCA CGCAAAGAAA 
CAGATCCCGT GTATTGTGTC CATGCTCACG AAAGAACTGT ACTTTTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouse.
Genetics188(3)615-24(2011 Jul)
Stottmann RW,Moran JL,Turbe-Doan A,Driver E,Kelley M,Beier DR

Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice.
Mammalian genome : official journal of the International Mammalian Genome Society21(11-12)565-76(2010 Dec)
Parker A,Hardisty-Hughes RE,Wisby L,Joyce S,Brown SD

Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.
Cell141(5)859-71(2010 May)
Li Z,Jo J,Jia JM,Lo SC,Whitcomb DJ,Jiao S,Cho K,Sheng M

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells.
The Journal of clinical investigation114(12)1704-13(2004 Dec)
Miura M,Chen XD,Allen MR,Bi Y,Gronthos S,Seo BM,Lakhani S,Flavell RA,Feng XH,Robey PG,Young M,Shi S

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Casp3 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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