CASP3 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CASP3
Entrez Gene ID	403567
Full Name	caspase 3
General protein information	Preferred Names caspase 3 Names caspase-3 CASP-3
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003042.1	NP_001003042.1	caspase-3

Pathways from BioSystems

Homologies

Homo sapiens (human)	CASP3	NP_004337.2
Canis lupus familiaris (dog)	CASP3	NP_001003042.1
Rattus norvegicus (Norway rat)	Casp3	NP_037054.1
Gallus gallus (chicken)	CASP3	NP_990056.1
	CASP3	XP_001083044.1
Anopheles gambiae (African malaria mosquito)	CASPS8	XP_318945.3
Xenopus tropicalis (tropical clawed frog)	casp3	NP_001120900.1
Pan troglodytes (chimpanzee)	CASP3	NP_001012435.1
Bos taurus (cattle)	CASP3	NP_001071308.1
Mus musculus (house mouse)	Casp3	NP_001271338.1

Gene Ontology
Bibliography

Related articles in PubMed

Study of optimal scheme of spinal image-guided radiotherapy based on expression of caspase-3 in spinal cord neurons by orthogonal design.
Xu WL, Tayerjiang JL, Zhao XB, Wang H, Wang Q, Yuan H
Genetics and molecular research : GMR14(2)3223-33(2015 Apr)

Bcl-2/caspase 3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory bowel disease.
Jergens A, Young J, Moore D, Wang C, Hostetter J, Augustine L, Allenspach K, Schmitz S, Mosher C
Veterinary immunology and immunopathology158(3-4)167-74(2014 Apr)

Increased immunoreactivities of cleaved ?II-spectrin and cleaved caspase-3 in the aged dog spinal cord.
Hwang IK, Ahn JH, Yoo DY, Lee CH, Yoo KY, Choi JH, Moon SM, Shin HC, Won MH
Neurochemical research37(3)480-6(2012 Mar)

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells.
K?per C, Bartels H, Beck FX, Neuhofer W
Kidney international80(9)938-45(2011 Nov)

Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus.
Del Puerto HL, Martins AS, Moro L, Milsted A, Alves F, Braz GF, Vasconcelos AC
Genetics and molecular research : GMR9(1)151-61(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that caspase-3 expression in the spinal cord neurons was lowest when a single dose of 16 Gy was applied at a dose rate of 4 Gy/min.
Title: Study of optimal scheme of spinal image-guided radiotherapy based on expression of caspase-3 in spinal cord neurons by orthogonal design.

Mucosal imbalance of Bcl-2/caspase 3 expression favors T cell resistance to apoptosis which may contribute to T cell accumulation and chronic intestinal inflammation.
Title: Bcl-2/caspase 3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory bowel disease.

findings suggest that the increases of cleaved alphaII-spectrin and cleaved caspase-3 immunoreactivity may be related to aging of the spinal cord in dog
Title: Increased immunoreactivities of cleaved ?II-spectrin and cleaved caspase-3 in the aged dog spinal cord.

The expression of Bax, Bcl-2, and caspase-3, -8 and -9, was evaluated by evaluating mRNA levels in the peripheral blood, lymph nodes and cerebellum of canine distemper virus (CDV)-infected (CDV+) and uninfected (CDV-) dogs.
Title: Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus.

The following CASP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00024	NM_001003042.1 Latest version!	Canis lupus familiaris caspase 3 (CASP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CASP3 ( NM_001003042.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003042.1 Canis lupus familiaris caspase 3 (CASP3), mRNA.

Price & Availability↑

CloneID	OCe00024
Clone ID Related Accession (Same CDS sequence)	NM_001003042.1
Accession Version	NM_001003042.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Canis lupus familiaris(dog)
Product	caspase-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB085580.1. ##Evidence-Data-START## CDS exon combination :: AB085580.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00991609, SAMN07419780 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END##

ATGGAGAACA CTGAAAACTC AGTGGATGCA AAATCCTTTA AAAATGCAGA AACAAAGATC 
TTACATGGAA GTAAATCAAT GGACTCGGGA ATGTCCTTCG ACAACAGTTA TAAAATGGAT 
TATCCTGAAA TGGGTTTATG TATAATAATT AATAATAAGA ACTTTCATAA AAGTACTGGA 
ATGGCACCTC GGTCTGGTAC AGATGTAGAT GCAGCAAACC TCAGGGAAAC ATTCACAAAC 
TTGAAATATG AAGTCAGAAA TAAAAATGAT CTCACATGCG AAGAAATTTT GGAATTAATG 
AACAGTGTCT CTAAAGAAGA TCATAGCAAA AGGAGCAGTT TTGTTTGCGT GCTTCTAAGC 
CATGGGGATG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAG AAAAGTAACA 
GGTTTCTTCC GAGGAGATTA CTGTAGAAGT CTGACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GAGGTACAGA ACTAGACTGT GGTATTGAGA CTGACAGTGG AATTGAGGAT 
GACATGGCCT GTCAGAAAAT ACCAGTCGAA GCGGACTTCT TGTATGCTTA CTCTACAGCC 
CCTGGTTACT ATTCCTGGCG AAATTCAAAG GATGGATCCT GGTTCATCCA GTCACTTTGT 
GCGATGCTGA AACTATACGC TCACAAGCTT GAGTTTATGC ACATTCTTAC TCGGGTTAAC 
CGAAAGGTCG CAACAGAATT TGAGTCCTTT TCTCTAGACT CTGCTTTTCA TGGAAAGAAA 
CAGATTCCAT GTATTGTGTC TATGCTCACA AAAGAACTGT ATCTTTATCA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003042.1
CDS	285..1118
Translation	MENTENSVDAKSFKNAETKILHGSKSMDSGMSFDNSYKMDYPEMGLCIIINNKNFHKSTGMAPRSGTDVDAANLRETFTNLKYEVRNKNDLTCEEILELMNSVSKEDHSKRSSFVCVLLSHGDEGIIFGTNGPVDLRKVTGFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGIEDDMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSAFHGKKQIPCIVSMLTKELYLYH

Target ORF information:

RefSeq Version	NM_001003042.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris caspase 3 (CASP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003042.1

ORF Insert Sequence:

ATGGAGAACA CTGAAAACTC AGTGGATGCA AAATCCTTTA AAAATGCAGA AACAAAGATC 
TTACATGGAA GTAAATCAAT GGACTCGGGA ATGTCCTTCG ACAACAGTTA TAAAATGGAT 
TATCCTGAAA TGGGTTTATG TATAATAATT AATAATAAGA ACTTTCATAA AAGTACTGGA 
ATGGCACCTC GGTCTGGTAC AGATGTAGAT GCAGCAAACC TCAGGGAAAC ATTCACAAAC 
TTGAAATATG AAGTCAGAAA TAAAAATGAT CTCACATGCG AAGAAATTTT GGAATTAATG 
AACAGTGTCT CTAAAGAAGA TCATAGCAAA AGGAGCAGTT TTGTTTGCGT GCTTCTAAGC 
CATGGGGATG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAG AAAAGTAACA 
GGTTTCTTCC GAGGAGATTA CTGTAGAAGT CTGACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GAGGTACAGA ACTAGACTGT GGTATTGAGA CTGACAGTGG AATTGAGGAT 
GACATGGCCT GTCAGAAAAT ACCAGTCGAA GCGGACTTCT TGTATGCTTA CTCTACAGCC 
CCTGGTTACT ATTCCTGGCG AAATTCAAAG GATGGATCCT GGTTCATCCA GTCACTTTGT 
GCGATGCTGA AACTATACGC TCACAAGCTT GAGTTTATGC ACATTCTTAC TCGGGTTAAC 
CGAAAGGTCG CAACAGAATT TGAGTCCTTT TCTCTAGACT CTGCTTTTCA TGGAAAGAAA 
CAGATTCCAT GTATTGTGTC TATGCTCACA AAAGAACTGT ATCTTTATCA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Study of optimal scheme of spinal image-guided radiotherapy based on expression of caspase-3 in spinal cord neurons by orthogonal design.
Genetics and molecular research : GMR14(2)3223-33(2015 Apr)
Xu WL,Tayerjiang JL,Zhao XB,Wang H,Wang Q,Yuan H

Bcl-2/caspase 3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory bowel disease.
Veterinary immunology and immunopathology158(3-4)167-74(2014 Apr)
Jergens A,Young J,Moore D,Wang C,Hostetter J,Augustine L,Allenspach K,Schmitz S,Mosher C

Increased immunoreactivities of cleaved ?II-spectrin and cleaved caspase-3 in the aged dog spinal cord.
Neurochemical research37(3)480-6(2012 Mar)
Hwang IK,Ahn JH,Yoo DY,Lee CH,Yoo KY,Choi JH,Moon SM,Shin HC,Won MH

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells.
Kidney international80(9)938-45(2011 Nov)
K?per C,Bartels H,Beck FX,Neuhofer W

Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus.
Genetics and molecular research : GMR9(1)151-61(2010 Jan)
Del Puerto HL,Martins AS,Moro L,Milsted A,Alves F,Braz GF,Vasconcelos AC

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CASP3 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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