Phb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Phb2
Entrez Gene ID	12034
Full Name	prohibitin 2
Synonyms	AU044498,BAP,Bap37,Bcap37,REA
General protein information	Preferred Names prohibitin 2 Names prohibitin-2 B-cell receptor-associated protein 37 B-cell receptor-associated protein BAP37 phb2 repressor of estrogen receptor activity
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F2\|6 59.17 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007531.2	NP_031557.2	prohibitin-2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	phb2b	NP_001002681.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009642	XP_318676.3
Saccharomyces cerevisiae (baker's yeast)	PHB2	NP_011747.2
Kluyveromyces lactis	KLLA0E15731g	XP_454659.1
Arabidopsis thaliana (thale cress)	PHB2	NP_973756.1
Eremothecium gossypii	AGOS_ADL141W	NP_983955.1
Magnaporthe oryzae (rice blast fungus)	MGG_09886	XP_003709979.1
Arabidopsis thaliana (thale cress)	PHB1	NP_194580.1
Homo sapiens (human)	PHB2	NP_001138303.1
	PHB2	XP_001111957.1
Bos taurus (cattle)	PHB2	NP_001039663.1
Mus musculus (house mouse)	Phb2	NP_031557.2
Rattus norvegicus (Norway rat)	Phb2	NP_001013053.1
Drosophila melanogaster (fruit fly)	l(2)03709	NP_001097372.1
Xenopus tropicalis (tropical clawed frog)	phb2	NP_001016551.1
Canis lupus familiaris (dog)	PHB2	XP_543843.3
Gallus gallus (chicken)	PHB2	NP_001074354.1
Caenorhabditis elegans (roundworm)	phb-2	NP_495250.2
Schizosaccharomyces pombe (fission yeast)	phb2	NP_588144.2
Arabidopsis thaliana (thale cress)	PHB6	NP_001077924.1
Arabidopsis thaliana (thale cress)	PHB7	NP_199227.1
Oryza sativa (rice)	Os03g0841700	NP_001051853.1
Pan troglodytes (chimpanzee)	PHB2	XP_508977.2
Danio rerio (zebrafish)	phb2a	NP_955975.1
Neurospora crassa	NCU03310	XP_964487.1
Oryza sativa (rice)	Os07g0262200	NP_001059325.1

Gene Ontology
Bibliography

Related articles in PubMed

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.
Koehler S, Br?hler S, Braun F, Hagmann H, Rinschen MM, Sp?th MR, H?hne M, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT
Kidney international91(6)1510-1517(2017 Jun)

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.
Ising C, Bharill P, Brinkkoetter S, Br?hler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, H?hne M, M?ller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT
The American journal of pathology186(5)1128-39(2016 May)

Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment.
Li Y, Wang Y, Zou L, Tang X, Yang Y, Ma L, Jia Q, Ni Q, Liu S, Tang L, Lin R, Wong E, Sun W, Wang L, Wei Q, Ran H, Zhang L, Lian H, Huang W, Wu Y, Li QJ, Wan Y
Immunity44(2)422-37(2016 Feb)

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Korwitz A, Merkwirth C, Richter-Dennerlein R, Tr?der SE, Sprenger HG, Quir?s PM, L?pez-Ot?n C, Rugarli EI, Langer T
The Journal of cell biology212(2)157-66(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

REA modulates cross talk among multiple cell types in the uterine tissue and host background, serving as a brake on the estradiol-ER axis and restraining multiple aspects that contribute to the pathologic progression of endometriosis.
Title: Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis.

Fluorizoline bind to prohibitin, inducing mitochondrial apoptotic pathway through NOXA and BIM upregulation.
Title: A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation.

These results demonstrate that estradiol upregulates REA expression and recruits REA via ERalpha to the EREs on the RORgammaT promoter region, thus inhibiting RORgammaT expression and Th17 differentiation.
Title: Estradiol inhibits Th17 cell differentiation through inhibition of ROR?T transcription by recruiting the ER?/REA complex to estrogen response elements of the ROR?T promoter.

CARL can suppress mitochondrial fission and apoptosis by targeting miR-539 and PHB2.
Title: CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation.

results suggest that PHB2 is a crucial mitochondrial regulator for homeostasis and lineage-specific differentiation of ES cells.
Title: Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria.

The following Phb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20878	NM_007531.2 Latest version!	Mus musculus prohibitin 2 (Phb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Phb2 ( NM_007531.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031557.2 Mus musculus prohibitin 2 (Phb2), mRNA.

Price & Availability↑

CloneID	OMu20878
Clone ID Related Accession (Same CDS sequence)	NM_007531.2
Accession Version	NM_007531.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Mus musculus(house mouse)
Product	prohibitin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB595613.1, AK132058.1, AK152375.1 and AK002334.1. On Mar 8, 2007 this sequence version replaced NM_007531.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151952.1, AK132058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCAGA ACTTGAAGGA CTTAGCTGGA CGCCTGCCCG CCGGGCCTCG GGGCATGGGC 
ACGGCGCTGA AGCTGCTGCT GGGGGCCGGG GCGGTGGCCT ACGGCGTCCG CGAATCCGTG 
TTCACCGTGG AAGGCGGTCA TAGAGCCATC TTTTTTAATC GTATTGGTGG CGTGCAGCAG 
GACACGATCC TGGCCGAAGG CCTTCACTTC AGGATCCCCT GGTTCCAGTA CCCCATCATC 
TATGACATTC GGGCCAGACC TCGAAAAATC TCCTCCCCCA CAGGCTCCAA AGACCTGCAG 
ATGGTGAACA TCTCCCTGCG TGTGCTGTCC CGACCCAATG CCCAGGAGCT CCCCAGCATG 
TACCAGCGTC TAGGGCTGGA CTATGAGGAG CGAGTGCTGC CGTCCATTGT TAATGAGGTG 
CTCAAGAGTG TGGTGGCCAA GTTCAATGCC TCGCAGCTGA TCACCCAGCG GGCTCAGGTG 
TCCCTGTTGA TCCGAAGAGA GCTGACAGAG CGCGCCAAGG ACTTCAGCCT CATCCTGGAT 
GATGTAGCTA TCACAGAGCT GAGCTTCAGC CGAGAGTACA CAGCTGCTGT AGAAGCCAAG 
CAAGTGGCCC AGCAGGAAGC CCAGCGGGCC CAGTTTTTGG TGGAGAAAGC GAAGCAGGAA 
CAGCGACAGA AGATTGTGCA GGCTGAGGGG GAGGCGGAGG CTGCCAAGAT GCTTGGAGAA 
GCACTGAGCA AGAATCCTGG CTATATCAAG CTCCGAAAGA TCCGGGCCGC CCAGAACATC 
TCTAAAACGA TCGCCACATC ACAGAACCGA ATCTATCTCA CAGCTGACAA CCTTGTGCTG 
AATCTACAGG ATGAAAGTTT TACTCGGGGA AGTGACAGCC TCATTAAGGG TAAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031557.2
CDS	149..1048
Translation	MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK

Target ORF information:

RefSeq Version	NM_007531.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus prohibitin 2 (Phb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007531.2

ORF Insert Sequence:

ATGGCCCAGA ACTTGAAGGA CTTAGCTGGA CGCCTGCCCG CCGGGCCTCG GGGCATGGGC 
ACGGCGCTGA AGCTGCTGCT GGGGGCCGGG GCGGTGGCCT ACGGCGTCCG CGAATCCGTG 
TTCACCGTGG AAGGCGGTCA TAGAGCCATC TTTTTTAATC GTATTGGTGG CGTGCAGCAG 
GACACGATCC TGGCCGAAGG CCTTCACTTC AGGATCCCCT GGTTCCAGTA CCCCATCATC 
TATGACATTC GGGCCAGACC TCGAAAAATC TCCTCCCCCA CAGGCTCCAA AGACCTGCAG 
ATGGTGAACA TCTCCCTGCG TGTGCTGTCC CGACCCAATG CCCAGGAGCT CCCCAGCATG 
TACCAGCGTC TAGGGCTGGA CTATGAGGAG CGAGTGCTGC CGTCCATTGT TAATGAGGTG 
CTCAAGAGTG TGGTGGCCAA GTTCAATGCC TCGCAGCTGA TCACCCAGCG GGCTCAGGTG 
TCCCTGTTGA TCCGAAGAGA GCTGACAGAG CGCGCCAAGG ACTTCAGCCT CATCCTGGAT 
GATGTAGCTA TCACAGAGCT GAGCTTCAGC CGAGAGTACA CAGCTGCTGT AGAAGCCAAG 
CAAGTGGCCC AGCAGGAAGC CCAGCGGGCC CAGTTTTTGG TGGAGAAAGC GAAGCAGGAA 
CAGCGACAGA AGATTGTGCA GGCTGAGGGG GAGGCGGAGG CTGCCAAGAT GCTTGGAGAA 
GCACTGAGCA AGAATCCTGG CTATATCAAG CTCCGAAAGA TCCGGGCCGC CCAGAACATC 
TCTAAAACGA TCGCCACATC ACAGAACCGA ATCTATCTCA CAGCTGACAA CCTTGTGCTG 
AATCTACAGG ATGAAAGTTT TACTCGGGGA AGTGACAGCC TCATTAAGGG TAAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.
Kidney international91(6)1510-1517(2017 Jun)
Koehler S,Br?hler S,Braun F,Hagmann H,Rinschen MM,Sp?th MR,H?hne M,Wunderlich FT,Schermer B,Benzing T,Brinkkoetter PT

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.
The American journal of pathology186(5)1128-39(2016 May)
Ising C,Bharill P,Brinkkoetter S,Br?hler S,Schroeter C,Koehler S,Hagmann H,Merkwirth C,H?hne M,M?ller RU,Fabretti F,Schermer B,Bloch W,Kerjaschki D,Kurschat CE,Benzing T,Brinkkoetter PT

Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment.
Immunity44(2)422-37(2016 Feb)
Li Y,Wang Y,Zou L,Tang X,Yang Y,Ma L,Jia Q,Ni Q,Liu S,Tang L,Lin R,Wong E,Sun W,Wang L,Wei Q,Ran H,Zhang L,Lian H,Huang W,Wu Y,Li QJ,Wan Y

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
The Journal of cell biology212(2)157-66(2016 Jan)
Korwitz A,Merkwirth C,Richter-Dennerlein R,Tr?der SE,Sprenger HG,Quir?s PM,L?pez-Ot?n C,Rugarli EI,Langer T

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Phb2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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