Ap2m1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ap2m1
Entrez Gene ID	11773
Full Name	adaptor-related protein complex 2, mu 1 subunit
General protein information	Preferred Names adaptor-related protein complex 2, mu 1 subunit Names AP-2 complex subunit mu AP-2 mu chain adapter-related protein complex 2 mu subunit adaptor protein complex AP-2 subunit mu adaptor protein complex AP-2, mu1 adaptor-related protein complex 2 subunit mu adaptor-related protein complex AP-2, mu1 clathrin assembly protein complex 2 medium chain clathrin assembly protein complex 2 mu medium chain clathrin coat assembly protein AP50 clathrin coat-associated protein AP50 clathrin-associated AP-2 mu2-adaptin plasma membrane adaptor AP-2 50 kDa protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 A3
Summary	This gene encodes the mu subunit of the clathrin adaptor protein complex AP-2. It mediates sorting of cargo proteins harboring Y-X-X-Phi motifs into clathrin-coated vesicles. Alternate splicing of this gene results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2, 8 and 19. [provided by RefSeq, Dec 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302970.1	NP_001289899.1	AP-2 complex subunit mu isoform 2
NM_009679.3	NP_033809.1	AP-2 complex subunit mu isoform 1

Pathways from BioSystems

Homologies

Magnaporthe oryzae (rice blast fungus)	MGG_05484	XP_003710350.1
Gallus gallus (chicken)	AP2M1	NP_001072962.1
Schizosaccharomyces pombe (fission yeast)	apm4	NP_592921.1
Neurospora crassa	NCU09673	XP_960763.1
Pan troglodytes (chimpanzee)	AP2M1	XP_001144097.2
Canis lupus familiaris (dog)	AP2M1	XP_849091.1
Bos taurus (cattle)	AP2M1	NP_001029695.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007131	XP_308629.2
Oryza sativa (rice)	Os02g0690700	NP_001047793.1
Xenopus tropicalis (tropical clawed frog)	ap2m1	NP_988975.1
Mus musculus (house mouse)	Ap2m1	NP_033809.1
Danio rerio (zebrafish)	ap2m1a	NP_997742.1
Danio rerio (zebrafish)	ap2m1b	NP_957320.1
Caenorhabditis elegans (roundworm)	dpy-23	NP_741770.1
Homo sapiens (human)	AP2M1	NP_004059.2
	AP2M1	XP_002802940.1
Rattus norvegicus (Norway rat)	Ap2m1	NP_446289.1
Drosophila melanogaster (fruit fly)	AP-50	NP_001163686.1
Arabidopsis thaliana (thale cress)	AT5G46630	NP_199475.1

Gene Ontology
Bibliography

Related articles in PubMed

Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration.
Kononenko NL, Cla?en GA, Kuijpers M, Puchkov D, Maritzen T, Tempes A, Malik AR, Skalecka A, Bera S, Jaworski J, Haucke V
Nature communications814819(2017 Apr)

Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron93(4)854-866.e4(2017 Feb)

Disruption of adaptor protein 2? (AP-2?) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.
Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T
The EMBO journal34(21)2686-702(2015 Nov)

Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses.
Kononenko NL, Puchkov D, Classen GA, Walter AM, Pechstein A, Sawade L, Kaempf N, Trimbuch T, Lorenz D, Rosenmund C, Maritzen T, Haucke V
Neuron82(5)981-8(2014 Jun)

Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression.
Matsuda S, Kakegawa W, Budisantoso T, Nomura T, Kohda K, Yuzaki M
Nature communications42759(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Binding of AP-2 to otoferlin facilitates replenishment of release sites, for example, via speeding AZ clearance of exocytosed material, in addition to a role of AP-2 in synaptic vesicle reformation.
Title: Disruption of adaptor protein 2? (AP-2?) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

Data shsow that mutation of residues at the DEP-mu2 contact or in the tyrosine motif reduce affinity of Dvl2 for mu2.
Title: Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.

The following Ap2m1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ap2m1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu67138	NM_001302970.1 Latest version!	Mus musculus adaptor-related protein complex 2, mu 1 subunit (Ap2m1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu04646	NM_009679.3 Latest version!	Mus musculus adaptor-related protein complex 2, mu 1 subunit (Ap2m1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ap2m1 ( NM_001302970.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001289899.1 Mus musculus adaptor-related protein complex 2, mu 1 subunit (Ap2m1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu67138
Clone ID Related Accession (Same CDS sequence)	NM_001302970.1
Accession Version	NM_001302970.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	AP-2 complex subunit mu isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK146517.1, AK172889.1 and AK141862.1. Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172889.1, AK159534.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCGGAG GCTTATTCAT CTATAATCAC AAGGGGGAGG TGCTTATCTC CCGGGTCTAC 
AGAGATGACA TCGGGAGGAA TGCTGTGGAT GCCTTTCGGG TCAATGTCAT TCATGCACGG 
CAGCAGGTGC GCAGCCCTGT CACAAACATC GCTCGCACCA GCTTCTTCCA TGTTAAGCGG 
TCCAACATCT GGCTGGCCGC AGTCACCAAG CAGAATGTCA ATGCTGCCAT GGTCTTCGAA 
TTCCTCTACA AGATGTGTGA TGTAATGGCT GCTTACTTTG GCAAAATCAG CGAGGAGAAC 
ATCAAGAACA ATTTTGTGCT CATATACGAG CTGCTGGATG AGATTCTGGA CTTTGGCTAC 
CCACAGAACT CAGAGACAGG TGCACTGAAA ACCTTCATCA CCCAGCAGGG TATCAAGAGT 
CAGACGAAGG AAGAACAGTC CCAGATCACC AGCCAGGTGA CCGGGCAGAT TGGCTGGCGG 
CGAGAAGGCA TCAAGTATCG CCGGAATGAA CTCTTCCTAG ATGTTCTGGA GAGTGTGAAC 
CTGCTTATGT CCCCACAGGG GCAGGTGCTG AGTGCCCATG TGTCAGGCCG GGTGGTGATG 
AAGAGTTACC TGAGTGGCAT GCCTGAGTGC AAGTTTGGAA TGAATGACAA GATTGTCATA 
GAAAAGCAGG GCAAAGGCAC AGCTGATGAA ACAAGCAAGA GTGGTAAGCA GTCGATCGCC 
ATTGATGACT GCACCTTCCA CCAGTGTGTG CGACTCAGCA AGTTTGACTC TGAGCGGAGC 
ATCAGCTTCA TCCCTCCCGA CGGAGAGTTT GAACTCATGA GATACCGTAC TACCAAGGAC 
ATCATCCTTC CTTTCCGGGT GATCCCATTG GTGCGGGAGG TGGGGCGCAC CAAACTGGAG 
GTCAAGGTGG TCATCAAGTC CAACTTCAAG CCCTCACTTC TGGCCCAGAA GATTGAGGTG 
AGGATCCCGA CTCCATTGAA CACAAGCGGG GTACAGGTGA TCTGCATGAA GGGGAAGGCC 
AAGTACAAGG CCAGCGAGAA CGCCATTGTA TGGAAGATCA AGCGCATGGC AGGCATGAAG 
GAATCCCAGA TCAGCGCAGA GATTGAGCTC CTGCCCACCA ACGATAAGAA GAAATGGGCT 
CGGCCCCCCA TTTCCATGAA CTTTGAGGTG CCATTCGCGC CTTCTGGCCT CAAGGTGCGC 
TACTTGAAGG TATTCGAACC GAAGCTGAAC TACAGCGACC ATGATGTCAT CAAATGGGTG 
CGATACATTG GCCGCAGTGG CATTTATGAA ACCCGCTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289899.1
CDS	166..1467
Translation	MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC

Target ORF information:

RefSeq Version	NM_001302970.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus adaptor-related protein complex 2, mu 1 subunit (Ap2m1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302970.1

ORF Insert Sequence:

ATGATCGGAG GCTTATTCAT CTATAATCAC AAGGGGGAGG TGCTTATCTC CCGGGTCTAC 
AGAGATGACA TCGGGAGGAA TGCTGTGGAT GCCTTTCGGG TCAATGTCAT TCATGCACGG 
CAGCAGGTGC GCAGCCCTGT CACAAACATC GCTCGCACCA GCTTCTTCCA TGTTAAGCGG 
TCCAACATCT GGCTGGCCGC AGTCACCAAG CAGAATGTCA ATGCTGCCAT GGTCTTCGAA 
TTCCTCTACA AGATGTGTGA TGTAATGGCT GCTTACTTTG GCAAAATCAG CGAGGAGAAC 
ATCAAGAACA ATTTTGTGCT CATATACGAG CTGCTGGATG AGATTCTGGA CTTTGGCTAC 
CCACAGAACT CAGAGACAGG TGCACTGAAA ACCTTCATCA CCCAGCAGGG TATCAAGAGT 
CAGACGAAGG AAGAACAGTC CCAGATCACC AGCCAGGTGA CCGGGCAGAT TGGCTGGCGG 
CGAGAAGGCA TCAAGTATCG CCGGAATGAA CTCTTCCTAG ATGTTCTGGA GAGTGTGAAC 
CTGCTTATGT CCCCACAGGG GCAGGTGCTG AGTGCCCATG TGTCAGGCCG GGTGGTGATG 
AAGAGTTACC TGAGTGGCAT GCCTGAGTGC AAGTTTGGAA TGAATGACAA GATTGTCATA 
GAAAAGCAGG GCAAAGGCAC AGCTGATGAA ACAAGCAAGA GTGGTAAGCA GTCGATCGCC 
ATTGATGACT GCACCTTCCA CCAGTGTGTG CGACTCAGCA AGTTTGACTC TGAGCGGAGC 
ATCAGCTTCA TCCCTCCCGA CGGAGAGTTT GAACTCATGA GATACCGTAC TACCAAGGAC 
ATCATCCTTC CTTTCCGGGT GATCCCATTG GTGCGGGAGG TGGGGCGCAC CAAACTGGAG 
GTCAAGGTGG TCATCAAGTC CAACTTCAAG CCCTCACTTC TGGCCCAGAA GATTGAGGTG 
AGGATCCCGA CTCCATTGAA CACAAGCGGG GTACAGGTGA TCTGCATGAA GGGGAAGGCC 
AAGTACAAGG CCAGCGAGAA CGCCATTGTA TGGAAGATCA AGCGCATGGC AGGCATGAAG 
GAATCCCAGA TCAGCGCAGA GATTGAGCTC CTGCCCACCA ACGATAAGAA GAAATGGGCT 
CGGCCCCCCA TTTCCATGAA CTTTGAGGTG CCATTCGCGC CTTCTGGCCT CAAGGTGCGC 
TACTTGAAGG TATTCGAACC GAAGCTGAAC TACAGCGACC ATGATGTCAT CAAATGGGTG 
CGATACATTG GCCGCAGTGG CATTTATGAA ACCCGCTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ap2m1 ( NM_009679.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033809.1 Mus musculus adaptor-related protein complex 2, mu 1 subunit (Ap2m1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu04646
Clone ID Related Accession (Same CDS sequence)	NM_009679.3
Accession Version	NM_009679.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	AP-2 complex subunit mu isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK146517.1 and AK141862.1. On Dec 10, 2014 this sequence version replaced NM_009679.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141862.1, SRR1660819.133651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCGGAG GCTTATTCAT CTATAATCAC AAGGGGGAGG TGCTTATCTC CCGGGTCTAC 
AGAGATGACA TCGGGAGGAA TGCTGTGGAT GCCTTTCGGG TCAATGTCAT TCATGCACGG 
CAGCAGGTGC GCAGCCCTGT CACAAACATC GCTCGCACCA GCTTCTTCCA TGTTAAGCGG 
TCCAACATCT GGCTGGCCGC AGTCACCAAG CAGAATGTCA ATGCTGCCAT GGTCTTCGAA 
TTCCTCTACA AGATGTGTGA TGTAATGGCT GCTTACTTTG GCAAAATCAG CGAGGAGAAC 
ATCAAGAACA ATTTTGTGCT CATATACGAG CTGCTGGATG AGATTCTGGA CTTTGGCTAC 
CCACAGAACT CAGAGACAGG TGCACTGAAA ACCTTCATCA CCCAGCAGGG TATCAAGAGT 
CAGCATCAGA CGAAGGAAGA ACAGTCCCAG ATCACCAGCC AGGTGACCGG GCAGATTGGC 
TGGCGGCGAG AAGGCATCAA GTATCGCCGG AATGAACTCT TCCTAGATGT TCTGGAGAGT 
GTGAACCTGC TTATGTCCCC ACAGGGGCAG GTGCTGAGTG CCCATGTGTC AGGCCGGGTG 
GTGATGAAGA GTTACCTGAG TGGCATGCCT GAGTGCAAGT TTGGAATGAA TGACAAGATT 
GTCATAGAAA AGCAGGGCAA AGGCACAGCT GATGAAACAA GCAAGAGTGG TAAGCAGTCG 
ATCGCCATTG ATGACTGCAC CTTCCACCAG TGTGTGCGAC TCAGCAAGTT TGACTCTGAG 
CGGAGCATCA GCTTCATCCC TCCCGACGGA GAGTTTGAAC TCATGAGATA CCGTACTACC 
AAGGACATCA TCCTTCCTTT CCGGGTGATC CCATTGGTGC GGGAGGTGGG GCGCACCAAA 
CTGGAGGTCA AGGTGGTCAT CAAGTCCAAC TTCAAGCCCT CACTTCTGGC CCAGAAGATT 
GAGGTGAGGA TCCCGACTCC ATTGAACACA AGCGGGGTAC AGGTGATCTG CATGAAGGGG 
AAGGCCAAGT ACAAGGCCAG CGAGAACGCC ATTGTATGGA AGATCAAGCG CATGGCAGGC 
ATGAAGGAAT CCCAGATCAG CGCAGAGATT GAGCTCCTGC CCACCAACGA TAAGAAGAAA 
TGGGCTCGGC CCCCCATTTC CATGAACTTT GAGGTGCCAT TCGCGCCTTC TGGCCTCAAG 
GTGCGCTACT TGAAGGTATT CGAACCGAAG CTGAACTACA GCGACCATGA TGTCATCAAA 
TGGGTGCGAT ACATTGGCCG CAGTGGCATT TATGAAACCC GCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033809.1
CDS	166..1473
Translation	MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC

Target ORF information:

RefSeq Version	NM_009679.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus adaptor-related protein complex 2, mu 1 subunit (Ap2m1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009679.3

ORF Insert Sequence:

ATGATCGGAG GCTTATTCAT CTATAATCAC AAGGGGGAGG TGCTTATCTC CCGGGTCTAC 
AGAGATGACA TCGGGAGGAA TGCTGTGGAT GCCTTTCGGG TCAATGTCAT TCATGCACGG 
CAGCAGGTGC GCAGCCCTGT CACAAACATC GCTCGCACCA GCTTCTTCCA TGTTAAGCGG 
TCCAACATCT GGCTGGCCGC AGTCACCAAG CAGAATGTCA ATGCTGCCAT GGTCTTCGAA 
TTCCTCTACA AGATGTGTGA TGTAATGGCT GCTTACTTTG GCAAAATCAG CGAGGAGAAC 
ATCAAGAACA ATTTTGTGCT CATATACGAG CTGCTGGATG AGATTCTGGA CTTTGGCTAC 
CCACAGAACT CAGAGACAGG TGCACTGAAA ACCTTCATCA CCCAGCAGGG TATCAAGAGT 
CAGCATCAGA CGAAGGAAGA ACAGTCCCAG ATCACCAGCC AGGTGACCGG GCAGATTGGC 
TGGCGGCGAG AAGGCATCAA GTATCGCCGG AATGAACTCT TCCTAGATGT TCTGGAGAGT 
GTGAACCTGC TTATGTCCCC ACAGGGGCAG GTGCTGAGTG CCCATGTGTC AGGCCGGGTG 
GTGATGAAGA GTTACCTGAG TGGCATGCCT GAGTGCAAGT TTGGAATGAA TGACAAGATT 
GTCATAGAAA AGCAGGGCAA AGGCACAGCT GATGAAACAA GCAAGAGTGG TAAGCAGTCG 
ATCGCCATTG ATGACTGCAC CTTCCACCAG TGTGTGCGAC TCAGCAAGTT TGACTCTGAG 
CGGAGCATCA GCTTCATCCC TCCCGACGGA GAGTTTGAAC TCATGAGATA CCGTACTACC 
AAGGACATCA TCCTTCCTTT CCGGGTGATC CCATTGGTGC GGGAGGTGGG GCGCACCAAA 
CTGGAGGTCA AGGTGGTCAT CAAGTCCAAC TTCAAGCCCT CACTTCTGGC CCAGAAGATT 
GAGGTGAGGA TCCCGACTCC ATTGAACACA AGCGGGGTAC AGGTGATCTG CATGAAGGGG 
AAGGCCAAGT ACAAGGCCAG CGAGAACGCC ATTGTATGGA AGATCAAGCG CATGGCAGGC 
ATGAAGGAAT CCCAGATCAG CGCAGAGATT GAGCTCCTGC CCACCAACGA TAAGAAGAAA 
TGGGCTCGGC CCCCCATTTC CATGAACTTT GAGGTGCCAT TCGCGCCTTC TGGCCTCAAG 
GTGCGCTACT TGAAGGTATT CGAACCGAAG CTGAACTACA GCGACCATGA TGTCATCAAA 
TGGGTGCGAT ACATTGGCCG CAGTGGCATT TATGAAACCC GCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration.
Nature communications814819(2017 Apr)
Kononenko NL,Cla?en GA,Kuijpers M,Puchkov D,Maritzen T,Tempes A,Malik AR,Skalecka A,Bera S,Jaworski J,Haucke V

Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Neuron93(4)854-866.e4(2017 Feb)
Soykan T,Kaempf N,Sakaba T,Vollweiter D,Goerdeler F,Puchkov D,Kononenko NL,Haucke V

Disruption of adaptor protein 2? (AP-2?) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.
The EMBO journal34(21)2686-702(2015 Nov)
Jung S,Maritzen T,Wichmann C,Jing Z,Neef A,Revelo NH,Al-Moyed H,Meese S,Wojcik SM,Panou I,Bulut H,Schu P,Ficner R,Reisinger E,Rizzoli SO,Neef J,Strenzke N,Haucke V,Moser T

Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses.
Neuron82(5)981-8(2014 Jun)
Kononenko NL,Puchkov D,Classen GA,Walter AM,Pechstein A,Sawade L,Kaempf N,Trimbuch T,Lorenz D,Rosenmund C,Maritzen T,Haucke V

Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression.
Nature communications42759(2013)
Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

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Ap2m1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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