Hsd17b11 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hsd17b11
Entrez Gene ID	114664
Full Name	hydroxysteroid (17-beta) dehydrogenase 11
Synonyms	Dhrs8,Pan1b,SDR2,retSDR2
General protein information	Preferred Names hydroxysteroid (17-beta) dehydrogenase 11 Names estradiol 17-beta-dehydrogenase 11 17-beta-HSD 11 17-beta-HSD XI 17-beta-hydroxysteroid dehydrogenase 11 17-beta-hydroxysteroid dehydrogenase XI 17bHSD11 17beta-HSD11 17betaHSD11 17betaHSDXI dehydrogenase/reductase (SDR family) member 8 retinal short-chain dehydrogenase/reductase 2 retinal short-chain dehydrogenase/reductase SDR2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 E5

mRNA and Protein(s)

mRNA	Protein	Name
NM_053262.3	NP_444492.1	estradiol 17-beta-dehydrogenase 11 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	HSD17B11	NP_057329.2
Pan troglodytes (chimpanzee)	HSD17B11	XP_003310475.1
Bos taurus (cattle)	HSD17B11	NP_001039751.1
Rattus norvegicus (Norway rat)	Hsd17b11	NP_001004209.1
Gallus gallus (chicken)	HSD17B11	XP_420547.1
Xenopus tropicalis (tropical clawed frog)	hsd17b11	NP_001011304.1
Canis lupus familiaris (dog)	HSD17B11	XP_544970.3
Mus musculus (house mouse)	Hsd17b11	NP_444492.1
	HSD17B11	XP_001096902.1
Gallus gallus (chicken)	LOC428754	XP_426310.2

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Placental PPAR? regulates spatiotemporally diverse genes and a unique metabolic network.
Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y
Developmental biology372(1)143-55(2012 Dec)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

Identification of genes expressed preferentially in the developing peripheral margin of the optic cup.
Trimarchi JM, Cho SH, Cepko CL
Developmental dynamics : an official publication of the American Association of Anatomists238(9)2327-9(2009 Sep)

Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis.
Sewell W, Sparrow DB, Smith AJ, Gonzalez DM, Rappaport EF, Dunwoodie SL, Kusumi K
Developmental biology329(2)400-9(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data indicate that 17beta-HSD11 localizes both in the endoplasmic reticulum and in lipid droplets, depending on physiologic conditions
Title: Regulated expression by PPARalpha and unique localization of 17beta-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver.

The following Hsd17b11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsd17b11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09455	NM_053262.3 Latest version!	Mus musculus hydroxysteroid (17-beta) dehydrogenase 11 (Hsd17b11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hsd17b11 ( NM_053262.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444492.1 Mus musculus hydroxysteroid (17-beta) dehydrogenase 11 (Hsd17b11), mRNA.

Price & Availability↑

CloneID	OMu09455
Clone ID Related Accession (Same CDS sequence)	NM_053262.3
Accession Version	NM_053262.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	estradiol 17-beta-dehydrogenase 11 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL714024.31. On Nov 17, 2006 this sequence version replaced NM_053262.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC038340.1, AK154803.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGAAGTATC TTCTTGACTT GATCCTGCTG CTGCCTTTGC TCATCGTCTT CAGCATTGAG 
TCTCTTGTCA AGCTTTTTAT TCCCAAGAAG AAAAAATCTG TCGCCGGAGA GATCGTCCTG 
ATCACCGGAG CTGGTCATGG GATTGGAAGA CTGACTGCCT ACGAATTTGC CAAACTTAAC 
ACCAAACTGG TTCTCTGGGA TATCAATAAG AACGGCATCG AGGAAACAGC TGCTAAGTGC 
AGGAAGCTGG GTGCCCAGGC CCATCCCTTT GTGGTGGACT GCAGCCAGCG GGAAGAGATT 
TACAGCGCTG CGAAAAAGGT AAAGGAAGAA GTTGGAGATG TTAGCATTCT GGTAAATAAC 
GCTGGCGTTG TCTACACTGC AGACTTATTT GCTACGCAGG ACCCTCAGAT TGAAAAGACT 
TTCGAAGTCA ATGTGCTTGC ACACTTTTGG ACCACCAAGG CATTTCTCCC AGTGATGATG 
AAGAATAATC ATGGCCACAT TGTCACTGTG GCATCAGCAG CAGGCCACAC CGTGGTCCCC 
TTCTTGCTGG CTTACTGCTC CAGCAAGTTT GCTGCCGTTG GCTTCCACAG AGCCTTGACT 
GATGAGCTGG CTGCCTTGGG ACGAACAGGA GTGCGAACAT CGTGCCTCTG CCCCAACTTC 
ATAAACACCG GCTTCATCAA GAACCCAAGC ACCAATTTAG GACCCACCCT GGAACCCGAG 
GAGGTGGTGG AACATCTCAT GCACGGGATC CTCACTGAGA AGCAAATGAT TTTCGTTCCG 
AGTTCCATAG CACTTCTGAC AGTATTGGAA AGGATCGTCC CTGAGAGGTT CCTGCAAGTC 
CTAAAACACA GGATCAACGT CAAGTTCGAT GCAGTTGTTG GGTACAAAGA CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444492.1
CDS	58..954
Translation	MKYLLDLILLLPLLIVFSIESLVKLFIPKKKKSVAGEIVLITGAGHGIGRLTAYEFAKLNTKLVLWDINKNGIEETAAKCRKLGAQAHPFVVDCSQREEIYSAAKKVKEEVGDVSILVNNAGVVYTADLFATQDPQIEKTFEVNVLAHFWTTKAFLPVMMKNNHGHIVTVASAAGHTVVPFLLAYCSSKFAAVGFHRALTDELAALGRTGVRTSCLCPNFINTGFIKNPSTNLGPTLEPEEVVEHLMHGILTEKQMIFVPSSIALLTVLERIVPERFLQVLKHRINVKFDAVVGYKDK

Target ORF information:

RefSeq Version	NM_053262.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus hydroxysteroid (17-beta) dehydrogenase 11 (Hsd17b11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053262.3

ORF Insert Sequence:

ATGAAGTATC TTCTTGACTT GATCCTGCTG CTGCCTTTGC TCATCGTCTT CAGCATTGAG 
TCTCTTGTCA AGCTTTTTAT TCCCAAGAAG AAAAAATCTG TCGCCGGAGA GATCGTCCTG 
ATCACCGGAG CTGGTCATGG GATTGGAAGA CTGACTGCCT ACGAATTTGC CAAACTTAAC 
ACCAAACTGG TTCTCTGGGA TATCAATAAG AACGGCATCG AGGAAACAGC TGCTAAGTGC 
AGGAAGCTGG GTGCCCAGGC CCATCCCTTT GTGGTGGACT GCAGCCAGCG GGAAGAGATT 
TACAGCGCTG CGAAAAAGGT AAAGGAAGAA GTTGGAGATG TTAGCATTCT GGTAAATAAC 
GCTGGCGTTG TCTACACTGC AGACTTATTT GCTACGCAGG ACCCTCAGAT TGAAAAGACT 
TTCGAAGTCA ATGTGCTTGC ACACTTTTGG ACCACCAAGG CATTTCTCCC AGTGATGATG 
AAGAATAATC ATGGCCACAT TGTCACTGTG GCATCAGCAG CAGGCCACAC CGTGGTCCCC 
TTCTTGCTGG CTTACTGCTC CAGCAAGTTT GCTGCCGTTG GCTTCCACAG AGCCTTGACT 
GATGAGCTGG CTGCCTTGGG ACGAACAGGA GTGCGAACAT CGTGCCTCTG CCCCAACTTC 
ATAAACACCG GCTTCATCAA GAACCCAAGC ACCAATTTAG GACCCACCCT GGAACCCGAG 
GAGGTGGTGG AACATCTCAT GCACGGGATC CTCACTGAGA AGCAAATGAT TTTCGTTCCG 
AGTTCCATAG CACTTCTGAC AGTATTGGAA AGGATCGTCC CTGAGAGGTT CCTGCAAGTC 
CTAAAACACA GGATCAACGT CAAGTTCGAT GCAGTTGTTG GGTACAAAGA CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Placental PPAR? regulates spatiotemporally diverse genes and a unique metabolic network.
Developmental biology372(1)143-55(2012 Dec)
Shalom-Barak T,Zhang X,Chu T,Timothy Schaiff W,Reddy JK,Xu J,Sadovsky Y,Barak Y

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

Identification of genes expressed preferentially in the developing peripheral margin of the optic cup.
Developmental dynamics : an official publication of the American Association of Anatomists238(9)2327-9(2009 Sep)
Trimarchi JM,Cho SH,Cepko CL

Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis.
Developmental biology329(2)400-9(2009 May)
Sewell W,Sparrow DB,Smith AJ,Gonzalez DM,Rappaport EF,Dunwoodie SL,Kusumi K

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Hsd17b11 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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