CDY2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDY2A
Entrez Gene ID	9426
Full Name	chromodomain Y-linked 2A
Synonyms	CDY,CDY2
General protein information	Preferred Names chromodomain Y-linked 2A Names testis-specific chromodomain protein Y 2 Y chromosome chromodomain protein 2A chromodomain protein, Y chromosome, 2 chromodomain protein, Y-linked, 2A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yq11.222
Summary	This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008].
Disorder MIM:	400018

mRNA and Protein(s)

mRNA	Protein	Name
NM_004825.2	NP_004816.1	testis-specific chromodomain protein Y 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CDY1	XP_003949290.1
Homo sapiens (human)	CDY1B	NP_001003894.1
Pan troglodytes (chimpanzee)	CDY2A	XP_003949291.1
Homo sapiens (human)	CDY2B	NP_001001722.1
Homo sapiens (human)	CDY2A	NP_004816.1
Homo sapiens (human)	CDY1	NP_733841.1

Gene Ontology
Bibliography

Related articles in PubMed

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC
Nature423(6942)825-37(2003 Jun)

Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.
Lahn BT, Tang ZL, Zhou J, Barndt RJ, Parvinen M, Allis CD, Page DC
Proceedings of the National Academy of Sciences of the United States of America99(13)8707-12(2002 Jun)

Comparative mapping of CDY and DAZ in higher primates.
Wimmer R, K?hl H, R?ttger S, Schempp W
Cytogenetic and genome research96(1-4)287-9(2002)

A fiber-FISH contig spanning the non-recombining region of the human Y chromosome.
R?ttger S, Yen PH, Schempp W
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology10(8)621-35(2002)

Mammalian chromodomain proteins: their role in genome organisation and expression.
Jones DO, Cowell IG, Singh PB
BioEssays : news and reviews in molecular, cellular and developmental biology22(2)124-37(2000 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data indicate that CDY2 and HSFY are located within a segment of the Y chromosome that is important for sperm maturation, and are underexpressed in testicular tissue derived from men with maturation arrest
Title: Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia.

The following CDY2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDY2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18362	NM_004825.2 Latest version!	Homo sapiens chromodomain Y-linked 2A (CDY2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDY2A ( NM_004825.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004816.1 Homo sapiens chromodomain Y-linked 2A (CDY2A), mRNA.

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CloneID	OHu18362
Clone ID Related Accession (Same CDS sequence)	NM_004825.2
Accession Version	NM_004825.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	testis-specific chromodomain protein Y 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009976.4. On Nov 26, 2002 this sequence version replaced NM_004825.1. ##Evidence-Data-START## Transcript is intronless :: AF080598.1, AK292233.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000250838.6/ ENSP00000250838.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCC AGGAGTTTGA GGTTGAAGCT ATTGTTGACA AAAGACAGGA TAAAAATGGG 
AATACACAGT ATTTGGTTCG GTGGAAAGGT TATGACAAAC AGGATGACAC TTGGGAACCA 
GAGCAGCACC TCATGAACTG TGAAAAATGT GTACATGATT TTAATAGACG ACAGACTGAA 
AAACAGAAAA AACTGACATG GACTACAACC AGTAGAATTT TTTCAAACAA TGCCAGAAGA 
AGAACTTCCA GATCTACAAA AGCAAACTAT TCTAAGAACT CTCCTAAAAC TCCAGTGACT 
GATAAACACC ACAGGTCCAA AAACTGCAAG TTATTTGCTG CCAGCAAGAA CGTTAGGAGA 
AAGGCAGCTT CAACTCTCTC CGACACAAAG AATATGGAGA TAATAAATTC AACTATTGAG 
ACCCTTGCAC CTGACAGCCC CTTTGACCAC AAGAAAACTG TGAGTGGCTT TCAGAAACTT 
GAGAAACTGG ACCCTATTGC AGCAGATCAG CAGGACACGG TGGTCTTCAA GGTGACAGAA 
GGGAAACTCC TCCGGGACCC TTTGTCACAT CCTGGTGCAG AACAGACTGG AATACAGAAC 
AAGACTCAGA TGCACCCACT AATGTCGCAG ATGTCTGGCT CAGTTACTGC TTCTATGGCC 
ACAGGTTCAG CTACCCGAAA GGGTATAGTG GTATTAATAG ACCCATTAGC AGCCAATGGG 
ACAACAGACA TGCATACCTC AGTTCCAAGA GTGAAAGGTG GGCAAAGAAA TATTACTGAT 
GACAGCAGAG GCCAGCCTTT TATCAAGAAG ATGCACTTCA CCATAAGGCT AACAGAAAGT 
GCCATCACAT ACAGAGACAT TGTAGTGAAG AAAGAGGATG GATTCACCCA GATAGTGCTA 
TCAACTAGAT CGACAGAAAA AAATGCACTG AATACAGAAG TAATTAAAGA AATGGTTAAT 
GCTCTGAATA GCGCTGCTGC AGATGACAGC AAGCTCGTGC TGTTCAGTGC AGCTGGAAGT 
GTCTTTTGCT GCGGTCTTGA TTTTGGGTAC TTTGTGAGGC ACTTAAGGAA TGACAGAAAC 
ACAGCAAGCC TTGAAATGGT GGACACCATC AAGAACTTTG TGAATACTTT TATTCAATTT 
AAAAAGCCTA TTGTTGTATC AGTCAATGGC CCTGCCATTG GACTAGGTGC ATCCATCCTG 
CCTCTTTGTG ATCTCGTGTG GGCTAATGAA AAGGCTTGGT TCCAAACCCC TTATACGACC 
TTTGGACAGA GTCCAGATGG CTGTTCTTCT ATTACATTCC CCAAAATGAT GGGTAAAGCA 
TCTGCCAATG AAATGTTAAT TGCTGGGCGA AAGCTGACAG CACGGGAGGC ATGCGCCAAA 
GGCCTGGTCT CTCAGGTATT TTTGACTGGA ACTTTCACCC AAGAGGTTAT GATTCAAATT 
AAGGAGCTTG CCTCATACAA TGCAATTGTA CTGGAAGAAT GTAAGGCCCT CGTTCGCTGT 
AATATTAAGT TGGAGTTGGA ACAGGCCAAT GAGAGAGAGT GTGAGGTGCT GAGGAAGATC 
TGGAGCTCAG CCCAAGGGAT AGAATCCATG TTAAAGTATG TTGAAAATAA AATTGATGAG 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004816.1
CDS	329..1954
Translation	MASQEFEVEAIVDKRQDKNGNTQYLVRWKGYDKQDDTWEPEQHLMNCEKCVHDFNRRQTEKQKKLTWTTTSRIFSNNARRRTSRSTKANYSKNSPKTPVTDKHHRSKNCKLFAASKNVRRKAASTLSDTKNMEIINSTIETLAPDSPFDHKKTVSGFQKLEKLDPIAADQQDTVVFKVTEGKLLRDPLSHPGAEQTGIQNKTQMHPLMSQMSGSVTASMATGSATRKGIVVLIDPLAANGTTDMHTSVPRVKGGQRNITDDSRGQPFIKKMHFTIRLTESAITYRDIVVKKEDGFTQIVLSTRSTEKNALNTEVIKEMVNALNSAAADDSKLVLFSAAGSVFCCGLDFGYFVRHLRNDRNTASLEMVDTIKNFVNTFIQFKKPIVVSVNGPAIGLGASILPLCDLVWANEKAWFQTPYTTFGQSPDGCSSITFPKMMGKASANEMLIAGRKLTAREACAKGLVSQVFLTGTFTQEVMIQIKELASYNAIVLEECKALVRCNIKLELEQANERECEVLRKIWSSAQGIESMLKYVENKIDEF

Target ORF information:

RefSeq Version	NM_004825.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chromodomain Y-linked 2A (CDY2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004825.2

ORF Insert Sequence:

ATGGCTTCCC AGGAGTTTGA GGTTGAAGCT ATTGTTGACA AAAGACAGGA TAAAAATGGG 
AATACACAGT ATTTGGTTCG GTGGAAAGGT TATGACAAAC AGGATGACAC TTGGGAACCA 
GAGCAGCACC TCATGAACTG TGAAAAATGT GTACATGATT TTAATAGACG ACAGACTGAA 
AAACAGAAAA AACTGACATG GACTACAACC AGTAGAATTT TTTCAAACAA TGCCAGAAGA 
AGAACTTCCA GATCTACAAA AGCAAACTAT TCTAAGAACT CTCCTAAAAC TCCAGTGACT 
GATAAACACC ACAGGTCCAA AAACTGCAAG TTATTTGCTG CCAGCAAGAA CGTTAGGAGA 
AAGGCAGCTT CAACTCTCTC CGACACAAAG AATATGGAGA TAATAAATTC AACTATTGAG 
ACCCTTGCAC CTGACAGCCC CTTTGACCAC AAGAAAACTG TGAGTGGCTT TCAGAAACTT 
GAGAAACTGG ACCCTATTGC AGCAGATCAG CAGGACACGG TGGTCTTCAA GGTGACAGAA 
GGGAAACTCC TCCGGGACCC TTTGTCACAT CCTGGTGCAG AACAGACTGG AATACAGAAC 
AAGACTCAGA TGCACCCACT AATGTCGCAG ATGTCTGGCT CAGTTACTGC TTCTATGGCC 
ACAGGTTCAG CTACCCGAAA GGGTATAGTG GTATTAATAG ACCCATTAGC AGCCAATGGG 
ACAACAGACA TGCATACCTC AGTTCCAAGA GTGAAAGGTG GGCAAAGAAA TATTACTGAT 
GACAGCAGAG GCCAGCCTTT TATCAAGAAG ATGCACTTCA CCATAAGGCT AACAGAAAGT 
GCCATCACAT ACAGAGACAT TGTAGTGAAG AAAGAGGATG GATTCACCCA GATAGTGCTA 
TCAACTAGAT CGACAGAAAA AAATGCACTG AATACAGAAG TAATTAAAGA AATGGTTAAT 
GCTCTGAATA GCGCTGCTGC AGATGACAGC AAGCTCGTGC TGTTCAGTGC AGCTGGAAGT 
GTCTTTTGCT GCGGTCTTGA TTTTGGGTAC TTTGTGAGGC ACTTAAGGAA TGACAGAAAC 
ACAGCAAGCC TTGAAATGGT GGACACCATC AAGAACTTTG TGAATACTTT TATTCAATTT 
AAAAAGCCTA TTGTTGTATC AGTCAATGGC CCTGCCATTG GACTAGGTGC ATCCATCCTG 
CCTCTTTGTG ATCTCGTGTG GGCTAATGAA AAGGCTTGGT TCCAAACCCC TTATACGACC 
TTTGGACAGA GTCCAGATGG CTGTTCTTCT ATTACATTCC CCAAAATGAT GGGTAAAGCA 
TCTGCCAATG AAATGTTAAT TGCTGGGCGA AAGCTGACAG CACGGGAGGC ATGCGCCAAA 
GGCCTGGTCT CTCAGGTATT TTTGACTGGA ACTTTCACCC AAGAGGTTAT GATTCAAATT 
AAGGAGCTTG CCTCATACAA TGCAATTGTA CTGGAAGAAT GTAAGGCCCT CGTTCGCTGT 
AATATTAAGT TGGAGTTGGA ACAGGCCAAT GAGAGAGAGT GTGAGGTGCT GAGGAAGATC 
TGGAGCTCAG CCCAAGGGAT AGAATCCATG TTAAAGTATG TTGAAAATAA AATTGATGAG 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Nature423(6942)825-37(2003 Jun)
Skaletsky H,Kuroda-Kawaguchi T,Minx PJ,Cordum HS,Hillier L,Brown LG,Repping S,Pyntikova T,Ali J,Bieri T,Chinwalla A,Delehaunty A,Delehaunty K,Du H,Fewell G,Fulton L,Fulton R,Graves T,Hou SF,Latrielle P,Leonard S,Mardis E,Maupin R,McPherson J,Miner T,Nash W,Nguyen C,Ozersky P,Pepin K,Rock S,Rohlfing T,Scott K,Schultz B,Strong C,Tin-Wollam A,Yang SP,Waterston RH,Wilson RK,Rozen S,Page DC

Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.
Proceedings of the National Academy of Sciences of the United States of America99(13)8707-12(2002 Jun)
Lahn BT,Tang ZL,Zhou J,Barndt RJ,Parvinen M,Allis CD,Page DC

Comparative mapping of CDY and DAZ in higher primates.
Cytogenetic and genome research96(1-4)287-9(2002)
Wimmer R,K?hl H,R?ttger S,Schempp W

A fiber-FISH contig spanning the non-recombining region of the human Y chromosome.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology10(8)621-35(2002)
R?ttger S,Yen PH,Schempp W

Mammalian chromodomain proteins: their role in genome organisation and expression.
BioEssays : news and reviews in molecular, cellular and developmental biology22(2)124-37(2000 Feb)
Jones DO,Cowell IG,Singh PB

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CDY2A cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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