CER1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CER1
Entrez Gene ID	9350
Full Name	cerberus 1, DAN family BMP antagonist
Synonyms	DAND4
General protein information	Preferred Names cerberus 1, DAN family BMP antagonist Names cerberus DAN domain family member 4 cerberus 1, cysteine knot superfamily, homolog cerberus-related 1 cerberus-related protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p22.3
Summary	This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008].
Disorder MIM:	603777

mRNA and Protein(s)

mRNA	Protein	Name
NM_005454.3	NP_005445.1	cerberus precursor
NM_005454.2	NP_005445.1	cerberus precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CER1	NP_005445.1
	CER1	XP_001110846.1
Mus musculus (house mouse)	Cer1	NP_034017.1
Canis lupus familiaris (dog)	CER1	XP_853753.1
Rattus norvegicus (Norway rat)	Cer1	NP_001108503.1
Gallus gallus (chicken)	CER1	NP_990154.1
Pan troglodytes (chimpanzee)	CER1	XP_528542.2
Bos taurus (cattle)	CER1	XP_002689623.1

Gene Ontology
Bibliography

Related articles in PubMed

New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand-Receptor Interactions and Antagonist Activity.
Aykul S, Martinez-Hackert E
Journal of molecular biology428(3)590-602(2016 Feb)

CER1 gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women.
Koromila T, Georgoulias P, Dailiana Z, Ntzani EE, Samara S, Chassanidis C, Aleporou-Marinou V, Kollia P
Human genomics721(2013 Oct)

Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells.
Iwashita H, Shiraki N, Sakano D, Ikegami T, Shiga M, Kume K, Kume S
PloS one8(5)e64291(2013)

Novel sequence variations in the CER1 gene are strongly associated with low bone mineral density and risk of osteoporotic fracture in postmenopausal women.
Koromila T, Dailiana Z, Samara S, Chassanidis C, Tzavara C, Patrinos GP, Aleporou-Marinou V, Kollia P
Calcified tissue international91(1)15-23(2012 Jul)

A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgraduate medical journal85(1008)515-24(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cerberus binds and inhibits Nodal, Activin B, BMP-6, and BMP-7 but not BMP-2 or Activin A.
Title: New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand-Receptor Interactions and Antagonist Activity.

No significant association between the studied DKK1 variations and osteoporosis was found, while CER1 variations seem to play a significant role in the determination of osteoporosis, combined with bone markers, in postmenopausal osteoporotic women.
Title: CER1 gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women.

results show that Cer1 (or CER1) serves as a good marker for quantification of definitive endoderm differentiation of mouse and human ES/iPS cells
Title: Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells.

CER1 gene variations play a significant role in determining BMD and vertebral or hip fractures, which might be helpful in clinical practice to identify patients with increased fracture risk
Title: Novel sequence variations in the CER1 gene are strongly associated with low bone mineral density and risk of osteoporotic fracture in postmenopausal women.

Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
Title: A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.

The following CER1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CER1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29786	NM_005454.3 Latest version!	Homo sapiens cerberus 1, DAN family BMP antagonist (CER1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu29786	NM_005454.2	Homo sapiens cerberus 1, DAN family BMP antagonist (CER1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CER1 ( NM_005454.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005445.1 Homo sapiens cerberus 1, DAN family BMP antagonist (CER1), mRNA.

Price & Availability↑

CloneID	OHu29786
Clone ID Related Accession (Same CDS sequence)	NM_005454.3 , NM_005454.2
Accession Version	NM_005454.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	cerberus precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390732.10, CD652441.1, AF400435.1 and BU071333.1. On May 17, 2019 this sequence version replaced NM_005454.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD652441.1, SRR1803614.23361.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153733, SAMEA2162328 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380911.4/ ENSP00000370297.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCATCTCC TCTTATTTCA GCTGCTGGTA CTCCTGCCTC TAGGAAAGAC CACACGGCAC 
CAGGATGGCC GCCAGAATCA GAGTTCTCTT TCCCCCGTAC TCCTGCCAAG GAATCAAAGA 
GAGCTTCCCA CAGGCAACCA TGAGGAAGCT GAGGAGAAGC CAGATCTGTT TGTCGCAGTG 
CCACACCTTG TAGCCACCAG CCCTGCAGGG GAAGGCCAGA GGCAGAGAGA GAAGATGCTG 
TCCAGATTTG GCAGGTTCTG GAAGAAGCCT GAGAGAGAAA TGCATCCATC CAGGGACTCA 
GATAGTGAGC CCTTCCCACC TGGGACCCAG TCCCTCATCC AGCCGATAGA TGGAATGAAA 
ATGGAGAAAT CTCCTCTTCG GGAAGAAGCC AAGAAATTCT GGCACCACTT CATGTTCAGA 
AAAACTCCGG CTTCTCAGGG GGTCATCTTG CCCATCAAAA GCCATGAAGT ACATTGGGAG 
ACCTGCAGGA CAGTGCCCTT CAGCCAGACT ATAACCCACG AAGGCTGTGA AAAAGTAGTT 
GTTCAGAACA ACCTTTGCTT TGGGAAATGC GGGTCTGTTC ATTTTCCTGG AGCCGCGCAG 
CACTCCCATA CCTCCTGCTC TCACTGTTTG CCTGCCAAGT TCACCACGAT GCACTTGCCA 
CTGAACTGCA CTGAACTTTC CTCCGTGATC AAGGTGGTGA TGCTGGTGGA GGAGTGCCAG 
TGCAAGGTGA AGACGGAGCA TGAAGATGGA CACATCCTAC ATGCTGGCTC CCAGGATTCC 
TTTATCCCAG GAGTTTCAGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005445.1
CDS	62..865
Translation	MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA

Target ORF information:

RefSeq Version	NM_005454.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cerberus 1, DAN family BMP antagonist (CER1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005454.3

ORF Insert Sequence:

ATGCATCTCC TCTTATTTCA GCTGCTGGTA CTCCTGCCTC TAGGAAAGAC CACACGGCAC 
CAGGATGGCC GCCAGAATCA GAGTTCTCTT TCCCCCGTAC TCCTGCCAAG GAATCAAAGA 
GAGCTTCCCA CAGGCAACCA TGAGGAAGCT GAGGAGAAGC CAGATCTGTT TGTCGCAGTG 
CCACACCTTG TAGCCACCAG CCCTGCAGGG GAAGGCCAGA GGCAGAGAGA GAAGATGCTG 
TCCAGATTTG GCAGGTTCTG GAAGAAGCCT GAGAGAGAAA TGCATCCATC CAGGGACTCA 
GATAGTGAGC CCTTCCCACC TGGGACCCAG TCCCTCATCC AGCCGATAGA TGGAATGAAA 
ATGGAGAAAT CTCCTCTTCG GGAAGAAGCC AAGAAATTCT GGCACCACTT CATGTTCAGA 
AAAACTCCGG CTTCTCAGGG GGTCATCTTG CCCATCAAAA GCCATGAAGT ACATTGGGAG 
ACCTGCAGGA CAGTGCCCTT CAGCCAGACT ATAACCCACG AAGGCTGTGA AAAAGTAGTT 
GTTCAGAACA ACCTTTGCTT TGGGAAATGC GGGTCTGTTC ATTTTCCTGG AGCCGCGCAG 
CACTCCCATA CCTCCTGCTC TCACTGTTTG CCTGCCAAGT TCACCACGAT GCACTTGCCA 
CTGAACTGCA CTGAACTTTC CTCCGTGATC AAGGTGGTGA TGCTGGTGGA GGAGTGCCAG 
TGCAAGGTGA AGACGGAGCA TGAAGATGGA CACATCCTAC ATGCTGGCTC CCAGGATTCC 
TTTATCCCAG GAGTTTCAGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CER1 ( NM_005454.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005445.1 Homo sapiens cerberus 1, DAN family BMP antagonist (CER1), mRNA.

Price & Availability↑

CloneID	OHu29786
Clone ID Related Accession (Same CDS sequence)	NM_005454.3 , NM_005454.2
Accession Version	NM_005454.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	cerberus precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD652441.1, AF400435.1 and BU071333.1. On Sep 15, 2005 this sequence version replaced NM_005454.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.23361.1, CX164353.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153733, SAMEA2162328 [ECO:0000348] ##Evidence-Data-END##

ATGCATCTCC TCTTATTTCA GCTGCTGGTA CTCCTGCCTC TAGGAAAGAC CACACGGCAC 
CAGGATGGCC GCCAGAATCA GAGTTCTCTT TCCCCCGTAC TCCTGCCAAG GAATCAAAGA 
GAGCTTCCCA CAGGCAACCA TGAGGAAGCT GAGGAGAAGC CAGATCTGTT TGTCGCAGTG 
CCACACCTTG TAGCCACCAG CCCTGCAGGG GAAGGCCAGA GGCAGAGAGA GAAGATGCTG 
TCCAGATTTG GCAGGTTCTG GAAGAAGCCT GAGAGAGAAA TGCATCCATC CAGGGACTCA 
GATAGTGAGC CCTTCCCACC TGGGACCCAG TCCCTCATCC AGCCGATAGA TGGAATGAAA 
ATGGAGAAAT CTCCTCTTCG GGAAGAAGCC AAGAAATTCT GGCACCACTT CATGTTCAGA 
AAAACTCCGG CTTCTCAGGG GGTCATCTTG CCCATCAAAA GCCATGAAGT ACATTGGGAG 
ACCTGCAGGA CAGTGCCCTT CAGCCAGACT ATAACCCACG AAGGCTGTGA AAAAGTAGTT 
GTTCAGAACA ACCTTTGCTT TGGGAAATGC GGGTCTGTTC ATTTTCCTGG AGCCGCGCAG 
CACTCCCATA CCTCCTGCTC TCACTGTTTG CCTGCCAAGT TCACCACGAT GCACTTGCCA 
CTGAACTGCA CTGAACTTTC CTCCGTGATC AAGGTGGTGA TGCTGGTGGA GGAGTGCCAG 
TGCAAGGTGA AGACGGAGCA TGAAGATGGA CACATCCTAC ATGCTGGCTC CCAGGATTCC 
TTTATCCCAG GAGTTTCAGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005445.1
CDS	46..849
Translation	MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA

Target ORF information:

RefSeq Version	NM_005454.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cerberus 1, DAN family BMP antagonist (CER1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005454.2

ORF Insert Sequence:

ATGCATCTCC TCTTATTTCA GCTGCTGGTA CTCCTGCCTC TAGGAAAGAC CACACGGCAC 
CAGGATGGCC GCCAGAATCA GAGTTCTCTT TCCCCCGTAC TCCTGCCAAG GAATCAAAGA 
GAGCTTCCCA CAGGCAACCA TGAGGAAGCT GAGGAGAAGC CAGATCTGTT TGTCGCAGTG 
CCACACCTTG TAGCCACCAG CCCTGCAGGG GAAGGCCAGA GGCAGAGAGA GAAGATGCTG 
TCCAGATTTG GCAGGTTCTG GAAGAAGCCT GAGAGAGAAA TGCATCCATC CAGGGACTCA 
GATAGTGAGC CCTTCCCACC TGGGACCCAG TCCCTCATCC AGCCGATAGA TGGAATGAAA 
ATGGAGAAAT CTCCTCTTCG GGAAGAAGCC AAGAAATTCT GGCACCACTT CATGTTCAGA 
AAAACTCCGG CTTCTCAGGG GGTCATCTTG CCCATCAAAA GCCATGAAGT ACATTGGGAG 
ACCTGCAGGA CAGTGCCCTT CAGCCAGACT ATAACCCACG AAGGCTGTGA AAAAGTAGTT 
GTTCAGAACA ACCTTTGCTT TGGGAAATGC GGGTCTGTTC ATTTTCCTGG AGCCGCGCAG 
CACTCCCATA CCTCCTGCTC TCACTGTTTG CCTGCCAAGT TCACCACGAT GCACTTGCCA 
CTGAACTGCA CTGAACTTTC CTCCGTGATC AAGGTGGTGA TGCTGGTGGA GGAGTGCCAG 
TGCAAGGTGA AGACGGAGCA TGAAGATGGA CACATCCTAC ATGCTGGCTC CCAGGATTCC 
TTTATCCCAG GAGTTTCAGC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand-Receptor Interactions and Antagonist Activity.
Journal of molecular biology428(3)590-602(2016 Feb)
Aykul S,Martinez-Hackert E

CER1 gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women.
Human genomics721(2013 Oct)
Koromila T,Georgoulias P,Dailiana Z,Ntzani EE,Samara S,Chassanidis C,Aleporou-Marinou V,Kollia P

Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells.
PloS one8(5)e64291(2013)
Iwashita H,Shiraki N,Sakano D,Ikegami T,Shiga M,Kume K,Kume S

Novel sequence variations in the CER1 gene are strongly associated with low bone mineral density and risk of osteoporotic fracture in postmenopausal women.
Calcified tissue international91(1)15-23(2012 Jul)
Koromila T,Dailiana Z,Samara S,Chassanidis C,Tzavara C,Patrinos GP,Aleporou-Marinou V,Kollia P

A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Postgraduate medical journal85(1008)515-24(2009 Oct)
Young RP,Hopkins RJ,Hay BA,Epton MJ,Mills GD,Black PN,Gardner HD,Sullivan R,Gamble GD

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CER1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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