RAB11B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB11B
Entrez Gene ID	9230
Full Name	RAB11B, member RAS oncogene family
Synonyms	H-YPT3,NDAGSCW
General protein information	Preferred Names RAB11B, member RAS oncogene family Names ras-related protein Rab-11B GTP-binding protein YPT3 RAB11B, member of RAS oncogene family
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010].
Disorder MIM:	604198
Disorder Html:	Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter, 617807 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004218.4	NP_004209.2	ras-related protein Rab-11B
NM_004218.3	NP_004209.2	ras-related protein Rab-11B

Pathways from BioSystems

Homologies

Homo sapiens (human)	RAB11B	NP_004209.2
Bos taurus (cattle)	RAB11B	NP_001030468.1
Mus musculus (house mouse)	Rab11b	NP_033023.1
Arabidopsis thaliana (thale cress)	RAB11c	NP_172434.1
Pan troglodytes (chimpanzee)	RAB11B	XP_001147785.2
Canis lupus familiaris (dog)	RAB11B	XP_854399.2
Danio rerio (zebrafish)	rab11bb	NP_001002555.1
Saccharomyces cerevisiae (baker's yeast)	YPT32	NP_011305.1
Xenopus tropicalis (tropical clawed frog)	rab11b.1	NP_001011048.1
Gallus gallus (chicken)	RAB11B	NP_001012569.1
Danio rerio (zebrafish)	LOC100536606	XP_003198017.1
	RAB11B	XP_001093925.1
Rattus norvegicus (Norway rat)	Rab11b	NP_116006.1
Oryza sativa (rice)	Os05g0105100	NP_001054408.1

Gene Ontology
Bibliography

Related articles in PubMed

Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype.
Lamers IJC, Reijnders MRF, Venselaar H, Kraus A, , Jansen S, de Vries BBA, Houge G, Gradek GA, Seo J, Choi M, Chae JH, van der Burgt I, Pfundt R, Letteboer SJF, van Beersum SEC, Dusseljee S, Brunner HG, Doherty D, Kleefstra T, Roepman R
American journal of human genetics101(5)824-832(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Rab11a sustains GSK3?/Wnt/?-catenin signaling to enhance cancer progression in pancreatic cancer.
Yu L, Li X, Li H, Chen H, Liu H
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(10)13821-13829(2016 Oct)

Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.
Grimsey NJ, Coronel LJ, Cordova IC, Trejo J
The Journal of biological chemistry291(5)2223-36(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Recurrent de novo mutations disturbing the GTP/GDP binding pocket of RAB11B cause intellectual disability and a distinctive brain phenotype.
Title: Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype.

High RAB11B expression is associated with pancreatic cancer.
Title: Rab11a sustains GSK3?/Wnt/?-catenin signaling to enhance cancer progression in pancreatic cancer.

Rab11A and Rab11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
Title: Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.

we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions
Title: Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions.

Upon Rab11b depletion, FGFR4 is trapped in the pericentriolar recycling compartment.
Title: Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling.

The following RAB11B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB11B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24337	NM_004218.4 Latest version!	Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu24337	NM_004218.3	Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB11B ( NM_004218.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004209.2 Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA.

Price & Availability↑

CloneID	OHu24337
Clone ID Related Accession (Same CDS sequence)	NM_004218.4 , NM_004218.3
Accession Version	NM_004218.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	ras-related protein Rab-11B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC136469.2. On Nov 23, 2018 this sequence version replaced NM_004218.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.185080.1, SRR3476690.808131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328024.11/ ENSP00000333547.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGACCC GGGACGACGA GTACGACTAC CTATTCAAAG TGGTGCTCAT CGGGGACTCA 
GGCGTGGGCA AGAGCAACCT GCTGTCGCGC TTCACCCGCA ACGAGTTCAA CCTGGAGAGC 
AAGAGCACCA TCGGCGTGGA GTTCGCCACC CGCAGCATCC AGGTGGACGG CAAGACCATC 
AAGGCGCAGA TCTGGGACAC CGCTGGCCAG GAGCGCTACC GCGCCATCAC CTCCGCGTAC 
TACCGTGGTG CAGTGGGCGC CCTGCTGGTG TACGACATCG CCAAGCACCT GACCTATGAG 
AACGTGGAGC GCTGGCTGAA GGAGCTGCGG GACCACGCAG ACAGCAACAT CGTCATCATG 
CTGGTGGGCA ACAAGAGTGA CCTGCGCCAC CTGCGGGCTG TGCCCACTGA CGAGGCCCGC 
GCCTTCGCAG AAAAGAACAA CTTGTCCTTC ATCGAGACCT CAGCCTTGGA TTCCACTAAC 
GTAGAGGAAG CATTCAAGAA CATCCTCACA GAGATCTACC GCATCGTGTC ACAGAAACAG 
ATCGCAGACC GCGCTGCCCA CGACGAGTCC CCGGGGAACA ACGTGGTGGA CATCAGCGTG 
CCGCCCACCA CGGACGGACA GAAGCCCAAC AAGCTGCAGT GCTGCCAGAA CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004209.2
CDS	58..714
Translation	MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPNKLQCCQNL

Target ORF information:

RefSeq Version	NM_004218.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004218.4

ORF Insert Sequence:

ATGGGGACCC GGGACGACGA GTACGACTAC CTATTCAAAG TGGTGCTCAT CGGGGACTCA 
GGCGTGGGCA AGAGCAACCT GCTGTCGCGC TTCACCCGCA ACGAGTTCAA CCTGGAGAGC 
AAGAGCACCA TCGGCGTGGA GTTCGCCACC CGCAGCATCC AGGTGGACGG CAAGACCATC 
AAGGCGCAGA TCTGGGACAC CGCTGGCCAG GAGCGCTACC GCGCCATCAC CTCCGCGTAC 
TACCGTGGTG CAGTGGGCGC CCTGCTGGTG TACGACATCG CCAAGCACCT GACCTATGAG 
AACGTGGAGC GCTGGCTGAA GGAGCTGCGG GACCACGCAG ACAGCAACAT CGTCATCATG 
CTGGTGGGCA ACAAGAGTGA CCTGCGCCAC CTGCGGGCTG TGCCCACTGA CGAGGCCCGC 
GCCTTCGCAG AAAAGAACAA CTTGTCCTTC ATCGAGACCT CAGCCTTGGA TTCCACTAAC 
GTAGAGGAAG CATTCAAGAA CATCCTCACA GAGATCTACC GCATCGTGTC ACAGAAACAG 
ATCGCAGACC GCGCTGCCCA CGACGAGTCC CCGGGGAACA ACGTGGTGGA CATCAGCGTG 
CCGCCCACCA CGGACGGACA GAAGCCCAAC AAGCTGCAGT GCTGCCAGAA CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB11B ( NM_004218.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004209.2 Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA.

Price & Availability↑

CloneID	OHu24337
Clone ID Related Accession (Same CDS sequence)	NM_004218.4 , NM_004218.3
Accession Version	NM_004218.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ras-related protein Rab-11B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP367041.1, AK225036.1, AK225642.1, CX787570.1 and BP396219.1. On Jun 14, 2008 this sequence version replaced NM_004218.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.186552.1, SRR1163657.538182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGGGACCC GGGACGACGA GTACGACTAC CTATTCAAAG TGGTGCTCAT CGGGGACTCA 
GGCGTGGGCA AGAGCAACCT GCTGTCGCGC TTCACCCGCA ACGAGTTCAA CCTGGAGAGC 
AAGAGCACCA TCGGCGTGGA GTTCGCCACC CGCAGCATCC AGGTGGACGG CAAGACCATC 
AAGGCGCAGA TCTGGGACAC CGCTGGCCAG GAGCGCTACC GCGCCATCAC CTCCGCGTAC 
TACCGTGGTG CAGTGGGCGC CCTGCTGGTG TACGACATCG CCAAGCACCT GACCTATGAG 
AACGTGGAGC GCTGGCTGAA GGAGCTGCGG GACCACGCAG ACAGCAACAT CGTCATCATG 
CTGGTGGGCA ACAAGAGTGA CCTGCGCCAC CTGCGGGCTG TGCCCACTGA CGAGGCCCGC 
GCCTTCGCAG AAAAGAACAA CTTGTCCTTC ATCGAGACCT CAGCCTTGGA TTCCACTAAC 
GTAGAGGAAG CATTCAAGAA CATCCTCACA GAGATCTACC GCATCGTGTC ACAGAAACAG 
ATCGCAGACC GCGCTGCCCA CGACGAGTCC CCGGGGAACA ACGTGGTGGA CATCAGCGTG 
CCGCCCACCA CGGACGGACA GAAGCCCAAC AAGCTGCAGT GCTGCCAGAA CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004209.2
CDS	97..753
Translation	MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPNKLQCCQNL

Target ORF information:

RefSeq Version	NM_004218.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004218.3

ORF Insert Sequence:

ATGGGGACCC GGGACGACGA GTACGACTAC CTATTCAAAG TGGTGCTCAT CGGGGACTCA 
GGCGTGGGCA AGAGCAACCT GCTGTCGCGC TTCACCCGCA ACGAGTTCAA CCTGGAGAGC 
AAGAGCACCA TCGGCGTGGA GTTCGCCACC CGCAGCATCC AGGTGGACGG CAAGACCATC 
AAGGCGCAGA TCTGGGACAC CGCTGGCCAG GAGCGCTACC GCGCCATCAC CTCCGCGTAC 
TACCGTGGTG CAGTGGGCGC CCTGCTGGTG TACGACATCG CCAAGCACCT GACCTATGAG 
AACGTGGAGC GCTGGCTGAA GGAGCTGCGG GACCACGCAG ACAGCAACAT CGTCATCATG 
CTGGTGGGCA ACAAGAGTGA CCTGCGCCAC CTGCGGGCTG TGCCCACTGA CGAGGCCCGC 
GCCTTCGCAG AAAAGAACAA CTTGTCCTTC ATCGAGACCT CAGCCTTGGA TTCCACTAAC 
GTAGAGGAAG CATTCAAGAA CATCCTCACA GAGATCTACC GCATCGTGTC ACAGAAACAG 
ATCGCAGACC GCGCTGCCCA CGACGAGTCC CCGGGGAACA ACGTGGTGGA CATCAGCGTG 
CCGCCCACCA CGGACGGACA GAAGCCCAAC AAGCTGCAGT GCTGCCAGAA CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype.
American journal of human genetics101(5)824-832(2017 Nov)
Lamers IJC,Reijnders MRF,Venselaar H,Kraus A,,Jansen S,de Vries BBA,Houge G,Gradek GA,Seo J,Choi M,Chae JH,van der Burgt I,Pfundt R,Letteboer SJF,van Beersum SEC,Dusseljee S,Brunner HG,Doherty D,Kleefstra T,Roepman R

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Rab11a sustains GSK3?/Wnt/?-catenin signaling to enhance cancer progression in pancreatic cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(10)13821-13829(2016 Oct)
Yu L,Li X,Li H,Chen H,Liu H

Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.
The Journal of biological chemistry291(5)2223-36(2016 Jan)
Grimsey NJ,Coronel LJ,Cordova IC,Trejo J

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

RAB11B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報