TIAF1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIAF1
Entrez Gene ID	9220
Full Name	TGFB1-induced anti-apoptotic factor 1
Synonyms	MAJN,SPR210
General protein information	Preferred Names TGFB1-induced anti-apoptotic factor 1 Names TGFB1-induced anti-apoptotic factor 1 12 kDa TGF-beta-1-induced antiapoptotic factor TGF-beta-1-induced antiapoptotic factor 1 molecule associated with Jak-3 N-terminal
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q11.2
Disorder MIM:	609517

mRNA and Protein(s)

mRNA	Protein	Name
NM_004740.3	NP_004731.2	TGFB1-induced anti-apoptotic factor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TIAF1	NP_004731.2
Pan troglodytes (chimpanzee)	TIAF1	XP_003315602.1

Gene Ontology
Bibliography

Related articles in PubMed

TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
Chang JY, Chiang MF, Lin SR, Lee MH, He H, Chou PY, Chen SJ, Chen YA, Yang LY, Lai FJ, Hsieh CC, Hsieh TH, Sheu HM, Sze CI, Chang NS
Cell death & disease3e302(2012 Apr)

TGF-? induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid ? plaques in Alzheimer's disease.
Lee MH, Lin SR, Chang JY, Schultz L, Heath J, Hsu LJ, Kuo YM, Hong Q, Chiang MF, Gong CX, Sze CI, Chang NS
Cell death & disease1e110(2010 Dec)

Alternative splice variants encoding unstable protein domains exist in the human brain.
Homma K, Kikuno RF, Nagase T, Ohara O, Nishikawa K
Journal of molecular biology343(5)1207-20(2004 Nov)

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Brajenovic M, Joberty G, K?ster B, Bouwmeester T, Drewes G
The Journal of biological chemistry279(13)12804-11(2004 Mar)

TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.
Schultz L, Khera S, Sleve D, Heath J, Chang NS
DNA and cell biology23(1)67-74(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In vitro induction of TIAF1 self-association upregulated the expression of tumor suppressors Smad4 and WW domain-containing oxidoreductase (WOX1 or WWOX), and WOX1 in turn increased the TIAF1 expression.
Title: TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.

TIAF1 undergoes self-aggregation in response to TGF-Beta1.
Title: TGF-? induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid ? plaques in Alzheimer's disease.

TIAF1 and p53 functionally interact in regulating apoptosis, and TIAF1 is likely to participate in the nuclear translocation of activated p53.
Title: TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.

Expression of TIAF-1 in the lymphocytes during chronic allograft rejection may be related to the predominance of a Th2 response in this condition and may protect these cells from apoptosis
Title: High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells.

The following TIAF1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIAF1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30154	NM_004740.3 Latest version!	Homo sapiens TGFB1-induced anti-apoptotic factor 1 (TIAF1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIAF1 ( NM_004740.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004731.2 Homo sapiens TGFB1-induced anti-apoptotic factor 1 (TIAF1), mRNA.

Price & Availability↑

CloneID	OHu30154
Clone ID Related Accession (Same CDS sequence)	NM_004740.3
Accession Version	NM_004740.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	TGFB1-induced anti-apoptotic factor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK126861.1 and BC047669.1. On Feb 23, 2004 this sequence version replaced NM_004740.2. ##Evidence-Data-START## Transcript is intronless :: AK054958.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCATCTC CATCTTCACC CTTCAGAGAG CAGTCCTTTC TCTGTGCAGC TGGAGACGCT 
GGTGAGGAGA GCCGGGTCCA GGTTCTTAAG AATGAGGTGC GGAGGGGCTC TCCGGTGCTG 
CTGGGCTGGG TTGAGCAAGC CTACGCAGAC AAGTGTGTGT GTGGACCATC CGCACCTCCA 
GCCCCCACCC CACCCTCTTT GTCTCAGCGT GTTATGTGCA ATGACCTATT TAAGGTAAAC 
CCATTCCAAC TACAGCAGTT CAGGGCTGAT CCAAGCACTG CCTCCCTCCT GCTCTGTCCA 
GGTGGTCTGG ACCATAAACT CAACTTGAGA GGGAAGGCTT GGGGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004731.2
CDS	1411..1758
Translation	MSSPSSPFREQSFLCAAGDAGEESRVQVLKNEVRRGSPVLLGWVEQAYADKCVCGPSAPPAPTPPSLSQRVMCNDLFKVNPFQLQQFRADPSTASLLLCPGGLDHKLNLRGKAWG

Target ORF information:

RefSeq Version	NM_004740.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TGFB1-induced anti-apoptotic factor 1 (TIAF1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004740.3

ORF Insert Sequence:

ATGTCATCTC CATCTTCACC CTTCAGAGAG CAGTCCTTTC TCTGTGCAGC TGGAGACGCT 
GGTGAGGAGA GCCGGGTCCA GGTTCTTAAG AATGAGGTGC GGAGGGGCTC TCCGGTGCTG 
CTGGGCTGGG TTGAGCAAGC CTACGCAGAC AAGTGTGTGT GTGGACCATC CGCACCTCCA 
GCCCCCACCC CACCCTCTTT GTCTCAGCGT GTTATGTGCA ATGACCTATT TAAGGTAAAC 
CCATTCCAAC TACAGCAGTT CAGGGCTGAT CCAAGCACTG CCTCCCTCCT GCTCTGTCCA 
GGTGGTCTGG ACCATAAACT CAACTTGAGA GGGAAGGCTT GGGGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
Cell death & disease3e302(2012 Apr)
Chang JY,Chiang MF,Lin SR,Lee MH,He H,Chou PY,Chen SJ,Chen YA,Yang LY,Lai FJ,Hsieh CC,Hsieh TH,Sheu HM,Sze CI,Chang NS

TGF-? induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid ? plaques in Alzheimer's disease.
Cell death & disease1e110(2010 Dec)
Lee MH,Lin SR,Chang JY,Schultz L,Heath J,Hsu LJ,Kuo YM,Hong Q,Chiang MF,Gong CX,Sze CI,Chang NS

Alternative splice variants encoding unstable protein domains exist in the human brain.
Journal of molecular biology343(5)1207-20(2004 Nov)
Homma K,Kikuno RF,Nagase T,Ohara O,Nishikawa K

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
The Journal of biological chemistry279(13)12804-11(2004 Mar)
Brajenovic M,Joberty G,K?ster B,Bouwmeester T,Drewes G

TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.
DNA and cell biology23(1)67-74(2004 Jan)
Schultz L,Khera S,Sleve D,Heath J,Chang NS

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TIAF1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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