TMSB4Y cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMSB4Y
Entrez Gene ID	9087
Full Name	thymosin beta 4, Y-linked
Synonyms	TB4Y
General protein information	Preferred Names thymosin beta 4, Y-linked Names thymosin beta-4, Y-chromosomal thymosin beta-4, Y isoform thymosin, beta 4, Y chromosome
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yq11.221
Summary	This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	400017

mRNA and Protein(s)

mRNA	Protein	Name
NM_004202.2	NP_004193.1	thymosin beta-4, Y-chromosomal
NM_004202.3	NP_004193.1	thymosin beta-4, Y-chromosomal

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.
Wong HY, Wang GM, Croessmann S, Zabransky DJ, Chu D, Garay JP, Cidado J, Cochran RL, Beaver JA, Aggarwal A, Liu ML, Argani P, Meeker A, Hurley PJ, Lauring J, Park BH
Oncotarget6(42)44927-40(2015 Dec)

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Lee OH, Kim H, He Q, Baek HJ, Yang D, Chen LY, Liang J, Chae HK, Safari A, Liu D, Songyang Z
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)

Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1.
Lee HR, Yoon SY, Kang HB, Park S, Kim KE, Cho YH, Kim S, Kim CW, Cho BJ, Lee WJ, Bang SI, Park H, Cho D
Immunology letters123(1)72-6(2009 Mar)

A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene.
Torikai H, Akatsuka Y, Miyazaki M, Warren EH 3rd, Oba T, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T
Journal of immunology (Baltimore, Md. : 1950)173(11)7046-54(2004 Dec)

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC
Nature423(6942)825-37(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest Y chromosome gene TMSB4Y may function as a tumor suppressor gene in male breast cancer.
Title: TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.

T beta 4 is a key activator of NK cell cytotoxicity.
Title: Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1.

TMSB4Y has been found to encode a novel HLA-A*3303-restricted minor histocompatibility H-Y antigen, revealed during cytotoxicity assays of T cell lines from a female-to-male hemopoietic stem cell transplantation patient.
Title: A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene.

The following TMSB4Y gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMSB4Y cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04537	NM_004202.3 Latest version!	Homo sapiens thymosin beta 4 Y-linked (TMSB4Y), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04537	NM_004202.2	Homo sapiens thymosin beta 4, Y-linked (TMSB4Y), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMSB4Y ( NM_004202.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004193.1 Homo sapiens thymosin beta 4, Y-linked (TMSB4Y), mRNA.

Price & Availability↑

CloneID	OHu04537
Clone ID Related Accession (Same CDS sequence)	NM_004202.2 , NM_004202.3
Accession Version	NM_004202.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 135bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	thymosin beta-4, Y-chromosomal
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF000989.1, BC119763.1 and BC022482.1. On Aug 28, 2003 this sequence version replaced NM_004202.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.54003.1, SRR1803612.247203.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGTCTGACA AACCTGGTAT GGCTGAGATC GAGAAATTCG ATAAGTCGAA ACTGAAGAAG 
ACAGAAACGC AAGAGAAGAA TCCATTGTCT TCCAAAGAAA CTATCGAACA GGAGAGGCAA 
GCAGGCGAAT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004193.1
CDS	770..904
Translation	MSDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES

Target ORF information:

RefSeq Version	NM_004202.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thymosin beta 4, Y-linked (TMSB4Y), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004202.2

ORF Insert Sequence:

1
61
121

ATGTCTGACA AACCTGGTAT GGCTGAGATC GAGAAATTCG ATAAGTCGAA ACTGAAGAAG 
ACAGAAACGC AAGAGAAGAA TCCATTGTCT TCCAAAGAAA CTATCGAACA GGAGAGGCAA 
GCAGGCGAAT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMSB4Y ( NM_004202.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004193.1 Homo sapiens thymosin beta 4 Y-linked (TMSB4Y), mRNA.

Price & Availability↑

CloneID	OHu04537
Clone ID Related Accession (Same CDS sequence)	NM_004202.2 , NM_004202.3
Accession Version	NM_004202.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 135bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	thymosin beta-4, Y-chromosomal
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC119763.1 and BC022482.1. On Nov 23, 2018 this sequence version replaced NM_004202.2. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1073402.1, SRR3476690.971176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000284856.4/ ENSP00000284856.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121

ATGTCTGACA AACCTGGTAT GGCTGAGATC GAGAAATTCG ATAAGTCGAA ACTGAAGAAG 
ACAGAAACGC AAGAGAAGAA TCCATTGTCT TCCAAAGAAA CTATCGAACA GGAGAGGCAA 
GCAGGCGAAT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004193.1
CDS	438..572
Translation	MSDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES

Target ORF information:

RefSeq Version	NM_004202.3
Organism	Homo sapiens(human)
Definition	Homo sapiens thymosin beta 4 Y-linked (TMSB4Y), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004202.3

ORF Insert Sequence:

1
61
121

ATGTCTGACA AACCTGGTAT GGCTGAGATC GAGAAATTCG ATAAGTCGAA ACTGAAGAAG 
ACAGAAACGC AAGAGAAGAA TCCATTGTCT TCCAAAGAAA CTATCGAACA GGAGAGGCAA 
GCAGGCGAAT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.
Oncotarget6(42)44927-40(2015 Dec)
Wong HY,Wang GM,Croessmann S,Zabransky DJ,Chu D,Garay JP,Cidado J,Cochran RL,Beaver JA,Aggarwal A,Liu ML,Argani P,Meeker A,Hurley PJ,Lauring J,Park BH

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)
Lee OH,Kim H,He Q,Baek HJ,Yang D,Chen LY,Liang J,Chae HK,Safari A,Liu D,Songyang Z

Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1.
Immunology letters123(1)72-6(2009 Mar)
Lee HR,Yoon SY,Kang HB,Park S,Kim KE,Cho YH,Kim S,Kim CW,Cho BJ,Lee WJ,Bang SI,Park H,Cho D

A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene.
Journal of immunology (Baltimore, Md. : 1950)173(11)7046-54(2004 Dec)
Torikai H,Akatsuka Y,Miyazaki M,Warren EH 3rd,Oba T,Tsujimura K,Motoyoshi K,Morishima Y,Kodera Y,Kuzushima K,Takahashi T

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Nature423(6942)825-37(2003 Jun)
Skaletsky H,Kuroda-Kawaguchi T,Minx PJ,Cordum HS,Hillier L,Brown LG,Repping S,Pyntikova T,Ali J,Bieri T,Chinwalla A,Delehaunty A,Delehaunty K,Du H,Fewell G,Fulton L,Fulton R,Graves T,Hou SF,Latrielle P,Leonard S,Mardis E,Maupin R,McPherson J,Miner T,Nash W,Nguyen C,Ozersky P,Pepin K,Rock S,Rohlfing T,Scott K,Schultz B,Strong C,Tin-Wollam A,Yang SP,Waterston RH,Wilson RK,Rozen S,Page DC

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TMSB4Y cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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