MAP3K6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAP3K6
Entrez Gene ID	9064
Full Name	mitogen-activated protein kinase kinase kinase 6
Synonyms	ASK2,MAPKKK6,MEKK6
General protein information	Preferred Names mitogen-activated protein kinase kinase kinase 6 Names mitogen-activated protein kinase kinase kinase 6 apoptosis signal-regulating kinase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Summary	This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Disorder MIM:	604468

mRNA and Protein(s)

mRNA	Protein	Name
XM_017002771.1	XP_016858260.1	mitogen-activated protein kinase kinase kinase 6 isoform X1
XM_017002772.1	XP_016858261.1	mitogen-activated protein kinase kinase kinase 6 isoform X2
NM_004672.4	NP_004663.3	mitogen-activated protein kinase kinase kinase 6 isoform 1
NM_004672.5	NP_004663.3	mitogen-activated protein kinase kinase kinase 6 isoform 1
NM_001297609.2	NP_001284538.1	mitogen-activated protein kinase kinase kinase 6 isoform 2
NM_001297609.1	NP_001284538.1	mitogen-activated protein kinase kinase kinase 6 isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MAP3K6	XP_005617983.1
Mus musculus (house mouse)	Map3k6	NP_057902.5
Homo sapiens (human)	MAP3K6	NP_004663.3
Gallus gallus (chicken)	MAP3K6	XP_003642613.2
Rattus norvegicus (Norway rat)	Map3k6	NP_001101379.1
Pan troglodytes (chimpanzee)	MAP3K6	XP_513244.2
	MAP3K6	XP_001111161.1
Bos taurus (cattle)	MAP3K6	NP_001180165.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of germline aberrations affecting
Weren RDA, van der Post RS, Vogelaar IP, van Krieken JH, Spruijt L, Lubinski J, Jakubowska A, Teodorczyk U, Aalfs CM, van Hest LP, Oliveira C, Kamping EJ, Schackert HK, Ranzani GN, G?mez Garc?a EB, Hes FJ, Holinski-Feder E, Genuardi M, Ausems MGEM, Sijmons RH, Wagner A, van der Kolk LE, Cats A, Bj?rnevoll I, Hoogerbrugge N, Ligtenberg MJL
Journal of medical genetics(2018 Jan)

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y
Science signaling8(388)ra78(2015 Aug)

Germline mutations in MAP3K6 are associated with familial gastric cancer.
Gaston D, Hansford S, Oliveira C, Nightingale M, Pinheiro H, Macgillivray C, Kaurah P, Rideout AL, Steele P, Soares G, Huang WY, Whitehouse S, Blowers S, LeBlanc MA, Jiang H, Greer W, Samuels ME, Orr A, Fernandez CV, Majewski J, Ludman M, Dyack S, Penney LS, McMaster CR, Huntsman D, Bedard K
PLoS genetics10(10)e1004669(2014 Oct)

Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome.
Cockrell LM, Puckett MC, Goldman EH, Khuri FR, Fu H
Oncogene29(6)822-30(2010 Feb)

Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression.
Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M
The American journal of pathology174(4)1553-63(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the MAPKKK6 ASK2, a modulator of MAPKKK5 ASK1 signaling, was essential for ASK1-dependent apoptosis, but not for inducing interferon-beta (IFNB) expression.
Title: The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.

MAP3K6 acts as a tumor suppressor, and studies showing the presence of somatic mutations in MAP3K6 in non-hereditary gastric cancers and gastric cancer cell lines, point towards MAP3K6 variants as a predisposing factor for familial gastric cancer
Title: Germline mutations in MAP3K6 are associated with familial gastric cancer.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

regulation of VEGF by MAP3K6 may play a crucial role in both angiogenesis and tumorigenesis.
Title: Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression.

The following MAP3K6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAP3K6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu90784	XM_017002771.1 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$475.30 $679.00
OHu28867	NM_004672.5 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$909.30 $1299.00
OHu28868	NM_001297609.2 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00
OHu90785	XM_017002772.1 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu28867	NM_004672.4	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$909.30 $1299.00
OHu28868	NM_001297609.1	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAP3K6 ( XM_017002771.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858260.1 Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant X3, mRNA.

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CloneID	OHu90784
Clone ID Related Accession (Same CDS sequence)	XM_017002771.1
Accession Version	XM_017002771.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2610bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTGG GCTGCCTGCT GGCCCGCAAA GGCTGCGTGG AGAAGATGCA GTATTACTGG 
GATGTGGGTT TCTACCTGGG AGCCCAGATC CTCGCCAATG ACCCCACCCA GGTGGTGCTG 
GCTGCAGAGC AGCTGTATAA GCTCAATGCC CCCATATGGT ACCTGGTGTC CGTGATGGAG 
ACCTTCCTGC TCTACCAGCA CTTCAGGCCC ACGCCAGAGC CCCCTGGAGG GCCACCACGC 
CGTGCCCACT TCTGGCTCCA CTTCTTGCTA CAGTCCTGCC AACCATTCAA GACAGCCTGT 
GCCCAGGGCG ACCAGTGCTT GGTGCTGGTC CTGGAGATGA ACAAGGTGCT GCTGCCTGCA 
AAGCTCGAGG TTCGGGGTAC TGACCCAGTA AGCACAGTGA CCCTGAGCCT GCTGGAGCCT 
GAGACCCAGG ACATTCCCTC CAGCTGGACC TTCCCAGTCG CCTCCATATG CGGAGTCAGC 
GCCTCAAAGC GCGACGAGCG CTGCTGCTTC CTCTATGCAC TCCCCCCGGC TCAGGACGTC 
CAGCTGTGCT TCCCCAGCGT AGGGCACTGC CAGTGGTTCT GCGGCCTGAT CCAGGCCTGG 
GTGACGAACC CGGATTCCAC GGCGCCCGCG GAGGAGGCGG AGGGCGCGGG GGAGATGTTG 
GAGTTTGATT ATGAGTACAC GGAGACGGGC GAGCGGCTGG TGCTGGGCAA GGGCACGTAT 
GGGGTGGTGT ACGCGGGCCG CGATCGCCAC ACGAGGGTGC GCATCGCCAT CAAGGAGATC 
CCGGAGCGGG ACAGCAGGTT CTCTCAGCCC CTGCATGAAG AGATCGCTCT TCACAGACGC 
CTGCGCCACA AGAACATAGT GCGCTATCTG GGCTCAGCTA GCCAGGGCGG CTACCTTAAG 
ATCTTCATGG AGGAAGTGCC TGGAGGCAGC CTGTCCTCCT TGCTGCGGTC GGTGTGGGGA 
CCCCTGAAGG ACAACGAGAG CACCATCAGT TTCTACACCC GCCAGATCCT GCAGGGACTT 
GGCTACTTGC ACGACAACCA CATCGTGCAC AGGGACATAA AAGGGGACAA TGTGCTGATC 
AACACCTTCA GTGGGCTGCT CAAGATTTCT GACTTCGGCA CCTCCAAGCG GCTGGCAGGC 
ATCACACCTT GCACTGAGAC CTTCACAGGA ACTCTGCAGT ATATGGCCCC AGAAATCATT 
GACCAGGGCC CACGCGGGTA TGGGAAAGCA GCTGACATCT GGTCACTGGG CTGCACTGTC 
ATTGAGATGG CCACAGGTCG CCCCCCCTTC CACGAGCTCG GGAGCCCACA GGCTGCCATG 
TTTCAGGTGG GTATGTACAA GGTCCATCCG CCAATGCCCA GCTCTCTGTC GGCCGAGGCC 
CAAGCCTTTC TCCTCCGAAC TTTTGAGCCA GACCCCCGCC TCCGAGCCAG CGCCCAGACA 
CTGCTGGGGG ACCCCTTCCT GCAGCCTGGG AAAAGGAGCC GCAGCCCCAG CTCCCCACGA 
CATGCTCCAC GGCCCTCAGA TGCCCCTTCT GCCAGTCCCA CTCCTTCAGC CAACTCAACC 
ACCCAGTCTC AGACATTCCC GTGCCCTCAG GCACCCTCTC AGCACCCACC CAGCCCCCCG 
AAGCGCTGCC TCAGTTATGG GGGCACCAGC CAGCTCCGGG TGCCCGAGGA GCCTGCGGCC 
GAGGAGCCTG CGTCTCCGGA GGAGAGTTCG GGGCTGAGCC TGCTGCACCA GGAGAGCAAG 
CGTCGGGCCA TGCTGGCCGC AGTATTGGAG CAGGAGCTGC CAGCGCTGGC GGAGAATCTG 
CACCAGGAGC AGAAGCAAGA GCAGGGGGCC CGTCTGGGCA GAAACCATGT GGAAGAGCTG 
CTGCGCTGCC TCGGGGCACA CATCCACACT CCCAACCGCC GGCAGCTCGC CCAGGAGCTG 
CGGGCGCTGC AAGGACGGCT GAGGGCCCAG GGCCTTGGGC CTGCGCTTCT GCACAGACCG 
CTGTTTGCCT TCCCGGATGC GGTGAAGCAG ATCCTCCGCA AGCGCCAGAT CCGTCCACAC 
TGGATGTTCG TTCTGGACTC ACTGCTCAGC CGTGCTGTGC GGGCAGCCCT GGGTGTGCTA 
GGACCGGAGG TGGAGAAGGA GGCGGTCTCA CCGAGGTCAG AGGAGCTGAG TAATGAAGGG 
GACTCCCAGC AGAGCCCAGG CCAGCAGAGC CCGCTTCCGG TGGAGCCCGA GCAGGGCCCC 
GCTCCTCTGA TGGTGCAGCT GAGCCTCTTG AGGGCAGAGA CTGATCGGCT GCGCGAAATC 
CTGGCGGGGA AGGAACGGGA GTACCAGGCC CTGGTGCAGC GGGCTCTACA GCGGCTGAAT 
GAGGAAGCCC GGACCTATGT CCTGGCCCCA GAGCCTCCAA CTGCTCTTTC AACGGACCAG 
GGCCTGGTGC AGTGGCTACA GGAACTGAAT GTGGATTCAG GCACCATCCA AATGCTGTTG 
AACCATAGCT TCACCCTCCA CACTCTGCTC ACCTATGCCA CTCGAGATGA CCTCATCTAC 
ACCCGCATCA GGGGAGGGAT GGTATGCCGC ATCTGGAGGG CCATCTTGGC ACAGCGAGCA 
GGATCCACAC CAGTCACCTC TGGACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858260.1
CDS	908..3517
Translation	MKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP

Target ORF information:

RefSeq Version	XM_017002771.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002771.1

ORF Insert Sequence:

ATGAAGCTGG GCTGCCTGCT GGCCCGCAAA GGCTGCGTGG AGAAGATGCA GTATTACTGG 
GATGTGGGTT TCTACCTGGG AGCCCAGATC CTCGCCAATG ACCCCACCCA GGTGGTGCTG 
GCTGCAGAGC AGCTGTATAA GCTCAATGCC CCCATATGGT ACCTGGTGTC CGTGATGGAG 
ACCTTCCTGC TCTACCAGCA CTTCAGGCCC ACGCCAGAGC CCCCTGGAGG GCCACCACGC 
CGTGCCCACT TCTGGCTCCA CTTCTTGCTA CAGTCCTGCC AACCATTCAA GACAGCCTGT 
GCCCAGGGCG ACCAGTGCTT GGTGCTGGTC CTGGAGATGA ACAAGGTGCT GCTGCCTGCA 
AAGCTCGAGG TTCGGGGTAC TGACCCAGTA AGCACAGTGA CCCTGAGCCT GCTGGAGCCT 
GAGACCCAGG ACATTCCCTC CAGCTGGACC TTCCCAGTCG CCTCCATATG CGGAGTCAGC 
GCCTCAAAGC GCGACGAGCG CTGCTGCTTC CTCTATGCAC TCCCCCCGGC TCAGGACGTC 
CAGCTGTGCT TCCCCAGCGT AGGGCACTGC CAGTGGTTCT GCGGCCTGAT CCAGGCCTGG 
GTGACGAACC CGGATTCCAC GGCGCCCGCG GAGGAGGCGG AGGGCGCGGG GGAGATGTTG 
GAGTTTGATT ATGAGTACAC GGAGACGGGC GAGCGGCTGG TGCTGGGCAA GGGCACGTAT 
GGGGTGGTGT ACGCGGGCCG CGATCGCCAC ACGAGGGTGC GCATCGCCAT CAAGGAGATC 
CCGGAGCGGG ACAGCAGGTT CTCTCAGCCC CTGCATGAAG AGATCGCTCT TCACAGACGC 
CTGCGCCACA AGAACATAGT GCGCTATCTG GGCTCAGCTA GCCAGGGCGG CTACCTTAAG 
ATCTTCATGG AGGAAGTGCC TGGAGGCAGC CTGTCCTCCT TGCTGCGGTC GGTGTGGGGA 
CCCCTGAAGG ACAACGAGAG CACCATCAGT TTCTACACCC GCCAGATCCT GCAGGGACTT 
GGCTACTTGC ACGACAACCA CATCGTGCAC AGGGACATAA AAGGGGACAA TGTGCTGATC 
AACACCTTCA GTGGGCTGCT CAAGATTTCT GACTTCGGCA CCTCCAAGCG GCTGGCAGGC 
ATCACACCTT GCACTGAGAC CTTCACAGGA ACTCTGCAGT ATATGGCCCC AGAAATCATT 
GACCAGGGCC CACGCGGGTA TGGGAAAGCA GCTGACATCT GGTCACTGGG CTGCACTGTC 
ATTGAGATGG CCACAGGTCG CCCCCCCTTC CACGAGCTCG GGAGCCCACA GGCTGCCATG 
TTTCAGGTGG GTATGTACAA GGTCCATCCG CCAATGCCCA GCTCTCTGTC GGCCGAGGCC 
CAAGCCTTTC TCCTCCGAAC TTTTGAGCCA GACCCCCGCC TCCGAGCCAG CGCCCAGACA 
CTGCTGGGGG ACCCCTTCCT GCAGCCTGGG AAAAGGAGCC GCAGCCCCAG CTCCCCACGA 
CATGCTCCAC GGCCCTCAGA TGCCCCTTCT GCCAGTCCCA CTCCTTCAGC CAACTCAACC 
ACCCAGTCTC AGACATTCCC GTGCCCTCAG GCACCCTCTC AGCACCCACC CAGCCCCCCG 
AAGCGCTGCC TCAGTTATGG GGGCACCAGC CAGCTCCGGG TGCCCGAGGA GCCTGCGGCC 
GAGGAGCCTG CGTCTCCGGA GGAGAGTTCG GGGCTGAGCC TGCTGCACCA GGAGAGCAAG 
CGTCGGGCCA TGCTGGCCGC AGTATTGGAG CAGGAGCTGC CAGCGCTGGC GGAGAATCTG 
CACCAGGAGC AGAAGCAAGA GCAGGGGGCC CGTCTGGGCA GAAACCATGT GGAAGAGCTG 
CTGCGCTGCC TCGGGGCACA CATCCACACT CCCAACCGCC GGCAGCTCGC CCAGGAGCTG 
CGGGCGCTGC AAGGACGGCT GAGGGCCCAG GGCCTTGGGC CTGCGCTTCT GCACAGACCG 
CTGTTTGCCT TCCCGGATGC GGTGAAGCAG ATCCTCCGCA AGCGCCAGAT CCGTCCACAC 
TGGATGTTCG TTCTGGACTC ACTGCTCAGC CGTGCTGTGC GGGCAGCCCT GGGTGTGCTA 
GGACCGGAGG TGGAGAAGGA GGCGGTCTCA CCGAGGTCAG AGGAGCTGAG TAATGAAGGG 
GACTCCCAGC AGAGCCCAGG CCAGCAGAGC CCGCTTCCGG TGGAGCCCGA GCAGGGCCCC 
GCTCCTCTGA TGGTGCAGCT GAGCCTCTTG AGGGCAGAGA CTGATCGGCT GCGCGAAATC 
CTGGCGGGGA AGGAACGGGA GTACCAGGCC CTGGTGCAGC GGGCTCTACA GCGGCTGAAT 
GAGGAAGCCC GGACCTATGT CCTGGCCCCA GAGCCTCCAA CTGCTCTTTC AACGGACCAG 
GGCCTGGTGC AGTGGCTACA GGAACTGAAT GTGGATTCAG GCACCATCCA AATGCTGTTG 
AACCATAGCT TCACCCTCCA CACTCTGCTC ACCTATGCCA CTCGAGATGA CCTCATCTAC 
ACCCGCATCA GGGGAGGGAT GGTATGCCGC ATCTGGAGGG CCATCTTGGC ACAGCGAGCA 
GGATCCACAC CAGTCACCTC TGGACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K6 ( NM_004672.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004663.3 Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28867
Clone ID Related Accession (Same CDS sequence)	NM_004672.4 , NM_004672.5
Accession Version	NM_004672.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW771625.1, AB167411.1, AF100318.1 and AI658745.1. This sequence is a reference standard in the RefSeqGene project. On Jul 4, 2014 this sequence version replaced NM_004672.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AB167411.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGCT ACACACTGAT CCCCTATGTG 
GTGACGGCCA CTGGTCGGGT GCTGTGTGGT GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 
GGGCTGGTAC AGGCTGGAGT GGGGACCGAG GCCCTGCTCA CTCCCCTGGT GGGCCGGCTT 
GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 
CGGGACATCC GGCAGGCGCG GGAGCGGTTC AGTGGGCCAC AGCTGCGGCA GGAGCTGGCT 
CGCCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 
CTGCTCTCCT ACCGCGATGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT GGAGACGCTG 
CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA CTACACTTTT 
GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGCGAAGG CCCTGTCTGT GCTGCTGCCG 
CTGGTACAGC TTGAGGGCTC TGTGGCGCCC GATCTGTACT GCATGTGTGG CCGTATCTAC 
AAGGACATGT TCTTCAGCTC GGGTTTCCAG GATGCTGGGC ACCGGGAGCA GGCCTATCAC 
TGGTATCGCA AGGCTTTTGA CGTAGAGCCC AGCCTTCACT CAGGCATCAA TGCAGCTGTG 
CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAAG AGCTCCGGCT AATAGGCATG 
AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 
GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 
GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTGTCCGT GATGGAGACC 
TTCCTGCTCT ACCAGCACTT CAGGCCCACG CCAGAGCCCC CTGGAGGGCC ACCACGCCGT 
GCCCACTTCT GGCTCCACTT CTTGCTACAG TCCTGCCAAC CATTCAAGAC AGCCTGTGCC 
CAGGGCGACC AGTGCTTGGT GCTGGTCCTG GAGATGAACA AGGTGCTGCT GCCTGCAAAG 
CTCGAGGTTC GGGGTACTGA CCCAGTAAGC ACAGTGACCC TGAGCCTGCT GGAGCCTGAG 
ACCCAGGACA TTCCCTCCAG CTGGACCTTC CCAGTCGCCT CCATATGCGG AGTCAGCGCC 
TCAAAGCGCG ACGAGCGCTG CTGCTTCCTC TATGCACTCC CCCCGGCTCA GGACGTCCAG 
CTGTGCTTCC CCAGCGTAGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA GGCCTGGGTG 
ACGAACCCGG ATTCCACGGC GCCCGCGGAG GAGGCGGAGG GCGCGGGGGA GATGTTGGAG 
TTTGATTATG AGTACACGGA GACGGGCGAG CGGCTGGTGC TGGGCAAGGG CACGTATGGG 
GTGGTGTACG CGGGCCGCGA TCGCCACACG AGGGTGCGCA TCGCCATCAA GGAGATCCCG 
GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TCGCTCTTCA CAGACGCCTG 
CGCCACAAGA ACATAGTGCG CTATCTGGGC TCAGCTAGCC AGGGCGGCTA CCTTAAGATC 
TTCATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCCTTGC TGCGGTCGGT GTGGGGACCC 
CTGAAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTTGGC 
TACTTGCACG ACAACCACAT CGTGCACAGG GACATAAAAG GGGACAATGT GCTGATCAAC 
ACCTTCAGTG GGCTGCTCAA GATTTCTGAC TTCGGCACCT CCAAGCGGCT GGCAGGCATC 
ACACCTTGCA CTGAGACCTT CACAGGAACT CTGCAGTATA TGGCCCCAGA AATCATTGAC 
CAGGGCCCAC GCGGGTATGG GAAAGCAGCT GACATCTGGT CACTGGGCTG CACTGTCATT 
GAGATGGCCA CAGGTCGCCC CCCCTTCCAC GAGCTCGGGA GCCCACAGGC TGCCATGTTT 
CAGGTGGGTA TGTACAAGGT CCATCCGCCA ATGCCCAGCT CTCTGTCGGC CGAGGCCCAA 
GCCTTTCTCC TCCGAACTTT TGAGCCAGAC CCCCGCCTCC GAGCCAGCGC CCAGACACTG 
CTGGGGGACC CCTTCCTGCA GCCTGGGAAA AGGAGCCGCA GCCCCAGCTC CCCACGACAT 
GCTCCACGGC CCTCAGATGC CCCTTCTGCC AGTCCCACTC CTTCAGCCAA CTCAACCACC 
CAGTCTCAGA CATTCCCGTG CCCTCAGGCA CCCTCTCAGC ACCCACCCAG CCCCCCGAAG 
CGCTGCCTCA GTTATGGGGG CACCAGCCAG CTCCGGGTGC CCGAGGAGCC TGCGGCCGAG 
GAGCCTGCGT CTCCGGAGGA GAGTTCGGGG CTGAGCCTGC TGCACCAGGA GAGCAAGCGT 
CGGGCCATGC TGGCCGCAGT ATTGGAGCAG GAGCTGCCAG CGCTGGCGGA GAATCTGCAC 
CAGGAGCAGA AGCAAGAGCA GGGGGCCCGT CTGGGCAGAA ACCATGTGGA AGAGCTGCTG 
CGCTGCCTCG GGGCACACAT CCACACTCCC AACCGCCGGC AGCTCGCCCA GGAGCTGCGG 
GCGCTGCAAG GACGGCTGAG GGCCCAGGGC CTTGGGCCTG CGCTTCTGCA CAGACCGCTG 
TTTGCCTTCC CGGATGCGGT GAAGCAGATC CTCCGCAAGC GCCAGATCCG TCCACACTGG 
ATGTTCGTTC TGGACTCACT GCTCAGCCGT GCTGTGCGGG CAGCCCTGGG TGTGCTAGGA 
CCGGAGGTGG AGAAGGAGGC GGTCTCACCG AGGTCAGAGG AGCTGAGTAA TGAAGGGGAC 
TCCCAGCAGA GCCCAGGCCA GCAGAGCCCG CTTCCGGTGG AGCCCGAGCA GGGCCCCGCT 
CCTCTGATGG TGCAGCTGAG CCTCTTGAGG GCAGAGACTG ATCGGCTGCG CGAAATCCTG 
GCGGGGAAGG AACGGGAGTA CCAGGCCCTG GTGCAGCGGG CTCTACAGCG GCTGAATGAG 
GAAGCCCGGA CCTATGTCCT GGCCCCAGAG CCTCCAACTG CTCTTTCAAC GGACCAGGGC 
CTGGTGCAGT GGCTACAGGA ACTGAATGTG GATTCAGGCA CCATCCAAAT GCTGTTGAAC 
CATAGCTTCA CCCTCCACAC TCTGCTCACC TATGCCACTC GAGATGACCT CATCTACACC 
CGCATCAGGG GAGGGATGGT ATGCCGCATC TGGAGGGCCA TCTTGGCACA GCGAGCAGGA 
TCCACACCAG TCACCTCTGG ACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004663.3
CDS	270..4136
Translation	MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP

Target ORF information:

RefSeq Version	NM_004672.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004672.4

ORF Insert Sequence:

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGCT ACACACTGAT CCCCTATGTG 
GTGACGGCCA CTGGTCGGGT GCTGTGTGGT GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 
GGGCTGGTAC AGGCTGGAGT GGGGACCGAG GCCCTGCTCA CTCCCCTGGT GGGCCGGCTT 
GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 
CGGGACATCC GGCAGGCGCG GGAGCGGTTC AGTGGGCCAC AGCTGCGGCA GGAGCTGGCT 
CGCCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 
CTGCTCTCCT ACCGCGATGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT GGAGACGCTG 
CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA CTACACTTTT 
GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGCGAAGG CCCTGTCTGT GCTGCTGCCG 
CTGGTACAGC TTGAGGGCTC TGTGGCGCCC GATCTGTACT GCATGTGTGG CCGTATCTAC 
AAGGACATGT TCTTCAGCTC GGGTTTCCAG GATGCTGGGC ACCGGGAGCA GGCCTATCAC 
TGGTATCGCA AGGCTTTTGA CGTAGAGCCC AGCCTTCACT CAGGCATCAA TGCAGCTGTG 
CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAAG AGCTCCGGCT AATAGGCATG 
AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 
GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 
GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTGTCCGT GATGGAGACC 
TTCCTGCTCT ACCAGCACTT CAGGCCCACG CCAGAGCCCC CTGGAGGGCC ACCACGCCGT 
GCCCACTTCT GGCTCCACTT CTTGCTACAG TCCTGCCAAC CATTCAAGAC AGCCTGTGCC 
CAGGGCGACC AGTGCTTGGT GCTGGTCCTG GAGATGAACA AGGTGCTGCT GCCTGCAAAG 
CTCGAGGTTC GGGGTACTGA CCCAGTAAGC ACAGTGACCC TGAGCCTGCT GGAGCCTGAG 
ACCCAGGACA TTCCCTCCAG CTGGACCTTC CCAGTCGCCT CCATATGCGG AGTCAGCGCC 
TCAAAGCGCG ACGAGCGCTG CTGCTTCCTC TATGCACTCC CCCCGGCTCA GGACGTCCAG 
CTGTGCTTCC CCAGCGTAGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA GGCCTGGGTG 
ACGAACCCGG ATTCCACGGC GCCCGCGGAG GAGGCGGAGG GCGCGGGGGA GATGTTGGAG 
TTTGATTATG AGTACACGGA GACGGGCGAG CGGCTGGTGC TGGGCAAGGG CACGTATGGG 
GTGGTGTACG CGGGCCGCGA TCGCCACACG AGGGTGCGCA TCGCCATCAA GGAGATCCCG 
GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TCGCTCTTCA CAGACGCCTG 
CGCCACAAGA ACATAGTGCG CTATCTGGGC TCAGCTAGCC AGGGCGGCTA CCTTAAGATC 
TTCATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCCTTGC TGCGGTCGGT GTGGGGACCC 
CTGAAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTTGGC 
TACTTGCACG ACAACCACAT CGTGCACAGG GACATAAAAG GGGACAATGT GCTGATCAAC 
ACCTTCAGTG GGCTGCTCAA GATTTCTGAC TTCGGCACCT CCAAGCGGCT GGCAGGCATC 
ACACCTTGCA CTGAGACCTT CACAGGAACT CTGCAGTATA TGGCCCCAGA AATCATTGAC 
CAGGGCCCAC GCGGGTATGG GAAAGCAGCT GACATCTGGT CACTGGGCTG CACTGTCATT 
GAGATGGCCA CAGGTCGCCC CCCCTTCCAC GAGCTCGGGA GCCCACAGGC TGCCATGTTT 
CAGGTGGGTA TGTACAAGGT CCATCCGCCA ATGCCCAGCT CTCTGTCGGC CGAGGCCCAA 
GCCTTTCTCC TCCGAACTTT TGAGCCAGAC CCCCGCCTCC GAGCCAGCGC CCAGACACTG 
CTGGGGGACC CCTTCCTGCA GCCTGGGAAA AGGAGCCGCA GCCCCAGCTC CCCACGACAT 
GCTCCACGGC CCTCAGATGC CCCTTCTGCC AGTCCCACTC CTTCAGCCAA CTCAACCACC 
CAGTCTCAGA CATTCCCGTG CCCTCAGGCA CCCTCTCAGC ACCCACCCAG CCCCCCGAAG 
CGCTGCCTCA GTTATGGGGG CACCAGCCAG CTCCGGGTGC CCGAGGAGCC TGCGGCCGAG 
GAGCCTGCGT CTCCGGAGGA GAGTTCGGGG CTGAGCCTGC TGCACCAGGA GAGCAAGCGT 
CGGGCCATGC TGGCCGCAGT ATTGGAGCAG GAGCTGCCAG CGCTGGCGGA GAATCTGCAC 
CAGGAGCAGA AGCAAGAGCA GGGGGCCCGT CTGGGCAGAA ACCATGTGGA AGAGCTGCTG 
CGCTGCCTCG GGGCACACAT CCACACTCCC AACCGCCGGC AGCTCGCCCA GGAGCTGCGG 
GCGCTGCAAG GACGGCTGAG GGCCCAGGGC CTTGGGCCTG CGCTTCTGCA CAGACCGCTG 
TTTGCCTTCC CGGATGCGGT GAAGCAGATC CTCCGCAAGC GCCAGATCCG TCCACACTGG 
ATGTTCGTTC TGGACTCACT GCTCAGCCGT GCTGTGCGGG CAGCCCTGGG TGTGCTAGGA 
CCGGAGGTGG AGAAGGAGGC GGTCTCACCG AGGTCAGAGG AGCTGAGTAA TGAAGGGGAC 
TCCCAGCAGA GCCCAGGCCA GCAGAGCCCG CTTCCGGTGG AGCCCGAGCA GGGCCCCGCT 
CCTCTGATGG TGCAGCTGAG CCTCTTGAGG GCAGAGACTG ATCGGCTGCG CGAAATCCTG 
GCGGGGAAGG AACGGGAGTA CCAGGCCCTG GTGCAGCGGG CTCTACAGCG GCTGAATGAG 
GAAGCCCGGA CCTATGTCCT GGCCCCAGAG CCTCCAACTG CTCTTTCAAC GGACCAGGGC 
CTGGTGCAGT GGCTACAGGA ACTGAATGTG GATTCAGGCA CCATCCAAAT GCTGTTGAAC 
CATAGCTTCA CCCTCCACAC TCTGCTCACC TATGCCACTC GAGATGACCT CATCTACACC 
CGCATCAGGG GAGGGATGGT ATGCCGCATC TGGAGGGCCA TCTTGGCACA GCGAGCAGGA 
TCCACACCAG TCACCTCTGG ACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K6 ( NM_004672.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004663.3 Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 1, mRNA.

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CloneID	OHu28867
Clone ID Related Accession (Same CDS sequence)	NM_004672.4 , NM_004672.5
Accession Version	NM_004672.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from FO393419.1, AW771625.1, AB167411.1 and AF100318.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004672.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AB167411.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357582.3/ ENSP00000350195.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGCT ACACACTGAT CCCCTATGTG 
GTGACGGCCA CTGGTCGGGT GCTGTGTGGT GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 
GGGCTGGTAC AGGCTGGAGT GGGGACCGAG GCCCTGCTCA CTCCCCTGGT GGGCCGGCTT 
GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 
CGGGACATCC GGCAGGCGCG GGAGCGGTTC AGTGGGCCAC AGCTGCGGCA GGAGCTGGCT 
CGCCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 
CTGCTCTCCT ACCGCGATGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT GGAGACGCTG 
CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA CTACACTTTT 
GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGCGAAGG CCCTGTCTGT GCTGCTGCCG 
CTGGTACAGC TTGAGGGCTC TGTGGCGCCC GATCTGTACT GCATGTGTGG CCGTATCTAC 
AAGGACATGT TCTTCAGCTC GGGTTTCCAG GATGCTGGGC ACCGGGAGCA GGCCTATCAC 
TGGTATCGCA AGGCTTTTGA CGTAGAGCCC AGCCTTCACT CAGGCATCAA TGCAGCTGTG 
CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAAG AGCTCCGGCT AATAGGCATG 
AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 
GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 
GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTGTCCGT GATGGAGACC 
TTCCTGCTCT ACCAGCACTT CAGGCCCACG CCAGAGCCCC CTGGAGGGCC ACCACGCCGT 
GCCCACTTCT GGCTCCACTT CTTGCTACAG TCCTGCCAAC CATTCAAGAC AGCCTGTGCC 
CAGGGCGACC AGTGCTTGGT GCTGGTCCTG GAGATGAACA AGGTGCTGCT GCCTGCAAAG 
CTCGAGGTTC GGGGTACTGA CCCAGTAAGC ACAGTGACCC TGAGCCTGCT GGAGCCTGAG 
ACCCAGGACA TTCCCTCCAG CTGGACCTTC CCAGTCGCCT CCATATGCGG AGTCAGCGCC 
TCAAAGCGCG ACGAGCGCTG CTGCTTCCTC TATGCACTCC CCCCGGCTCA GGACGTCCAG 
CTGTGCTTCC CCAGCGTAGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA GGCCTGGGTG 
ACGAACCCGG ATTCCACGGC GCCCGCGGAG GAGGCGGAGG GCGCGGGGGA GATGTTGGAG 
TTTGATTATG AGTACACGGA GACGGGCGAG CGGCTGGTGC TGGGCAAGGG CACGTATGGG 
GTGGTGTACG CGGGCCGCGA TCGCCACACG AGGGTGCGCA TCGCCATCAA GGAGATCCCG 
GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TCGCTCTTCA CAGACGCCTG 
CGCCACAAGA ACATAGTGCG CTATCTGGGC TCAGCTAGCC AGGGCGGCTA CCTTAAGATC 
TTCATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCCTTGC TGCGGTCGGT GTGGGGACCC 
CTGAAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTTGGC 
TACTTGCACG ACAACCACAT CGTGCACAGG GACATAAAAG GGGACAATGT GCTGATCAAC 
ACCTTCAGTG GGCTGCTCAA GATTTCTGAC TTCGGCACCT CCAAGCGGCT GGCAGGCATC 
ACACCTTGCA CTGAGACCTT CACAGGAACT CTGCAGTATA TGGCCCCAGA AATCATTGAC 
CAGGGCCCAC GCGGGTATGG GAAAGCAGCT GACATCTGGT CACTGGGCTG CACTGTCATT 
GAGATGGCCA CAGGTCGCCC CCCCTTCCAC GAGCTCGGGA GCCCACAGGC TGCCATGTTT 
CAGGTGGGTA TGTACAAGGT CCATCCGCCA ATGCCCAGCT CTCTGTCGGC CGAGGCCCAA 
GCCTTTCTCC TCCGAACTTT TGAGCCAGAC CCCCGCCTCC GAGCCAGCGC CCAGACACTG 
CTGGGGGACC CCTTCCTGCA GCCTGGGAAA AGGAGCCGCA GCCCCAGCTC CCCACGACAT 
GCTCCACGGC CCTCAGATGC CCCTTCTGCC AGTCCCACTC CTTCAGCCAA CTCAACCACC 
CAGTCTCAGA CATTCCCGTG CCCTCAGGCA CCCTCTCAGC ACCCACCCAG CCCCCCGAAG 
CGCTGCCTCA GTTATGGGGG CACCAGCCAG CTCCGGGTGC CCGAGGAGCC TGCGGCCGAG 
GAGCCTGCGT CTCCGGAGGA GAGTTCGGGG CTGAGCCTGC TGCACCAGGA GAGCAAGCGT 
CGGGCCATGC TGGCCGCAGT ATTGGAGCAG GAGCTGCCAG CGCTGGCGGA GAATCTGCAC 
CAGGAGCAGA AGCAAGAGCA GGGGGCCCGT CTGGGCAGAA ACCATGTGGA AGAGCTGCTG 
CGCTGCCTCG GGGCACACAT CCACACTCCC AACCGCCGGC AGCTCGCCCA GGAGCTGCGG 
GCGCTGCAAG GACGGCTGAG GGCCCAGGGC CTTGGGCCTG CGCTTCTGCA CAGACCGCTG 
TTTGCCTTCC CGGATGCGGT GAAGCAGATC CTCCGCAAGC GCCAGATCCG TCCACACTGG 
ATGTTCGTTC TGGACTCACT GCTCAGCCGT GCTGTGCGGG CAGCCCTGGG TGTGCTAGGA 
CCGGAGGTGG AGAAGGAGGC GGTCTCACCG AGGTCAGAGG AGCTGAGTAA TGAAGGGGAC 
TCCCAGCAGA GCCCAGGCCA GCAGAGCCCG CTTCCGGTGG AGCCCGAGCA GGGCCCCGCT 
CCTCTGATGG TGCAGCTGAG CCTCTTGAGG GCAGAGACTG ATCGGCTGCG CGAAATCCTG 
GCGGGGAAGG AACGGGAGTA CCAGGCCCTG GTGCAGCGGG CTCTACAGCG GCTGAATGAG 
GAAGCCCGGA CCTATGTCCT GGCCCCAGAG CCTCCAACTG CTCTTTCAAC GGACCAGGGC 
CTGGTGCAGT GGCTACAGGA ACTGAATGTG GATTCAGGCA CCATCCAAAT GCTGTTGAAC 
CATAGCTTCA CCCTCCACAC TCTGCTCACC TATGCCACTC GAGATGACCT CATCTACACC 
CGCATCAGGG GAGGGATGGT ATGCCGCATC TGGAGGGCCA TCTTGGCACA GCGAGCAGGA 
TCCACACCAG TCACCTCTGG ACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004663.3
CDS	365..4231
Translation	MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP

Target ORF information:

RefSeq Version	NM_004672.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004672.5

ORF Insert Sequence:

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGCT ACACACTGAT CCCCTATGTG 
GTGACGGCCA CTGGTCGGGT GCTGTGTGGT GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 
GGGCTGGTAC AGGCTGGAGT GGGGACCGAG GCCCTGCTCA CTCCCCTGGT GGGCCGGCTT 
GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 
CGGGACATCC GGCAGGCGCG GGAGCGGTTC AGTGGGCCAC AGCTGCGGCA GGAGCTGGCT 
CGCCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 
CTGCTCTCCT ACCGCGATGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT GGAGACGCTG 
CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA CTACACTTTT 
GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGCGAAGG CCCTGTCTGT GCTGCTGCCG 
CTGGTACAGC TTGAGGGCTC TGTGGCGCCC GATCTGTACT GCATGTGTGG CCGTATCTAC 
AAGGACATGT TCTTCAGCTC GGGTTTCCAG GATGCTGGGC ACCGGGAGCA GGCCTATCAC 
TGGTATCGCA AGGCTTTTGA CGTAGAGCCC AGCCTTCACT CAGGCATCAA TGCAGCTGTG 
CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAAG AGCTCCGGCT AATAGGCATG 
AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 
GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 
GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTGTCCGT GATGGAGACC 
TTCCTGCTCT ACCAGCACTT CAGGCCCACG CCAGAGCCCC CTGGAGGGCC ACCACGCCGT 
GCCCACTTCT GGCTCCACTT CTTGCTACAG TCCTGCCAAC CATTCAAGAC AGCCTGTGCC 
CAGGGCGACC AGTGCTTGGT GCTGGTCCTG GAGATGAACA AGGTGCTGCT GCCTGCAAAG 
CTCGAGGTTC GGGGTACTGA CCCAGTAAGC ACAGTGACCC TGAGCCTGCT GGAGCCTGAG 
ACCCAGGACA TTCCCTCCAG CTGGACCTTC CCAGTCGCCT CCATATGCGG AGTCAGCGCC 
TCAAAGCGCG ACGAGCGCTG CTGCTTCCTC TATGCACTCC CCCCGGCTCA GGACGTCCAG 
CTGTGCTTCC CCAGCGTAGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA GGCCTGGGTG 
ACGAACCCGG ATTCCACGGC GCCCGCGGAG GAGGCGGAGG GCGCGGGGGA GATGTTGGAG 
TTTGATTATG AGTACACGGA GACGGGCGAG CGGCTGGTGC TGGGCAAGGG CACGTATGGG 
GTGGTGTACG CGGGCCGCGA TCGCCACACG AGGGTGCGCA TCGCCATCAA GGAGATCCCG 
GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TCGCTCTTCA CAGACGCCTG 
CGCCACAAGA ACATAGTGCG CTATCTGGGC TCAGCTAGCC AGGGCGGCTA CCTTAAGATC 
TTCATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCCTTGC TGCGGTCGGT GTGGGGACCC 
CTGAAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTTGGC 
TACTTGCACG ACAACCACAT CGTGCACAGG GACATAAAAG GGGACAATGT GCTGATCAAC 
ACCTTCAGTG GGCTGCTCAA GATTTCTGAC TTCGGCACCT CCAAGCGGCT GGCAGGCATC 
ACACCTTGCA CTGAGACCTT CACAGGAACT CTGCAGTATA TGGCCCCAGA AATCATTGAC 
CAGGGCCCAC GCGGGTATGG GAAAGCAGCT GACATCTGGT CACTGGGCTG CACTGTCATT 
GAGATGGCCA CAGGTCGCCC CCCCTTCCAC GAGCTCGGGA GCCCACAGGC TGCCATGTTT 
CAGGTGGGTA TGTACAAGGT CCATCCGCCA ATGCCCAGCT CTCTGTCGGC CGAGGCCCAA 
GCCTTTCTCC TCCGAACTTT TGAGCCAGAC CCCCGCCTCC GAGCCAGCGC CCAGACACTG 
CTGGGGGACC CCTTCCTGCA GCCTGGGAAA AGGAGCCGCA GCCCCAGCTC CCCACGACAT 
GCTCCACGGC CCTCAGATGC CCCTTCTGCC AGTCCCACTC CTTCAGCCAA CTCAACCACC 
CAGTCTCAGA CATTCCCGTG CCCTCAGGCA CCCTCTCAGC ACCCACCCAG CCCCCCGAAG 
CGCTGCCTCA GTTATGGGGG CACCAGCCAG CTCCGGGTGC CCGAGGAGCC TGCGGCCGAG 
GAGCCTGCGT CTCCGGAGGA GAGTTCGGGG CTGAGCCTGC TGCACCAGGA GAGCAAGCGT 
CGGGCCATGC TGGCCGCAGT ATTGGAGCAG GAGCTGCCAG CGCTGGCGGA GAATCTGCAC 
CAGGAGCAGA AGCAAGAGCA GGGGGCCCGT CTGGGCAGAA ACCATGTGGA AGAGCTGCTG 
CGCTGCCTCG GGGCACACAT CCACACTCCC AACCGCCGGC AGCTCGCCCA GGAGCTGCGG 
GCGCTGCAAG GACGGCTGAG GGCCCAGGGC CTTGGGCCTG CGCTTCTGCA CAGACCGCTG 
TTTGCCTTCC CGGATGCGGT GAAGCAGATC CTCCGCAAGC GCCAGATCCG TCCACACTGG 
ATGTTCGTTC TGGACTCACT GCTCAGCCGT GCTGTGCGGG CAGCCCTGGG TGTGCTAGGA 
CCGGAGGTGG AGAAGGAGGC GGTCTCACCG AGGTCAGAGG AGCTGAGTAA TGAAGGGGAC 
TCCCAGCAGA GCCCAGGCCA GCAGAGCCCG CTTCCGGTGG AGCCCGAGCA GGGCCCCGCT 
CCTCTGATGG TGCAGCTGAG CCTCTTGAGG GCAGAGACTG ATCGGCTGCG CGAAATCCTG 
GCGGGGAAGG AACGGGAGTA CCAGGCCCTG GTGCAGCGGG CTCTACAGCG GCTGAATGAG 
GAAGCCCGGA CCTATGTCCT GGCCCCAGAG CCTCCAACTG CTCTTTCAAC GGACCAGGGC 
CTGGTGCAGT GGCTACAGGA ACTGAATGTG GATTCAGGCA CCATCCAAAT GCTGTTGAAC 
CATAGCTTCA CCCTCCACAC TCTGCTCACC TATGCCACTC GAGATGACCT CATCTACACC 
CGCATCAGGG GAGGGATGGT ATGCCGCATC TGGAGGGCCA TCTTGGCACA GCGAGCAGGA 
TCCACACCAG TCACCTCTGG ACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K6 ( NM_001297609.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284538.1 Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28868
Clone ID Related Accession (Same CDS sequence)	NM_001297609.2 , NM_001297609.1
Accession Version	NM_001297609.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from FO393419.1, AW771625.1, AB208805.1 and AI658745.1. On May 31, 2019 this sequence version replaced NM_001297609.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AB208805.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GATTGCGTTG GCAGCTACAC ACTGATCCCC TATGTGGTGA CGGCCACTGG TCGGGTGCTG 
TGTGGTGATG CAGGCCTTCT GCGGGGCCTG GCTGATGGGC TGGTACAGGC TGGAGTGGGG 
ACCGAGGCCC TGCTCACTCC CCTGGTGGGC CGGCTTGCCC GCCTGCTGGA GGCCACACCC 
ACAGACTCTT GTGGCTATTT CCGGGAGACC ATTCGGCGGG ACATCCGGCA GGCGCGGGAG 
CGGTTCAGTG GGCCACAGCT GCGGCAGGAG CTGGCTCGCC TGCAGCGGAG ACTGGACAGC 
GTGGAGCTGC TGAGCCCCGA CATCATCATG AACTTGCTGC TCTCCTACCG CGATGTGCAG 
GACTACTCGG CCATCATTGA GCTGGTGGAG ACGCTGCAGG CCTTGCCCAC CTGTGATGTG 
GCCGAGCAGC ATAATGTCTG CTTCCACTAC ACTTTTGCCC TCAACCGGAG GAACAGGCCT 
GGGGACCGGG CGAAGGCCCT GTCTGTGCTG CTGCCGCTGG TACAGCTTGA GGGCTCTGTG 
GCGCCCGATC TGTACTGCAT GTGTGGCCGT ATCTACAAGG ACATGTTCTT CAGCTCGGGT 
TTCCAGGATG CTGGGCACCG GGAGCAGGCC TATCACTGGT ATCGCAAGGC TTTTGACGTA 
GAGCCCAGCC TTCACTCAGG CATCAATGCA GCTGTGCTCC TCATTGCTGC CGGGCAGCAC 
TTTGAGGATT CCAAAGAGCT CCGGCTAATA GGCATGAAGC TGGGCTGCCT GCTGGCCCGC 
AAAGGCTGCG TGGAGAAGAT GCAGTATTAC TGGGATGTGG GTTTCTACCT GGGAGCCCAG 
ATCCTCGCCA ATGACCCCAC CCAGGTGGTG CTGGCTGCAG AGCAGCTGTA TAAGCTCAAT 
GCCCCCATAT GGTACCTGGT GTCCGTGATG GAGACCTTCC TGCTCTACCA GCACTTCAGG 
CCCACGCCAG AGCCCCCTGG AGGGCCACCA CGCCGTGCCC ACTTCTGGCT CCACTTCTTG 
CTACAGTCCT GCCAACCATT CAAGACAGCC TGTGCCCAGG GCGACCAGTG CTTGGTGCTG 
GTCCTGGAGA TGAACAAGGT GCTGCTGCCT GCAAAGCTCG AGGTTCGGGG TACTGACCCA 
GTAAGCACAG TGACCCTGAG CCTGCTGGAG CCTGAGACCC AGGACATTCC CTCCAGCTGG 
ACCTTCCCAG TCGCCTCCAT ATGCGGAGTC AGCGCCTCAA AGCGCGACGA GCGCTGCTGC 
TTCCTCTATG CACTCCCCCC GGCTCAGGAC GTCCAGCTGT GCTTCCCCAG CGTAGGGCAC 
TGCCAGTGGT TCTGCGGCCT GATCCAGGCC TGGGTGACGA ACCCGGATTC CACGGCGCCC 
GCGGAGGAGG CGGAGGGCGC GGGGGAGATG TTGGAGTTTG ATTATGAGTA CACGGAGACG 
GGCGAGCGGC TGGTGCTGGG CAAGGGCACG TATGGGGTGG TGTACGCGGG CCGCGATCGC 
CACACGAGGG TGCGCATCGC CATCAAGGAG ATCCCGGAGC GGGACAGCAG GTTCTCTCAG 
CCCCTGCATG AAGAGATCGC TCTTCACAGA CGCCTGCGCC ACAAGAACAT AGTGCGCTAT 
CTGGGCTCAG CTAGCCAGGG CGGCTACCTT AAGATCTTCA TGGAGGAAGT GCCTGGAGGC 
AGCCTGTCCT CCTTGCTGCG GTCGGTGTGG GGACCCCTGA AGGACAACGA GAGCACCATC 
AGTTTCTACA CCCGCCAGAT CCTGCAGGGA CTTGGCTACT TGCACGACAA CCACATCGTG 
CACAGGGACA TAAAAGGGGA CAATGTGCTG ATCAACACCT TCAGTGGGCT GCTCAAGATT 
TCTGACTTCG GCACCTCCAA GCGGCTGGCA GGCATCACAC CTTGCACTGA GACCTTCACA 
GGAACTCTGC AGTATATGGC CCCAGAAATC ATTGACCAGG GCCCACGCGG GTATGGGAAA 
GCAGCTGACA TCTGGTCACT GGGCTGCACT GTCATTGAGA TGGCCACAGG TCGCCCCCCC 
TTCCACGAGC TCGGGAGCCC ACAGGCTGCC ATGTTTCAGG TGGGTATGTA CAAGGTCCAT 
CCGCCAATGC CCAGCTCTCT GTCGGCCGAG GCCCAAGCCT TTCTCCTCCG AACTTTTGAG 
CCAGACCCCC GCCTCCGAGC CAGCGCCCAG ACACTGCTGG GGGACCCCTT CCTGCAGCCT 
GGGAAAAGGA GCCGCAGCCC CAGCTCCCCA CGACATGCTC CACGGCCCTC AGATGCCCCT 
TCTGCCAGTC CCACTCCTTC AGCCAACTCA ACCACCCAGT CTCAGACATT CCCGTGCCCT 
CAGGCACCCT CTCAGCACCC ACCCAGCCCC CCGAAGCGCT GCCTCAGTTA TGGGGGCACC 
AGCCAGCTCC GGGTGCCCGA GGAGCCTGCG GCCGAGGAGC CTGCGTCTCC GGAGGAGAGT 
TCGGGGCTGA GCCTGCTGCA CCAGGAGAGC AAGCGTCGGG CCATGCTGGC CGCAGTATTG 
GAGCAGGAGC TGCCAGCGCT GGCGGAGAAT CTGCACCAGG AGCAGAAGCA AGAGCAGGGG 
GCCCGTCTGG GCAGAAACCA TGTGGAAGAG CTGCTGCGCT GCCTCGGGGC ACACATCCAC 
ACTCCCAACC GCCGGCAGCT CGCCCAGGAG CTGCGGGCGC TGCAAGGACG GCTGAGGGCC 
CAGGGCCTTG GGCCTGCGCT TCTGCACAGA CCGCTGTTTG CCTTCCCGGA TGCGGTGAAG 
CAGATCCTCC GCAAGCGCCA GATCCGTCCA CACTGGATGT TCGTTCTGGA CTCACTGCTC 
AGCCGTGCTG TGCGGGCAGC CCTGGGTGTG CTAGGACCGG AGGTGGAGAA GGAGGCGGTC 
TCACCGAGGT CAGAGGAGCT GAGTAATGAA GGGGACTCCC AGCAGAGCCC AGGCCAGCAG 
AGCCCGCTTC CGGTGGAGCC CGAGCAGGGC CCCGCTCCTC TGATGGTGCA GCTGAGCCTC 
TTGAGGGCAG AGACTGATCG GCTGCGCGAA ATCCTGGCGG GGAAGGAACG GGAGTACCAG 
GCCCTGGTGC AGCGGGCTCT ACAGCGGCTG AATGAGGAAG CCCGGACCTA TGTCCTGGCC 
CCAGAGCCTC CAACTGCTCT TTCAACGGAC CAGGGCCTGG TGCAGTGGCT ACAGGAACTG 
AATGTGGATT CAGGCACCAT CCAAATGCTG TTGAACCATA GCTTCACCCT CCACACTCTG 
CTCACCTATG CCACTCGAGA TGACCTCATC TACACCCGCA TCAGGGGAGG GATGGTATGC 
CGCATCTGGA GGGCCATCTT GGCACAGCGA GCAGGATCCA CACCAGTCAC CTCTGGACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284538.1
CDS	365..4207
Translation	MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALRDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP

Target ORF information:

RefSeq Version	NM_001297609.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297609.2

ORF Insert Sequence:

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GATTGCGTTG GCAGCTACAC ACTGATCCCC TATGTGGTGA CGGCCACTGG TCGGGTGCTG 
TGTGGTGATG CAGGCCTTCT GCGGGGCCTG GCTGATGGGC TGGTACAGGC TGGAGTGGGG 
ACCGAGGCCC TGCTCACTCC CCTGGTGGGC CGGCTTGCCC GCCTGCTGGA GGCCACACCC 
ACAGACTCTT GTGGCTATTT CCGGGAGACC ATTCGGCGGG ACATCCGGCA GGCGCGGGAG 
CGGTTCAGTG GGCCACAGCT GCGGCAGGAG CTGGCTCGCC TGCAGCGGAG ACTGGACAGC 
GTGGAGCTGC TGAGCCCCGA CATCATCATG AACTTGCTGC TCTCCTACCG CGATGTGCAG 
GACTACTCGG CCATCATTGA GCTGGTGGAG ACGCTGCAGG CCTTGCCCAC CTGTGATGTG 
GCCGAGCAGC ATAATGTCTG CTTCCACTAC ACTTTTGCCC TCAACCGGAG GAACAGGCCT 
GGGGACCGGG CGAAGGCCCT GTCTGTGCTG CTGCCGCTGG TACAGCTTGA GGGCTCTGTG 
GCGCCCGATC TGTACTGCAT GTGTGGCCGT ATCTACAAGG ACATGTTCTT CAGCTCGGGT 
TTCCAGGATG CTGGGCACCG GGAGCAGGCC TATCACTGGT ATCGCAAGGC TTTTGACGTA 
GAGCCCAGCC TTCACTCAGG CATCAATGCA GCTGTGCTCC TCATTGCTGC CGGGCAGCAC 
TTTGAGGATT CCAAAGAGCT CCGGCTAATA GGCATGAAGC TGGGCTGCCT GCTGGCCCGC 
AAAGGCTGCG TGGAGAAGAT GCAGTATTAC TGGGATGTGG GTTTCTACCT GGGAGCCCAG 
ATCCTCGCCA ATGACCCCAC CCAGGTGGTG CTGGCTGCAG AGCAGCTGTA TAAGCTCAAT 
GCCCCCATAT GGTACCTGGT GTCCGTGATG GAGACCTTCC TGCTCTACCA GCACTTCAGG 
CCCACGCCAG AGCCCCCTGG AGGGCCACCA CGCCGTGCCC ACTTCTGGCT CCACTTCTTG 
CTACAGTCCT GCCAACCATT CAAGACAGCC TGTGCCCAGG GCGACCAGTG CTTGGTGCTG 
GTCCTGGAGA TGAACAAGGT GCTGCTGCCT GCAAAGCTCG AGGTTCGGGG TACTGACCCA 
GTAAGCACAG TGACCCTGAG CCTGCTGGAG CCTGAGACCC AGGACATTCC CTCCAGCTGG 
ACCTTCCCAG TCGCCTCCAT ATGCGGAGTC AGCGCCTCAA AGCGCGACGA GCGCTGCTGC 
TTCCTCTATG CACTCCCCCC GGCTCAGGAC GTCCAGCTGT GCTTCCCCAG CGTAGGGCAC 
TGCCAGTGGT TCTGCGGCCT GATCCAGGCC TGGGTGACGA ACCCGGATTC CACGGCGCCC 
GCGGAGGAGG CGGAGGGCGC GGGGGAGATG TTGGAGTTTG ATTATGAGTA CACGGAGACG 
GGCGAGCGGC TGGTGCTGGG CAAGGGCACG TATGGGGTGG TGTACGCGGG CCGCGATCGC 
CACACGAGGG TGCGCATCGC CATCAAGGAG ATCCCGGAGC GGGACAGCAG GTTCTCTCAG 
CCCCTGCATG AAGAGATCGC TCTTCACAGA CGCCTGCGCC ACAAGAACAT AGTGCGCTAT 
CTGGGCTCAG CTAGCCAGGG CGGCTACCTT AAGATCTTCA TGGAGGAAGT GCCTGGAGGC 
AGCCTGTCCT CCTTGCTGCG GTCGGTGTGG GGACCCCTGA AGGACAACGA GAGCACCATC 
AGTTTCTACA CCCGCCAGAT CCTGCAGGGA CTTGGCTACT TGCACGACAA CCACATCGTG 
CACAGGGACA TAAAAGGGGA CAATGTGCTG ATCAACACCT TCAGTGGGCT GCTCAAGATT 
TCTGACTTCG GCACCTCCAA GCGGCTGGCA GGCATCACAC CTTGCACTGA GACCTTCACA 
GGAACTCTGC AGTATATGGC CCCAGAAATC ATTGACCAGG GCCCACGCGG GTATGGGAAA 
GCAGCTGACA TCTGGTCACT GGGCTGCACT GTCATTGAGA TGGCCACAGG TCGCCCCCCC 
TTCCACGAGC TCGGGAGCCC ACAGGCTGCC ATGTTTCAGG TGGGTATGTA CAAGGTCCAT 
CCGCCAATGC CCAGCTCTCT GTCGGCCGAG GCCCAAGCCT TTCTCCTCCG AACTTTTGAG 
CCAGACCCCC GCCTCCGAGC CAGCGCCCAG ACACTGCTGG GGGACCCCTT CCTGCAGCCT 
GGGAAAAGGA GCCGCAGCCC CAGCTCCCCA CGACATGCTC CACGGCCCTC AGATGCCCCT 
TCTGCCAGTC CCACTCCTTC AGCCAACTCA ACCACCCAGT CTCAGACATT CCCGTGCCCT 
CAGGCACCCT CTCAGCACCC ACCCAGCCCC CCGAAGCGCT GCCTCAGTTA TGGGGGCACC 
AGCCAGCTCC GGGTGCCCGA GGAGCCTGCG GCCGAGGAGC CTGCGTCTCC GGAGGAGAGT 
TCGGGGCTGA GCCTGCTGCA CCAGGAGAGC AAGCGTCGGG CCATGCTGGC CGCAGTATTG 
GAGCAGGAGC TGCCAGCGCT GGCGGAGAAT CTGCACCAGG AGCAGAAGCA AGAGCAGGGG 
GCCCGTCTGG GCAGAAACCA TGTGGAAGAG CTGCTGCGCT GCCTCGGGGC ACACATCCAC 
ACTCCCAACC GCCGGCAGCT CGCCCAGGAG CTGCGGGCGC TGCAAGGACG GCTGAGGGCC 
CAGGGCCTTG GGCCTGCGCT TCTGCACAGA CCGCTGTTTG CCTTCCCGGA TGCGGTGAAG 
CAGATCCTCC GCAAGCGCCA GATCCGTCCA CACTGGATGT TCGTTCTGGA CTCACTGCTC 
AGCCGTGCTG TGCGGGCAGC CCTGGGTGTG CTAGGACCGG AGGTGGAGAA GGAGGCGGTC 
TCACCGAGGT CAGAGGAGCT GAGTAATGAA GGGGACTCCC AGCAGAGCCC AGGCCAGCAG 
AGCCCGCTTC CGGTGGAGCC CGAGCAGGGC CCCGCTCCTC TGATGGTGCA GCTGAGCCTC 
TTGAGGGCAG AGACTGATCG GCTGCGCGAA ATCCTGGCGG GGAAGGAACG GGAGTACCAG 
GCCCTGGTGC AGCGGGCTCT ACAGCGGCTG AATGAGGAAG CCCGGACCTA TGTCCTGGCC 
CCAGAGCCTC CAACTGCTCT TTCAACGGAC CAGGGCCTGG TGCAGTGGCT ACAGGAACTG 
AATGTGGATT CAGGCACCAT CCAAATGCTG TTGAACCATA GCTTCACCCT CCACACTCTG 
CTCACCTATG CCACTCGAGA TGACCTCATC TACACCCGCA TCAGGGGAGG GATGGTATGC 
CGCATCTGGA GGGCCATCTT GGCACAGCGA GCAGGATCCA CACCAGTCAC CTCTGGACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K6 ( NM_001297609.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284538.1 Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28868
Clone ID Related Accession (Same CDS sequence)	NM_001297609.2 , NM_001297609.1
Accession Version	NM_001297609.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW771625.1, AB208805.1, FO393419.1 and AI658745.1. On Jul 4, 2014 this sequence version replaced XM_005246029.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AB208805.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GATTGCGTTG GCAGCTACAC ACTGATCCCC TATGTGGTGA CGGCCACTGG TCGGGTGCTG 
TGTGGTGATG CAGGCCTTCT GCGGGGCCTG GCTGATGGGC TGGTACAGGC TGGAGTGGGG 
ACCGAGGCCC TGCTCACTCC CCTGGTGGGC CGGCTTGCCC GCCTGCTGGA GGCCACACCC 
ACAGACTCTT GTGGCTATTT CCGGGAGACC ATTCGGCGGG ACATCCGGCA GGCGCGGGAG 
CGGTTCAGTG GGCCACAGCT GCGGCAGGAG CTGGCTCGCC TGCAGCGGAG ACTGGACAGC 
GTGGAGCTGC TGAGCCCCGA CATCATCATG AACTTGCTGC TCTCCTACCG CGATGTGCAG 
GACTACTCGG CCATCATTGA GCTGGTGGAG ACGCTGCAGG CCTTGCCCAC CTGTGATGTG 
GCCGAGCAGC ATAATGTCTG CTTCCACTAC ACTTTTGCCC TCAACCGGAG GAACAGGCCT 
GGGGACCGGG CGAAGGCCCT GTCTGTGCTG CTGCCGCTGG TACAGCTTGA GGGCTCTGTG 
GCGCCCGATC TGTACTGCAT GTGTGGCCGT ATCTACAAGG ACATGTTCTT CAGCTCGGGT 
TTCCAGGATG CTGGGCACCG GGAGCAGGCC TATCACTGGT ATCGCAAGGC TTTTGACGTA 
GAGCCCAGCC TTCACTCAGG CATCAATGCA GCTGTGCTCC TCATTGCTGC CGGGCAGCAC 
TTTGAGGATT CCAAAGAGCT CCGGCTAATA GGCATGAAGC TGGGCTGCCT GCTGGCCCGC 
AAAGGCTGCG TGGAGAAGAT GCAGTATTAC TGGGATGTGG GTTTCTACCT GGGAGCCCAG 
ATCCTCGCCA ATGACCCCAC CCAGGTGGTG CTGGCTGCAG AGCAGCTGTA TAAGCTCAAT 
GCCCCCATAT GGTACCTGGT GTCCGTGATG GAGACCTTCC TGCTCTACCA GCACTTCAGG 
CCCACGCCAG AGCCCCCTGG AGGGCCACCA CGCCGTGCCC ACTTCTGGCT CCACTTCTTG 
CTACAGTCCT GCCAACCATT CAAGACAGCC TGTGCCCAGG GCGACCAGTG CTTGGTGCTG 
GTCCTGGAGA TGAACAAGGT GCTGCTGCCT GCAAAGCTCG AGGTTCGGGG TACTGACCCA 
GTAAGCACAG TGACCCTGAG CCTGCTGGAG CCTGAGACCC AGGACATTCC CTCCAGCTGG 
ACCTTCCCAG TCGCCTCCAT ATGCGGAGTC AGCGCCTCAA AGCGCGACGA GCGCTGCTGC 
TTCCTCTATG CACTCCCCCC GGCTCAGGAC GTCCAGCTGT GCTTCCCCAG CGTAGGGCAC 
TGCCAGTGGT TCTGCGGCCT GATCCAGGCC TGGGTGACGA ACCCGGATTC CACGGCGCCC 
GCGGAGGAGG CGGAGGGCGC GGGGGAGATG TTGGAGTTTG ATTATGAGTA CACGGAGACG 
GGCGAGCGGC TGGTGCTGGG CAAGGGCACG TATGGGGTGG TGTACGCGGG CCGCGATCGC 
CACACGAGGG TGCGCATCGC CATCAAGGAG ATCCCGGAGC GGGACAGCAG GTTCTCTCAG 
CCCCTGCATG AAGAGATCGC TCTTCACAGA CGCCTGCGCC ACAAGAACAT AGTGCGCTAT 
CTGGGCTCAG CTAGCCAGGG CGGCTACCTT AAGATCTTCA TGGAGGAAGT GCCTGGAGGC 
AGCCTGTCCT CCTTGCTGCG GTCGGTGTGG GGACCCCTGA AGGACAACGA GAGCACCATC 
AGTTTCTACA CCCGCCAGAT CCTGCAGGGA CTTGGCTACT TGCACGACAA CCACATCGTG 
CACAGGGACA TAAAAGGGGA CAATGTGCTG ATCAACACCT TCAGTGGGCT GCTCAAGATT 
TCTGACTTCG GCACCTCCAA GCGGCTGGCA GGCATCACAC CTTGCACTGA GACCTTCACA 
GGAACTCTGC AGTATATGGC CCCAGAAATC ATTGACCAGG GCCCACGCGG GTATGGGAAA 
GCAGCTGACA TCTGGTCACT GGGCTGCACT GTCATTGAGA TGGCCACAGG TCGCCCCCCC 
TTCCACGAGC TCGGGAGCCC ACAGGCTGCC ATGTTTCAGG TGGGTATGTA CAAGGTCCAT 
CCGCCAATGC CCAGCTCTCT GTCGGCCGAG GCCCAAGCCT TTCTCCTCCG AACTTTTGAG 
CCAGACCCCC GCCTCCGAGC CAGCGCCCAG ACACTGCTGG GGGACCCCTT CCTGCAGCCT 
GGGAAAAGGA GCCGCAGCCC CAGCTCCCCA CGACATGCTC CACGGCCCTC AGATGCCCCT 
TCTGCCAGTC CCACTCCTTC AGCCAACTCA ACCACCCAGT CTCAGACATT CCCGTGCCCT 
CAGGCACCCT CTCAGCACCC ACCCAGCCCC CCGAAGCGCT GCCTCAGTTA TGGGGGCACC 
AGCCAGCTCC GGGTGCCCGA GGAGCCTGCG GCCGAGGAGC CTGCGTCTCC GGAGGAGAGT 
TCGGGGCTGA GCCTGCTGCA CCAGGAGAGC AAGCGTCGGG CCATGCTGGC CGCAGTATTG 
GAGCAGGAGC TGCCAGCGCT GGCGGAGAAT CTGCACCAGG AGCAGAAGCA AGAGCAGGGG 
GCCCGTCTGG GCAGAAACCA TGTGGAAGAG CTGCTGCGCT GCCTCGGGGC ACACATCCAC 
ACTCCCAACC GCCGGCAGCT CGCCCAGGAG CTGCGGGCGC TGCAAGGACG GCTGAGGGCC 
CAGGGCCTTG GGCCTGCGCT TCTGCACAGA CCGCTGTTTG CCTTCCCGGA TGCGGTGAAG 
CAGATCCTCC GCAAGCGCCA GATCCGTCCA CACTGGATGT TCGTTCTGGA CTCACTGCTC 
AGCCGTGCTG TGCGGGCAGC CCTGGGTGTG CTAGGACCGG AGGTGGAGAA GGAGGCGGTC 
TCACCGAGGT CAGAGGAGCT GAGTAATGAA GGGGACTCCC AGCAGAGCCC AGGCCAGCAG 
AGCCCGCTTC CGGTGGAGCC CGAGCAGGGC CCCGCTCCTC TGATGGTGCA GCTGAGCCTC 
TTGAGGGCAG AGACTGATCG GCTGCGCGAA ATCCTGGCGG GGAAGGAACG GGAGTACCAG 
GCCCTGGTGC AGCGGGCTCT ACAGCGGCTG AATGAGGAAG CCCGGACCTA TGTCCTGGCC 
CCAGAGCCTC CAACTGCTCT TTCAACGGAC CAGGGCCTGG TGCAGTGGCT ACAGGAACTG 
AATGTGGATT CAGGCACCAT CCAAATGCTG TTGAACCATA GCTTCACCCT CCACACTCTG 
CTCACCTATG CCACTCGAGA TGACCTCATC TACACCCGCA TCAGGGGAGG GATGGTATGC 
CGCATCTGGA GGGCCATCTT GGCACAGCGA GCAGGATCCA CACCAGTCAC CTCTGGACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284538.1
CDS	270..4112
Translation	MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALRDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP

Target ORF information:

RefSeq Version	NM_001297609.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297609.1

ORF Insert Sequence:

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GATTGCGTTG GCAGCTACAC ACTGATCCCC TATGTGGTGA CGGCCACTGG TCGGGTGCTG 
TGTGGTGATG CAGGCCTTCT GCGGGGCCTG GCTGATGGGC TGGTACAGGC TGGAGTGGGG 
ACCGAGGCCC TGCTCACTCC CCTGGTGGGC CGGCTTGCCC GCCTGCTGGA GGCCACACCC 
ACAGACTCTT GTGGCTATTT CCGGGAGACC ATTCGGCGGG ACATCCGGCA GGCGCGGGAG 
CGGTTCAGTG GGCCACAGCT GCGGCAGGAG CTGGCTCGCC TGCAGCGGAG ACTGGACAGC 
GTGGAGCTGC TGAGCCCCGA CATCATCATG AACTTGCTGC TCTCCTACCG CGATGTGCAG 
GACTACTCGG CCATCATTGA GCTGGTGGAG ACGCTGCAGG CCTTGCCCAC CTGTGATGTG 
GCCGAGCAGC ATAATGTCTG CTTCCACTAC ACTTTTGCCC TCAACCGGAG GAACAGGCCT 
GGGGACCGGG CGAAGGCCCT GTCTGTGCTG CTGCCGCTGG TACAGCTTGA GGGCTCTGTG 
GCGCCCGATC TGTACTGCAT GTGTGGCCGT ATCTACAAGG ACATGTTCTT CAGCTCGGGT 
TTCCAGGATG CTGGGCACCG GGAGCAGGCC TATCACTGGT ATCGCAAGGC TTTTGACGTA 
GAGCCCAGCC TTCACTCAGG CATCAATGCA GCTGTGCTCC TCATTGCTGC CGGGCAGCAC 
TTTGAGGATT CCAAAGAGCT CCGGCTAATA GGCATGAAGC TGGGCTGCCT GCTGGCCCGC 
AAAGGCTGCG TGGAGAAGAT GCAGTATTAC TGGGATGTGG GTTTCTACCT GGGAGCCCAG 
ATCCTCGCCA ATGACCCCAC CCAGGTGGTG CTGGCTGCAG AGCAGCTGTA TAAGCTCAAT 
GCCCCCATAT GGTACCTGGT GTCCGTGATG GAGACCTTCC TGCTCTACCA GCACTTCAGG 
CCCACGCCAG AGCCCCCTGG AGGGCCACCA CGCCGTGCCC ACTTCTGGCT CCACTTCTTG 
CTACAGTCCT GCCAACCATT CAAGACAGCC TGTGCCCAGG GCGACCAGTG CTTGGTGCTG 
GTCCTGGAGA TGAACAAGGT GCTGCTGCCT GCAAAGCTCG AGGTTCGGGG TACTGACCCA 
GTAAGCACAG TGACCCTGAG CCTGCTGGAG CCTGAGACCC AGGACATTCC CTCCAGCTGG 
ACCTTCCCAG TCGCCTCCAT ATGCGGAGTC AGCGCCTCAA AGCGCGACGA GCGCTGCTGC 
TTCCTCTATG CACTCCCCCC GGCTCAGGAC GTCCAGCTGT GCTTCCCCAG CGTAGGGCAC 
TGCCAGTGGT TCTGCGGCCT GATCCAGGCC TGGGTGACGA ACCCGGATTC CACGGCGCCC 
GCGGAGGAGG CGGAGGGCGC GGGGGAGATG TTGGAGTTTG ATTATGAGTA CACGGAGACG 
GGCGAGCGGC TGGTGCTGGG CAAGGGCACG TATGGGGTGG TGTACGCGGG CCGCGATCGC 
CACACGAGGG TGCGCATCGC CATCAAGGAG ATCCCGGAGC GGGACAGCAG GTTCTCTCAG 
CCCCTGCATG AAGAGATCGC TCTTCACAGA CGCCTGCGCC ACAAGAACAT AGTGCGCTAT 
CTGGGCTCAG CTAGCCAGGG CGGCTACCTT AAGATCTTCA TGGAGGAAGT GCCTGGAGGC 
AGCCTGTCCT CCTTGCTGCG GTCGGTGTGG GGACCCCTGA AGGACAACGA GAGCACCATC 
AGTTTCTACA CCCGCCAGAT CCTGCAGGGA CTTGGCTACT TGCACGACAA CCACATCGTG 
CACAGGGACA TAAAAGGGGA CAATGTGCTG ATCAACACCT TCAGTGGGCT GCTCAAGATT 
TCTGACTTCG GCACCTCCAA GCGGCTGGCA GGCATCACAC CTTGCACTGA GACCTTCACA 
GGAACTCTGC AGTATATGGC CCCAGAAATC ATTGACCAGG GCCCACGCGG GTATGGGAAA 
GCAGCTGACA TCTGGTCACT GGGCTGCACT GTCATTGAGA TGGCCACAGG TCGCCCCCCC 
TTCCACGAGC TCGGGAGCCC ACAGGCTGCC ATGTTTCAGG TGGGTATGTA CAAGGTCCAT 
CCGCCAATGC CCAGCTCTCT GTCGGCCGAG GCCCAAGCCT TTCTCCTCCG AACTTTTGAG 
CCAGACCCCC GCCTCCGAGC CAGCGCCCAG ACACTGCTGG GGGACCCCTT CCTGCAGCCT 
GGGAAAAGGA GCCGCAGCCC CAGCTCCCCA CGACATGCTC CACGGCCCTC AGATGCCCCT 
TCTGCCAGTC CCACTCCTTC AGCCAACTCA ACCACCCAGT CTCAGACATT CCCGTGCCCT 
CAGGCACCCT CTCAGCACCC ACCCAGCCCC CCGAAGCGCT GCCTCAGTTA TGGGGGCACC 
AGCCAGCTCC GGGTGCCCGA GGAGCCTGCG GCCGAGGAGC CTGCGTCTCC GGAGGAGAGT 
TCGGGGCTGA GCCTGCTGCA CCAGGAGAGC AAGCGTCGGG CCATGCTGGC CGCAGTATTG 
GAGCAGGAGC TGCCAGCGCT GGCGGAGAAT CTGCACCAGG AGCAGAAGCA AGAGCAGGGG 
GCCCGTCTGG GCAGAAACCA TGTGGAAGAG CTGCTGCGCT GCCTCGGGGC ACACATCCAC 
ACTCCCAACC GCCGGCAGCT CGCCCAGGAG CTGCGGGCGC TGCAAGGACG GCTGAGGGCC 
CAGGGCCTTG GGCCTGCGCT TCTGCACAGA CCGCTGTTTG CCTTCCCGGA TGCGGTGAAG 
CAGATCCTCC GCAAGCGCCA GATCCGTCCA CACTGGATGT TCGTTCTGGA CTCACTGCTC 
AGCCGTGCTG TGCGGGCAGC CCTGGGTGTG CTAGGACCGG AGGTGGAGAA GGAGGCGGTC 
TCACCGAGGT CAGAGGAGCT GAGTAATGAA GGGGACTCCC AGCAGAGCCC AGGCCAGCAG 
AGCCCGCTTC CGGTGGAGCC CGAGCAGGGC CCCGCTCCTC TGATGGTGCA GCTGAGCCTC 
TTGAGGGCAG AGACTGATCG GCTGCGCGAA ATCCTGGCGG GGAAGGAACG GGAGTACCAG 
GCCCTGGTGC AGCGGGCTCT ACAGCGGCTG AATGAGGAAG CCCGGACCTA TGTCCTGGCC 
CCAGAGCCTC CAACTGCTCT TTCAACGGAC CAGGGCCTGG TGCAGTGGCT ACAGGAACTG 
AATGTGGATT CAGGCACCAT CCAAATGCTG TTGAACCATA GCTTCACCCT CCACACTCTG 
CTCACCTATG CCACTCGAGA TGACCTCATC TACACCCGCA TCAGGGGAGG GATGGTATGC 
CGCATCTGGA GGGCCATCTT GGCACAGCGA GCAGGATCCA CACCAGTCAC CTCTGGACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K6 ( XM_017002772.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858261.1 Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant X4, mRNA.

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CloneID	OHu90785
Clone ID Related Accession (Same CDS sequence)	XM_017002772.1
Accession Version	XM_017002772.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2406bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 6 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGCT ACACACTGAT CCCCTATGTG 
GTGACGGCCA CTGGTCGGGT GCTGTGTGGT GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 
GGGCTGGTAC AGGCTGGAGT GGGGACCGAG GCCCTGCTCA CTCCCCTGGT GGGCCGGCTT 
GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 
CGGGACATCC GGCAGGCGCG GGAGCGGTTC AGTGGGCCAC AGCTGCGGCA GGAGCTGGCT 
CGCCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 
CTGCTCTCCT ACCGCGATGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT GGAGACGCTG 
CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA CTACACTTTT 
GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGCGAAGG CCCTGTCTGT GCTGCTGCCG 
CTGGTACAGC TTGAGGGCTC TGTGGCGCCC GATCTGTACT GCATGTGTGG CCGTATCTAC 
AAGGACATGT TCTTCAGCTC GGGTTTCCAG GATGCTGGGC ACCGGGAGCA GGCCTATCAC 
TGGTATCGCA AGGCTTTTGA CGTAGAGCCC AGCCTTCACT CAGGCATCAA TGCAGCTGTG 
CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAAG AGCTCCGGCT AATAGGCATG 
AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 
GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 
GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTGTCCGT GATGGAGACC 
TTCCTGCTCT ACCAGCACTT CAGGCCCACG CCAGAGCCCC CTGGAGGGCC ACCACGCCGT 
GCCCACTTCT GGCTCCACTT CTTGCTACAG TCCTGCCAAC CATTCAAGAC AGCCTGTGCC 
CAGGGCGACC AGTGCTTGGT GCTGGTCCTG GAGATGAACA AGGTGCTGCT GCCTGCAAAG 
CTCGAGGTTC GGGGTACTGA CCCAGTAAGC ACAGTGACCC TGAGCCTGCT GGAGCCTGAG 
ACCCAGGACA TTCCCTCCAG CTGGACCTTC CCAGTCGCCT CCATATGCGG AGTCAGCGCC 
TCAAAGCGCG ACGAGCGCTG CTGCTTCCTC TATGCACTCC CCCCGGCTCA GGACGTCCAG 
CTGTGCTTCC CCAGCGTAGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA GGCCTGGGTG 
ACGAACCCGG ATTCCACGGC GCCCGCGGAG GAGGCGGAGG GCGCGGGGGA GATGTTGGAG 
TTTGATTATG AGTACACGGA GACGGGCGAG CGGCTGGTGC TGGGCAAGGG CACGTATGGG 
GTGGTGTACG CGGGCCGCGA TCGCCACACG AGGGTGCGCA TCGCCATCAA GGAGATCCCG 
GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TCGCTCTTCA CAGACGCCTG 
CGCCACAAGA ACATAGTGCG CTATCTGGGC TCAGCTAGCC AGGGCGGCTA CCTTAAGATC 
TTCATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCCTTGC TGCGGTCGGT GTGGGGACCC 
CTGAAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTTGGC 
TACTTGCACG ACAACCACAT CGTGCACAGG GACATAAAAG GGCCCAGACC AGTGTCCACT 
AATGGCTGTC AATCAGGGGG ACAATGTGCT GATCAACACC TTCAGTGGGC TGCTCAAGAT 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858261.1
CDS	1441..3846
Translation	MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGPRPVSTNGCQSGGQCADQHLQWAAQDF

Target ORF information:

RefSeq Version	XM_017002772.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 6 (MAP3K6), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002772.1

ORF Insert Sequence:

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 
CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 
CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 
CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 
CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 
CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 
AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 
ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 
GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGCT ACACACTGAT CCCCTATGTG 
GTGACGGCCA CTGGTCGGGT GCTGTGTGGT GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 
GGGCTGGTAC AGGCTGGAGT GGGGACCGAG GCCCTGCTCA CTCCCCTGGT GGGCCGGCTT 
GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 
CGGGACATCC GGCAGGCGCG GGAGCGGTTC AGTGGGCCAC AGCTGCGGCA GGAGCTGGCT 
CGCCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 
CTGCTCTCCT ACCGCGATGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT GGAGACGCTG 
CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA CTACACTTTT 
GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGCGAAGG CCCTGTCTGT GCTGCTGCCG 
CTGGTACAGC TTGAGGGCTC TGTGGCGCCC GATCTGTACT GCATGTGTGG CCGTATCTAC 
AAGGACATGT TCTTCAGCTC GGGTTTCCAG GATGCTGGGC ACCGGGAGCA GGCCTATCAC 
TGGTATCGCA AGGCTTTTGA CGTAGAGCCC AGCCTTCACT CAGGCATCAA TGCAGCTGTG 
CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAAG AGCTCCGGCT AATAGGCATG 
AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 
GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 
GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTGTCCGT GATGGAGACC 
TTCCTGCTCT ACCAGCACTT CAGGCCCACG CCAGAGCCCC CTGGAGGGCC ACCACGCCGT 
GCCCACTTCT GGCTCCACTT CTTGCTACAG TCCTGCCAAC CATTCAAGAC AGCCTGTGCC 
CAGGGCGACC AGTGCTTGGT GCTGGTCCTG GAGATGAACA AGGTGCTGCT GCCTGCAAAG 
CTCGAGGTTC GGGGTACTGA CCCAGTAAGC ACAGTGACCC TGAGCCTGCT GGAGCCTGAG 
ACCCAGGACA TTCCCTCCAG CTGGACCTTC CCAGTCGCCT CCATATGCGG AGTCAGCGCC 
TCAAAGCGCG ACGAGCGCTG CTGCTTCCTC TATGCACTCC CCCCGGCTCA GGACGTCCAG 
CTGTGCTTCC CCAGCGTAGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA GGCCTGGGTG 
ACGAACCCGG ATTCCACGGC GCCCGCGGAG GAGGCGGAGG GCGCGGGGGA GATGTTGGAG 
TTTGATTATG AGTACACGGA GACGGGCGAG CGGCTGGTGC TGGGCAAGGG CACGTATGGG 
GTGGTGTACG CGGGCCGCGA TCGCCACACG AGGGTGCGCA TCGCCATCAA GGAGATCCCG 
GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TCGCTCTTCA CAGACGCCTG 
CGCCACAAGA ACATAGTGCG CTATCTGGGC TCAGCTAGCC AGGGCGGCTA CCTTAAGATC 
TTCATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCCTTGC TGCGGTCGGT GTGGGGACCC 
CTGAAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTTGGC 
TACTTGCACG ACAACCACAT CGTGCACAGG GACATAAAAG GGCCCAGACC AGTGTCCACT 
AATGGCTGTC AATCAGGGGG ACAATGTGCT GATCAACACC TTCAGTGGGC TGCTCAAGAT 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of germline aberrations affecting
Journal of medical genetics(2018 Jan)
Weren RDA,van der Post RS,Vogelaar IP,van Krieken JH,Spruijt L,Lubinski J,Jakubowska A,Teodorczyk U,Aalfs CM,van Hest LP,Oliveira C,Kamping EJ,Schackert HK,Ranzani GN,G?mez Garc?a EB,Hes FJ,Holinski-Feder E,Genuardi M,Ausems MGEM,Sijmons RH,Wagner A,van der Kolk LE,Cats A,Bj?rnevoll I,Hoogerbrugge N,Ligtenberg MJL

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Science signaling8(388)ra78(2015 Aug)
Okazaki T,Higuchi M,Takeda K,Iwatsuki-Horimoto K,Kiso M,Miyagishi M,Yanai H,Kato A,Yoneyama M,Fujita T,Taniguchi T,Kawaoka Y,Ichijo H,Gotoh Y

Germline mutations in MAP3K6 are associated with familial gastric cancer.
PLoS genetics10(10)e1004669(2014 Oct)
Gaston D,Hansford S,Oliveira C,Nightingale M,Pinheiro H,Macgillivray C,Kaurah P,Rideout AL,Steele P,Soares G,Huang WY,Whitehouse S,Blowers S,LeBlanc MA,Jiang H,Greer W,Samuels ME,Orr A,Fernandez CV,Majewski J,Ludman M,Dyack S,Penney LS,McMaster CR,Huntsman D,Bedard K

Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome.
Oncogene29(6)822-30(2010 Feb)
Cockrell LM,Puckett MC,Goldman EH,Khuri FR,Fu H

Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression.
The American journal of pathology174(4)1553-63(2009 Apr)
Eto N,Miyagishi M,Inagi R,Fujita T,Nangaku M

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MAP3K6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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