SIGLEC12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIGLEC12
Entrez Gene ID	89858
Full Name	sialic acid binding Ig like lectin 12 (gene/pseudogene)
Synonyms	S2V,SIGLECL1,SLG,Siglec-XII
General protein information	Preferred Names sialic acid binding Ig like lectin 12 (gene/pseudogene) Names sialic acid-binding Ig-like lectin 12 SIGLEC-like 1 sialic acid binding Ig-like lectin 12 sialic acid-binding Ig-like lectin-like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.41
Summary	Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Disorder MIM:	606094

mRNA and Protein(s)

mRNA	Protein	Name
XM_011527441.2	XP_011525743.1	sialic acid-binding Ig-like lectin 12 isoform X1
NM_053003.3	NP_443729.1	sialic acid-binding Ig-like lectin 12 isoform a precursor
NM_033329.2	NP_201586.1	sialic acid-binding Ig-like lectin 12 isoform b precursor
XM_011527442.2	XP_011525744.1	sialic acid-binding Ig-like lectin 12 isoform X2
NM_053003.4	NP_443729.1	sialic acid-binding Ig-like lectin 12 isoform a precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes.
McDonough CW, Gong Y, Padmanabhan S, Burkley B, Langaee TY, Melander O, Pepine CJ, Dominiczak AF, Cooper-Dehoff RM, Johnson JA
Hypertension (Dallas, Tex. : 1979)62(1)48-54(2013 Jul)

SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
Mitra N, Banda K, Altheide TK, Schaffer L, Johnson-Pais TL, Beuten J, Leach RJ, Angata T, Varki N, Varki A
The Journal of biological chemistry286(26)23003-11(2011 Jul)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes and immunity11(3)232-8(2010 Apr)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cardiovascular outcomes may differ based on SIGLEC12 genotype, and antihypertensive treatment strategy.
Title: Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes.

SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
Title: SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following SIGLEC12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIGLEC12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00552	NM_053003.4 Latest version!	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu00169	NM_033329.2 Latest version!	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu00169	XM_011527441.2 Latest version!	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu74106	XM_011527442.2 Latest version!	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu00552	NM_053003.3	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIGLEC12 ( NM_053003.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_443729.1 Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00552
Clone ID Related Accession (Same CDS sequence)	NM_053003.3 , NM_053003.4
Accession Version	NM_053003.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1788bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 12 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC020914.9, DA562082.1, BC035809.1 and AY358140.1. On May 17, 2019 this sequence version replaced NM_053003.3. Transcript Variant: This variant (1), also known as SLG-Long (SLG-L), encodes the longer isoform (a). Unlike other members of the SIGLEC3-like subfamily, which contain only one V-set immunoglobin-like domain, isoform a contains two. ##Evidence-Data-START## Transcript exon combination :: AY358140.1, BC035809.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000291707.8/ ENSP00000291707.3 polymorphic pseudogene :: PMID: 21555517 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTACTGC TGCTGCTACT GCTGCCACCC CTGCTCTGTG GGAGAGTGGG GGCTAAGGAA 
CAGAAGGATT ACCTGCTGAC AATGCAGAAG TCCGTGACGG TGCAGGAGGG CCTGTGTGTC 
TCTGTGCTTT GCTCCTTCTC CTACCCCCAA AATGGCTGGA CTGCCTCCGA TCCAGTTCAT 
GGCTACTGGT TCCGGGCAGG GGACCATGTA AGCCGGAACA TTCCAGTGGC CACAAACAAC 
CCAGCTCGAG CAGTGCAGGA GGAGACTCGG GACCGATTCC ACCTCCTTGG GGACCCACAG 
AACAAGGATT GTACCCTGAG CATCAGAGAC ACCAGAGAGA GTGATGCAGG GACATACGTC 
TTTTGTGTAG AGAGAGGAAA TATGAAATGG AATTATAAAT ATGACCAGCT CTCTGTGAAT 
GTGACAGCGT CCCAGGACCT ACTGTCAAGA TACAGGCTGG AGGTGCCAGA GTCGGTGACT 
GTGCAGGAGG GTCTGTGTGT CTCTGTGCCC TGCAGTGTCC TTTACCCCCA TTACAACTGG 
ACTGCCTCTA GCCCTGTTTA TGGATCCTGG TTCAAGGAAG GGGCCGATAT ACCATGGGAT 
ATTCCAGTGG CCACAAACAC CCCAAGTGGA AAAGTGCAAG AGGATACCCA CGGTCGATTC 
CTCCTCCTTG GGGACCCACA GACCAACAAC TGCTCCCTGA GCATCAGAGA TGCCAGGAAG 
GGGGATTCAG GGAAGTACTA CTTCCAGGTG GAGAGAGGAA GCAGGAAATG GAACTACATA 
TATGACAAGC TCTCTGTGCA TGTGACAGCC CTGACTCACA TGCCCACCTT CTCCATCCCG 
GGGACCCTGG AGTCTGGCCA CCCCAGGAAC CTGACCTGCT CTGTGCCCTG GGCCTGTGAA 
CAGGGGACGC CCCCCACGAT CACCTGGATG GGGGCCTCCG TGTCCTCCCT GGACCCCACT 
ATCACTCGCT CCTCGATGCT CAGCCTCATC CCACAGCCCC AGGACCATGG CACCAGCCTC 
ACCTGTCAGG TGACCTTGCC TGGGGCCGGC GTGACCATGA CCAGGGCTGT CCGACTCAAC 
ATATCCTATC CTCCTCAGAA CTTGACCATG ACTGTCTTCC AAGGAGATGG CACAGCATCC 
ACAACCTTGA GGAATGGCTC GGCCCTTTCA GTCCTGGAGG GCCAGTCCCT GCACCTTGTC 
TGTGCTGTCG ACAGCAATCC CCCTGCCAGG CTGAGCTGGA CCTGGGGGAG CCTGACCCTG 
AGCCCCTCAC AGTCCTCGAA CCTTGGGGTG CTGGAGCTGC CTCGAGTGCA TGTGAAGGAT 
GAAGGGGAAT TCACCTGCCG AGCTCAGAAC CCTCTAGGCT CCCAGCACAT TTCCCTGAGC 
CTCTCCCTGC AAAACGAGTA CACAGGCAAA ATGAGGCCTA TATCAGGAGT GACGCTAGGG 
GCATTCGGGG GAGCTGGAGC CACAGCCCTG GTCTTCCTGT ACTTCTGCAT CATCTTCGTT 
GTAGTGAGGT CCTGCAGGAA GAAATCGGCA AGGCCAGCAG TGGGCGTGGG GGATACAGGC 
ATGGAGGACG CAAACGCTGT CAGGGGCTCA GCCTCTCAGG GACCCCTGAT TGAATCCCCG 
GCAGATGACA GCCCCCCACA CCATGCTCCG CCAGCCCTGG CCACCCCCTC CCCAGAGGAA 
GGAGAGATCC AGTATGCATC CCTCAGCTTC CACAAAGCGA GGCCTCAGTA CCCACAGGAA 
CAGGAGGCCA TCGGCTATGA GTACTCCGAG ATCAACATCC CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443729.1
CDS	68..1855
Translation	MLLLLLLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIPK

Target ORF information:

RefSeq Version	NM_053003.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053003.4

ORF Insert Sequence:

ATGCTACTGC TGCTGCTACT GCTGCCACCC CTGCTCTGTG GGAGAGTGGG GGCTAAGGAA 
CAGAAGGATT ACCTGCTGAC AATGCAGAAG TCCGTGACGG TGCAGGAGGG CCTGTGTGTC 
TCTGTGCTTT GCTCCTTCTC CTACCCCCAA AATGGCTGGA CTGCCTCCGA TCCAGTTCAT 
GGCTACTGGT TCCGGGCAGG GGACCATGTA AGCCGGAACA TTCCAGTGGC CACAAACAAC 
CCAGCTCGAG CAGTGCAGGA GGAGACTCGG GACCGATTCC ACCTCCTTGG GGACCCACAG 
AACAAGGATT GTACCCTGAG CATCAGAGAC ACCAGAGAGA GTGATGCAGG GACATACGTC 
TTTTGTGTAG AGAGAGGAAA TATGAAATGG AATTATAAAT ATGACCAGCT CTCTGTGAAT 
GTGACAGCGT CCCAGGACCT ACTGTCAAGA TACAGGCTGG AGGTGCCAGA GTCGGTGACT 
GTGCAGGAGG GTCTGTGTGT CTCTGTGCCC TGCAGTGTCC TTTACCCCCA TTACAACTGG 
ACTGCCTCTA GCCCTGTTTA TGGATCCTGG TTCAAGGAAG GGGCCGATAT ACCATGGGAT 
ATTCCAGTGG CCACAAACAC CCCAAGTGGA AAAGTGCAAG AGGATACCCA CGGTCGATTC 
CTCCTCCTTG GGGACCCACA GACCAACAAC TGCTCCCTGA GCATCAGAGA TGCCAGGAAG 
GGGGATTCAG GGAAGTACTA CTTCCAGGTG GAGAGAGGAA GCAGGAAATG GAACTACATA 
TATGACAAGC TCTCTGTGCA TGTGACAGCC CTGACTCACA TGCCCACCTT CTCCATCCCG 
GGGACCCTGG AGTCTGGCCA CCCCAGGAAC CTGACCTGCT CTGTGCCCTG GGCCTGTGAA 
CAGGGGACGC CCCCCACGAT CACCTGGATG GGGGCCTCCG TGTCCTCCCT GGACCCCACT 
ATCACTCGCT CCTCGATGCT CAGCCTCATC CCACAGCCCC AGGACCATGG CACCAGCCTC 
ACCTGTCAGG TGACCTTGCC TGGGGCCGGC GTGACCATGA CCAGGGCTGT CCGACTCAAC 
ATATCCTATC CTCCTCAGAA CTTGACCATG ACTGTCTTCC AAGGAGATGG CACAGCATCC 
ACAACCTTGA GGAATGGCTC GGCCCTTTCA GTCCTGGAGG GCCAGTCCCT GCACCTTGTC 
TGTGCTGTCG ACAGCAATCC CCCTGCCAGG CTGAGCTGGA CCTGGGGGAG CCTGACCCTG 
AGCCCCTCAC AGTCCTCGAA CCTTGGGGTG CTGGAGCTGC CTCGAGTGCA TGTGAAGGAT 
GAAGGGGAAT TCACCTGCCG AGCTCAGAAC CCTCTAGGCT CCCAGCACAT TTCCCTGAGC 
CTCTCCCTGC AAAACGAGTA CACAGGCAAA ATGAGGCCTA TATCAGGAGT GACGCTAGGG 
GCATTCGGGG GAGCTGGAGC CACAGCCCTG GTCTTCCTGT ACTTCTGCAT CATCTTCGTT 
GTAGTGAGGT CCTGCAGGAA GAAATCGGCA AGGCCAGCAG TGGGCGTGGG GGATACAGGC 
ATGGAGGACG CAAACGCTGT CAGGGGCTCA GCCTCTCAGG GACCCCTGAT TGAATCCCCG 
GCAGATGACA GCCCCCCACA CCATGCTCCG CCAGCCCTGG CCACCCCCTC CCCAGAGGAA 
GGAGAGATCC AGTATGCATC CCTCAGCTTC CACAAAGCGA GGCCTCAGTA CCCACAGGAA 
CAGGAGGCCA TCGGCTATGA GTACTCCGAG ATCAACATCC CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC12 ( NM_033329.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_201586.1 Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00169
Clone ID Related Accession (Same CDS sequence)	XM_011527441.2 , NM_033329.2
Accession Version	NM_033329.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 12 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC020914.9. On Aug 18, 2013 this sequence version replaced NM_033329.1. Transcript Variant: This variant (2), also known as SLG-Short (SLG-S), differs in the 5' UTR and uses an alternate segment in the 5' coding region compared to variant 1, resulting in the use of an alternate in-frame translation initiation codon. It encodes an isoform (b) with a different and shorter N-terminus compared to isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 21555517 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC CCCTGCTATG GGCAAATGAA GAGAGGGACA GTGGGGGCTG GGCTGACCCT 
CGTTTCTCCA CAGCGTCCCA GGACCTACTG TCAAGATACA GGCTGGAGGT GCCAGAGTCG 
GTGACTGTGC AGGAGGGTCT GTGTGTCTCT GTGCCCTGCA GTGTCCTTTA CCCCCATTAC 
AACTGGACTG CCTCTAGCCC TGTTTATGGA TCCTGGTTCA AGGAAGGGGC CGATATACCA 
TGGGATATTC CAGTGGCCAC AAACACCCCA AGTGGAAAAG TGCAAGAGGA TACCCACGGT 
CGATTCCTCC TCCTTGGGGA CCCACAGACC AACAACTGCT CCCTGAGCAT CAGAGATGCC 
AGGAAGGGGG ATTCAGGGAA GTACTACTTC CAGGTGGAGA GAGGAAGCAG GAAATGGAAC 
TACATATATG ACAAGCTCTC TGTGCATGTG ACAGCCCTGA CTCACATGCC CACCTTCTCC 
ATCCCGGGGA CCCTGGAGTC TGGCCACCCC AGGAACCTGA CCTGCTCTGT GCCCTGGGCC 
TGTGAACAGG GGACGCCCCC CACGATCACC TGGATGGGGG CCTCCGTGTC CTCCCTGGAC 
CCCACTATCA CTCGCTCCTC GATGCTCAGC CTCATCCCAC AGCCCCAGGA CCATGGCACC 
AGCCTCACCT GTCAGGTGAC CTTGCCTGGG GCCGGCGTGA CCATGACCAG GGCTGTCCGA 
CTCAACATAT CCTATCCTCC TCAGAACTTG ACCATGACTG TCTTCCAAGG AGATGGCACA 
GCATCCACAA CCTTGAGGAA TGGCTCGGCC CTTTCAGTCC TGGAGGGCCA GTCCCTGCAC 
CTTGTCTGTG CTGTCGACAG CAATCCCCCT GCCAGGCTGA GCTGGACCTG GGGGAGCCTG 
ACCCTGAGCC CCTCACAGTC CTCGAACCTT GGGGTGCTGG AGCTGCCTCG AGTGCATGTG 
AAGGATGAAG GGGAATTCAC CTGCCGAGCT CAGAACCCTC TAGGCTCCCA GCACATTTCC 
CTGAGCCTCT CCCTGCAAAA CGAGTACACA GGCAAAATGA GGCCTATATC AGGAGTGACG 
CTAGGGGCAT TCGGGGGAGC TGGAGCCACA GCCCTGGTCT TCCTGTACTT CTGCATCATC 
TTCGTTGTAG TGAGGTCCTG CAGGAAGAAA TCGGCAAGGC CAGCAGTGGG CGTGGGGGAT 
ACAGGCATGG AGGACGCAAA CGCTGTCAGG GGCTCAGCCT CTCAGGGACC CCTGATTGAA 
TCCCCGGCAG ATGACAGCCC CCCACACCAT GCTCCGCCAG CCCTGGCCAC CCCCTCCCCA 
GAGGAAGGAG AGATCCAGTA TGCATCCCTC AGCTTCCACA AAGCGAGGCC TCAGTACCCA 
CAGGAACAGG AGGCCATCGG CTATGAGTAC TCCGAGATCA ACATCCCCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_201586.1
CDS	21..1454
Translation	MLLPLLWANEERDSGGWADPRFSTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIPK

Target ORF information:

RefSeq Version	NM_033329.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033329.2

ORF Insert Sequence:

ATGCTGCTGC CCCTGCTATG GGCAAATGAA GAGAGGGACA GTGGGGGCTG GGCTGACCCT 
CGTTTCTCCA CAGCGTCCCA GGACCTACTG TCAAGATACA GGCTGGAGGT GCCAGAGTCG 
GTGACTGTGC AGGAGGGTCT GTGTGTCTCT GTGCCCTGCA GTGTCCTTTA CCCCCATTAC 
AACTGGACTG CCTCTAGCCC TGTTTATGGA TCCTGGTTCA AGGAAGGGGC CGATATACCA 
TGGGATATTC CAGTGGCCAC AAACACCCCA AGTGGAAAAG TGCAAGAGGA TACCCACGGT 
CGATTCCTCC TCCTTGGGGA CCCACAGACC AACAACTGCT CCCTGAGCAT CAGAGATGCC 
AGGAAGGGGG ATTCAGGGAA GTACTACTTC CAGGTGGAGA GAGGAAGCAG GAAATGGAAC 
TACATATATG ACAAGCTCTC TGTGCATGTG ACAGCCCTGA CTCACATGCC CACCTTCTCC 
ATCCCGGGGA CCCTGGAGTC TGGCCACCCC AGGAACCTGA CCTGCTCTGT GCCCTGGGCC 
TGTGAACAGG GGACGCCCCC CACGATCACC TGGATGGGGG CCTCCGTGTC CTCCCTGGAC 
CCCACTATCA CTCGCTCCTC GATGCTCAGC CTCATCCCAC AGCCCCAGGA CCATGGCACC 
AGCCTCACCT GTCAGGTGAC CTTGCCTGGG GCCGGCGTGA CCATGACCAG GGCTGTCCGA 
CTCAACATAT CCTATCCTCC TCAGAACTTG ACCATGACTG TCTTCCAAGG AGATGGCACA 
GCATCCACAA CCTTGAGGAA TGGCTCGGCC CTTTCAGTCC TGGAGGGCCA GTCCCTGCAC 
CTTGTCTGTG CTGTCGACAG CAATCCCCCT GCCAGGCTGA GCTGGACCTG GGGGAGCCTG 
ACCCTGAGCC CCTCACAGTC CTCGAACCTT GGGGTGCTGG AGCTGCCTCG AGTGCATGTG 
AAGGATGAAG GGGAATTCAC CTGCCGAGCT CAGAACCCTC TAGGCTCCCA GCACATTTCC 
CTGAGCCTCT CCCTGCAAAA CGAGTACACA GGCAAAATGA GGCCTATATC AGGAGTGACG 
CTAGGGGCAT TCGGGGGAGC TGGAGCCACA GCCCTGGTCT TCCTGTACTT CTGCATCATC 
TTCGTTGTAG TGAGGTCCTG CAGGAAGAAA TCGGCAAGGC CAGCAGTGGG CGTGGGGGAT 
ACAGGCATGG AGGACGCAAA CGCTGTCAGG GGCTCAGCCT CTCAGGGACC CCTGATTGAA 
TCCCCGGCAG ATGACAGCCC CCCACACCAT GCTCCGCCAG CCCTGGCCAC CCCCTCCCCA 
GAGGAAGGAG AGATCCAGTA TGCATCCCTC AGCTTCCACA AAGCGAGGCC TCAGTACCCA 
CAGGAACAGG AGGCCATCGG CTATGAGTAC TCCGAGATCA ACATCCCCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC12 ( NM_053003.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_443729.1 Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00552
Clone ID Related Accession (Same CDS sequence)	NM_053003.3 , NM_053003.4
Accession Version	NM_053003.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1788bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 12 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA562082.1, BC035809.1 and AY358140.1. On Aug 18, 2013 this sequence version replaced NM_053003.2. Transcript Variant: This variant (1), also known as SLG-Long (SLG-L), encodes the longer isoform (a). Unlike other members of the SIGLEC3-like subfamily, which contain only one V-set immunoglobin-like domain, isoform a contains two. ##Evidence-Data-START## Transcript exon combination :: AY358140.1, BC035809.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 21555517 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTACTGC TGCTGCTACT GCTGCCACCC CTGCTCTGTG GGAGAGTGGG GGCTAAGGAA 
CAGAAGGATT ACCTGCTGAC AATGCAGAAG TCCGTGACGG TGCAGGAGGG CCTGTGTGTC 
TCTGTGCTTT GCTCCTTCTC CTACCCCCAA AATGGCTGGA CTGCCTCCGA TCCAGTTCAT 
GGCTACTGGT TCCGGGCAGG GGACCATGTA AGCCGGAACA TTCCAGTGGC CACAAACAAC 
CCAGCTCGAG CAGTGCAGGA GGAGACTCGG GACCGATTCC ACCTCCTTGG GGACCCACAG 
AACAAGGATT GTACCCTGAG CATCAGAGAC ACCAGAGAGA GTGATGCAGG GACATACGTC 
TTTTGTGTAG AGAGAGGAAA TATGAAATGG AATTATAAAT ATGACCAGCT CTCTGTGAAT 
GTGACAGCGT CCCAGGACCT ACTGTCAAGA TACAGGCTGG AGGTGCCAGA GTCGGTGACT 
GTGCAGGAGG GTCTGTGTGT CTCTGTGCCC TGCAGTGTCC TTTACCCCCA TTACAACTGG 
ACTGCCTCTA GCCCTGTTTA TGGATCCTGG TTCAAGGAAG GGGCCGATAT ACCATGGGAT 
ATTCCAGTGG CCACAAACAC CCCAAGTGGA AAAGTGCAAG AGGATACCCA CGGTCGATTC 
CTCCTCCTTG GGGACCCACA GACCAACAAC TGCTCCCTGA GCATCAGAGA TGCCAGGAAG 
GGGGATTCAG GGAAGTACTA CTTCCAGGTG GAGAGAGGAA GCAGGAAATG GAACTACATA 
TATGACAAGC TCTCTGTGCA TGTGACAGCC CTGACTCACA TGCCCACCTT CTCCATCCCG 
GGGACCCTGG AGTCTGGCCA CCCCAGGAAC CTGACCTGCT CTGTGCCCTG GGCCTGTGAA 
CAGGGGACGC CCCCCACGAT CACCTGGATG GGGGCCTCCG TGTCCTCCCT GGACCCCACT 
ATCACTCGCT CCTCGATGCT CAGCCTCATC CCACAGCCCC AGGACCATGG CACCAGCCTC 
ACCTGTCAGG TGACCTTGCC TGGGGCCGGC GTGACCATGA CCAGGGCTGT CCGACTCAAC 
ATATCCTATC CTCCTCAGAA CTTGACCATG ACTGTCTTCC AAGGAGATGG CACAGCATCC 
ACAACCTTGA GGAATGGCTC GGCCCTTTCA GTCCTGGAGG GCCAGTCCCT GCACCTTGTC 
TGTGCTGTCG ACAGCAATCC CCCTGCCAGG CTGAGCTGGA CCTGGGGGAG CCTGACCCTG 
AGCCCCTCAC AGTCCTCGAA CCTTGGGGTG CTGGAGCTGC CTCGAGTGCA TGTGAAGGAT 
GAAGGGGAAT TCACCTGCCG AGCTCAGAAC CCTCTAGGCT CCCAGCACAT TTCCCTGAGC 
CTCTCCCTGC AAAACGAGTA CACAGGCAAA ATGAGGCCTA TATCAGGAGT GACGCTAGGG 
GCATTCGGGG GAGCTGGAGC CACAGCCCTG GTCTTCCTGT ACTTCTGCAT CATCTTCGTT 
GTAGTGAGGT CCTGCAGGAA GAAATCGGCA AGGCCAGCAG TGGGCGTGGG GGATACAGGC 
ATGGAGGACG CAAACGCTGT CAGGGGCTCA GCCTCTCAGG GACCCCTGAT TGAATCCCCG 
GCAGATGACA GCCCCCCACA CCATGCTCCG CCAGCCCTGG CCACCCCCTC CCCAGAGGAA 
GGAGAGATCC AGTATGCATC CCTCAGCTTC CACAAAGCGA GGCCTCAGTA CCCACAGGAA 
CAGGAGGCCA TCGGCTATGA GTACTCCGAG ATCAACATCC CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443729.1
CDS	57..1844
Translation	MLLLLLLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIPK

Target ORF information:

RefSeq Version	NM_053003.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053003.3

ORF Insert Sequence:

ATGCTACTGC TGCTGCTACT GCTGCCACCC CTGCTCTGTG GGAGAGTGGG GGCTAAGGAA 
CAGAAGGATT ACCTGCTGAC AATGCAGAAG TCCGTGACGG TGCAGGAGGG CCTGTGTGTC 
TCTGTGCTTT GCTCCTTCTC CTACCCCCAA AATGGCTGGA CTGCCTCCGA TCCAGTTCAT 
GGCTACTGGT TCCGGGCAGG GGACCATGTA AGCCGGAACA TTCCAGTGGC CACAAACAAC 
CCAGCTCGAG CAGTGCAGGA GGAGACTCGG GACCGATTCC ACCTCCTTGG GGACCCACAG 
AACAAGGATT GTACCCTGAG CATCAGAGAC ACCAGAGAGA GTGATGCAGG GACATACGTC 
TTTTGTGTAG AGAGAGGAAA TATGAAATGG AATTATAAAT ATGACCAGCT CTCTGTGAAT 
GTGACAGCGT CCCAGGACCT ACTGTCAAGA TACAGGCTGG AGGTGCCAGA GTCGGTGACT 
GTGCAGGAGG GTCTGTGTGT CTCTGTGCCC TGCAGTGTCC TTTACCCCCA TTACAACTGG 
ACTGCCTCTA GCCCTGTTTA TGGATCCTGG TTCAAGGAAG GGGCCGATAT ACCATGGGAT 
ATTCCAGTGG CCACAAACAC CCCAAGTGGA AAAGTGCAAG AGGATACCCA CGGTCGATTC 
CTCCTCCTTG GGGACCCACA GACCAACAAC TGCTCCCTGA GCATCAGAGA TGCCAGGAAG 
GGGGATTCAG GGAAGTACTA CTTCCAGGTG GAGAGAGGAA GCAGGAAATG GAACTACATA 
TATGACAAGC TCTCTGTGCA TGTGACAGCC CTGACTCACA TGCCCACCTT CTCCATCCCG 
GGGACCCTGG AGTCTGGCCA CCCCAGGAAC CTGACCTGCT CTGTGCCCTG GGCCTGTGAA 
CAGGGGACGC CCCCCACGAT CACCTGGATG GGGGCCTCCG TGTCCTCCCT GGACCCCACT 
ATCACTCGCT CCTCGATGCT CAGCCTCATC CCACAGCCCC AGGACCATGG CACCAGCCTC 
ACCTGTCAGG TGACCTTGCC TGGGGCCGGC GTGACCATGA CCAGGGCTGT CCGACTCAAC 
ATATCCTATC CTCCTCAGAA CTTGACCATG ACTGTCTTCC AAGGAGATGG CACAGCATCC 
ACAACCTTGA GGAATGGCTC GGCCCTTTCA GTCCTGGAGG GCCAGTCCCT GCACCTTGTC 
TGTGCTGTCG ACAGCAATCC CCCTGCCAGG CTGAGCTGGA CCTGGGGGAG CCTGACCCTG 
AGCCCCTCAC AGTCCTCGAA CCTTGGGGTG CTGGAGCTGC CTCGAGTGCA TGTGAAGGAT 
GAAGGGGAAT TCACCTGCCG AGCTCAGAAC CCTCTAGGCT CCCAGCACAT TTCCCTGAGC 
CTCTCCCTGC AAAACGAGTA CACAGGCAAA ATGAGGCCTA TATCAGGAGT GACGCTAGGG 
GCATTCGGGG GAGCTGGAGC CACAGCCCTG GTCTTCCTGT ACTTCTGCAT CATCTTCGTT 
GTAGTGAGGT CCTGCAGGAA GAAATCGGCA AGGCCAGCAG TGGGCGTGGG GGATACAGGC 
ATGGAGGACG CAAACGCTGT CAGGGGCTCA GCCTCTCAGG GACCCCTGAT TGAATCCCCG 
GCAGATGACA GCCCCCCACA CCATGCTCCG CCAGCCCTGG CCACCCCCTC CCCAGAGGAA 
GGAGAGATCC AGTATGCATC CCTCAGCTTC CACAAAGCGA GGCCTCAGTA CCCACAGGAA 
CAGGAGGCCA TCGGCTATGA GTACTCCGAG ATCAACATCC CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC12 ( XM_011527441.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525743.1 Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant X1, mRNA.

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CloneID	OHu00169
Clone ID Related Accession (Same CDS sequence)	XM_011527441.2 , NM_033329.2
Accession Version	XM_011527441.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527441.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCTGC CCCTGCTATG GGCAAATGAA GAGAGGGACA GTGGGGGCTG GGCTGACCCT 
CGTTTCTCCA CAGCGTCCCA GGACCTACTG TCAAGATACA GGCTGGAGGT GCCAGAGTCG 
GTGACTGTGC AGGAGGGTCT GTGTGTCTCT GTGCCCTGCA GTGTCCTTTA CCCCCATTAC 
AACTGGACTG CCTCTAGCCC TGTTTATGGA TCCTGGTTCA AGGAAGGGGC CGATATACCA 
TGGGATATTC CAGTGGCCAC AAACACCCCA AGTGGAAAAG TGCAAGAGGA TACCCACGGT 
CGATTCCTCC TCCTTGGGGA CCCACAGACC AACAACTGCT CCCTGAGCAT CAGAGATGCC 
AGGAAGGGGG ATTCAGGGAA GTACTACTTC CAGGTGGAGA GAGGAAGCAG GAAATGGAAC 
TACATATATG ACAAGCTCTC TGTGCATGTG ACAGCCCTGA CTCACATGCC CACCTTCTCC 
ATCCCGGGGA CCCTGGAGTC TGGCCACCCC AGGAACCTGA CCTGCTCTGT GCCCTGGGCC 
TGTGAACAGG GGACGCCCCC CACGATCACC TGGATGGGGG CCTCCGTGTC CTCCCTGGAC 
CCCACTATCA CTCGCTCCTC GATGCTCAGC CTCATCCCAC AGCCCCAGGA CCATGGCACC 
AGCCTCACCT GTCAGGTGAC CTTGCCTGGG GCCGGCGTGA CCATGACCAG GGCTGTCCGA 
CTCAACATAT CCTATCCTCC TCAGAACTTG ACCATGACTG TCTTCCAAGG AGATGGCACA 
GCATCCACAA CCTTGAGGAA TGGCTCGGCC CTTTCAGTCC TGGAGGGCCA GTCCCTGCAC 
CTTGTCTGTG CTGTCGACAG CAATCCCCCT GCCAGGCTGA GCTGGACCTG GGGGAGCCTG 
ACCCTGAGCC CCTCACAGTC CTCGAACCTT GGGGTGCTGG AGCTGCCTCG AGTGCATGTG 
AAGGATGAAG GGGAATTCAC CTGCCGAGCT CAGAACCCTC TAGGCTCCCA GCACATTTCC 
CTGAGCCTCT CCCTGCAAAA CGAGTACACA GGCAAAATGA GGCCTATATC AGGAGTGACG 
CTAGGGGCAT TCGGGGGAGC TGGAGCCACA GCCCTGGTCT TCCTGTACTT CTGCATCATC 
TTCGTTGTAG TGAGGTCCTG CAGGAAGAAA TCGGCAAGGC CAGCAGTGGG CGTGGGGGAT 
ACAGGCATGG AGGACGCAAA CGCTGTCAGG GGCTCAGCCT CTCAGGGACC CCTGATTGAA 
TCCCCGGCAG ATGACAGCCC CCCACACCAT GCTCCGCCAG CCCTGGCCAC CCCCTCCCCA 
GAGGAAGGAG AGATCCAGTA TGCATCCCTC AGCTTCCACA AAGCGAGGCC TCAGTACCCA 
CAGGAACAGG AGGCCATCGG CTATGAGTAC TCCGAGATCA ACATCCCCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525743.1
CDS	108..1541
Translation	MLLPLLWANEERDSGGWADPRFSTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIPK

Target ORF information:

RefSeq Version	XM_011527441.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527441.2

ORF Insert Sequence:

ATGCTGCTGC CCCTGCTATG GGCAAATGAA GAGAGGGACA GTGGGGGCTG GGCTGACCCT 
CGTTTCTCCA CAGCGTCCCA GGACCTACTG TCAAGATACA GGCTGGAGGT GCCAGAGTCG 
GTGACTGTGC AGGAGGGTCT GTGTGTCTCT GTGCCCTGCA GTGTCCTTTA CCCCCATTAC 
AACTGGACTG CCTCTAGCCC TGTTTATGGA TCCTGGTTCA AGGAAGGGGC CGATATACCA 
TGGGATATTC CAGTGGCCAC AAACACCCCA AGTGGAAAAG TGCAAGAGGA TACCCACGGT 
CGATTCCTCC TCCTTGGGGA CCCACAGACC AACAACTGCT CCCTGAGCAT CAGAGATGCC 
AGGAAGGGGG ATTCAGGGAA GTACTACTTC CAGGTGGAGA GAGGAAGCAG GAAATGGAAC 
TACATATATG ACAAGCTCTC TGTGCATGTG ACAGCCCTGA CTCACATGCC CACCTTCTCC 
ATCCCGGGGA CCCTGGAGTC TGGCCACCCC AGGAACCTGA CCTGCTCTGT GCCCTGGGCC 
TGTGAACAGG GGACGCCCCC CACGATCACC TGGATGGGGG CCTCCGTGTC CTCCCTGGAC 
CCCACTATCA CTCGCTCCTC GATGCTCAGC CTCATCCCAC AGCCCCAGGA CCATGGCACC 
AGCCTCACCT GTCAGGTGAC CTTGCCTGGG GCCGGCGTGA CCATGACCAG GGCTGTCCGA 
CTCAACATAT CCTATCCTCC TCAGAACTTG ACCATGACTG TCTTCCAAGG AGATGGCACA 
GCATCCACAA CCTTGAGGAA TGGCTCGGCC CTTTCAGTCC TGGAGGGCCA GTCCCTGCAC 
CTTGTCTGTG CTGTCGACAG CAATCCCCCT GCCAGGCTGA GCTGGACCTG GGGGAGCCTG 
ACCCTGAGCC CCTCACAGTC CTCGAACCTT GGGGTGCTGG AGCTGCCTCG AGTGCATGTG 
AAGGATGAAG GGGAATTCAC CTGCCGAGCT CAGAACCCTC TAGGCTCCCA GCACATTTCC 
CTGAGCCTCT CCCTGCAAAA CGAGTACACA GGCAAAATGA GGCCTATATC AGGAGTGACG 
CTAGGGGCAT TCGGGGGAGC TGGAGCCACA GCCCTGGTCT TCCTGTACTT CTGCATCATC 
TTCGTTGTAG TGAGGTCCTG CAGGAAGAAA TCGGCAAGGC CAGCAGTGGG CGTGGGGGAT 
ACAGGCATGG AGGACGCAAA CGCTGTCAGG GGCTCAGCCT CTCAGGGACC CCTGATTGAA 
TCCCCGGCAG ATGACAGCCC CCCACACCAT GCTCCGCCAG CCCTGGCCAC CCCCTCCCCA 
GAGGAAGGAG AGATCCAGTA TGCATCCCTC AGCTTCCACA AAGCGAGGCC TCAGTACCCA 
CAGGAACAGG AGGCCATCGG CTATGAGTAC TCCGAGATCA ACATCCCCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC12 ( XM_011527442.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525744.1 Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu74106
Clone ID Related Accession (Same CDS sequence)	XM_011527442.2
Accession Version	XM_011527442.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 12 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527442.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTACTGC TGCTGCTACT GCTGCCACCC CTGCTCTGTG GGAGAGTGGG GGCTAAGGAA 
CAGAAGGATT ACCTGCTGAC AATGCAGAAG TCCGTGACGG TGCAGGAGGG CCTGTGTGTC 
TCTGTGCTTT GCTCCTTCTC CTACCCCCAA AATGGCTGGA CTGCCTCCGA TCCAGTTCAT 
GGCTACTGGT TCCGGGCAGG GGACCATGTA AGCCGGAACA TTCCAGTGGC CACAAACAAC 
CCAGCTCGAG CAGTGCAGGA GGAGACTCGG GACCGATTCC ACCTCCTTGG GGACCCACAG 
AACAAGGATT GTACCCTGAG CATCAGAGAC ACCAGAGAGA GTGATGCAGG GACATACGTC 
TTTTGTGTAG AGAGAGGAAA TATGAAATGG AATTATAAAT ATGACCAGCT CTCTGTGAAT 
GTGACAGCGT CCCAGGACCT ACTGTCAAGA TACAGGCTGG AGGTGCCAGA GTCGGTGACT 
GTGCAGGAGG GTCTGTGTGT CTCTGTGCCC TGCAGTGTCC TTTACCCCCA TTACAACTGG 
ACTGCCTCTA GCCCTGTTTA TGGATCCTGG TTCAAGGAAG GGGCCGATAT ACCATGGGAT 
ATTCCAGTGG CCACAAACAC CCCAAGTGGA AAAGTGCAAG AGGATACCCA CGGTCGATTC 
CTCCTCCTTG GGGACCCACA GACCAACAAC TGCTCCCTGA GCATCAGAGA TGCCAGGAAG 
GGGGATTCAG GGAAGTACTA CTTCCAGGTG GAGAGAGGAA GCAGGAAATG GAACTACATA 
TATGACAAGC TCTCTGTGCA TGTGACAGCC CTGACTCACA TGCCCACCTT CTCCATCCCG 
GGGACCCTGG AGTCTGGCCA CCCCAGGAAC CTGACCTGCT CTGTGCCCTG GGCCTGTGAA 
CAGGGGACGC CCCCCACGAT CACCTGGATG GGGGCCTCCG TGTCCTCCCT GGACCCCACT 
ATCACTCGCT CCTCGATGCT CAGCCTCATC CCACAGCCCC AGGACCATGG CACCAGCCTC 
ACCTGTCAGG TGACCTTGCC TGGGGCCGGC GTGACCATGA CCAGGGCTGT CCGACTCAAC 
ATATCCTATC CTCCTCAGAA CTTGACCATG ACTGTCTTCC AAGGAGATGG CACAGCATCC 
ACAACCTTGA GGAATGGCTC GGCCCTTTCA GTCCTGGAGG GCCAGTCCCT GCACCTTGTC 
TGTGCTGTCG ACAGCAATCC CCCTGCCAGG CTGAGCTGGA CCTGGGGGAG CCTGACCCTG 
AGCCCCTCAC AGTCCTCGAA CCTTGGGGTG CTGGAGCTGC CTCGAGTGCA TGTGAAGGAT 
GAAGGGGAAT TCACCTGCCG AGCTCAGAAC CCTCTAGGCT CCCAGCACAT TTCCCTGAGC 
CTCTCCCTGC AAAACGAGTA CACAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525744.1
CDS	57..1466
Translation	MLLLLLLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTE

Target ORF information:

RefSeq Version	XM_011527442.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527442.2

ORF Insert Sequence:

ATGCTACTGC TGCTGCTACT GCTGCCACCC CTGCTCTGTG GGAGAGTGGG GGCTAAGGAA 
CAGAAGGATT ACCTGCTGAC AATGCAGAAG TCCGTGACGG TGCAGGAGGG CCTGTGTGTC 
TCTGTGCTTT GCTCCTTCTC CTACCCCCAA AATGGCTGGA CTGCCTCCGA TCCAGTTCAT 
GGCTACTGGT TCCGGGCAGG GGACCATGTA AGCCGGAACA TTCCAGTGGC CACAAACAAC 
CCAGCTCGAG CAGTGCAGGA GGAGACTCGG GACCGATTCC ACCTCCTTGG GGACCCACAG 
AACAAGGATT GTACCCTGAG CATCAGAGAC ACCAGAGAGA GTGATGCAGG GACATACGTC 
TTTTGTGTAG AGAGAGGAAA TATGAAATGG AATTATAAAT ATGACCAGCT CTCTGTGAAT 
GTGACAGCGT CCCAGGACCT ACTGTCAAGA TACAGGCTGG AGGTGCCAGA GTCGGTGACT 
GTGCAGGAGG GTCTGTGTGT CTCTGTGCCC TGCAGTGTCC TTTACCCCCA TTACAACTGG 
ACTGCCTCTA GCCCTGTTTA TGGATCCTGG TTCAAGGAAG GGGCCGATAT ACCATGGGAT 
ATTCCAGTGG CCACAAACAC CCCAAGTGGA AAAGTGCAAG AGGATACCCA CGGTCGATTC 
CTCCTCCTTG GGGACCCACA GACCAACAAC TGCTCCCTGA GCATCAGAGA TGCCAGGAAG 
GGGGATTCAG GGAAGTACTA CTTCCAGGTG GAGAGAGGAA GCAGGAAATG GAACTACATA 
TATGACAAGC TCTCTGTGCA TGTGACAGCC CTGACTCACA TGCCCACCTT CTCCATCCCG 
GGGACCCTGG AGTCTGGCCA CCCCAGGAAC CTGACCTGCT CTGTGCCCTG GGCCTGTGAA 
CAGGGGACGC CCCCCACGAT CACCTGGATG GGGGCCTCCG TGTCCTCCCT GGACCCCACT 
ATCACTCGCT CCTCGATGCT CAGCCTCATC CCACAGCCCC AGGACCATGG CACCAGCCTC 
ACCTGTCAGG TGACCTTGCC TGGGGCCGGC GTGACCATGA CCAGGGCTGT CCGACTCAAC 
ATATCCTATC CTCCTCAGAA CTTGACCATG ACTGTCTTCC AAGGAGATGG CACAGCATCC 
ACAACCTTGA GGAATGGCTC GGCCCTTTCA GTCCTGGAGG GCCAGTCCCT GCACCTTGTC 
TGTGCTGTCG ACAGCAATCC CCCTGCCAGG CTGAGCTGGA CCTGGGGGAG CCTGACCCTG 
AGCCCCTCAC AGTCCTCGAA CCTTGGGGTG CTGGAGCTGC CTCGAGTGCA TGTGAAGGAT 
GAAGGGGAAT TCACCTGCCG AGCTCAGAAC CCTCTAGGCT CCCAGCACAT TTCCCTGAGC 
CTCTCCCTGC AAAACGAGTA CACAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes.
Hypertension (Dallas, Tex. : 1979)62(1)48-54(2013 Jul)
McDonough CW,Gong Y,Padmanabhan S,Burkley B,Langaee TY,Melander O,Pepine CJ,Dominiczak AF,Cooper-Dehoff RM,Johnson JA

SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
The Journal of biological chemistry286(26)23003-11(2011 Jul)
Mitra N,Banda K,Altheide TK,Schaffer L,Johnson-Pais TL,Beuten J,Leach RJ,Angata T,Varki N,Varki A

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

New genetic associations detected in a host response study to hepatitis B vaccine.
Genes and immunity11(3)232-8(2010 Apr)
Davila S,Froeling FE,Tan A,Bonnard C,Boland GJ,Snippe H,Hibberd ML,Seielstad M

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

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SIGLEC12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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