SAP30 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SAP30
Entrez Gene ID	8819
Full Name	Sin3A associated protein 30
General protein information	Preferred Names Sin3A associated protein 30 Names histone deacetylase complex subunit SAP30 30 kDa Sin3-associated polypeptide Sin3 corepressor complex subunit SAP30 Sin3-associated polypeptide, 30kDa Sin3A-associated protein, 30kDa sin3-associated polypeptide p30 sin3-associated polypeptide, 30 kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q34.1
Summary	Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008].
Disorder MIM:	603378

mRNA and Protein(s)

mRNA	Protein	Name
NM_003864.4	NP_003855.1	histone deacetylase complex subunit SAP30
NM_003864.3	NP_003855.1	histone deacetylase complex subunit SAP30

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sap30	XP_006253148.1
Xenopus tropicalis (tropical clawed frog)	sap30	NP_001016618.1
Pan troglodytes (chimpanzee)	SAP30	XP_526733.2
	SAP30	XP_001085487.1
Canis lupus familiaris (dog)	SAP30	XP_849083.1
Mus musculus (house mouse)	Sap30	NP_068560.1
Bos taurus (cattle)	SAP30	NP_001178053.1
Homo sapiens (human)	SAP30	NP_003855.1

Gene Ontology
Bibliography

Related articles in PubMed

SLy2 targets the nuclear SAP30/HDAC1 complex.
Brandt S, Ellwanger K, Beuter-Gunia C, Schuster M, Hausser A, Schmitz I, Beer-Hammer S
The international journal of biochemistry & cell biology42(9)1472-81(2010 Sep)

DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides.
Viiri KM, J?nis J, Siggers T, Heinonen TY, Valjakka J, Bulyk ML, M?ki M, Lohi O
Molecular and cellular biology29(2)342-56(2009 Jan)

Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.
Sichtig N, K?rfer N, Steger G
Archives of biochemistry and biophysics467(1)67-75(2007 Nov)

Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M
Genome biology8(8)R154(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1.
Title: SLy2 targets the nuclear SAP30/HDAC1 complex.

findings demonstrate new functions for SAP30L and SAP30 by showing that they can associate directly with core histones as well as naked DNA
Title: DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides.

PBF binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex
Title: Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.

occurrence of an unusual TG 3' splice site in intron 1
Title: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.

The SAP30 gene may be involved in basal cell carcinogenesis.
Title: Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes.

The following SAP30 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SAP30 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30370	NM_003864.4 Latest version!	Homo sapiens Sin3A associated protein 30 (SAP30), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu30370	NM_003864.3	Homo sapiens Sin3A associated protein 30 (SAP30), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SAP30 ( NM_003864.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003855.1 Homo sapiens Sin3A associated protein 30 (SAP30), mRNA.

Price & Availability↑

CloneID	OHu30370
Clone ID Related Accession (Same CDS sequence)	NM_003864.4 , NM_003864.3
Accession Version	NM_003864.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	histone deacetylase complex subunit SAP30
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW236579.1, BC016757.1 and AF055993.1. On Nov 22, 2018 this sequence version replaced NM_003864.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF055993.1, BC016757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296504.4/ ENSP00000296504.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACGGCT TCACGCCTGA CGAGATGAGC CGCGGCGGGG ATGCGGCCGC CGCAGTGGCC 
GCAGTGGTCG CTGCCGCGGC CGCCGCCGCC TCGGCGGGGA ACGGGACCGG CGCGGGCACC 
GGGGCTGAGG TGCCGGGCGC GGGGGCGGTC TCAGCGGCTG GGCCCCCGGG GGCGGCCGGG 
CCGGGCCCCG GGCAACTGTG CTGCCTGCGG GAGGATGGTG AGCGGTGCGG CCGGGCGGCA 
GGCAACGCCA GCTTCAGCAA GAGGATCCAG AAGAGCATCT CCCAGAAGAA GGTGAAGATC 
GAGCTGGATA AGAGCGCAAG GCATCTTTAC ATATGTGATT ATCATAAAAA CTTAATTCAG 
AGTGTTCGAA ACAGAAGAAA GAGAAAAGGG AGTGATGATG ATGGAGGTGA TTCACCTGTT 
CAAGATATTG ATACCCCAGA GGTTGATTTA TACCAATTAC AAGTAAATAC ACTTAGGAGA 
TACAAAAGAC ACTTCAAGCT ACCAACCAGA CCAGGACTTA ATAAAGCACA ACTTGTTGAG 
ATAGTTGGTT GCCACTTTAG GTCTATTCCA GTGAATGAAA AAGACACCTT AACATATTTC 
ATCTACTCAG TGAAGAATGA CAAGAACAAA TCAGATCTCA AGGTTGATAG TGGTGTTCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003855.1
CDS	230..892
Translation	MNGFTPDEMSRGGDAAAAVAAVVAAAAAAASAGNGTGAGTGAEVPGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSGVH

Target ORF information:

RefSeq Version	NM_003864.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Sin3A associated protein 30 (SAP30), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003864.4

ORF Insert Sequence:

ATGAACGGCT TCACGCCTGA CGAGATGAGC CGCGGCGGGG ATGCGGCCGC CGCAGTGGCC 
GCAGTGGTCG CTGCCGCGGC CGCCGCCGCC TCGGCGGGGA ACGGGACCGG CGCGGGCACC 
GGGGCTGAGG TGCCGGGCGC GGGGGCGGTC TCAGCGGCTG GGCCCCCGGG GGCGGCCGGG 
CCGGGCCCCG GGCAACTGTG CTGCCTGCGG GAGGATGGTG AGCGGTGCGG CCGGGCGGCA 
GGCAACGCCA GCTTCAGCAA GAGGATCCAG AAGAGCATCT CCCAGAAGAA GGTGAAGATC 
GAGCTGGATA AGAGCGCAAG GCATCTTTAC ATATGTGATT ATCATAAAAA CTTAATTCAG 
AGTGTTCGAA ACAGAAGAAA GAGAAAAGGG AGTGATGATG ATGGAGGTGA TTCACCTGTT 
CAAGATATTG ATACCCCAGA GGTTGATTTA TACCAATTAC AAGTAAATAC ACTTAGGAGA 
TACAAAAGAC ACTTCAAGCT ACCAACCAGA CCAGGACTTA ATAAAGCACA ACTTGTTGAG 
ATAGTTGGTT GCCACTTTAG GTCTATTCCA GTGAATGAAA AAGACACCTT AACATATTTC 
ATCTACTCAG TGAAGAATGA CAAGAACAAA TCAGATCTCA AGGTTGATAG TGGTGTTCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SAP30 ( NM_003864.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003855.1 Homo sapiens Sin3A associated protein 30 (SAP30), mRNA.

Price & Availability↑

CloneID	OHu30370
Clone ID Related Accession (Same CDS sequence)	NM_003864.4 , NM_003864.3
Accession Version	NM_003864.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	histone deacetylase complex subunit SAP30
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW236579.1, BC016757.1 and AF055993.1. On Apr 7, 2006 this sequence version replaced NM_003864.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF055993.1, BC016757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGGCT TCACGCCTGA CGAGATGAGC CGCGGCGGGG ATGCGGCCGC CGCAGTGGCC 
GCAGTGGTCG CTGCCGCGGC CGCCGCCGCC TCGGCGGGGA ACGGGACCGG CGCGGGCACC 
GGGGCTGAGG TGCCGGGCGC GGGGGCGGTC TCAGCGGCTG GGCCCCCGGG GGCGGCCGGG 
CCGGGCCCCG GGCAACTGTG CTGCCTGCGG GAGGATGGTG AGCGGTGCGG CCGGGCGGCA 
GGCAACGCCA GCTTCAGCAA GAGGATCCAG AAGAGCATCT CCCAGAAGAA GGTGAAGATC 
GAGCTGGATA AGAGCGCAAG GCATCTTTAC ATATGTGATT ATCATAAAAA CTTAATTCAG 
AGTGTTCGAA ACAGAAGAAA GAGAAAAGGG AGTGATGATG ATGGAGGTGA TTCACCTGTT 
CAAGATATTG ATACCCCAGA GGTTGATTTA TACCAATTAC AAGTAAATAC ACTTAGGAGA 
TACAAAAGAC ACTTCAAGCT ACCAACCAGA CCAGGACTTA ATAAAGCACA ACTTGTTGAG 
ATAGTTGGTT GCCACTTTAG GTCTATTCCA GTGAATGAAA AAGACACCTT AACATATTTC 
ATCTACTCAG TGAAGAATGA CAAGAACAAA TCAGATCTCA AGGTTGATAG TGGTGTTCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003855.1
CDS	242..904
Translation	MNGFTPDEMSRGGDAAAAVAAVVAAAAAAASAGNGTGAGTGAEVPGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSGVH

Target ORF information:

RefSeq Version	NM_003864.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Sin3A associated protein 30 (SAP30), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003864.3

ORF Insert Sequence:

ATGAACGGCT TCACGCCTGA CGAGATGAGC CGCGGCGGGG ATGCGGCCGC CGCAGTGGCC 
GCAGTGGTCG CTGCCGCGGC CGCCGCCGCC TCGGCGGGGA ACGGGACCGG CGCGGGCACC 
GGGGCTGAGG TGCCGGGCGC GGGGGCGGTC TCAGCGGCTG GGCCCCCGGG GGCGGCCGGG 
CCGGGCCCCG GGCAACTGTG CTGCCTGCGG GAGGATGGTG AGCGGTGCGG CCGGGCGGCA 
GGCAACGCCA GCTTCAGCAA GAGGATCCAG AAGAGCATCT CCCAGAAGAA GGTGAAGATC 
GAGCTGGATA AGAGCGCAAG GCATCTTTAC ATATGTGATT ATCATAAAAA CTTAATTCAG 
AGTGTTCGAA ACAGAAGAAA GAGAAAAGGG AGTGATGATG ATGGAGGTGA TTCACCTGTT 
CAAGATATTG ATACCCCAGA GGTTGATTTA TACCAATTAC AAGTAAATAC ACTTAGGAGA 
TACAAAAGAC ACTTCAAGCT ACCAACCAGA CCAGGACTTA ATAAAGCACA ACTTGTTGAG 
ATAGTTGGTT GCCACTTTAG GTCTATTCCA GTGAATGAAA AAGACACCTT AACATATTTC 
ATCTACTCAG TGAAGAATGA CAAGAACAAA TCAGATCTCA AGGTTGATAG TGGTGTTCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SLy2 targets the nuclear SAP30/HDAC1 complex.
The international journal of biochemistry & cell biology42(9)1472-81(2010 Sep)
Brandt S,Ellwanger K,Beuter-Gunia C,Schuster M,Hausser A,Schmitz I,Beer-Hammer S

DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides.
Molecular and cellular biology29(2)342-56(2009 Jan)
Viiri KM,J?nis J,Siggers T,Heinonen TY,Valjakka J,Bulyk ML,M?ki M,Lohi O

Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.
Archives of biochemistry and biophysics467(1)67-75(2007 Nov)
Sichtig N,K?rfer N,Steger G

Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
Genome biology8(8)R154(2007)
Szafranski K,Schindler S,Taudien S,Hiller M,Huse K,Jahn N,Schreiber S,Backofen R,Platzer M

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SAP30 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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