TNFRSF10D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFRSF10D
Entrez Gene ID	8793
Full Name	TNF receptor superfamily member 10d
Synonyms	CD264,DCR2,TRAIL-R4,TRAILR4,TRUNDD
General protein information	Preferred Names TNF receptor superfamily member 10d Names tumor necrosis factor receptor superfamily member 10D TNF receptor-related receptor for TRAIL TNF-related apoptosis-inducing ligand receptor 4 TRAIL receptor 4 TRAIL receptor with a truncated death domain decoy receptor 2 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p21.3
Summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008].
Disorder MIM:	603614

mRNA and Protein(s)

mRNA	Protein	Name
NM_003840.4	NP_003831.2	tumor necrosis factor receptor superfamily member 10D precursor
NM_003840.5	NP_003831.2	tumor necrosis factor receptor superfamily member 10D precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TNFRSF10D	NP_003831.2
Pan troglodytes (chimpanzee)	TNFRSF10D	XP_528087.2
	TNFRSF10D	XP_001107922.1

Gene Ontology
Bibliography

Related articles in PubMed

Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells.
Madsen SD, Russell KC, Tucker HA, Glowacki J, Bunnell BA, O'Connor KC
Stem cell research & therapy8(1)201(2017 Sep)

Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy.
Chen J, Zhang WW, Chen KH, Lin LR, Dai HZ, Li KL, Zhang JG, Zheng LQ, Fu BQ, He YN
American journal of physiology. Renal physiology313(2)F273-F281(2017 Aug)

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.
O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, Correa de Sampaio P, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E
Oncogene35(10)1261-70(2016 Mar)

Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer.
Narayan G, Xie D, Ishdorj G, Scotto L, Mansukhani M, Pothuri B, Wright JD, Kaufmann AM, Schneider A, Arias-Pulido H, Murty VV
Genes, chromosomes & cancer55(2)177-89(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Urinary DcR2 could potentially serve as a novel biomarker for tubulointerstitial injury and may reflect senescence of renal proximal tubular cells in diabetic nephropathy.
Title: Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy.

DcRs regulate TRAIL sensitivity at a supracellular level
Title: Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

Results identified epigenetic inactivation of TNFRSF10C and TNFRSF10D in majority of cervical cancer cases.
Title: Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer.

This study identified TNFRSF10D DNA methylation status as an independent prognostic biomarker for relapse-free survival and overall mortality in non-metastatic melanoma patients.
Title: Association of TNFRSF10D DNA-methylation with the survival of melanoma patients.

membrane expression more common in endometrioid endometrial cancer than in normal endometrium
Title: Membrane expression of trail receptors DcR1 and DcR2 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer.

The following TNFRSF10D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF10D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22433	NM_003840.5 Latest version!	Homo sapiens TNF receptor superfamily member 10d (TNFRSF10D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu22433	NM_003840.4	Homo sapiens TNF receptor superfamily member 10d (TNFRSF10D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFRSF10D ( NM_003840.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003831.2 Homo sapiens TNF receptor superfamily member 10d (TNFRSF10D), mRNA.

Price & Availability↑

CloneID	OHu22433
Clone ID Related Accession (Same CDS sequence)	NM_003840.4 , NM_003840.5
Accession Version	NM_003840.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-24
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 10D precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC100861.2, AY358285.1, AF021233.1, BU199149.1 and AA743393.1. This sequence is a reference standard in the RefSeqGene project. On Apr 20, 2012 this sequence version replaced NM_003840.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358285.1, SRR1660803.35943.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGACTTT GGGGACAAAG CGTCCCGACC GCCTCGAGCG CTCGAGCAGG GCGCTATCCA 
GGAGCCAGGA CAGCGTCGGG AACCAGACCA TGGCTCCTGG ACCCCAAGAT CCTTAAGTTC 
GTCGTCTTCA TCGTCGCGGT TCTGCTGCCG GTCCGGGTTG ACTCTGCCAC CATCCCCCGG 
CAGGACGAAG TTCCCCAGCA GACAGTGGCC CCACAGCAAC AGAGGCGCAG CCTCAAGGAG 
GAGGAGTGTC CAGCAGGATC TCATAGATCA GAATATACTG GAGCCTGTAA CCCGTGCACA 
GAGGGTGTGG ATTACACCAT TGCTTCCAAC AATTTGCCTT CTTGCCTGCT ATGTACAGTT 
TGTAAATCAG GTCAAACAAA TAAAAGTTCC TGTACCACGA CCAGAGACAC CGTGTGTCAG 
TGTGAAAAAG GAAGCTTCCA GGATAAAAAC TCCCCTGAGA TGTGCCGGAC GTGTAGAACA 
GGGTGTCCCA GAGGGATGGT CAAGGTCAGT AATTGTACGC CCCGGAGTGA CATCAAGTGC 
AAAAATGAAT CAGCTGCCAG TTCCACTGGG AAAACCCCAG CAGCGGAGGA GACAGTGACC 
ACCATCCTGG GGATGCTTGC CTCTCCCTAT CACTACCTTA TCATCATAGT GGTTTTAGTC 
ATCATTTTAG CTGTGGTTGT GGTTGGCTTT TCATGTCGGA AGAAATTCAT TTCTTACCTC 
AAAGGCATCT GCTCAGGTGG TGGAGGAGGT CCCGAACGTG TGCACAGAGT CCTTTTCCGG 
CGGCGTTCAT GTCCTTCACG AGTTCCTGGG GCGGAGGACA ATGCCCGCAA CGAGACCCTG 
AGTAACAGAT ACTTGCAGCC CACCCAGGTC TCTGAGCAGG AAATCCAAGG TCAGGAGCTG 
GCAGAGCTAA CAGGTGTGAC TGTAGAGTTG CCAGAGGAGC CACAGCGTCT GCTGGAACAG 
GCAGAAGCTG AAGGGTGTCA GAGGAGGAGG CTGCTGGTTC CAGTGAATGA CGCTGACTCC 
GCTGACATCA GCACCTTGCT GGATGCCTCG GCAACACTGG AAGAAGGACA TGCAAAGGAA 
ACAATTCAGG ACCAACTGGT GGGCTCCGAA AAGCTCTTTT ATGAAGAAGA TGAGGCAGGC 
TCTGCTACGT CCTGCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003831.2
CDS	96..1256
Translation	MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL

Target ORF information:

RefSeq Version	NM_003840.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 10d (TNFRSF10D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003840.4

ORF Insert Sequence:

ATGGGACTTT GGGGACAAAG CGTCCCGACC GCCTCGAGCG CTCGAGCAGG GCGCTATCCA 
GGAGCCAGGA CAGCGTCGGG AACCAGACCA TGGCTCCTGG ACCCCAAGAT CCTTAAGTTC 
GTCGTCTTCA TCGTCGCGGT TCTGCTGCCG GTCCGGGTTG ACTCTGCCAC CATCCCCCGG 
CAGGACGAAG TTCCCCAGCA GACAGTGGCC CCACAGCAAC AGAGGCGCAG CCTCAAGGAG 
GAGGAGTGTC CAGCAGGATC TCATAGATCA GAATATACTG GAGCCTGTAA CCCGTGCACA 
GAGGGTGTGG ATTACACCAT TGCTTCCAAC AATTTGCCTT CTTGCCTGCT ATGTACAGTT 
TGTAAATCAG GTCAAACAAA TAAAAGTTCC TGTACCACGA CCAGAGACAC CGTGTGTCAG 
TGTGAAAAAG GAAGCTTCCA GGATAAAAAC TCCCCTGAGA TGTGCCGGAC GTGTAGAACA 
GGGTGTCCCA GAGGGATGGT CAAGGTCAGT AATTGTACGC CCCGGAGTGA CATCAAGTGC 
AAAAATGAAT CAGCTGCCAG TTCCACTGGG AAAACCCCAG CAGCGGAGGA GACAGTGACC 
ACCATCCTGG GGATGCTTGC CTCTCCCTAT CACTACCTTA TCATCATAGT GGTTTTAGTC 
ATCATTTTAG CTGTGGTTGT GGTTGGCTTT TCATGTCGGA AGAAATTCAT TTCTTACCTC 
AAAGGCATCT GCTCAGGTGG TGGAGGAGGT CCCGAACGTG TGCACAGAGT CCTTTTCCGG 
CGGCGTTCAT GTCCTTCACG AGTTCCTGGG GCGGAGGACA ATGCCCGCAA CGAGACCCTG 
AGTAACAGAT ACTTGCAGCC CACCCAGGTC TCTGAGCAGG AAATCCAAGG TCAGGAGCTG 
GCAGAGCTAA CAGGTGTGAC TGTAGAGTTG CCAGAGGAGC CACAGCGTCT GCTGGAACAG 
GCAGAAGCTG AAGGGTGTCA GAGGAGGAGG CTGCTGGTTC CAGTGAATGA CGCTGACTCC 
GCTGACATCA GCACCTTGCT GGATGCCTCG GCAACACTGG AAGAAGGACA TGCAAAGGAA 
ACAATTCAGG ACCAACTGGT GGGCTCCGAA AAGCTCTTTT ATGAAGAAGA TGAGGCAGGC 
TCTGCTACGT CCTGCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFRSF10D ( NM_003840.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003831.2 Homo sapiens TNF receptor superfamily member 10d (TNFRSF10D), mRNA.

Price & Availability↑

CloneID	OHu22433
Clone ID Related Accession (Same CDS sequence)	NM_003840.4 , NM_003840.5
Accession Version	NM_003840.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 10D precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC100861.2, AY358285.1, AF021233.1, BU199149.1 and AA743393.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_003840.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358285.1, SRR1660803.35943.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000312584.4/ ENSP00000310263.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGACTTT GGGGACAAAG CGTCCCGACC GCCTCGAGCG CTCGAGCAGG GCGCTATCCA 
GGAGCCAGGA CAGCGTCGGG AACCAGACCA TGGCTCCTGG ACCCCAAGAT CCTTAAGTTC 
GTCGTCTTCA TCGTCGCGGT TCTGCTGCCG GTCCGGGTTG ACTCTGCCAC CATCCCCCGG 
CAGGACGAAG TTCCCCAGCA GACAGTGGCC CCACAGCAAC AGAGGCGCAG CCTCAAGGAG 
GAGGAGTGTC CAGCAGGATC TCATAGATCA GAATATACTG GAGCCTGTAA CCCGTGCACA 
GAGGGTGTGG ATTACACCAT TGCTTCCAAC AATTTGCCTT CTTGCCTGCT ATGTACAGTT 
TGTAAATCAG GTCAAACAAA TAAAAGTTCC TGTACCACGA CCAGAGACAC CGTGTGTCAG 
TGTGAAAAAG GAAGCTTCCA GGATAAAAAC TCCCCTGAGA TGTGCCGGAC GTGTAGAACA 
GGGTGTCCCA GAGGGATGGT CAAGGTCAGT AATTGTACGC CCCGGAGTGA CATCAAGTGC 
AAAAATGAAT CAGCTGCCAG TTCCACTGGG AAAACCCCAG CAGCGGAGGA GACAGTGACC 
ACCATCCTGG GGATGCTTGC CTCTCCCTAT CACTACCTTA TCATCATAGT GGTTTTAGTC 
ATCATTTTAG CTGTGGTTGT GGTTGGCTTT TCATGTCGGA AGAAATTCAT TTCTTACCTC 
AAAGGCATCT GCTCAGGTGG TGGAGGAGGT CCCGAACGTG TGCACAGAGT CCTTTTCCGG 
CGGCGTTCAT GTCCTTCACG AGTTCCTGGG GCGGAGGACA ATGCCCGCAA CGAGACCCTG 
AGTAACAGAT ACTTGCAGCC CACCCAGGTC TCTGAGCAGG AAATCCAAGG TCAGGAGCTG 
GCAGAGCTAA CAGGTGTGAC TGTAGAGTTG CCAGAGGAGC CACAGCGTCT GCTGGAACAG 
GCAGAAGCTG AAGGGTGTCA GAGGAGGAGG CTGCTGGTTC CAGTGAATGA CGCTGACTCC 
GCTGACATCA GCACCTTGCT GGATGCCTCG GCAACACTGG AAGAAGGACA TGCAAAGGAA 
ACAATTCAGG ACCAACTGGT GGGCTCCGAA AAGCTCTTTT ATGAAGAAGA TGAGGCAGGC 
TCTGCTACGT CCTGCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003831.2
CDS	93..1253
Translation	MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL

Target ORF information:

RefSeq Version	NM_003840.5
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 10d (TNFRSF10D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003840.5

ORF Insert Sequence:

ATGGGACTTT GGGGACAAAG CGTCCCGACC GCCTCGAGCG CTCGAGCAGG GCGCTATCCA 
GGAGCCAGGA CAGCGTCGGG AACCAGACCA TGGCTCCTGG ACCCCAAGAT CCTTAAGTTC 
GTCGTCTTCA TCGTCGCGGT TCTGCTGCCG GTCCGGGTTG ACTCTGCCAC CATCCCCCGG 
CAGGACGAAG TTCCCCAGCA GACAGTGGCC CCACAGCAAC AGAGGCGCAG CCTCAAGGAG 
GAGGAGTGTC CAGCAGGATC TCATAGATCA GAATATACTG GAGCCTGTAA CCCGTGCACA 
GAGGGTGTGG ATTACACCAT TGCTTCCAAC AATTTGCCTT CTTGCCTGCT ATGTACAGTT 
TGTAAATCAG GTCAAACAAA TAAAAGTTCC TGTACCACGA CCAGAGACAC CGTGTGTCAG 
TGTGAAAAAG GAAGCTTCCA GGATAAAAAC TCCCCTGAGA TGTGCCGGAC GTGTAGAACA 
GGGTGTCCCA GAGGGATGGT CAAGGTCAGT AATTGTACGC CCCGGAGTGA CATCAAGTGC 
AAAAATGAAT CAGCTGCCAG TTCCACTGGG AAAACCCCAG CAGCGGAGGA GACAGTGACC 
ACCATCCTGG GGATGCTTGC CTCTCCCTAT CACTACCTTA TCATCATAGT GGTTTTAGTC 
ATCATTTTAG CTGTGGTTGT GGTTGGCTTT TCATGTCGGA AGAAATTCAT TTCTTACCTC 
AAAGGCATCT GCTCAGGTGG TGGAGGAGGT CCCGAACGTG TGCACAGAGT CCTTTTCCGG 
CGGCGTTCAT GTCCTTCACG AGTTCCTGGG GCGGAGGACA ATGCCCGCAA CGAGACCCTG 
AGTAACAGAT ACTTGCAGCC CACCCAGGTC TCTGAGCAGG AAATCCAAGG TCAGGAGCTG 
GCAGAGCTAA CAGGTGTGAC TGTAGAGTTG CCAGAGGAGC CACAGCGTCT GCTGGAACAG 
GCAGAAGCTG AAGGGTGTCA GAGGAGGAGG CTGCTGGTTC CAGTGAATGA CGCTGACTCC 
GCTGACATCA GCACCTTGCT GGATGCCTCG GCAACACTGG AAGAAGGACA TGCAAAGGAA 
ACAATTCAGG ACCAACTGGT GGGCTCCGAA AAGCTCTTTT ATGAAGAAGA TGAGGCAGGC 
TCTGCTACGT CCTGCCTGTG A