SIGLEC5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIGLEC5
Entrez Gene ID	8778
Full Name	sialic acid binding Ig like lectin 5
Synonyms	CD170,CD33L2,OB-BP2,OBBP2,SIGLEC-5
General protein information	Preferred Names sialic acid binding Ig like lectin 5 Names sialic acid-binding Ig-like lectin 5 CD33 antigen-like 2 OB-binding protein 2 obesity-binding protein 2 sialic acid-binding immunoglobulin-like lectin 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.41
Summary	This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012].
Disorder MIM:	604200

mRNA and Protein(s)

mRNA	Protein	Name
NM_003830.3	NP_003821.1	sialic acid-binding Ig-like lectin 5 precursor
XM_011527438.2	XP_011525740.1	sialic acid-binding Ig-like lectin 5 isoform X2
XM_017027419.1	XP_016882908.1	sialic acid-binding Ig-like lectin 5 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SIGLEC5	NP_003821.1
Canis lupus familiaris (dog)	SIGLEC5	XP_533599.4
Bos taurus (cattle)	SIGLEC5	XP_005219620.1
	SIGLEC5	NP_001103356.1

Gene Ontology
Bibliography

Related articles in PubMed

Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes.
Li JY, Yang XY, Wang XF, Jia X, Wang ZJ, Deng AP, Bai XL, Zhu L, Li BH, Feng ZB, Li Y, Wang L, Jin S
Scientific reports7(1)11272(2017 Sep)

Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity.
Pepin M, Mezouar S, Pegon J, Muczynski V, Adam F, Bianchini EP, Bazaa A, Proulle V, Rupin A, Paysant J, Panicot-Dubois L, Christophe OD, Dubois C, Lenting PJ, Denis CV
Scientific reports637953(2016 Nov)

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and?Siglec-14.
Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A
The EMBO journal34(22)2775-88(2015 Nov)

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
Liu H, Irwanto A, Fu X, Yu G, Yu Y, Sun Y, Wang C, Wang Z, Okada Y, Low H, Li Y, Liany H, Chen M, Bao F, Li J, You J, Zhang Q, Liu J, Chu T, Andiappan AK, Wang N, Niu G, Liu D, Yu X, Zhang L, Tian H, Zhou G, Rotzschke O, Chen S, Zhang X, Liu J, Zhang F
Nature genetics47(3)267-71(2015 Mar)

Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5.
Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V
The Journal of experimental medicine206(8)1691-9(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory.
Title: Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and?Siglec-14.

Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.
Title: Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

we found that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 acting as a co-receptor.
Title: Dectin-1 is essential for reverse transcytosis of glycosylated SIgA-antigen complexes by intestinal M cells.

These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function.
Title: Refolded recombinant Siglec5 for NMR investigation of complex carbohydrate binding.

Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees.
Title: Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells.

The following SIGLEC5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIGLEC5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15706	NM_003830.3 Latest version!	Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu62174	XM_011527438.2 Latest version!	Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu88789	XM_017027419.1 Latest version!	Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIGLEC5 ( NM_003830.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003821.1 Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), mRNA.

Price & Availability↑

CloneID	OHu15706
Clone ID Related Accession (Same CDS sequence)	NM_003830.3
Accession Version	NM_003830.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018755.3 and U71383.1. On Feb 28, 2012 this sequence version replaced NM_003830.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U71383.1, AK225753.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGATGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GACCATCACC 
ATCTTCAGGA ACGGCATAGC CCTAGAGATC CTGCAAAACA CCTCATACCT TCCGGTCCTG 
GAGGGCCAGG CTCTGCGGCT GCTCTGTGAT GCTCCCAGCA ACCCCCCTGC ACACCTGAGC 
TGGTTCCAGG GCTCCCCTGC CCTGAACGCC ACCCCCATCT CCAATACCGG GATCTTGGAG 
CTTCGTCGAG TAAGGTCTGC AGAAGAAGGA GGCTTCACCT GCCGCGCTCA GCACCCGCTG 
GGCTTCCTGC AAATTTTTCT GAATCTCTCA GTTTACTCCC TCCCACAGTT GCTGGGCCCC 
TCCTGCTCCT GGGAGGCTGA GGGTCTGCAC TGCAGATGCT CCTTTCGAGC CCGGCCGGCC 
CCCTCCCTGT GCTGGCGGCT TGAGGAGAAG CCGCTGGAGG GGAACAGCAG CCAGGGCTCA 
TTCAAGGTCA ACTCCAGCTC AGCTGGGCCC TGGGCCAACA GCTCCCTGAT CCTCCACGGG 
GGGCTCAGCT CCGACCTCAA AGTCAGCTGC AAGGCCTGGA ACATCTATGG GTCCCAGAGC 
GGCTCTGTCC TGCTGCTGCA AGGGAGATCG AACCTCGGGA CAGGAGTGGT TCCTGCAGCC 
CTTGGTGGTG CTGGTGTCAT GGCCCTGCTC TGTATCTGTC TGTGCCTCAT CTTCTTTTTA 
ATAGTGAAAG CCCGCAGGAA GCAAGCAGCT GGGAGACCAG AGAAAATGGA TGATGAAGAC 
CCCATTATGG GTACCATCAC CTCGGGTTCC AGGAAGAAGC CCTGGCCAGA CAGCCCCGGA 
GATCAAGCAT CTCCTCCTGG GGATGCCCCT CCCTTGGAAG AACAAAAGGA GCTCCATTAT 
GCCTCCCTTA GTTTTTCTGA GATGAAGTCG AGGGAGCCTA AGGACCAGGA GGCCCCAAGC 
ACCACGGAGT ACTCGGAGAT CAAGACAAGC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003821.1
CDS	140..1795
Translation	MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK

Target ORF information:

RefSeq Version	NM_003830.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003830.3

ORF Insert Sequence:

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGATGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GACCATCACC 
ATCTTCAGGA ACGGCATAGC CCTAGAGATC CTGCAAAACA CCTCATACCT TCCGGTCCTG 
GAGGGCCAGG CTCTGCGGCT GCTCTGTGAT GCTCCCAGCA ACCCCCCTGC ACACCTGAGC 
TGGTTCCAGG GCTCCCCTGC CCTGAACGCC ACCCCCATCT CCAATACCGG GATCTTGGAG 
CTTCGTCGAG TAAGGTCTGC AGAAGAAGGA GGCTTCACCT GCCGCGCTCA GCACCCGCTG 
GGCTTCCTGC AAATTTTTCT GAATCTCTCA GTTTACTCCC TCCCACAGTT GCTGGGCCCC 
TCCTGCTCCT GGGAGGCTGA GGGTCTGCAC TGCAGATGCT CCTTTCGAGC CCGGCCGGCC 
CCCTCCCTGT GCTGGCGGCT TGAGGAGAAG CCGCTGGAGG GGAACAGCAG CCAGGGCTCA 
TTCAAGGTCA ACTCCAGCTC AGCTGGGCCC TGGGCCAACA GCTCCCTGAT CCTCCACGGG 
GGGCTCAGCT CCGACCTCAA AGTCAGCTGC AAGGCCTGGA ACATCTATGG GTCCCAGAGC 
GGCTCTGTCC TGCTGCTGCA AGGGAGATCG AACCTCGGGA CAGGAGTGGT TCCTGCAGCC 
CTTGGTGGTG CTGGTGTCAT GGCCCTGCTC TGTATCTGTC TGTGCCTCAT CTTCTTTTTA 
ATAGTGAAAG CCCGCAGGAA GCAAGCAGCT GGGAGACCAG AGAAAATGGA TGATGAAGAC 
CCCATTATGG GTACCATCAC CTCGGGTTCC AGGAAGAAGC CCTGGCCAGA CAGCCCCGGA 
GATCAAGCAT CTCCTCCTGG GGATGCCCCT CCCTTGGAAG AACAAAAGGA GCTCCATTAT 
GCCTCCCTTA GTTTTTCTGA GATGAAGTCG AGGGAGCCTA AGGACCAGGA GGCCCCAAGC 
ACCACGGAGT ACTCGGAGAT CAAGACAAGC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC5 ( XM_011527438.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525740.1 Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu62174
Clone ID Related Accession (Same CDS sequence)	XM_011527438.2
Accession Version	XM_011527438.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 5 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527438.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGATGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GACCATCACC 
ATCTTCAGGA ACGGCATAGC CCTAGAGATC CTGCAAAACA CCTCATACCT TCCGGTCCTG 
GAGGGCCAGG CTCTGCGGCT GCTCTGTGAT GCTCCCAGCA ACCCCCCTGC ACACCTGAGC 
TGGTTCCAGG GCTCCCCTGC CCTGAACGCC ACCCCCATCT CCAATACCGG GATCTTGGAG 
CTTCGTCGAG TAAGGTCTGC AGAAGAAGGA GGCTTCACCT GCCGCGCTCA GCACCCGCTG 
GGCTTCCTGC AAATTTTTCT GAATCTCTCA GTTTACTCCC TCCCACAGTT GCTGGGCCCC 
TCCTGCTCCT GGGAGGCTGA GGGTCTGCAC TGCAGATGCT CCTTTCGAGC CCGGCCGGCC 
CCCTCCCTGT GCTGGCGGCT TGAGGAGAAG CCGCTGGAGG GGAACAGCAG CCAGGGCTCA 
TTCAAGGTCA ACTCCAGCTC AGCTGGGCCC TGGGCCAACA GCTCCCTGAT CCTCCACGGG 
GGGCTCAGCT CCGACCTCAA AGTCAGCTGC AAGGCCTGGA ACATCTATGG GTCCCAGAGC 
GGCTCTGTCC TGCTGCTGCA AGGGAGATCG AACCTCGGGA CAGGAGTGGT TCCTGCAGCC 
CTTGGTGGTG CTGGTGTCAT GGCCCTGCTC TGTATCTGTC TGTGCCTCAT CTTCTTTTTA 
ATGGTTCCAG GAAGAAGCCC TGGCCAGACA GCCCCGGAGA TCAAGCATCT CCTCCTGGGG 
ATGCCCCTCC CTTGGAAGAA CAAAAGGAGC TCCATTATGC CTCCCTTAGT TTTTCTGAGA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525740.1
CDS	94..1596
Translation	MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLMVPGRSPGQTAPEIKHLLLGMPLPWKNKRSSIMPPLVFLR

Target ORF information:

RefSeq Version	XM_011527438.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527438.2

ORF Insert Sequence:

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGATGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GACCATCACC 
ATCTTCAGGA ACGGCATAGC CCTAGAGATC CTGCAAAACA CCTCATACCT TCCGGTCCTG 
GAGGGCCAGG CTCTGCGGCT GCTCTGTGAT GCTCCCAGCA ACCCCCCTGC ACACCTGAGC 
TGGTTCCAGG GCTCCCCTGC CCTGAACGCC ACCCCCATCT CCAATACCGG GATCTTGGAG 
CTTCGTCGAG TAAGGTCTGC AGAAGAAGGA GGCTTCACCT GCCGCGCTCA GCACCCGCTG 
GGCTTCCTGC AAATTTTTCT GAATCTCTCA GTTTACTCCC TCCCACAGTT GCTGGGCCCC 
TCCTGCTCCT GGGAGGCTGA GGGTCTGCAC TGCAGATGCT CCTTTCGAGC CCGGCCGGCC 
CCCTCCCTGT GCTGGCGGCT TGAGGAGAAG CCGCTGGAGG GGAACAGCAG CCAGGGCTCA 
TTCAAGGTCA ACTCCAGCTC AGCTGGGCCC TGGGCCAACA GCTCCCTGAT CCTCCACGGG 
GGGCTCAGCT CCGACCTCAA AGTCAGCTGC AAGGCCTGGA ACATCTATGG GTCCCAGAGC 
GGCTCTGTCC TGCTGCTGCA AGGGAGATCG AACCTCGGGA CAGGAGTGGT TCCTGCAGCC 
CTTGGTGGTG CTGGTGTCAT GGCCCTGCTC TGTATCTGTC TGTGCCTCAT CTTCTTTTTA 
ATGGTTCCAG GAAGAAGCCC TGGCCAGACA GCCCCGGAGA TCAAGCATCT CCTCCTGGGG 
ATGCCCCTCC CTTGGAAGAA CAAAAGGAGC TCCATTATGC CTCCCTTAGT TTTTCTGAGA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC5 ( XM_017027419.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882908.1 Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88789
Clone ID Related Accession (Same CDS sequence)	XM_017027419.1
Accession Version	XM_017027419.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGATGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GACCATCACC 
ATCTTCAGGA ACGGCATAGC CCTAGAGATC CTGCAAAACA CCTCATACCT TCCGGTCCTG 
GAGGGCCAGG CTCTGCGGCT GCTCTGTGAT GCTCCCAGCA ACCCCCCTGC ACACCTGAGC 
TGGTTCCAGG GCTCCCCTGC CCTGAACGCC ACCCCCATCT CCAATACCGG GATCTTGGAG 
CTTCGTCGAG TAAGGTCTGC AGAAGAAGGA GGCTTCACCT GCCGCGCTCA GCACCCGCTG 
GGCTTCCTGC AAATTTTTCT GAATCTCTCA GTTTACTCCC TCCCACAGTT GCTGGGCCCC 
TCCTGCTCCT GGGAGGCTGA GGGTCTGCAC TGCAGATGCT CCTTTCGAGC CCGGCCGGCC 
CCCTCCCTGT GCTGGCGGCT TGAGGAGAAG CCGCTGGAGG GGAACAGCAG CCAGGGCTCA 
TTCAAGGTCA ACTCCAGCTC AGCTGGGCCC TGGGCCAACA GCTCCCTGAT CCTCCACGGG 
GGGCTCAGCT CCGACCTCAA AGTCAGCTGC AAGGCCTGGA ACATCTATGG GTCCCAGAGC 
GGCTCTGTCC TGCTGCTGCA AGGGAGATCG AACCTCGGGA CAGGAGTGGT TCCTGCAGCC 
CTTGGTGGTG CTGGTGTCAT GGCCCTGCTC TGTATCTGTC TGTGCCTCAT CTTCTTTTTA 
ATCTGCACTG TGCTGGTTTC TTTCCTTAGA GTGAAAGCCC GCAGGAAGCA AGCAGCTGGG 
AGACCAGAGA AAATGGATGA TGAAGACCCC ATTATGGGTA CCATCACCTC GGGTTCCAGG 
AAGAAGCCCT GGCCAGACAG CCCCGGAGAT CAAGCATCTC CTCCTGGGGA TGCCCCTCCC 
TTGGAAGAAC AAAAGGAGCT CCATTATGCC TCCCTTAGTT TTTCTGAGAT GAAGTCGAGG 
GAGCCTAAGG ACCAGGAGGC CCCAAGCACC ACGGAGTACT CGGAGATCAA GACAAGCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882908.1
CDS	94..1776
Translation	MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLICTVLVSFLRVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK

Target ORF information:

RefSeq Version	XM_017027419.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027419.1

ORF Insert Sequence:

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGATGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GACCATCACC 
ATCTTCAGGA ACGGCATAGC CCTAGAGATC CTGCAAAACA CCTCATACCT TCCGGTCCTG 
GAGGGCCAGG CTCTGCGGCT GCTCTGTGAT GCTCCCAGCA ACCCCCCTGC ACACCTGAGC 
TGGTTCCAGG GCTCCCCTGC CCTGAACGCC ACCCCCATCT CCAATACCGG GATCTTGGAG 
CTTCGTCGAG TAAGGTCTGC AGAAGAAGGA GGCTTCACCT GCCGCGCTCA GCACCCGCTG 
GGCTTCCTGC AAATTTTTCT GAATCTCTCA GTTTACTCCC TCCCACAGTT GCTGGGCCCC 
TCCTGCTCCT GGGAGGCTGA GGGTCTGCAC TGCAGATGCT CCTTTCGAGC CCGGCCGGCC 
CCCTCCCTGT GCTGGCGGCT TGAGGAGAAG CCGCTGGAGG GGAACAGCAG CCAGGGCTCA 
TTCAAGGTCA ACTCCAGCTC AGCTGGGCCC TGGGCCAACA GCTCCCTGAT CCTCCACGGG 
GGGCTCAGCT CCGACCTCAA AGTCAGCTGC AAGGCCTGGA ACATCTATGG GTCCCAGAGC 
GGCTCTGTCC TGCTGCTGCA AGGGAGATCG AACCTCGGGA CAGGAGTGGT TCCTGCAGCC 
CTTGGTGGTG CTGGTGTCAT GGCCCTGCTC TGTATCTGTC TGTGCCTCAT CTTCTTTTTA 
ATCTGCACTG TGCTGGTTTC TTTCCTTAGA GTGAAAGCCC GCAGGAAGCA AGCAGCTGGG 
AGACCAGAGA AAATGGATGA TGAAGACCCC ATTATGGGTA CCATCACCTC GGGTTCCAGG 
AAGAAGCCCT GGCCAGACAG CCCCGGAGAT CAAGCATCTC CTCCTGGGGA TGCCCCTCCC 
TTGGAAGAAC AAAAGGAGCT CCATTATGCC TCCCTTAGTT TTTCTGAGAT GAAGTCGAGG 
GAGCCTAAGG ACCAGGAGGC CCCAAGCACC ACGGAGTACT CGGAGATCAA GACAAGCAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes.
Scientific reports7(1)11272(2017 Sep)
Li JY,Yang XY,Wang XF,Jia X,Wang ZJ,Deng AP,Bai XL,Zhu L,Li BH,Feng ZB,Li Y,Wang L,Jin S

Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity.
Scientific reports637953(2016 Nov)
Pepin M,Mezouar S,Pegon J,Muczynski V,Adam F,Bianchini EP,Bazaa A,Proulle V,Rupin A,Paysant J,Panicot-Dubois L,Christophe OD,Dubois C,Lenting PJ,Denis CV

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and?Siglec-14.
The EMBO journal34(22)2775-88(2015 Nov)
Fong JJ,Sreedhara K,Deng L,Varki NM,Angata T,Liu Q,Nizet V,Varki A

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
Nature genetics47(3)267-71(2015 Mar)
Liu H,Irwanto A,Fu X,Yu G,Yu Y,Sun Y,Wang C,Wang Z,Okada Y,Low H,Li Y,Liany H,Chen M,Bao F,Li J,You J,Zhang Q,Liu J,Chu T,Andiappan AK,Wang N,Niu G,Liu D,Yu X,Zhang L,Tian H,Zhou G,Rotzschke O,Chen S,Zhang X,Liu J,Zhang F

Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5.
The Journal of experimental medicine206(8)1691-9(2009 Aug)
Carlin AF,Chang YC,Areschoug T,Lindahl G,Hurtado-Ziola N,King CC,Varki A,Nizet V

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SIGLEC5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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