RHPN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RHPN2
Entrez Gene ID	85415
Full Name	rhophilin Rho GTPase binding protein 2
Synonyms	P76RBE,RHOBP
General protein information	Preferred Names rhophilin Rho GTPase binding protein 2 Names rhophilin-2 76 kDa RhoB effector protein GTP-Rho-binding protein 2 rhophilin-like Rho-GTPase binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.11
Summary	This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009].

mRNA and Protein(s)

mRNA	Protein	Name
NM_033103.4	NP_149094.3	rhophilin-2
NM_033103.5	NP_149094.3	rhophilin-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RHPN2	XP_001152684.1
Bos taurus (cattle)	RHPN2	NP_001076939.1
Xenopus tropicalis (tropical clawed frog)	rhpn2	NP_001120536.1
Homo sapiens (human)	RHPN2	NP_149094.3
Danio rerio (zebrafish)	rhpn2	NP_957472.1
Gallus gallus (chicken)	RHPN2	XP_414133.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000243	XP_310883.5
Mus musculus (house mouse)	Rhpn2	NP_082173.3
Drosophila melanogaster (fruit fly)	Rhp	NP_511168.3
Canis lupus familiaris (dog)	RHPN2	NP_001003008.1
Rattus norvegicus (Norway rat)	Rhpn2	NP_001100975.1

Gene Ontology
Bibliography

Related articles in PubMed

Analyzing large-scale samples highlights significant association between rs10411210 polymorphism and colorectal cancer.
He D, Ma L, Feng R, Zhang L, Jiang Y, Zhang Y, Liu G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie74164-8(2015 Aug)

Association between GWAS-identified genetic variations and disease prognosis for patients with colorectal cancer.
Kang BW, Jeon HS, Chae YS, Lee SJ, Park JY, Choi JE, Park JS, Choi GS, Kim JG
PloS one10(3)e0119649(2015)

Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
Whiffin N, Hosking FJ, Farrington SM, Palles C, Dobbins SE, Zgaga L, Lloyd A, Kinnersley B, Gorman M, Tenesa A, Broderick P, Wang Y, Barclay E, Hayward C, Martin L, Buchanan DD, Win AK, Hopper J, Jenkins M, Lindor NM, Newcomb PA, Gallinger S, Conti D, Schumacher F, Casey G, Liu T, , Campbell H, Lindblom A, Houlston RS, Tomlinson IP, Dunlop MG
Human molecular genetics23(17)4729-37(2014 Sep)

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Zhang B, Jia WH, Matsuda K, Kweon SS, Matsuo K, Xiang YB, Shin A, Jee SH, Kim DH, Cai Q, Long J, Shi J, Wen W, Yang G, Zhang Y, Li C, Li B, Guo Y, Ren Z, Ji BT, Pan ZZ, Takahashi A, Shin MH, Matsuda F, Gao YT, Oh JH, Kim S, Ahn YO, , Chan AT, Chang-Claude J, Slattery ML, , Gruber SB, Schumacher FR, Stenzel SL, , Casey G, Kim HR, Jeong JY, Park JW, Li HL, Hosono S, Cho SH, Kubo M, Shu XO, Zeng YX, Zheng W
Nature genetics46(6)533-42(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We found significant association between RHPN2 gene rs10411210 and colorectal cancer in European and Asian populations, but not American population
Title: Analyzing large-scale samples highlights significant association between rs10411210 polymorphism and colorectal cancer.

Single nucleotide polymorphism in RHPN2 gene is associated with colorectal cancer.
Title: Association between GWAS-identified genetic variations and disease prognosis for patients with colorectal cancer.

These effects were implemented through RHPN2-mediated activation of RhoA.
Title: RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic heterogeneity in colorectal cancer associations between African and European americans.

The following RHPN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RHPN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12378	NM_033103.5 Latest version!	Homo sapiens rhophilin Rho GTPase binding protein 2 (RHPN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu12378	NM_033103.4	Homo sapiens rhophilin Rho GTPase binding protein 2 (RHPN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RHPN2 ( NM_033103.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_149094.3 Homo sapiens rhophilin Rho GTPase binding protein 2 (RHPN2), mRNA.

Price & Availability↑

CloneID	OHu12378
Clone ID Related Accession (Same CDS sequence)	NM_033103.4 , NM_033103.5
Accession Version	NM_033103.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	rhophilin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC348657.1, AJ347750.1, AC011449.6 and BC036447.2. On Apr 29, 2009 this sequence version replaced NM_033103.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036447.2, SRR1660807.247652.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGACG CGCTGTTGCC CGCGGCCCCC CAGCCGCTGG AGAAGGAGAA CGACGGCTAC 
TTTCGGAAGG GCTGTAATCC CCTTGCACAA ACCGGCCGGA GTAAATTGCA GAATCAAAGA 
GCTGCTTTGA ATCAGCAGAT CCTGAAAGCC GTGCGGATGA GGACCGGAGC GGAAAACCTT 
CTGAAAGTGG CCACAAACTC AAAGGTGCGG GAGCAAGTGC GGCTGGAGCT GAGCTTCGTC 
AACTCAGACC TGCAGATGCT CAAGGAAGAG CTGGAGGGGC TGAACATCTC GGTGGGCGTC 
TATCAGAACA CAGAGGAGGC ATTTACGATT CCCCTGATTC CTCTTGGCCT GAAGGAAACG 
AAAGACGTCG ACTTTGCAGT CGTCCTCAAG GATTTTATCC TGGAACATTA CAGTGAAGAT 
GGCTATTTAT ATGAAGATGA AATTGCAGAT CTTATGGATC TGAGACAAGC TTGTCGGACG 
CCTAGCCGGG ATGAGGCCGG GGTGGAACTG CTGATGACAT ACTTCATCCA GCTGGGCTTT 
GTCGAGAGTC GATTCTTCCC GCCCACACGG CAGATGGGAC TCCTGTTCAC CTGGTATGAC 
TCTCTCACCG GGGTTCCGGT CAGCCAGCAG AACCTGCTGC TGGAGAAGGC CAGTGTCCTG 
TTCAACACTG GGGCCCTCTA CACCCAGATT GGGACCCGGT GTGATCGGCA GACGCAGGCT 
GGGCTGGAGA GTGCCATAGA TGCCTTTCAG AGAGCCGCAG GGGTTTTAAA TTACCTGAAA 
GACACATTTA CCCATACTCC AAGTTACGAC ATGAGCCCTG CCATGCTCAG CGTGCTCGTC 
AAAATGATGC TTGCACAAGC CCAAGAAAGC GTGTTTGAGA AAATCAGCCT TCCTGGGATC 
CGGAATGAAT TCTTCATGCT GGTGAAGGTG GCTCAGGAGG CTGCTAAGGT GGGAGAGGTC 
TACCAACAGC TACACGCAGC CATGAGCCAG GCGCCGGTGA AAGAGAACAT CCCCTACTCC 
TGGGCCAGCT TAGCCTGCGT GAAGGCCCAC CACTACGCGG CCCTGGCCCA CTACTTCACT 
GCCATCCTCC TCATCGACCA CCAGGTGAAG CCAGGCACGG ATCTGGACCA CCAGGAGAAG 
TGCCTGTCCC AGCTCTACGA CCACATGCCA GAGGGGCTGA CACCCTTGGC CACACTGAAG 
AATGATCAGC AGCGCCGACA GCTGGGGAAG TCCCACTTGC GCAGAGCCAT GGCTCATCAC 
GAGGAGTCGG TGCGGGAGGC CAGCCTCTGC AAGAAGCTGC GGAGCATTGA GGTGCTACAG 
AAGGTGCTGT GTGCCGCACA GGAACGCTCC CGGCTCACGT ACGCCCAGCA CCAGGAGGAG 
GATGACCTGC TGAACCTGAT CGACGCCCCC AGTGTTGTTG CTAAAACTGA GCAAGAGGTT 
GACATTATAT TGCCCCAGTT CTCCAAGCTG ACAGTCACGG ACTTCTTCCA GAAGCTGGGC 
CCCTTATCTG TGTTTTCGGC TAACAAGCGG TGGACGCCTC CTCGAAGCAT CCGCTTCACT 
GCAGAAGAAG GGGACTTGGG GTTCACCTTG AGAGGGAACG CCCCCGTTCA GGTTCACTTC 
CTGGATCCTT ACTGCTCTGC CTCGGTGGCA GGAGCCCGGG AAGGAGATTA TATTGTCTCC 
ATTCAGCTTG TGGATTGTAA GTGGCTGACG CTGAGTGAGG TTATGAAGCT GCTGAAGAGC 
TTTGGCGAGG ACGAGATCGA GATGAAAGTC GTGAGCCTCC TGGACTCCAC ATCATCCATG 
CATAATAAGA GTGCCACATA CTCCGTGGGA ATGCAGAAAA CGTACTCCAT GATCTGCTTA 
GCCATTGATG ATGACGACAA AACTGATAAA ACCAAGAAAA TCTCCAAGAA GCTTTCCTTC 
CTGAGTTGGG GCACCAACAA GAACAGACAG AAGTCAGCCA GCACCTTGTG CCTCCCATCG 
GTCGGGGCTG CACGGCCTCA GGTCAAGAAG AAGCTGCCCT CCCCTTTCAG CCTTCTCAAC 
TCAGACAGTT CTTGGTACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149094.3
CDS	67..2127
Translation	MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKETKDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGFVESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQAGLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGIRNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFTAILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHHEESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEVDIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSMHNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSASTLCLPSVGAARPQVKKKLPSPFSLLNSDSSWY

Target ORF information:

RefSeq Version	NM_033103.4
Organism	Homo sapiens(human)
Definition	Homo sapiens rhophilin Rho GTPase binding protein 2 (RHPN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033103.4

ORF Insert Sequence:

ATGACCGACG CGCTGTTGCC CGCGGCCCCC CAGCCGCTGG AGAAGGAGAA CGACGGCTAC 
TTTCGGAAGG GCTGTAATCC CCTTGCACAA ACCGGCCGGA GTAAATTGCA GAATCAAAGA 
GCTGCTTTGA ATCAGCAGAT CCTGAAAGCC GTGCGGATGA GGACCGGAGC GGAAAACCTT 
CTGAAAGTGG CCACAAACTC AAAGGTGCGG GAGCAAGTGC GGCTGGAGCT GAGCTTCGTC 
AACTCAGACC TGCAGATGCT CAAGGAAGAG CTGGAGGGGC TGAACATCTC GGTGGGCGTC 
TATCAGAACA CAGAGGAGGC ATTTACGATT CCCCTGATTC CTCTTGGCCT GAAGGAAACG 
AAAGACGTCG ACTTTGCAGT CGTCCTCAAG GATTTTATCC TGGAACATTA CAGTGAAGAT 
GGCTATTTAT ATGAAGATGA AATTGCAGAT CTTATGGATC TGAGACAAGC TTGTCGGACG 
CCTAGCCGGG ATGAGGCCGG GGTGGAACTG CTGATGACAT ACTTCATCCA GCTGGGCTTT 
GTCGAGAGTC GATTCTTCCC GCCCACACGG CAGATGGGAC TCCTGTTCAC CTGGTATGAC 
TCTCTCACCG GGGTTCCGGT CAGCCAGCAG AACCTGCTGC TGGAGAAGGC CAGTGTCCTG 
TTCAACACTG GGGCCCTCTA CACCCAGATT GGGACCCGGT GTGATCGGCA GACGCAGGCT 
GGGCTGGAGA GTGCCATAGA TGCCTTTCAG AGAGCCGCAG GGGTTTTAAA TTACCTGAAA 
GACACATTTA CCCATACTCC AAGTTACGAC ATGAGCCCTG CCATGCTCAG CGTGCTCGTC 
AAAATGATGC TTGCACAAGC CCAAGAAAGC GTGTTTGAGA AAATCAGCCT TCCTGGGATC 
CGGAATGAAT TCTTCATGCT GGTGAAGGTG GCTCAGGAGG CTGCTAAGGT GGGAGAGGTC 
TACCAACAGC TACACGCAGC CATGAGCCAG GCGCCGGTGA AAGAGAACAT CCCCTACTCC 
TGGGCCAGCT TAGCCTGCGT GAAGGCCCAC CACTACGCGG CCCTGGCCCA CTACTTCACT 
GCCATCCTCC TCATCGACCA CCAGGTGAAG CCAGGCACGG ATCTGGACCA CCAGGAGAAG 
TGCCTGTCCC AGCTCTACGA CCACATGCCA GAGGGGCTGA CACCCTTGGC CACACTGAAG 
AATGATCAGC AGCGCCGACA GCTGGGGAAG TCCCACTTGC GCAGAGCCAT GGCTCATCAC 
GAGGAGTCGG TGCGGGAGGC CAGCCTCTGC AAGAAGCTGC GGAGCATTGA GGTGCTACAG 
AAGGTGCTGT GTGCCGCACA GGAACGCTCC CGGCTCACGT ACGCCCAGCA CCAGGAGGAG 
GATGACCTGC TGAACCTGAT CGACGCCCCC AGTGTTGTTG CTAAAACTGA GCAAGAGGTT 
GACATTATAT TGCCCCAGTT CTCCAAGCTG ACAGTCACGG ACTTCTTCCA GAAGCTGGGC 
CCCTTATCTG TGTTTTCGGC TAACAAGCGG TGGACGCCTC CTCGAAGCAT CCGCTTCACT 
GCAGAAGAAG GGGACTTGGG GTTCACCTTG AGAGGGAACG CCCCCGTTCA GGTTCACTTC 
CTGGATCCTT ACTGCTCTGC CTCGGTGGCA GGAGCCCGGG AAGGAGATTA TATTGTCTCC 
ATTCAGCTTG TGGATTGTAA GTGGCTGACG CTGAGTGAGG TTATGAAGCT GCTGAAGAGC 
TTTGGCGAGG ACGAGATCGA GATGAAAGTC GTGAGCCTCC TGGACTCCAC ATCATCCATG 
CATAATAAGA GTGCCACATA CTCCGTGGGA ATGCAGAAAA CGTACTCCAT GATCTGCTTA 
GCCATTGATG ATGACGACAA AACTGATAAA ACCAAGAAAA TCTCCAAGAA GCTTTCCTTC 
CTGAGTTGGG GCACCAACAA GAACAGACAG AAGTCAGCCA GCACCTTGTG CCTCCCATCG 
GTCGGGGCTG CACGGCCTCA GGTCAAGAAG AAGCTGCCCT CCCCTTTCAG CCTTCTCAAC 
TCAGACAGTT CTTGGTACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHPN2 ( NM_033103.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_149094.3 Homo sapiens rhophilin Rho GTPase binding protein 2 (RHPN2), mRNA.

Price & Availability↑

CloneID	OHu12378
Clone ID Related Accession (Same CDS sequence)	NM_033103.4 , NM_033103.5
Accession Version	NM_033103.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	rhophilin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC348657.1, AJ347750.1, AC011449.6 and BC036447.2. On Nov 23, 2018 this sequence version replaced NM_033103.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036447.2, SRR1660807.247652.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000254260.8/ ENSP00000254260.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCGACG CGCTGTTGCC CGCGGCCCCC CAGCCGCTGG AGAAGGAGAA CGACGGCTAC 
TTTCGGAAGG GCTGTAATCC CCTTGCACAA ACCGGCCGGA GTAAATTGCA GAATCAAAGA 
GCTGCTTTGA ATCAGCAGAT CCTGAAAGCC GTGCGGATGA GGACCGGAGC GGAAAACCTT 
CTGAAAGTGG CCACAAACTC AAAGGTGCGG GAGCAAGTGC GGCTGGAGCT GAGCTTCGTC 
AACTCAGACC TGCAGATGCT CAAGGAAGAG CTGGAGGGGC TGAACATCTC GGTGGGCGTC 
TATCAGAACA CAGAGGAGGC ATTTACGATT CCCCTGATTC CTCTTGGCCT GAAGGAAACG 
AAAGACGTCG ACTTTGCAGT CGTCCTCAAG GATTTTATCC TGGAACATTA CAGTGAAGAT 
GGCTATTTAT ATGAAGATGA AATTGCAGAT CTTATGGATC TGAGACAAGC TTGTCGGACG 
CCTAGCCGGG ATGAGGCCGG GGTGGAACTG CTGATGACAT ACTTCATCCA GCTGGGCTTT 
GTCGAGAGTC GATTCTTCCC GCCCACACGG CAGATGGGAC TCCTGTTCAC CTGGTATGAC 
TCTCTCACCG GGGTTCCGGT CAGCCAGCAG AACCTGCTGC TGGAGAAGGC CAGTGTCCTG 
TTCAACACTG GGGCCCTCTA CACCCAGATT GGGACCCGGT GTGATCGGCA GACGCAGGCT 
GGGCTGGAGA GTGCCATAGA TGCCTTTCAG AGAGCCGCAG GGGTTTTAAA TTACCTGAAA 
GACACATTTA CCCATACTCC AAGTTACGAC ATGAGCCCTG CCATGCTCAG CGTGCTCGTC 
AAAATGATGC TTGCACAAGC CCAAGAAAGC GTGTTTGAGA AAATCAGCCT TCCTGGGATC 
CGGAATGAAT TCTTCATGCT GGTGAAGGTG GCTCAGGAGG CTGCTAAGGT GGGAGAGGTC 
TACCAACAGC TACACGCAGC CATGAGCCAG GCGCCGGTGA AAGAGAACAT CCCCTACTCC 
TGGGCCAGCT TAGCCTGCGT GAAGGCCCAC CACTACGCGG CCCTGGCCCA CTACTTCACT 
GCCATCCTCC TCATCGACCA CCAGGTGAAG CCAGGCACGG ATCTGGACCA CCAGGAGAAG 
TGCCTGTCCC AGCTCTACGA CCACATGCCA GAGGGGCTGA CACCCTTGGC CACACTGAAG 
AATGATCAGC AGCGCCGACA GCTGGGGAAG TCCCACTTGC GCAGAGCCAT GGCTCATCAC 
GAGGAGTCGG TGCGGGAGGC CAGCCTCTGC AAGAAGCTGC GGAGCATTGA GGTGCTACAG 
AAGGTGCTGT GTGCCGCACA GGAACGCTCC CGGCTCACGT ACGCCCAGCA CCAGGAGGAG 
GATGACCTGC TGAACCTGAT CGACGCCCCC AGTGTTGTTG CTAAAACTGA GCAAGAGGTT 
GACATTATAT TGCCCCAGTT CTCCAAGCTG ACAGTCACGG ACTTCTTCCA GAAGCTGGGC 
CCCTTATCTG TGTTTTCGGC TAACAAGCGG TGGACGCCTC CTCGAAGCAT CCGCTTCACT 
GCAGAAGAAG GGGACTTGGG GTTCACCTTG AGAGGGAACG CCCCCGTTCA GGTTCACTTC 
CTGGATCCTT ACTGCTCTGC CTCGGTGGCA GGAGCCCGGG AAGGAGATTA TATTGTCTCC 
ATTCAGCTTG TGGATTGTAA GTGGCTGACG CTGAGTGAGG TTATGAAGCT GCTGAAGAGC 
TTTGGCGAGG ACGAGATCGA GATGAAAGTC GTGAGCCTCC TGGACTCCAC ATCATCCATG 
CATAATAAGA GTGCCACATA CTCCGTGGGA ATGCAGAAAA CGTACTCCAT GATCTGCTTA 
GCCATTGATG ATGACGACAA AACTGATAAA ACCAAGAAAA TCTCCAAGAA GCTTTCCTTC 
CTGAGTTGGG GCACCAACAA GAACAGACAG AAGTCAGCCA GCACCTTGTG CCTCCCATCG 
GTCGGGGCTG CACGGCCTCA GGTCAAGAAG AAGCTGCCCT CCCCTTTCAG CCTTCTCAAC 
TCAGACAGTT CTTGGTACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149094.3
CDS	37..2097
Translation	MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKETKDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGFVESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQAGLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGIRNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFTAILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHHEESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEVDIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSMHNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSASTLCLPSVGAARPQVKKKLPSPFSLLNSDSSWY

Target ORF information:

RefSeq Version	NM_033103.5
Organism	Homo sapiens(human)
Definition	Homo sapiens rhophilin Rho GTPase binding protein 2 (RHPN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033103.5

ORF Insert Sequence:

ATGACCGACG CGCTGTTGCC CGCGGCCCCC CAGCCGCTGG AGAAGGAGAA CGACGGCTAC 
TTTCGGAAGG GCTGTAATCC CCTTGCACAA ACCGGCCGGA GTAAATTGCA GAATCAAAGA 
GCTGCTTTGA ATCAGCAGAT CCTGAAAGCC GTGCGGATGA GGACCGGAGC GGAAAACCTT 
CTGAAAGTGG CCACAAACTC AAAGGTGCGG GAGCAAGTGC GGCTGGAGCT GAGCTTCGTC 
AACTCAGACC TGCAGATGCT CAAGGAAGAG CTGGAGGGGC TGAACATCTC GGTGGGCGTC 
TATCAGAACA CAGAGGAGGC ATTTACGATT CCCCTGATTC CTCTTGGCCT GAAGGAAACG 
AAAGACGTCG ACTTTGCAGT CGTCCTCAAG GATTTTATCC TGGAACATTA CAGTGAAGAT 
GGCTATTTAT ATGAAGATGA AATTGCAGAT CTTATGGATC TGAGACAAGC TTGTCGGACG 
CCTAGCCGGG ATGAGGCCGG GGTGGAACTG CTGATGACAT ACTTCATCCA GCTGGGCTTT 
GTCGAGAGTC GATTCTTCCC GCCCACACGG CAGATGGGAC TCCTGTTCAC CTGGTATGAC 
TCTCTCACCG GGGTTCCGGT CAGCCAGCAG AACCTGCTGC TGGAGAAGGC CAGTGTCCTG 
TTCAACACTG GGGCCCTCTA CACCCAGATT GGGACCCGGT GTGATCGGCA GACGCAGGCT 
GGGCTGGAGA GTGCCATAGA TGCCTTTCAG AGAGCCGCAG GGGTTTTAAA TTACCTGAAA 
GACACATTTA CCCATACTCC AAGTTACGAC ATGAGCCCTG CCATGCTCAG CGTGCTCGTC 
AAAATGATGC TTGCACAAGC CCAAGAAAGC GTGTTTGAGA AAATCAGCCT TCCTGGGATC 
CGGAATGAAT TCTTCATGCT GGTGAAGGTG GCTCAGGAGG CTGCTAAGGT GGGAGAGGTC 
TACCAACAGC TACACGCAGC CATGAGCCAG GCGCCGGTGA AAGAGAACAT CCCCTACTCC 
TGGGCCAGCT TAGCCTGCGT GAAGGCCCAC CACTACGCGG CCCTGGCCCA CTACTTCACT 
GCCATCCTCC TCATCGACCA CCAGGTGAAG CCAGGCACGG ATCTGGACCA CCAGGAGAAG 
TGCCTGTCCC AGCTCTACGA CCACATGCCA GAGGGGCTGA CACCCTTGGC CACACTGAAG 
AATGATCAGC AGCGCCGACA GCTGGGGAAG TCCCACTTGC GCAGAGCCAT GGCTCATCAC 
GAGGAGTCGG TGCGGGAGGC CAGCCTCTGC AAGAAGCTGC GGAGCATTGA GGTGCTACAG 
AAGGTGCTGT GTGCCGCACA GGAACGCTCC CGGCTCACGT ACGCCCAGCA CCAGGAGGAG 
GATGACCTGC TGAACCTGAT CGACGCCCCC AGTGTTGTTG CTAAAACTGA GCAAGAGGTT 
GACATTATAT TGCCCCAGTT CTCCAAGCTG ACAGTCACGG ACTTCTTCCA GAAGCTGGGC 
CCCTTATCTG TGTTTTCGGC TAACAAGCGG TGGACGCCTC CTCGAAGCAT CCGCTTCACT 
GCAGAAGAAG GGGACTTGGG GTTCACCTTG AGAGGGAACG CCCCCGTTCA GGTTCACTTC 
CTGGATCCTT ACTGCTCTGC CTCGGTGGCA GGAGCCCGGG AAGGAGATTA TATTGTCTCC 
ATTCAGCTTG TGGATTGTAA GTGGCTGACG CTGAGTGAGG TTATGAAGCT GCTGAAGAGC 
TTTGGCGAGG ACGAGATCGA GATGAAAGTC GTGAGCCTCC TGGACTCCAC ATCATCCATG 
CATAATAAGA GTGCCACATA CTCCGTGGGA ATGCAGAAAA CGTACTCCAT GATCTGCTTA 
GCCATTGATG ATGACGACAA AACTGATAAA ACCAAGAAAA TCTCCAAGAA GCTTTCCTTC 
CTGAGTTGGG GCACCAACAA GAACAGACAG AAGTCAGCCA GCACCTTGTG CCTCCCATCG 
GTCGGGGCTG CACGGCCTCA GGTCAAGAAG AAGCTGCCCT CCCCTTTCAG CCTTCTCAAC 
TCAGACAGTT CTTGGTACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analyzing large-scale samples highlights significant association between rs10411210 polymorphism and colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie74164-8(2015 Aug)
He D,Ma L,Feng R,Zhang L,Jiang Y,Zhang Y,Liu G

Association between GWAS-identified genetic variations and disease prognosis for patients with colorectal cancer.
PloS one10(3)e0119649(2015)
Kang BW,Jeon HS,Chae YS,Lee SJ,Park JY,Choi JE,Park JS,Choi GS,Kim JG

Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
Human molecular genetics23(17)4729-37(2014 Sep)
Whiffin N,Hosking FJ,Farrington SM,Palles C,Dobbins SE,Zgaga L,Lloyd A,Kinnersley B,Gorman M,Tenesa A,Broderick P,Wang Y,Barclay E,Hayward C,Martin L,Buchanan DD,Win AK,Hopper J,Jenkins M,Lindor NM,Newcomb PA,Gallinger S,Conti D,Schumacher F,Casey G,Liu T,,Campbell H,Lindblom A,Houlston RS,Tomlinson IP,Dunlop MG

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Nature genetics46(6)533-42(2014 Jun)
Zhang B,Jia WH,Matsuda K,Kweon SS,Matsuo K,Xiang YB,Shin A,Jee SH,Kim DH,Cai Q,Long J,Shi J,Wen W,Yang G,Zhang Y,Li C,Li B,Guo Y,Ren Z,Ji BT,Pan ZZ,Takahashi A,Shin MH,Matsuda F,Gao YT,Oh JH,Kim S,Ahn YO,,Chan AT,Chang-Claude J,Slattery ML,,Gruber SB,Schumacher FR,Stenzel SL,,Casey G,Kim HR,Jeong JY,Park JW,Li HL,Hosono S,Cho SH,Kubo M,Shu XO,Zeng YX,Zheng W

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RHPN2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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