H3C3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H3C3
Entrez Gene ID	8352
Full Name	histone cluster 1 H3 family member c
Synonyms	H3.1,H3/c,H3FC
General protein information	Preferred Names histone cluster 1 H3 family member c Names histone H3.1 H3 histone family, member C histone 1, H3c histone H3/c histone cluster 1, H3c
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	602812

mRNA and Protein(s)

mRNA	Protein	Name
NM_003531.2	NP_003522.1	histone H3.1
NM_003531.3	NP_003522.1	histone H3.1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC488263	XP_005640158.1
Danio rerio (zebrafish)	si:ch211-113a14.14	XP_688577.1
Pan troglodytes (chimpanzee)	LOC100608783	XP_003950813.1
	LOC703889	XP_001095574.1
Bos taurus (cattle)	LOC616800	XP_002697506.1
Mus musculus (house mouse)	Hist2h3c1	NP_835734.2
Drosophila melanogaster (fruit fly)	His3:CG33863	NP_001027383.1
Xenopus tropicalis (tropical clawed frog)	LOC100497406	XP_002943900.2
Homo sapiens (human)	HIST1H3C	NP_003522.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Huang H, Str?mme CB, Saredi G, H?dl M, Strandsby A, Gonz?lez-Aguilera C, Chen S, Groth A, Patel DJ
Nature structural & molecular biology22(8)618-26(2015 Aug)

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Kato D, Osakabe A, Tachiwana H, Tanaka H, Kurumizaka H
Biochemistry54(5)1171-9(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that HIST1H3C and GNAS methylation was associated with overall and/or event-free survival.
Title: Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers.

The following H3C3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3C3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13149	NM_003531.3 Latest version!	Homo sapiens H3 clustered histone 3 (H3C3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13149	NM_003531.2	Homo sapiens histone cluster 1 H3 family member c (HIST1H3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3C3 ( NM_003531.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003522.1 Homo sapiens histone cluster 1 H3 family member c (HIST1H3C), mRNA.

Price & Availability↑

CloneID	OHu13149
Clone ID Related Accession (Same CDS sequence)	NM_003531.2 , NM_003531.3
Accession Version	NM_003531.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X57128.1. On May 22, 2002 this sequence version replaced NM_003531.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC127610.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGTA CGAAGCAAAC AGCTCGCAAG TCTACCGGCG GCAAAGCTCC GCGCAAGCAG 
CTTGCTACTA AAGCAGCCCG TAAGAGCGCT CCGGCCACCG GTGGCGTGAA GAAACCTCAT 
CGCTACCGCC CGGGCACCGT GGCCTTGCGC GAAATCCGTC GCTACCAGAA GTCCACCGAG 
CTGCTGATCC GGAAGCTGCC GTTCCAGCGC CTGGTGCGAG AAATCGCCCA GGACTTCAAA 
ACCGACCTGC GTTTCCAGAG CTCTGCGGTG ATGGCGCTGC AGGAGGCTTG TGAGGCCTAC 
CTGGTGGGAC TCTTCGAAGA CACCAATCTG TGCGCTATTC ACGCTAAACG CGTCACCATC 
ATGCCCAAAG ATATCCAGCT GGCACGTCGC ATCCGTGGGG AAAGGGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003522.1
CDS	1..411
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_003531.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H3 family member c (HIST1H3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003531.2

ORF Insert Sequence:

ATGGCTCGTA CGAAGCAAAC AGCTCGCAAG TCTACCGGCG GCAAAGCTCC GCGCAAGCAG 
CTTGCTACTA AAGCAGCCCG TAAGAGCGCT CCGGCCACCG GTGGCGTGAA GAAACCTCAT 
CGCTACCGCC CGGGCACCGT GGCCTTGCGC GAAATCCGTC GCTACCAGAA GTCCACCGAG 
CTGCTGATCC GGAAGCTGCC GTTCCAGCGC CTGGTGCGAG AAATCGCCCA GGACTTCAAA 
ACCGACCTGC GTTTCCAGAG CTCTGCGGTG ATGGCGCTGC AGGAGGCTTG TGAGGCCTAC 
CTGGTGGGAC TCTTCGAAGA CACCAATCTG TGCGCTATTC ACGCTAAACG CGTCACCATC 
ATGCCCAAAG ATATCCAGCT GGCACGTCGC ATCCGTGGGG AAAGGGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3C3 ( NM_003531.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003522.1 Homo sapiens H3 clustered histone 3 (H3C3), mRNA.

Price & Availability↑

CloneID	OHu13149
Clone ID Related Accession (Same CDS sequence)	NM_003531.2 , NM_003531.3
Accession Version	NM_003531.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U91328.1. On Dec 3, 2019 this sequence version replaced NM_003531.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC127610.1, BU568766.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGTA CGAAGCAAAC AGCTCGCAAG TCTACCGGCG GCAAAGCTCC GCGCAAGCAG 
CTTGCTACTA AAGCAGCCCG TAAGAGCGCT CCGGCCACCG GTGGCGTGAA GAAACCTCAT 
CGCTACCGCC CGGGCACCGT GGCCTTGCGC GAAATCCGTC GCTACCAGAA GTCCACCGAG 
CTGCTGATCC GGAAGCTGCC GTTCCAGCGC CTGGTGCGAG AAATCGCCCA GGACTTCAAA 
ACCGACCTGC GTTTCCAGAG CTCTGCGGTG ATGGCGCTGC AGGAGGCTTG TGAGGCCTAC 
CTGGTGGGAC TCTTCGAAGA CACCAATCTG TGCGCTATTC ACGCTAAACG CGTCACCATC 
ATGCCCAAAG ATATCCAGCT GGCACGTCGC ATCCGTGGGG AAAGGGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003522.1
CDS	28..438
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_003531.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 clustered histone 3 (H3C3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003531.3

ORF Insert Sequence:

ATGGCTCGTA CGAAGCAAAC AGCTCGCAAG TCTACCGGCG GCAAAGCTCC GCGCAAGCAG 
CTTGCTACTA AAGCAGCCCG TAAGAGCGCT CCGGCCACCG GTGGCGTGAA GAAACCTCAT 
CGCTACCGCC CGGGCACCGT GGCCTTGCGC GAAATCCGTC GCTACCAGAA GTCCACCGAG 
CTGCTGATCC GGAAGCTGCC GTTCCAGCGC CTGGTGCGAG AAATCGCCCA GGACTTCAAA 
ACCGACCTGC GTTTCCAGAG CTCTGCGGTG ATGGCGCTGC AGGAGGCTTG TGAGGCCTAC 
CTGGTGGGAC TCTTCGAAGA CACCAATCTG TGCGCTATTC ACGCTAAACG CGTCACCATC 
ATGCCCAAAG ATATCCAGCT GGCACGTCGC ATCCGTGGGG AAAGGGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Nature structural & molecular biology22(8)618-26(2015 Aug)
Huang H,Str?mme CB,Saredi G,H?dl M,Strandsby A,Gonz?lez-Aguilera C,Chen S,Groth A,Patel DJ

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Biochemistry54(5)1171-9(2015 Feb)
Kato D,Osakabe A,Tachiwana H,Tanaka H,Kurumizaka H

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H3C3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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