H3C4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H3C4
Entrez Gene ID	8351
Full Name	histone cluster 1 H3 family member d
Synonyms	H3/b,H3FB
General protein information	Preferred Names histone cluster 1 H3 family member d Names histone H3.1 H3 histone family, member B histone 1, H3d histone H3/b histone cluster 1, H3d
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	602811

mRNA and Protein(s)

mRNA	Protein	Name
NM_001376937.1	NP_001363866.1	histone H3.1
NM_003530.4	NP_003521.2	histone H3.1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC462506	XP_003950810.1
Canis lupus familiaris (dog)	LOC100684574	XP_005640156.1
Bos taurus (cattle)	LOC525511	XP_005223856.1
Rattus norvegicus (Norway rat)	LOC691496	NP_001103112.1
Homo sapiens (human)	HIST1H3D	NP_003521.2
	LOC698731	XP_001088393.1
Drosophila melanogaster (fruit fly)	His3:CG33848	NP_001027358.1
Mus musculus (house mouse)	Hist1h3a	NP_038578.2
Danio rerio (zebrafish)	LOC100329422	XP_002666952.2
Xenopus tropicalis (tropical clawed frog)	LOC100487139	XP_002944966.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

HIST1H3D: A promising therapeutic target for lung cancer.
Rui Y, Peng WJ, Wang M, Wang Q, Liu ZL, Chen YQ, Huang LN
International journal of oncology50(3)815-822(2017 Mar)

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Huang H, Str?mme CB, Saredi G, H?dl M, Strandsby A, Gonz?lez-Aguilera C, Chen S, Groth A, Patel DJ
Nature structural & molecular biology22(8)618-26(2015 Aug)

The human and mouse replication-dependent histone genes.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ
Genomics80(5)487-98(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HIST1H3D is highly expressed in lung cancer cell lines and tissues, and may be important in cell proliferation, apoptosis and cell cycle progression, and is implicated as a potential therapeutic target for lung cancer.
Title: HIST1H3D: A promising therapeutic target for lung cancer.

HIST1H3D expression in the bone marrow, peripheral blood, and primary tumor of stage IV patients is higher than that in stage I patients.
Title: Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer.

The following H3C4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3C4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu16779	NM_001376937.1 Latest version!	Homo sapiens H3 clustered histone 4 (H3C4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16779	NM_003530.4 Latest version!	Homo sapiens H3 clustered histone 4 (H3C4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3C4 ( NM_001376937.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001363866.1 Homo sapiens H3 clustered histone 4 (H3C4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16779
Clone ID Related Accession (Same CDS sequence)	NM_001376937.1 , NM_003530.4
Accession Version	NM_001376937.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031777.5. Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BM007476.1, CD694188.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGTA CCAAGCAGAC TGCTCGCAAG TCCACGGGTG GGAAAGCGCC ACGCAAGCAG 
CTGGCCACCA AGGCTGCTCG AAAGAGCGCT CCAGCCACCG GCGGCGTGAA GAAGCCCCAC 
CGTTACCGGC CCGGCACGGT GGCTCTGCGC GAGATCCGCC GCTACCAGAA GTCGACCGAG 
CTGCTGATTC GCAAACTGCC ATTCCAGCGT CTAGTCCGTG AGATCGCGCA GGACTTCAAG 
ACTGATCTGC GTTTTCAGAG CTCGGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC 
CTGGTGGGGC TGTTTGAGGA CACCAACCTA TGCGCCATTC ACGCCAAGCG AGTGACTATC 
ATGCCCAAGG ACATCCAGCT TGCTCGCCGC ATTCGTGGGG AGAGGGCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001363866.1
CDS	37..447
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_001376937.1
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 clustered histone 4 (H3C4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001376937.1

ORF Insert Sequence:

ATGGCTCGTA CCAAGCAGAC TGCTCGCAAG TCCACGGGTG GGAAAGCGCC ACGCAAGCAG 
CTGGCCACCA AGGCTGCTCG AAAGAGCGCT CCAGCCACCG GCGGCGTGAA GAAGCCCCAC 
CGTTACCGGC CCGGCACGGT GGCTCTGCGC GAGATCCGCC GCTACCAGAA GTCGACCGAG 
CTGCTGATTC GCAAACTGCC ATTCCAGCGT CTAGTCCGTG AGATCGCGCA GGACTTCAAG 
ACTGATCTGC GTTTTCAGAG CTCGGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC 
CTGGTGGGGC TGTTTGAGGA CACCAACCTA TGCGCCATTC ACGCCAAGCG AGTGACTATC 
ATGCCCAAGG ACATCCAGCT TGCTCGCCGC ATTCGTGGGG AGAGGGCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3C4 ( NM_003530.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003521.2 Homo sapiens H3 clustered histone 4 (H3C4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16779
Clone ID Related Accession (Same CDS sequence)	NM_001376937.1 , NM_003530.4
Accession Version	NM_003530.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB242999.1 and BC031333.1. On Feb 5, 2013 this sequence version replaced NM_003530.3. Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK316611.1, BQ051491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGTA CCAAGCAGAC TGCTCGCAAG TCCACGGGTG GGAAAGCGCC ACGCAAGCAG 
CTGGCCACCA AGGCTGCTCG AAAGAGCGCT CCAGCCACCG GCGGCGTGAA GAAGCCCCAC 
CGTTACCGGC CCGGCACGGT GGCTCTGCGC GAGATCCGCC GCTACCAGAA GTCGACCGAG 
CTGCTGATTC GCAAACTGCC ATTCCAGCGT CTAGTCCGTG AGATCGCGCA GGACTTCAAG 
ACTGATCTGC GTTTTCAGAG CTCGGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC 
CTGGTGGGGC TGTTTGAGGA CACCAACCTA TGCGCCATTC ACGCCAAGCG AGTGACTATC 
ATGCCCAAGG ACATCCAGCT TGCTCGCCGC ATTCGTGGGG AGAGGGCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003521.2
CDS	455..865
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_003530.4
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 clustered histone 4 (H3C4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003530.4

ORF Insert Sequence:

ATGGCTCGTA CCAAGCAGAC TGCTCGCAAG TCCACGGGTG GGAAAGCGCC ACGCAAGCAG 
CTGGCCACCA AGGCTGCTCG AAAGAGCGCT CCAGCCACCG GCGGCGTGAA GAAGCCCCAC 
CGTTACCGGC CCGGCACGGT GGCTCTGCGC GAGATCCGCC GCTACCAGAA GTCGACCGAG 
CTGCTGATTC GCAAACTGCC ATTCCAGCGT CTAGTCCGTG AGATCGCGCA GGACTTCAAG 
ACTGATCTGC GTTTTCAGAG CTCGGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC 
CTGGTGGGGC TGTTTGAGGA CACCAACCTA TGCGCCATTC ACGCCAAGCG AGTGACTATC 
ATGCCCAAGG ACATCCAGCT TGCTCGCCGC ATTCGTGGGG AGAGGGCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

HIST1H3D: A promising therapeutic target for lung cancer.
International journal of oncology50(3)815-822(2017 Mar)
Rui Y,Peng WJ,Wang M,Wang Q,Liu ZL,Chen YQ,Huang LN

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Nature structural & molecular biology22(8)618-26(2015 Aug)
Huang H,Str?mme CB,Saredi G,H?dl M,Strandsby A,Gonz?lez-Aguilera C,Chen S,Groth A,Patel DJ

The human and mouse replication-dependent histone genes.
Genomics80(5)487-98(2002 Nov)
Marzluff WF,Gongidi P,Woods KR,Jin J,Maltais LJ

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H3C4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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