CAMLG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CAMLG
Entrez Gene ID	819
Full Name	calcium modulating ligand
Synonyms	CAML,GET2
General protein information	Preferred Names calcium modulating ligand Names calcium signal-modulating cyclophilin ligand calcium-modulating cyclophilin ligand cyclophilin B-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.1
Summary	The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008].
Disorder MIM:	601118

mRNA and Protein(s)

mRNA	Protein	Name
NM_001745.4	NP_001736.1	calcium signal-modulating cyclophilin ligand
NM_001745.3	NP_001736.1	calcium signal-modulating cyclophilin ligand
XM_011543653.1	XP_011541955.1	calcium signal-modulating cyclophilin ligand isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CAMLG	XP_518170.2
Rattus norvegicus (Norway rat)	Camlg	NP_445786.1
Danio rerio (zebrafish)	camlg	NP_996973.2
Homo sapiens (human)	CAMLG	NP_001736.1
Bos taurus (cattle)	CAMLG	NP_001032714.1
	CAMLG	XP_001109668.1
Mus musculus (house mouse)	Caml	NP_031622.2
Gallus gallus (chicken)	CAMLG	NP_990293.1
Xenopus tropicalis (tropical clawed frog)	camlg	NP_001016600.2
Canis lupus familiaris (dog)	CAMLG	XP_531910.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Petschnigg J, Groisman B, Kotlyar M, Taipale M, Zheng Y, Kurat CF, Sayad A, Sierra JR, Mattiazzi Usaj M, Snider J, Nachman A, Krykbaeva I, Tsao MS, Moffat J, Pawson T, Lindquist S, Jurisica I, Stagljar I
Nature methods11(5)585-92(2014 May)

WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.
Vilardi F, Stephan M, Clancy A, Janshoff A, Schwappach B
PloS one9(1)e85033(2014)

A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.
Long T, Su J, Tang W, Luo Z, Liu S, Liu Z, Zhou H, Qi M, Zeng W, Zhang J, Chen X
Cancer letters339(1)93-101(2013 Oct)

Type IV pilus protein PilA of Pseudomonas aeruginosa modulates calcium signaling through binding the calcium-modulating cyclophilin ligand.
Okuda J, Hayashi N, Arakawa M, Minagawa S, Gotoh N
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy19(4)653-64(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.
Title: A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.

Found that the calcium-modulating cyclophilin ligand (CAMLG), which is involved in Ca(2+) signaling, was the major host cell PilA binding protein.
Title: Type IV pilus protein PilA of Pseudomonas aeruginosa modulates calcium signaling through binding the calcium-modulating cyclophilin ligand.

Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.

this study demonstrated that DENV manipulated the levels of CAML to subvert the apoptotic process which in turn favoured efficient virus production.
Title: Dengue virus utilizes calcium modulating cyclophilin-binding ligand to subvert apoptosis.

CAML was found to play a crucial role in the PRL/PRLR-dependent growth of breast cancer cells.
Title: CAML promotes prolactin-dependent proliferation of breast cancer cells by facilitating prolactin receptor signaling pathways.

The following CAMLG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAMLG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29171	NM_001745.4 Latest version!	Homo sapiens calcium modulating ligand (CAMLG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu56637	XM_011543653.1 Latest version!	Homo sapiens calcium modulating ligand (CAMLG), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu29171	NM_001745.3	Homo sapiens calcium modulating ligand (CAMLG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CAMLG ( NM_001745.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001736.1 Homo sapiens calcium modulating ligand (CAMLG), mRNA.

Price & Availability↑

CloneID	OHu29171
Clone ID Related Accession (Same CDS sequence)	NM_001745.4 , NM_001745.3
Accession Version	NM_001745.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Homo sapiens(human)
Product	calcium signal-modulating cyclophilin ligand
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA727548.1, U18242.1, AC010301.7 and BX111055.1. On Nov 22, 2018 this sequence version replaced NM_001745.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.480092.1, SRR3476690.273731.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297156.4/ ENSP00000297156.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGTCGA TGGCCGTCGC TACCGACGGC GGGGAGAGGC CGGGGGTCCC AGCGGGCTCA 
GGTCTGTCGG CTTCCCAGCG TCGGGCGGAG CTGCGTCGGA GAAAGCTGCT CATGAACTCG 
GAACAGCGCA TCAACCGGAT CATGGGCTTT CACAGGCCCG GGAGCGGCGC GGAAGAAGAA 
AGTCAAACAA AATCAAAGCA GCAGGACAGT GATAAACTGA ACTCCCTCAG CGTTCCTTCC 
GTTTCAAAGC GAGTAGTGCT GGGTGATTCA GTCAGTACAG GAACAACTGA CCAGCAGGGT 
GGTGTGGCCG AGGTAAAGGG GACCCAACTG GGAGACAAAT TGGACTCGTT CATTAAACCA 
CCTGAGTGCA GTAGTGATGT CAACCTTGAG CTCCGGCAGC GGAACAGAGG GGACCTGACA 
GCGGACTCGG TCCAGAGGGG TTCCCGCCAT GGCCTAGAGC AGTACCTTTC CAGATTCGAA 
GAAGCAATGA AGCTAAGGAA ACAGCTGATT AGTGAAAAAC CCAGTCAAGA GGATGGAAAT 
ACAACAGAAG AATTTGACTC TTTTCGAATA TTTAGATTGG TGGGATGTGC TCTTCTTGCT 
CTTGGAGTCA GAGCTTTTGT TTGCAAATAC TTGTCCATAT TTGCTCCATT TCTTACTTTA 
CAACTTGCGT ACATGGGATT ATACAAATAT TTTCCCAAGA GTGAAAAGAA GATAAAGACA 
ACAGTACTAA CAGCTGCACT TCTATTGTCG GGAATTCCTG CCGAAGTGAT AAATCGATCA 
ATGGATACCT ATAGCAAAAT GGGCGAAGTC TTCACAGATC TCTGTGTCTA CTTTTTCACT 
TTTATCTTTT GTCATGAACT GCTTGATTAT TGGGGCTCTG AAGTACCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001736.1
CDS	74..964
Translation	MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGSEVP

Target ORF information:

RefSeq Version	NM_001745.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium modulating ligand (CAMLG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001745.4

ORF Insert Sequence:

ATGGAGTCGA TGGCCGTCGC TACCGACGGC GGGGAGAGGC CGGGGGTCCC AGCGGGCTCA 
GGTCTGTCGG CTTCCCAGCG TCGGGCGGAG CTGCGTCGGA GAAAGCTGCT CATGAACTCG 
GAACAGCGCA TCAACCGGAT CATGGGCTTT CACAGGCCCG GGAGCGGCGC GGAAGAAGAA 
AGTCAAACAA AATCAAAGCA GCAGGACAGT GATAAACTGA ACTCCCTCAG CGTTCCTTCC 
GTTTCAAAGC GAGTAGTGCT GGGTGATTCA GTCAGTACAG GAACAACTGA CCAGCAGGGT 
GGTGTGGCCG AGGTAAAGGG GACCCAACTG GGAGACAAAT TGGACTCGTT CATTAAACCA 
CCTGAGTGCA GTAGTGATGT CAACCTTGAG CTCCGGCAGC GGAACAGAGG GGACCTGACA 
GCGGACTCGG TCCAGAGGGG TTCCCGCCAT GGCCTAGAGC AGTACCTTTC CAGATTCGAA 
GAAGCAATGA AGCTAAGGAA ACAGCTGATT AGTGAAAAAC CCAGTCAAGA GGATGGAAAT 
ACAACAGAAG AATTTGACTC TTTTCGAATA TTTAGATTGG TGGGATGTGC TCTTCTTGCT 
CTTGGAGTCA GAGCTTTTGT TTGCAAATAC TTGTCCATAT TTGCTCCATT TCTTACTTTA 
CAACTTGCGT ACATGGGATT ATACAAATAT TTTCCCAAGA GTGAAAAGAA GATAAAGACA 
ACAGTACTAA CAGCTGCACT TCTATTGTCG GGAATTCCTG CCGAAGTGAT AAATCGATCA 
ATGGATACCT ATAGCAAAAT GGGCGAAGTC TTCACAGATC TCTGTGTCTA CTTTTTCACT 
TTTATCTTTT GTCATGAACT GCTTGATTAT TGGGGCTCTG AAGTACCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAMLG ( NM_001745.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001736.1 Homo sapiens calcium modulating ligand (CAMLG), mRNA.

Price & Availability↑

CloneID	OHu29171
Clone ID Related Accession (Same CDS sequence)	NM_001745.4 , NM_001745.3
Accession Version	NM_001745.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	calcium signal-modulating cyclophilin ligand
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA727548.1, U18242.1, AC010301.7 and BX111055.1. On Mar 15, 2011 this sequence version replaced NM_001745.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.66241.1, SRR1660807.96257.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCGA TGGCCGTCGC TACCGACGGC GGGGAGAGGC CGGGGGTCCC AGCGGGCTCA 
GGTCTGTCGG CTTCCCAGCG TCGGGCGGAG CTGCGTCGGA GAAAGCTGCT CATGAACTCG 
GAACAGCGCA TCAACCGGAT CATGGGCTTT CACAGGCCCG GGAGCGGCGC GGAAGAAGAA 
AGTCAAACAA AATCAAAGCA GCAGGACAGT GATAAACTGA ACTCCCTCAG CGTTCCTTCC 
GTTTCAAAGC GAGTAGTGCT GGGTGATTCA GTCAGTACAG GAACAACTGA CCAGCAGGGT 
GGTGTGGCCG AGGTAAAGGG GACCCAACTG GGAGACAAAT TGGACTCGTT CATTAAACCA 
CCTGAGTGCA GTAGTGATGT CAACCTTGAG CTCCGGCAGC GGAACAGAGG GGACCTGACA 
GCGGACTCGG TCCAGAGGGG TTCCCGCCAT GGCCTAGAGC AGTACCTTTC CAGATTCGAA 
GAAGCAATGA AGCTAAGGAA ACAGCTGATT AGTGAAAAAC CCAGTCAAGA GGATGGAAAT 
ACAACAGAAG AATTTGACTC TTTTCGAATA TTTAGATTGG TGGGATGTGC TCTTCTTGCT 
CTTGGAGTCA GAGCTTTTGT TTGCAAATAC TTGTCCATAT TTGCTCCATT TCTTACTTTA 
CAACTTGCGT ACATGGGATT ATACAAATAT TTTCCCAAGA GTGAAAAGAA GATAAAGACA 
ACAGTACTAA CAGCTGCACT TCTATTGTCG GGAATTCCTG CCGAAGTGAT AAATCGATCA 
ATGGATACCT ATAGCAAAAT GGGCGAAGTC TTCACAGATC TCTGTGTCTA CTTTTTCACT 
TTTATCTTTT GTCATGAACT GCTTGATTAT TGGGGCTCTG AAGTACCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001736.1
CDS	142..1032
Translation	MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGSEVP

Target ORF information:

RefSeq Version	NM_001745.3
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium modulating ligand (CAMLG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001745.3

ORF Insert Sequence:

ATGGAGTCGA TGGCCGTCGC TACCGACGGC GGGGAGAGGC CGGGGGTCCC AGCGGGCTCA 
GGTCTGTCGG CTTCCCAGCG TCGGGCGGAG CTGCGTCGGA GAAAGCTGCT CATGAACTCG 
GAACAGCGCA TCAACCGGAT CATGGGCTTT CACAGGCCCG GGAGCGGCGC GGAAGAAGAA 
AGTCAAACAA AATCAAAGCA GCAGGACAGT GATAAACTGA ACTCCCTCAG CGTTCCTTCC 
GTTTCAAAGC GAGTAGTGCT GGGTGATTCA GTCAGTACAG GAACAACTGA CCAGCAGGGT 
GGTGTGGCCG AGGTAAAGGG GACCCAACTG GGAGACAAAT TGGACTCGTT CATTAAACCA 
CCTGAGTGCA GTAGTGATGT CAACCTTGAG CTCCGGCAGC GGAACAGAGG GGACCTGACA 
GCGGACTCGG TCCAGAGGGG TTCCCGCCAT GGCCTAGAGC AGTACCTTTC CAGATTCGAA 
GAAGCAATGA AGCTAAGGAA ACAGCTGATT AGTGAAAAAC CCAGTCAAGA GGATGGAAAT 
ACAACAGAAG AATTTGACTC TTTTCGAATA TTTAGATTGG TGGGATGTGC TCTTCTTGCT 
CTTGGAGTCA GAGCTTTTGT TTGCAAATAC TTGTCCATAT TTGCTCCATT TCTTACTTTA 
CAACTTGCGT ACATGGGATT ATACAAATAT TTTCCCAAGA GTGAAAAGAA GATAAAGACA 
ACAGTACTAA CAGCTGCACT TCTATTGTCG GGAATTCCTG CCGAAGTGAT AAATCGATCA 
ATGGATACCT ATAGCAAAAT GGGCGAAGTC TTCACAGATC TCTGTGTCTA CTTTTTCACT 
TTTATCTTTT GTCATGAACT GCTTGATTAT TGGGGCTCTG AAGTACCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAMLG ( XM_011543653.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541955.1 Homo sapiens calcium modulating ligand (CAMLG), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu56637
Clone ID Related Accession (Same CDS sequence)	XM_011543653.1
Accession Version	XM_011543653.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	calcium signal-modulating cyclophilin ligand isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCGA TGGCCGTCGC TACCGACGGC GGGGAGAGGC CGGGGGTCCC AGCGGGCTCA 
GGTCTGTCGG CTTCCCAGCG TCGGGCGGAG CTGCGTCGGA GAAAGCTGCT CATGAACTCG 
GAACAGCGCA TCAACCGGAT CATGGGCTTT CACAGGCCCG GGAGCGGCGC GGAAGAAGAA 
AGTCAAACAA AATCAAAGCA GCAGGACAGT GATAAACTGA ACTCCCTCAG CGTTCCTTCC 
GTTTCAAAGC GAGTAGTGCT GGGTGATTCA GTCAGTACAG GAACAACTGA CCAGCAGGGT 
GGTGTGGCCG AGGTAAAGGG GACCCAACTG GGAGACAAAT TGGACTCGTT CATTAAACCA 
CCTGAGTGCA GTAGTGATGT CAACCTTGAG CTCCGGCAGC GGAACAGAGG GGACCTGACA 
GCGGACTCGG TCCAGAGGGG TTCCCGCCAT GGCCTAGAGC AGTACCTTTC CAGATTCGAA 
GAAGCAATGA AGCTAAGGAA ACAGCTGATT AGTGAAAAAC CCAGTCAAGA GGATGGAAAT 
ACAACAGAAG AATTTGACTC TTTTCGAATA TTTAGATTGG TGGGATGTGC TCTTCTTGCT 
CTTGGAGTCA GAGCTTTTGT TTGCAAATAC TTGAGTGAAA AGAAGATAAA GACAACAGTA 
CTAACAGCTG CACTTCTATT GTCGGGAATT CCTGCCGAAG TGATAAATCG ATCAATGGAT 
ACCTATAGCA AAATGGGCGA AGTCTTCACA GATCTCTGTG TCTACTTTTT CACTTTTATC 
TTTTGTCATG AACTGCTTGA TTATTGGGGC TCTGAAGTAC CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541955.1
CDS	695..1519
Translation	MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKYLSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGSEVP

Target ORF information:

RefSeq Version	XM_011543653.1
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium modulating ligand (CAMLG), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011543653.1

ORF Insert Sequence:

ATGGAGTCGA TGGCCGTCGC TACCGACGGC GGGGAGAGGC CGGGGGTCCC AGCGGGCTCA 
GGTCTGTCGG CTTCCCAGCG TCGGGCGGAG CTGCGTCGGA GAAAGCTGCT CATGAACTCG 
GAACAGCGCA TCAACCGGAT CATGGGCTTT CACAGGCCCG GGAGCGGCGC GGAAGAAGAA 
AGTCAAACAA AATCAAAGCA GCAGGACAGT GATAAACTGA ACTCCCTCAG CGTTCCTTCC 
GTTTCAAAGC GAGTAGTGCT GGGTGATTCA GTCAGTACAG GAACAACTGA CCAGCAGGGT 
GGTGTGGCCG AGGTAAAGGG GACCCAACTG GGAGACAAAT TGGACTCGTT CATTAAACCA 
CCTGAGTGCA GTAGTGATGT CAACCTTGAG CTCCGGCAGC GGAACAGAGG GGACCTGACA 
GCGGACTCGG TCCAGAGGGG TTCCCGCCAT GGCCTAGAGC AGTACCTTTC CAGATTCGAA 
GAAGCAATGA AGCTAAGGAA ACAGCTGATT AGTGAAAAAC CCAGTCAAGA GGATGGAAAT 
ACAACAGAAG AATTTGACTC TTTTCGAATA TTTAGATTGG TGGGATGTGC TCTTCTTGCT 
CTTGGAGTCA GAGCTTTTGT TTGCAAATAC TTGAGTGAAA AGAAGATAAA GACAACAGTA 
CTAACAGCTG CACTTCTATT GTCGGGAATT CCTGCCGAAG TGATAAATCG ATCAATGGAT 
ACCTATAGCA AAATGGGCGA AGTCTTCACA GATCTCTGTG TCTACTTTTT CACTTTTATC 
TTTTGTCATG AACTGCTTGA TTATTGGGGC TCTGAAGTAC CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Nature methods11(5)585-92(2014 May)
Petschnigg J,Groisman B,Kotlyar M,Taipale M,Zheng Y,Kurat CF,Sayad A,Sierra JR,Mattiazzi Usaj M,Snider J,Nachman A,Krykbaeva I,Tsao MS,Moffat J,Pawson T,Lindquist S,Jurisica I,Stagljar I

WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.
PloS one9(1)e85033(2014)
Vilardi F,Stephan M,Clancy A,Janshoff A,Schwappach B

A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.
Cancer letters339(1)93-101(2013 Oct)
Long T,Su J,Tang W,Luo Z,Liu S,Liu Z,Zhou H,Qi M,Zeng W,Zhang J,Chen X

Type IV pilus protein PilA of Pseudomonas aeruginosa modulates calcium signaling through binding the calcium-modulating cyclophilin ligand.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy19(4)653-64(2013 Aug)
Okuda J,Hayashi N,Arakawa M,Minagawa S,Gotoh N

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CAMLG cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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