PDRG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDRG1
Entrez Gene ID	81572
Full Name	p53 and DNA damage regulated 1
Synonyms	C20orf126,PDRG
General protein information	Preferred Names p53 and DNA damage regulated 1 Names p53 and DNA damage-regulated protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.21
Disorder MIM:	610789

mRNA and Protein(s)

mRNA	Protein	Name
NM_030815.3	NP_110442.1	p53 and DNA damage-regulated protein 1
XM_005260563.2	XP_005260620.1	p53 and DNA damage-regulated protein 1 isoform X1
NM_030815.2	NP_110442.1	p53 and DNA damage-regulated protein 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PDRG1	NP_001071583.1
Canis lupus familiaris (dog)	PDRG1	XP_003639904.1
Danio rerio (zebrafish)	pdrg1	NP_001017757.1
Pan troglodytes (chimpanzee)	PDRG1	XP_003953750.1
Mus musculus (house mouse)	Pdrg1	NP_849270.1
Rattus norvegicus (Norway rat)	Pdrg1	NP_001014762.1
Homo sapiens (human)	PDRG1	NP_110442.1
	PDRG1	XP_001109201.1
Xenopus tropicalis (tropical clawed frog)	pdrg1	NP_001015688.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Yadav L, Tamene F, G??s H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M
Cell systems4(4)430-444.e5(2017 Apr)

The PDRG1 is an oncogene in lung cancer cells, promoting radioresistance via the ATM-P53 signaling pathway.
Tao Z, Chen S, Mao G, Xia H, Huang H, Ma H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie831471-1477(2016 Oct)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer.
Wang J, Zhang X, Wang L, Yang Y, Dong Z, Wang H, Du L, Wang C
PloS one10(2)e0118086(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

It was found that PDRG1 could promote radio-resistance that involved the ATM-p53 signaling pathway in lung cancer cells.
Title: The PDRG1 is an oncogene in lung cancer cells, promoting radioresistance via the ATM-P53 signaling pathway.

PDRG1 was significantly increased in tumors low of miR-214.
Title: MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer.

PDRG1 expression is increased in multiple human malignancies suggesting it to be a high-value novel tumor marker that could play a role in cancer development and/or progression.
Title: PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress.

Is part of an RNA polymerase II-associated complex with possible chaperone activity.
Title: High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.

Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation
Title: Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation.

The following PDRG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDRG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04524	NM_030815.3 Latest version!	Homo sapiens p53 and DNA damage regulated 1 (PDRG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04524	XM_005260563.2 Latest version!	Homo sapiens p53 and DNA-damage regulated 1 (PDRG1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04524	NM_030815.2	Homo sapiens p53 and DNA damage regulated 1 (PDRG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDRG1 ( NM_030815.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_110442.1 Homo sapiens p53 and DNA damage regulated 1 (PDRG1), mRNA.

Price & Availability↑

CloneID	OHu04524
Clone ID Related Accession (Same CDS sequence)	NM_030815.3 , XM_005260563.2 , NM_030815.2
Accession Version	NM_030815.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	p53 and DNA damage-regulated protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY286301.1, BC009334.2, BM679702.1 and AL031658.11. On Nov 23, 2018 this sequence version replaced NM_030815.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.286180.1, SRR1660803.202192.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000202017.6/ ENSP00000202017.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTATCAC CCGAGGCAGA GCGAGTGCTG CGGTACCTTG TAGAAGTGGA GGAGCTCGCC 
GAGGAGGTGC TGGCGGACAA GCGGCAGATT GTGGACCTGG ACACTAAAAG GAATCAGAAT 
CGAGAGGGCC TGAGGGCCCT GCAGAAGGAT CTCAGCCTCT CTGAAGATGT GATGGTTTGC 
TTCGGGAACA TGTTTATCAA GATGCCTCAC CCTGAGACAA AGGAAATGAT TGAAAAAGAT 
CAAGATCATC TGGATAAAGA AATAGAAAAA CTGCGGAAGC AACTTAAAGT GAAGGTCAAC 
CGCCTTTTTG AGGCCCAAGG CAAACCGGAG CTGAAGGGTT TTAACTTGAA CCCCCTCAAC 
CAGGATGAGC TTAAAGCTCT CAAGGTCATC TTGAAAGGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110442.1
CDS	86..487
Translation	MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRLFEAQGKPELKGFNLNPLNQDELKALKVILKG

Target ORF information:

RefSeq Version	NM_030815.3
Organism	Homo sapiens(human)
Definition	Homo sapiens p53 and DNA damage regulated 1 (PDRG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030815.3

ORF Insert Sequence:

ATGCTATCAC CCGAGGCAGA GCGAGTGCTG CGGTACCTTG TAGAAGTGGA GGAGCTCGCC 
GAGGAGGTGC TGGCGGACAA GCGGCAGATT GTGGACCTGG ACACTAAAAG GAATCAGAAT 
CGAGAGGGCC TGAGGGCCCT GCAGAAGGAT CTCAGCCTCT CTGAAGATGT GATGGTTTGC 
TTCGGGAACA TGTTTATCAA GATGCCTCAC CCTGAGACAA AGGAAATGAT TGAAAAAGAT 
CAAGATCATC TGGATAAAGA AATAGAAAAA CTGCGGAAGC AACTTAAAGT GAAGGTCAAC 
CGCCTTTTTG AGGCCCAAGG CAAACCGGAG CTGAAGGGTT TTAACTTGAA CCCCCTCAAC 
CAGGATGAGC TTAAAGCTCT CAAGGTCATC TTGAAAGGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDRG1 ( NM_030815.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_110442.1 Homo sapiens p53 and DNA damage regulated 1 (PDRG1), mRNA.

Price & Availability↑

CloneID	OHu04524
Clone ID Related Accession (Same CDS sequence)	NM_030815.3 , XM_005260563.2 , NM_030815.2
Accession Version	NM_030815.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	p53 and DNA damage-regulated protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY286301.1, BC009334.2 and BM679702.1. On Jan 13, 2004 this sequence version replaced NM_030815.1. ##Evidence-Data-START## Transcript exon combination :: AY286301.1, SRR1163657.251443.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTATCAC CCGAGGCAGA GCGAGTGCTG CGGTACCTTG TAGAAGTGGA GGAGCTCGCC 
GAGGAGGTGC TGGCGGACAA GCGGCAGATT GTGGACCTGG ACACTAAAAG GAATCAGAAT 
CGAGAGGGCC TGAGGGCCCT GCAGAAGGAT CTCAGCCTCT CTGAAGATGT GATGGTTTGC 
TTCGGGAACA TGTTTATCAA GATGCCTCAC CCTGAGACAA AGGAAATGAT TGAAAAAGAT 
CAAGATCATC TGGATAAAGA AATAGAAAAA CTGCGGAAGC AACTTAAAGT GAAGGTCAAC 
CGCCTTTTTG AGGCCCAAGG CAAACCGGAG CTGAAGGGTT TTAACTTGAA CCCCCTCAAC 
CAGGATGAGC TTAAAGCTCT CAAGGTCATC TTGAAAGGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110442.1
CDS	120..521
Translation	MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRLFEAQGKPELKGFNLNPLNQDELKALKVILKG

Target ORF information:

RefSeq Version	NM_030815.2
Organism	Homo sapiens(human)
Definition	Homo sapiens p53 and DNA damage regulated 1 (PDRG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030815.2

ORF Insert Sequence:

ATGCTATCAC CCGAGGCAGA GCGAGTGCTG CGGTACCTTG TAGAAGTGGA GGAGCTCGCC 
GAGGAGGTGC TGGCGGACAA GCGGCAGATT GTGGACCTGG ACACTAAAAG GAATCAGAAT 
CGAGAGGGCC TGAGGGCCCT GCAGAAGGAT CTCAGCCTCT CTGAAGATGT GATGGTTTGC 
TTCGGGAACA TGTTTATCAA GATGCCTCAC CCTGAGACAA AGGAAATGAT TGAAAAAGAT 
CAAGATCATC TGGATAAAGA AATAGAAAAA CTGCGGAAGC AACTTAAAGT GAAGGTCAAC 
CGCCTTTTTG AGGCCCAAGG CAAACCGGAG CTGAAGGGTT TTAACTTGAA CCCCCTCAAC 
CAGGATGAGC TTAAAGCTCT CAAGGTCATC TTGAAAGGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDRG1 ( XM_005260563.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005260620.1 Homo sapiens p53 and DNA-damage regulated 1 (PDRG1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04524
Clone ID Related Accession (Same CDS sequence)	NM_030815.3 , XM_005260563.2 , NM_030815.2
Accession Version	XM_005260563.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	p53 and DNA damage-regulated protein 1 isoform X1
Comment

ATGCTATCAC CCGAGGCAGA GCGAGTGCTG CGGTACCTTG TAGAAGTGGA GGAGCTCGCC 
GAGGAGGTGC TGGCGGACAA GCGGCAGATT GTGGACCTGG ACACTAAAAG GAATCAGAAT 
CGAGAGGGCC TGAGGGCCCT GCAGAAGGAT CTCAGCCTCT CTGAAGATGT GATGGTTTGC 
TTCGGGAACA TGTTTATCAA GATGCCTCAC CCTGAGACAA AGGAAATGAT TGAAAAAGAT 
CAAGATCATC TGGATAAAGA AATAGAAAAA CTGCGGAAGC AACTTAAAGT GAAGGTCAAC 
CGCCTTTTTG AGGCCCAAGG CAAACCGGAG CTGAAGGGTT TTAACTTGAA CCCCCTCAAC 
CAGGATGAGC TTAAAGCTCT CAAGGTCATC TTGAAAGGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005260620.1
Translation	MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRLFEAQGKPELKGFNLNPLNQDELKALKVILKG

Target ORF information:

RefSeq Version	XM_005260563.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens p53 and DNA-damage regulated 1 (PDRG1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005260563.2

ORF Insert Sequence:

ATGCTATCAC CCGAGGCAGA GCGAGTGCTG CGGTACCTTG TAGAAGTGGA GGAGCTCGCC 
GAGGAGGTGC TGGCGGACAA GCGGCAGATT GTGGACCTGG ACACTAAAAG GAATCAGAAT 
CGAGAGGGCC TGAGGGCCCT GCAGAAGGAT CTCAGCCTCT CTGAAGATGT GATGGTTTGC 
TTCGGGAACA TGTTTATCAA GATGCCTCAC CCTGAGACAA AGGAAATGAT TGAAAAAGAT 
CAAGATCATC TGGATAAAGA AATAGAAAAA CTGCGGAAGC AACTTAAAGT GAAGGTCAAC 
CGCCTTTTTG AGGCCCAAGG CAAACCGGAG CTGAAGGGTT TTAACTTGAA CCCCCTCAAC 
CAGGATGAGC TTAAAGCTCT CAAGGTCATC TTGAAAGGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Cell systems4(4)430-444.e5(2017 Apr)
Yadav L,Tamene F,G??s H,van Drogen A,Katainen R,Aebersold R,Gstaiger M,Varjosalo M

The PDRG1 is an oncogene in lung cancer cells, promoting radioresistance via the ATM-P53 signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie831471-1477(2016 Oct)
Tao Z,Chen S,Mao G,Xia H,Huang H,Ma H

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer.
PloS one10(2)e0118086(2015)
Wang J,Zhang X,Wang L,Yang Y,Dong Z,Wang H,Du L,Wang C

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PDRG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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