CXXC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXXC4
Entrez Gene ID	80319
Full Name	CXXC finger protein 4
Synonyms	IDAX
General protein information	Preferred Names CXXC finger protein 4 Names CXXC-type zinc finger protein 4 CXXC finger 4 Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex) inhibition of the Dvl and axin complex protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q24
Summary	This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Disorder MIM:	611645

mRNA and Protein(s)

mRNA	Protein	Name
XM_017008652.1	XP_016864141.1	CXXC-type zinc finger protein 4 isoform X1
NM_025212.4	NP_079488.2	CXXC-type zinc finger protein 4
NM_025212.3	NP_079488.2	CXXC-type zinc finger protein 4
XM_011532284.2	XP_011530586.1	CXXC-type zinc finger protein 4 isoform X1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	cxxc4	NP_001072200.2
Pan troglodytes (chimpanzee)	CXXC4	XP_526643.3
Mus musculus (house mouse)	Cxxc4	NP_001004367.2
Rattus norvegicus (Norway rat)	Cxxc4	NP_445794.2
	LOC693620	XP_002804221.1
Canis lupus familiaris (dog)	CXXC4	XP_005639390.1
Danio rerio (zebrafish)	LOC100006754	XP_001345418.2
Homo sapiens (human)	CXXC4	NP_079488.2
Bos taurus (cattle)	CXXC4	XP_003586234.2

Gene Ontology
Bibliography

Related articles in PubMed

BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX.
Yu F, Zhou C, Zeng H, Liu Y, Li S
Biochemical and biophysical research communications(2018 Jan)

CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients.
Li S, Fan R, Zhao XL, Wang XQ
Leukemia research38(9)1072-8(2014 Sep)

New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.
Lu H, Jin W, Sun J, Feng L, Lan H, Shen Q, Ma Y, Li J, Yue Y, Jin H, Wang X
FEBS letters588(18)3322-6(2014 Sep)

Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4.
Lu H, Sun J, Wang F, Feng L, Ma Y, Shen Q, Jiang Z, Sun X, Wang X, Jin H
Cell death & disease4e776(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Age of patients and levels of CXXC4 mRNA, hemoglobin, and marrow blast associated with survival of Myelodysplastic syndrome patients.
Title: CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients.

EZH2 can activate MAPK signaling by inhibiting CXXC4 expression.
Title: New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.

CXXC4 is a novel potential tumor suppressor directly regulated by EZH2, and its expression is a significant prognosis factor for patients with early stages of gastric cancer.
Title: Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4.

IDAX expression results in caspase activation and TET2 protein downregulation, in a manner that depends on DNA binding through the IDAX CXXC domain, suggesting that IDAX recruits TET2 to DNA before degradation
Title: Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.

The following CXXC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXXC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12318	NM_025212.4 Latest version!	Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu12318	XM_017008652.1 Latest version!	Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu12318	XM_011532284.2 Latest version!	Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu12318	NM_025212.3	Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXXC4 ( NM_025212.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_079488.2 Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12318
Clone ID Related Accession (Same CDS sequence)	XM_017008652.1 , NM_025212.4 , NM_025212.3 , XM_011532284.2
Accession Version	NM_025212.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	CXXC-type zinc finger protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA804531.1, AC093628.3, AK125395.1, CB068467.1 and AA708035.1. On Nov 23, 2018 this sequence version replaced NM_025212.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.414910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000394767.3/ ENSP00000378248.2 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACACCA ATGTCTGCGT GGAGCCCGGG CCGAGCCCGG AGGCCCCGGG CTTGCCCAAG 
GAAAGCCACT TGCCCGAGGG GGCTCTGAAC AGCCTTGTGG ATTACAACTC GGAAATGGAG 
CGCTACCGCT CCTTTGCCAC CTCCTTCTAC AAGACCAACG GGGGCGCCTT CCCACAGGCG 
GCCAAGATCG CGCGCATCAC CACCCCCATC TTCCCCAGCA GCGCCGCCGC CGCCGCGGCC 
GCCGCGCGCA TCGGCATGTC CCCCTGGAAC TGCGACAACG CGGCCACCGC CGCCGCCGCC 
ACCGCCATGC TCTGGGGCAG CGGCGGGGGC GGGGGCGGCG GCGGGGGGGG TGGCGGCGGC 
GGCGGCGGCG GCGGAGGCGG GGGCGGGGGT GGTGGGGGCG GCAGGAAATC CTCCTCCGCC 
GCCGCCTCCT CCTCCGCCTC CTCCTCCTCG GCGATCCTCC CCGCCGGCGG TGGCGGCGGC 
GGCGGCGGCG GCGGCAGCAG GACCAGCATG CACCACCGAA ACGACTCCCA GAGGCTGGGG 
AAAGCTGGCT GCCCGCCAGA GCCGTCGTTG CAAATGGCAA ATACTAATTT CCTCTCCACC 
TTATCCCCTG AACACTGCAG ACCTTTGGCG GGGGAATGCA TGAACAAGCT CAAATGCGGC 
GCTGCTGAAG CAGAGATAAT GAATCTCCCC GAGCGCGTGG GGACTTTTTC CGCTATCCCG 
GCTTTAGGGG GCATCTCATT ACCTCCAGGG GTCATCGTCA TGACAGCCCT TCACTCCCCC 
GCAGCAGCCT CAGCAGCCGT CACAGACAGT GCGTTTCAAA TTGCCAATCT GGCAGACTGC 
CCGCAGAATC ATTCCTCCTC CTCCTCGTCC TCCTCAGGGG GAGCTGGCGG AGCCAACCCA 
GCCAAGAAGA AGAGGAAAAG GTGTGGGGTC TGCGTGCCCT GCAAGAGGCT CATCAACTGT 
GGCGTCTGCA GCAGTTGCAG GAACCGCAAA ACGGGACACC AGATCTGCAA ATTTAGAAAA 
TGTGAAGAGC TAAAGAAAAA ACCTGGCACT TCACTAGAGA GAACACCTGT TCCCAGCGCT 
GAAGCATTCC GATGGTTCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079488.2
CDS	452..1555
Translation	MNTNVCVEPGPSPEAPGLPKESHLPEGALNSLVDYNSEMERYRSFATSFYKTNGGAFPQAAKIARITTPIFPSSAAAAAAAARIGMSPWNCDNAATAAAATAMLWGSGGGGGGGGGGGGGGGGGGGGGGGGGGGRKSSSAAASSSASSSSAILPAGGGGGGGGGGSRTSMHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF

Target ORF information:

RefSeq Version	NM_025212.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025212.4

ORF Insert Sequence:

ATGAACACCA ATGTCTGCGT GGAGCCCGGG CCGAGCCCGG AGGCCCCGGG CTTGCCCAAG 
GAAAGCCACT TGCCCGAGGG GGCTCTGAAC AGCCTTGTGG ATTACAACTC GGAAATGGAG 
CGCTACCGCT CCTTTGCCAC CTCCTTCTAC AAGACCAACG GGGGCGCCTT CCCACAGGCG 
GCCAAGATCG CGCGCATCAC CACCCCCATC TTCCCCAGCA GCGCCGCCGC CGCCGCGGCC 
GCCGCGCGCA TCGGCATGTC CCCCTGGAAC TGCGACAACG CGGCCACCGC CGCCGCCGCC 
ACCGCCATGC TCTGGGGCAG CGGCGGGGGC GGGGGCGGCG GCGGGGGGGG TGGCGGCGGC 
GGCGGCGGCG GCGGAGGCGG GGGCGGGGGT GGTGGGGGCG GCAGGAAATC CTCCTCCGCC 
GCCGCCTCCT CCTCCGCCTC CTCCTCCTCG GCGATCCTCC CCGCCGGCGG TGGCGGCGGC 
GGCGGCGGCG GCGGCAGCAG GACCAGCATG CACCACCGAA ACGACTCCCA GAGGCTGGGG 
AAAGCTGGCT GCCCGCCAGA GCCGTCGTTG CAAATGGCAA ATACTAATTT CCTCTCCACC 
TTATCCCCTG AACACTGCAG ACCTTTGGCG GGGGAATGCA TGAACAAGCT CAAATGCGGC 
GCTGCTGAAG CAGAGATAAT GAATCTCCCC GAGCGCGTGG GGACTTTTTC CGCTATCCCG 
GCTTTAGGGG GCATCTCATT ACCTCCAGGG GTCATCGTCA TGACAGCCCT TCACTCCCCC 
GCAGCAGCCT CAGCAGCCGT CACAGACAGT GCGTTTCAAA TTGCCAATCT GGCAGACTGC 
CCGCAGAATC ATTCCTCCTC CTCCTCGTCC TCCTCAGGGG GAGCTGGCGG AGCCAACCCA 
GCCAAGAAGA AGAGGAAAAG GTGTGGGGTC TGCGTGCCCT GCAAGAGGCT CATCAACTGT 
GGCGTCTGCA GCAGTTGCAG GAACCGCAAA ACGGGACACC AGATCTGCAA ATTTAGAAAA 
TGTGAAGAGC TAAAGAAAAA ACCTGGCACT TCACTAGAGA GAACACCTGT TCCCAGCGCT 
GAAGCATTCC GATGGTTCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXXC4 ( NM_025212.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079488.2 Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12318
Clone ID Related Accession (Same CDS sequence)	XM_017008652.1 , NM_025212.4 , NM_025212.3 , XM_011532284.2
Accession Version	NM_025212.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-03
Organism	Homo sapiens(human)
Product	CXXC-type zinc finger protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CR627201.1, DA804531.1, AC093628.3, AK125395.1, CB068467.1 and AA708035.1. On Sep 19, 2015 this sequence version replaced NM_025212.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACACCA ATGTCTGCGT GGAGCCCGGG CCGAGCCCGG AGGCCCCGGG CTTGCCCAAG 
GAAAGCCACT TGCCCGAGGG GGCTCTGAAC AGCCTTGTGG ATTACAACTC GGAAATGGAG 
CGCTACCGCT CCTTTGCCAC CTCCTTCTAC AAGACCAACG GGGGCGCCTT CCCACAGGCG 
GCCAAGATCG CGCGCATCAC CACCCCCATC TTCCCCAGCA GCGCCGCCGC CGCCGCGGCC 
GCCGCGCGCA TCGGCATGTC CCCCTGGAAC TGCGACAACG CGGCCACCGC CGCCGCCGCC 
ACCGCCATGC TCTGGGGCAG CGGCGGGGGC GGGGGCGGCG GCGGGGGGGG TGGCGGCGGC 
GGCGGCGGCG GCGGAGGCGG GGGCGGGGGT GGTGGGGGCG GCAGGAAATC CTCCTCCGCC 
GCCGCCTCCT CCTCCGCCTC CTCCTCCTCG GCGATCCTCC CCGCCGGCGG TGGCGGCGGC 
GGCGGCGGCG GCGGCAGCAG GACCAGCATG CACCACCGAA ACGACTCCCA GAGGCTGGGG 
AAAGCTGGCT GCCCGCCAGA GCCGTCGTTG CAAATGGCAA ATACTAATTT CCTCTCCACC 
TTATCCCCTG AACACTGCAG ACCTTTGGCG GGGGAATGCA TGAACAAGCT CAAATGCGGC 
GCTGCTGAAG CAGAGATAAT GAATCTCCCC GAGCGCGTGG GGACTTTTTC CGCTATCCCG 
GCTTTAGGGG GCATCTCATT ACCTCCAGGG GTCATCGTCA TGACAGCCCT TCACTCCCCC 
GCAGCAGCCT CAGCAGCCGT CACAGACAGT GCGTTTCAAA TTGCCAATCT GGCAGACTGC 
CCGCAGAATC ATTCCTCCTC CTCCTCGTCC TCCTCAGGGG GAGCTGGCGG AGCCAACCCA 
GCCAAGAAGA AGAGGAAAAG GTGTGGGGTC TGCGTGCCCT GCAAGAGGCT CATCAACTGT 
GGCGTCTGCA GCAGTTGCAG GAACCGCAAA ACGGGACACC AGATCTGCAA ATTTAGAAAA 
TGTGAAGAGC TAAAGAAAAA ACCTGGCACT TCACTAGAGA GAACACCTGT TCCCAGCGCT 
GAAGCATTCC GATGGTTCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079488.2
CDS	459..1562
Translation	MNTNVCVEPGPSPEAPGLPKESHLPEGALNSLVDYNSEMERYRSFATSFYKTNGGAFPQAAKIARITTPIFPSSAAAAAAAARIGMSPWNCDNAATAAAATAMLWGSGGGGGGGGGGGGGGGGGGGGGGGGGGGRKSSSAAASSSASSSSAILPAGGGGGGGGGGSRTSMHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF

Target ORF information:

RefSeq Version	NM_025212.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025212.3

ORF Insert Sequence:

ATGAACACCA ATGTCTGCGT GGAGCCCGGG CCGAGCCCGG AGGCCCCGGG CTTGCCCAAG 
GAAAGCCACT TGCCCGAGGG GGCTCTGAAC AGCCTTGTGG ATTACAACTC GGAAATGGAG 
CGCTACCGCT CCTTTGCCAC CTCCTTCTAC AAGACCAACG GGGGCGCCTT CCCACAGGCG 
GCCAAGATCG CGCGCATCAC CACCCCCATC TTCCCCAGCA GCGCCGCCGC CGCCGCGGCC 
GCCGCGCGCA TCGGCATGTC CCCCTGGAAC TGCGACAACG CGGCCACCGC CGCCGCCGCC 
ACCGCCATGC TCTGGGGCAG CGGCGGGGGC GGGGGCGGCG GCGGGGGGGG TGGCGGCGGC 
GGCGGCGGCG GCGGAGGCGG GGGCGGGGGT GGTGGGGGCG GCAGGAAATC CTCCTCCGCC 
GCCGCCTCCT CCTCCGCCTC CTCCTCCTCG GCGATCCTCC CCGCCGGCGG TGGCGGCGGC 
GGCGGCGGCG GCGGCAGCAG GACCAGCATG CACCACCGAA ACGACTCCCA GAGGCTGGGG 
AAAGCTGGCT GCCCGCCAGA GCCGTCGTTG CAAATGGCAA ATACTAATTT CCTCTCCACC 
TTATCCCCTG AACACTGCAG ACCTTTGGCG GGGGAATGCA TGAACAAGCT CAAATGCGGC 
GCTGCTGAAG CAGAGATAAT GAATCTCCCC GAGCGCGTGG GGACTTTTTC CGCTATCCCG 
GCTTTAGGGG GCATCTCATT ACCTCCAGGG GTCATCGTCA TGACAGCCCT TCACTCCCCC 
GCAGCAGCCT CAGCAGCCGT CACAGACAGT GCGTTTCAAA TTGCCAATCT GGCAGACTGC 
CCGCAGAATC ATTCCTCCTC CTCCTCGTCC TCCTCAGGGG GAGCTGGCGG AGCCAACCCA 
GCCAAGAAGA AGAGGAAAAG GTGTGGGGTC TGCGTGCCCT GCAAGAGGCT CATCAACTGT 
GGCGTCTGCA GCAGTTGCAG GAACCGCAAA ACGGGACACC AGATCTGCAA ATTTAGAAAA 
TGTGAAGAGC TAAAGAAAAA ACCTGGCACT TCACTAGAGA GAACACCTGT TCCCAGCGCT 
GAAGCATTCC GATGGTTCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXXC4 ( XM_017008652.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864141.1 Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu12318
Clone ID Related Accession (Same CDS sequence)	XM_017008652.1 , NM_025212.4 , NM_025212.3 , XM_011532284.2
Accession Version	XM_017008652.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	CXXC-type zinc finger protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACACCA ATGTCTGCGT GGAGCCCGGG CCGAGCCCGG AGGCCCCGGG CTTGCCCAAG 
GAAAGCCACT TGCCCGAGGG GGCTCTGAAC AGCCTTGTGG ATTACAACTC GGAAATGGAG 
CGCTACCGCT CCTTTGCCAC CTCCTTCTAC AAGACCAACG GGGGCGCCTT CCCACAGGCG 
GCCAAGATCG CGCGCATCAC CACCCCCATC TTCCCCAGCA GCGCCGCCGC CGCCGCGGCC 
GCCGCGCGCA TCGGCATGTC CCCCTGGAAC TGCGACAACG CGGCCACCGC CGCCGCCGCC 
ACCGCCATGC TCTGGGGCAG CGGCGGGGGC GGGGGCGGCG GCGGGGGGGG TGGCGGCGGC 
GGCGGCGGCG GCGGAGGCGG GGGCGGGGGT GGTGGGGGCG GCAGGAAATC CTCCTCCGCC 
GCCGCCTCCT CCTCCGCCTC CTCCTCCTCG GCGATCCTCC CCGCCGGCGG TGGCGGCGGC 
GGCGGCGGCG GCGGCAGCAG GACCAGCATG CACCACCGAA ACGACTCCCA GAGGCTGGGG 
AAAGCTGGCT GCCCGCCAGA GCCGTCGTTG CAAATGGCAA ATACTAATTT CCTCTCCACC 
TTATCCCCTG AACACTGCAG ACCTTTGGCG GGGGAATGCA TGAACAAGCT CAAATGCGGC 
GCTGCTGAAG CAGAGATAAT GAATCTCCCC GAGCGCGTGG GGACTTTTTC CGCTATCCCG 
GCTTTAGGGG GCATCTCATT ACCTCCAGGG GTCATCGTCA TGACAGCCCT TCACTCCCCC 
GCAGCAGCCT CAGCAGCCGT CACAGACAGT GCGTTTCAAA TTGCCAATCT GGCAGACTGC 
CCGCAGAATC ATTCCTCCTC CTCCTCGTCC TCCTCAGGGG GAGCTGGCGG AGCCAACCCA 
GCCAAGAAGA AGAGGAAAAG GTGTGGGGTC TGCGTGCCCT GCAAGAGGCT CATCAACTGT 
GGCGTCTGCA GCAGTTGCAG GAACCGCAAA ACGGGACACC AGATCTGCAA ATTTAGAAAA 
TGTGAAGAGC TAAAGAAAAA ACCTGGCACT TCACTAGAGA GAACACCTGT TCCCAGCGCT 
GAAGCATTCC GATGGTTCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864141.1
CDS	442..1545
Translation	MNTNVCVEPGPSPEAPGLPKESHLPEGALNSLVDYNSEMERYRSFATSFYKTNGGAFPQAAKIARITTPIFPSSAAAAAAAARIGMSPWNCDNAATAAAATAMLWGSGGGGGGGGGGGGGGGGGGGGGGGGGGGRKSSSAAASSSASSSSAILPAGGGGGGGGGGSRTSMHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF

Target ORF information:

RefSeq Version	XM_017008652.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008652.1

ORF Insert Sequence:

ATGAACACCA ATGTCTGCGT GGAGCCCGGG CCGAGCCCGG AGGCCCCGGG CTTGCCCAAG 
GAAAGCCACT TGCCCGAGGG GGCTCTGAAC AGCCTTGTGG ATTACAACTC GGAAATGGAG 
CGCTACCGCT CCTTTGCCAC CTCCTTCTAC AAGACCAACG GGGGCGCCTT CCCACAGGCG 
GCCAAGATCG CGCGCATCAC CACCCCCATC TTCCCCAGCA GCGCCGCCGC CGCCGCGGCC 
GCCGCGCGCA TCGGCATGTC CCCCTGGAAC TGCGACAACG CGGCCACCGC CGCCGCCGCC 
ACCGCCATGC TCTGGGGCAG CGGCGGGGGC GGGGGCGGCG GCGGGGGGGG TGGCGGCGGC 
GGCGGCGGCG GCGGAGGCGG GGGCGGGGGT GGTGGGGGCG GCAGGAAATC CTCCTCCGCC 
GCCGCCTCCT CCTCCGCCTC CTCCTCCTCG GCGATCCTCC CCGCCGGCGG TGGCGGCGGC 
GGCGGCGGCG GCGGCAGCAG GACCAGCATG CACCACCGAA ACGACTCCCA GAGGCTGGGG 
AAAGCTGGCT GCCCGCCAGA GCCGTCGTTG CAAATGGCAA ATACTAATTT CCTCTCCACC 
TTATCCCCTG AACACTGCAG ACCTTTGGCG GGGGAATGCA TGAACAAGCT CAAATGCGGC 
GCTGCTGAAG CAGAGATAAT GAATCTCCCC GAGCGCGTGG GGACTTTTTC CGCTATCCCG 
GCTTTAGGGG GCATCTCATT ACCTCCAGGG GTCATCGTCA TGACAGCCCT TCACTCCCCC 
GCAGCAGCCT CAGCAGCCGT CACAGACAGT GCGTTTCAAA TTGCCAATCT GGCAGACTGC 
CCGCAGAATC ATTCCTCCTC CTCCTCGTCC TCCTCAGGGG GAGCTGGCGG AGCCAACCCA 
GCCAAGAAGA AGAGGAAAAG GTGTGGGGTC TGCGTGCCCT GCAAGAGGCT CATCAACTGT 
GGCGTCTGCA GCAGTTGCAG GAACCGCAAA ACGGGACACC AGATCTGCAA ATTTAGAAAA 
TGTGAAGAGC TAAAGAAAAA ACCTGGCACT TCACTAGAGA GAACACCTGT TCCCAGCGCT 
GAAGCATTCC GATGGTTCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXXC4 ( XM_011532284.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530586.1 Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant X1, mRNA.

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CloneID	OHu12318
Clone ID Related Accession (Same CDS sequence)	XM_017008652.1 , NM_025212.4 , NM_025212.3 , XM_011532284.2
Accession Version	XM_011532284.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	CXXC-type zinc finger protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532284.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACACCA ATGTCTGCGT GGAGCCCGGG CCGAGCCCGG AGGCCCCGGG CTTGCCCAAG 
GAAAGCCACT TGCCCGAGGG GGCTCTGAAC AGCCTTGTGG ATTACAACTC GGAAATGGAG 
CGCTACCGCT CCTTTGCCAC CTCCTTCTAC AAGACCAACG GGGGCGCCTT CCCACAGGCG 
GCCAAGATCG CGCGCATCAC CACCCCCATC TTCCCCAGCA GCGCCGCCGC CGCCGCGGCC 
GCCGCGCGCA TCGGCATGTC CCCCTGGAAC TGCGACAACG CGGCCACCGC CGCCGCCGCC 
ACCGCCATGC TCTGGGGCAG CGGCGGGGGC GGGGGCGGCG GCGGGGGGGG TGGCGGCGGC 
GGCGGCGGCG GCGGAGGCGG GGGCGGGGGT GGTGGGGGCG GCAGGAAATC CTCCTCCGCC 
GCCGCCTCCT CCTCCGCCTC CTCCTCCTCG GCGATCCTCC CCGCCGGCGG TGGCGGCGGC 
GGCGGCGGCG GCGGCAGCAG GACCAGCATG CACCACCGAA ACGACTCCCA GAGGCTGGGG 
AAAGCTGGCT GCCCGCCAGA GCCGTCGTTG CAAATGGCAA ATACTAATTT CCTCTCCACC 
TTATCCCCTG AACACTGCAG ACCTTTGGCG GGGGAATGCA TGAACAAGCT CAAATGCGGC 
GCTGCTGAAG CAGAGATAAT GAATCTCCCC GAGCGCGTGG GGACTTTTTC CGCTATCCCG 
GCTTTAGGGG GCATCTCATT ACCTCCAGGG GTCATCGTCA TGACAGCCCT TCACTCCCCC 
GCAGCAGCCT CAGCAGCCGT CACAGACAGT GCGTTTCAAA TTGCCAATCT GGCAGACTGC 
CCGCAGAATC ATTCCTCCTC CTCCTCGTCC TCCTCAGGGG GAGCTGGCGG AGCCAACCCA 
GCCAAGAAGA AGAGGAAAAG GTGTGGGGTC TGCGTGCCCT GCAAGAGGCT CATCAACTGT 
GGCGTCTGCA GCAGTTGCAG GAACCGCAAA ACGGGACACC AGATCTGCAA ATTTAGAAAA 
TGTGAAGAGC TAAAGAAAAA ACCTGGCACT TCACTAGAGA GAACACCTGT TCCCAGCGCT 
GAAGCATTCC GATGGTTCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530586.1
CDS	601..1704
Translation	MNTNVCVEPGPSPEAPGLPKESHLPEGALNSLVDYNSEMERYRSFATSFYKTNGGAFPQAAKIARITTPIFPSSAAAAAAAARIGMSPWNCDNAATAAAATAMLWGSGGGGGGGGGGGGGGGGGGGGGGGGGGGRKSSSAAASSSASSSSAILPAGGGGGGGGGGSRTSMHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF

Target ORF information:

RefSeq Version	XM_011532284.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CXXC finger protein 4 (CXXC4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532284.2

ORF Insert Sequence:

ATGAACACCA ATGTCTGCGT GGAGCCCGGG CCGAGCCCGG AGGCCCCGGG CTTGCCCAAG 
GAAAGCCACT TGCCCGAGGG GGCTCTGAAC AGCCTTGTGG ATTACAACTC GGAAATGGAG 
CGCTACCGCT CCTTTGCCAC CTCCTTCTAC AAGACCAACG GGGGCGCCTT CCCACAGGCG 
GCCAAGATCG CGCGCATCAC CACCCCCATC TTCCCCAGCA GCGCCGCCGC CGCCGCGGCC 
GCCGCGCGCA TCGGCATGTC CCCCTGGAAC TGCGACAACG CGGCCACCGC CGCCGCCGCC 
ACCGCCATGC TCTGGGGCAG CGGCGGGGGC GGGGGCGGCG GCGGGGGGGG TGGCGGCGGC 
GGCGGCGGCG GCGGAGGCGG GGGCGGGGGT GGTGGGGGCG GCAGGAAATC CTCCTCCGCC 
GCCGCCTCCT CCTCCGCCTC CTCCTCCTCG GCGATCCTCC CCGCCGGCGG TGGCGGCGGC 
GGCGGCGGCG GCGGCAGCAG GACCAGCATG CACCACCGAA ACGACTCCCA GAGGCTGGGG 
AAAGCTGGCT GCCCGCCAGA GCCGTCGTTG CAAATGGCAA ATACTAATTT CCTCTCCACC 
TTATCCCCTG AACACTGCAG ACCTTTGGCG GGGGAATGCA TGAACAAGCT CAAATGCGGC 
GCTGCTGAAG CAGAGATAAT GAATCTCCCC GAGCGCGTGG GGACTTTTTC CGCTATCCCG 
GCTTTAGGGG GCATCTCATT ACCTCCAGGG GTCATCGTCA TGACAGCCCT TCACTCCCCC 
GCAGCAGCCT CAGCAGCCGT CACAGACAGT GCGTTTCAAA TTGCCAATCT GGCAGACTGC 
CCGCAGAATC ATTCCTCCTC CTCCTCGTCC TCCTCAGGGG GAGCTGGCGG AGCCAACCCA 
GCCAAGAAGA AGAGGAAAAG GTGTGGGGTC TGCGTGCCCT GCAAGAGGCT CATCAACTGT 
GGCGTCTGCA GCAGTTGCAG GAACCGCAAA ACGGGACACC AGATCTGCAA ATTTAGAAAA 
TGTGAAGAGC TAAAGAAAAA ACCTGGCACT TCACTAGAGA GAACACCTGT TCCCAGCGCT 
GAAGCATTCC GATGGTTCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX.
Biochemical and biophysical research communications(2018 Jan)
Yu F,Zhou C,Zeng H,Liu Y,Li S

CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients.
Leukemia research38(9)1072-8(2014 Sep)
Li S,Fan R,Zhao XL,Wang XQ

New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.
FEBS letters588(18)3322-6(2014 Sep)
Lu H,Jin W,Sun J,Feng L,Lan H,Shen Q,Ma Y,Li J,Yue Y,Jin H,Wang X

Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4.
Cell death & disease4e776(2013 Aug)
Lu H,Sun J,Wang F,Feng L,Ma Y,Shen Q,Jiang Z,Sun X,Wang X,Jin H

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CXXC4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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