TMEM43 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM43
Entrez Gene ID	79188
Full Name	transmembrane protein 43
Synonyms	ARVC5,ARVD5,EDMD7,LUMA
General protein information	Preferred Names transmembrane protein 43 Names transmembrane protein 43
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p25.1
Summary	This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008].
Disorder MIM:	612048
Disorder Html:	Arrhythmogenic right ventricular dysplasia 5, 604400 (3); Emery-Dreifuss muscular dystrophy 7, AD, 614302 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_024334.2	NP_077310.1	transmembrane protein 43
XM_017007176.1	XP_016862665.1	transmembrane protein 43 isoform X1
XM_017007176.2	XP_016862665.1	transmembrane protein 43 isoform X1
NM_024334.3	NP_077310.1	transmembrane protein 43

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	tmem43	NP_998403.1
Pan troglodytes (chimpanzee)	TMEM43	XP_001157301.1
	TMEM43	XP_001091243.1
Gallus gallus (chicken)	TMEM43	XP_414378.1
Xenopus tropicalis (tropical clawed frog)	tmem43	XP_002938277.1
Homo sapiens (human)	TMEM43	NP_077310.1
Bos taurus (cattle)	TMEM43	NP_001095950.1
Canis lupus familiaris (dog)	TMEM43	XP_541751.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005797	XP_315811.2
Mus musculus (house mouse)	Tmem43	NP_083042.1
Rattus norvegicus (Norway rat)	Tmem43	NP_001007746.1
Drosophila melanogaster (fruit fly)	CG8111	NP_648162.2

Gene Ontology
Bibliography

Related articles in PubMed

Ventricular tachycardia ablation in arrhythmogenic right ventricular cardiomyopathy patients with TMEM43 gene mutations.
AbdelWahab A, Gardner M, Parkash R, Gray C, Sapp J
Journal of cardiovascular electrophysiology29(1)90-97(2018 Jan)

TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-?B activation and tumor progression.
Jiang C, Zhu Y, Zhou Z, Gumin J, Bengtsson L, Wu W, Songyang Z, Lang FF, Lin X
Oncogene36(20)2813-2823(2017 May)

Early and late manifestation of Brugada syndrome ECG in arrhythmogenic cardiomyopathy.
Peters S
International journal of cardiology220260-1(2016 Oct)

Long-Term Clinical Outcome of Arrhythmogenic Right Ventricular Cardiomyopathy in Individuals With a p.S358L Mutation in TMEM43 Following Implantable Cardioverter Defibrillator Therapy.
Hodgkinson KA, Howes AJ, Boland P, Shen XS, Stuckless S, Young TL, Curtis F, Collier A, Parfrey PS, Connors SP
Circulation. Arrhythmia and electrophysiology9(3)(2016 Mar)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TMEM43 deficiency significantly affects colony formation, survival of anoikis-induced cell death, migration and invasion of cancer cells in vitro, as well as tumor progression in vivo.
Title: TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-?B activation and tumor progression.

A very rare mutation in TMEM 43 for the development of Arrhythmogenic cardiomyopathy has a definite connection with desmosomal proteins (plakoglobin) and justifies in a highly arrhythmogenic form of the disease.
Title: Early and late manifestation of Brugada syndrome ECG in arrhythmogenic cardiomyopathy.

Implantable cardioverter defibrillator therapy is indicated for primary prevention in postpubertal males and in females >/= 30 years with the p.S358L TMEM43 mutation.
Title: Long-Term Clinical Outcome of Arrhythmogenic Right Ventricular Cardiomyopathy in Individuals With a p.S358L Mutation in TMEM43 Following Implantable Cardioverter Defibrillator Therapy.

Results suggest a link between missense mutation in this protein and the risk of familial ARVC
Title: The TMEM43 Newfoundland mutation p.S358L causing ARVC-5 was imported from Europe and increases the stiffness of the cell nucleus.

These observations suggest that expression of the p.S358L mutant of TMEM43 found in ARVC type 5 may affect localization of proteins involved in conduction, alter gap junction function and reduce conduction velocity in cardiac tissue.
Title: TMEM43 mutation p.S358L alters intercalated disc protein expression and reduces conduction velocity in arrhythmogenic right ventricular cardiomyopathy.

The following TMEM43 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM43 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19231	NM_024334.3 Latest version!	Homo sapiens transmembrane protein 43 (TMEM43), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu71826	XM_017007176.2 Latest version!	Homo sapiens transmembrane protein 43 (TMEM43), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OHu71826	XM_017007176.1	Homo sapiens transmembrane protein 43 (TMEM43), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu19231	NM_024334.2	Homo sapiens transmembrane protein 43 (TMEM43), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM43 ( NM_024334.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_077310.1 Homo sapiens transmembrane protein 43 (TMEM43), mRNA.

Price & Availability↑

CloneID	OHu19231
Clone ID Related Accession (Same CDS sequence)	NM_024334.2 , NM_024334.3
Accession Version	NM_024334.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	transmembrane protein 43
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA259919.1, BC003125.1 and AY358625.1. This sequence is a reference standard in the RefSeqGene project. On Sep 13, 2008 this sequence version replaced NM_024334.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.236364.1, SRR1660805.238668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCGA ATTATTCCAG TACCAGTACC CGGAGAGAAC ATGTCAAAGT TAAAACCAGC 
TCCCAGCCAG GCTTCCTGGA ACGGCTGAGC GAGACCTCGG GTGGGATGTT TGTGGGGCTC 
ATGGCCTTCC TGCTCTCCTT CTACCTAATT TTCACCAATG AGGGCCGCGC ATTGAAGACG 
GCAACCTCAT TGGCTGAGGG GCTCTCGCTT GTGGTGTCTC CCGACAGCAT CCACAGTGTG 
GCTCCGGAGA ATGAAGGAAG GCTGGTGCAC ATCATTGGCG CCTTACGGAC ATCCAAGCTT 
TTGTCTGATC CAAACTATGG GGTCCATCTT CCGGCTGTGA AACTGCGGAG GCACGTGGAG 
ATGTACCAAT GGGTAGAAAC TGAGGAGTCC AGGGAGTACA CCGAGGATGG GCAGGTGAAG 
AAGGAGACGA GGTATTCCTA CAACACTGAA TGGAGGTCAG AAATCATCAA CAGCAAAAAC 
TTCGACCGAG AGATTGGCCA CAAAAACCCC AGTGCCATGG CAGTGGAGTC ATTCATGGCA 
ACAGCCCCCT TTGTCCAAAT TGGCAGGTTT TTCCTCTCGT CAGGCCTCAT CGACAAAGTC 
GACAACTTCA AGTCCCTGAG CCTATCCAAG CTGGAGGACC CTCATGTGGA CATCATTCGC 
CGTGGAGACT TTTTCTACCA CAGCGAAAAT CCCAAGTATC CAGAGGTGGG AGACTTGCGT 
GTCTCCTTTT CCTATGCTGG ACTGAGCGGC GATGACCCTG ACCTGGGCCC AGCTCACGTG 
GTCACTGTGA TTGCCCGGCA GCGGGGTGAC CAGCTAGTCC CATTCTCCAC CAAGTCTGGG 
GATACCTTAC TGCTCCTGCA CCACGGGGAC TTCTCAGCAG AGGAGGTGTT TCATAGAGAA 
CTAAGGAGCA ACTCCATGAA GACCTGGGGC CTGCGGGCAG CTGGCTGGAT GGCCATGTTC 
ATGGGCCTCA ACCTTATGAC ACGGATCCTC TACACCTTGG TGGACTGGTT TCCTGTTTTC 
CGAGACCTGG TCAACATTGG CCTGAAAGCC TTTGCCTTCT GTGTGGCCAC CTCGCTGACC 
CTGCTGACCG TGGCGGCTGG CTGGCTCTTC TACCGACCCC TGTGGGCCCT CCTCATTGCC 
GGCCTGGCCC TTGTGCCCAT CCTTGTTGCT CGGACACGGG TGCCAGCCAA AAAGTTGGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077310.1
CDS	255..1457
Translation	MAANYSSTSTRREHVKVKTSSQPGFLERLSETSGGMFVGLMAFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWALLIAGLALVPILVARTRVPAKKLE

Target ORF information:

RefSeq Version	NM_024334.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 43 (TMEM43), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024334.2

ORF Insert Sequence:

ATGGCCGCGA ATTATTCCAG TACCAGTACC CGGAGAGAAC ATGTCAAAGT TAAAACCAGC 
TCCCAGCCAG GCTTCCTGGA ACGGCTGAGC GAGACCTCGG GTGGGATGTT TGTGGGGCTC 
ATGGCCTTCC TGCTCTCCTT CTACCTAATT TTCACCAATG AGGGCCGCGC ATTGAAGACG 
GCAACCTCAT TGGCTGAGGG GCTCTCGCTT GTGGTGTCTC CCGACAGCAT CCACAGTGTG 
GCTCCGGAGA ATGAAGGAAG GCTGGTGCAC ATCATTGGCG CCTTACGGAC ATCCAAGCTT 
TTGTCTGATC CAAACTATGG GGTCCATCTT CCGGCTGTGA AACTGCGGAG GCACGTGGAG 
ATGTACCAAT GGGTAGAAAC TGAGGAGTCC AGGGAGTACA CCGAGGATGG GCAGGTGAAG 
AAGGAGACGA GGTATTCCTA CAACACTGAA TGGAGGTCAG AAATCATCAA CAGCAAAAAC 
TTCGACCGAG AGATTGGCCA CAAAAACCCC AGTGCCATGG CAGTGGAGTC ATTCATGGCA 
ACAGCCCCCT TTGTCCAAAT TGGCAGGTTT TTCCTCTCGT CAGGCCTCAT CGACAAAGTC 
GACAACTTCA AGTCCCTGAG CCTATCCAAG CTGGAGGACC CTCATGTGGA CATCATTCGC 
CGTGGAGACT TTTTCTACCA CAGCGAAAAT CCCAAGTATC CAGAGGTGGG AGACTTGCGT 
GTCTCCTTTT CCTATGCTGG ACTGAGCGGC GATGACCCTG ACCTGGGCCC AGCTCACGTG 
GTCACTGTGA TTGCCCGGCA GCGGGGTGAC CAGCTAGTCC CATTCTCCAC CAAGTCTGGG 
GATACCTTAC TGCTCCTGCA CCACGGGGAC TTCTCAGCAG AGGAGGTGTT TCATAGAGAA 
CTAAGGAGCA ACTCCATGAA GACCTGGGGC CTGCGGGCAG CTGGCTGGAT GGCCATGTTC 
ATGGGCCTCA ACCTTATGAC ACGGATCCTC TACACCTTGG TGGACTGGTT TCCTGTTTTC 
CGAGACCTGG TCAACATTGG CCTGAAAGCC TTTGCCTTCT GTGTGGCCAC CTCGCTGACC 
CTGCTGACCG TGGCGGCTGG CTGGCTCTTC TACCGACCCC TGTGGGCCCT CCTCATTGCC 
GGCCTGGCCC TTGTGCCCAT CCTTGTTGCT CGGACACGGG TGCCAGCCAA AAAGTTGGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM43 ( NM_024334.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_077310.1 Homo sapiens transmembrane protein 43 (TMEM43), mRNA.

Price & Availability↑

CloneID	OHu19231
Clone ID Related Accession (Same CDS sequence)	NM_024334.2 , NM_024334.3
Accession Version	NM_024334.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	transmembrane protein 43
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC003125.1 and AY358625.1. On Nov 30, 2019 this sequence version replaced NM_024334.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003125.1, AL136916.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCGA ATTATTCCAG TACCAGTACC CGGAGAGAAC ATGTCAAAGT TAAAACCAGC 
TCCCAGCCAG GCTTCCTGGA ACGGCTGAGC GAGACCTCGG GTGGGATGTT TGTGGGGCTC 
ATGGCCTTCC TGCTCTCCTT CTACCTAATT TTCACCAATG AGGGCCGCGC ATTGAAGACG 
GCAACCTCAT TGGCTGAGGG GCTCTCGCTT GTGGTGTCTC CCGACAGCAT CCACAGTGTG 
GCTCCGGAGA ATGAAGGAAG GCTGGTGCAC ATCATTGGCG CCTTACGGAC ATCCAAGCTT 
TTGTCTGATC CAAACTATGG GGTCCATCTT CCGGCTGTGA AACTGCGGAG GCACGTGGAG 
ATGTACCAAT GGGTAGAAAC TGAGGAGTCC AGGGAGTACA CCGAGGATGG GCAGGTGAAG 
AAGGAGACGA GGTATTCCTA CAACACTGAA TGGAGGTCAG AAATCATCAA CAGCAAAAAC 
TTCGACCGAG AGATTGGCCA CAAAAACCCC AGTGCCATGG CAGTGGAGTC ATTCATGGCA 
ACAGCCCCCT TTGTCCAAAT TGGCAGGTTT TTCCTCTCGT CAGGCCTCAT CGACAAAGTC 
GACAACTTCA AGTCCCTGAG CCTATCCAAG CTGGAGGACC CTCATGTGGA CATCATTCGC 
CGTGGAGACT TTTTCTACCA CAGCGAAAAT CCCAAGTATC CAGAGGTGGG AGACTTGCGT 
GTCTCCTTTT CCTATGCTGG ACTGAGCGGC GATGACCCTG ACCTGGGCCC AGCTCACGTG 
GTCACTGTGA TTGCCCGGCA GCGGGGTGAC CAGCTAGTCC CATTCTCCAC CAAGTCTGGG 
GATACCTTAC TGCTCCTGCA CCACGGGGAC TTCTCAGCAG AGGAGGTGTT TCATAGAGAA 
CTAAGGAGCA ACTCCATGAA GACCTGGGGC CTGCGGGCAG CTGGCTGGAT GGCCATGTTC 
ATGGGCCTCA ACCTTATGAC ACGGATCCTC TACACCTTGG TGGACTGGTT TCCTGTTTTC 
CGAGACCTGG TCAACATTGG CCTGAAAGCC TTTGCCTTCT GTGTGGCCAC CTCGCTGACC 
CTGCTGACCG TGGCGGCTGG CTGGCTCTTC TACCGACCCC TGTGGGCCCT CCTCATTGCC 
GGCCTGGCCC TTGTGCCCAT CCTTGTTGCT CGGACACGGG TGCCAGCCAA AAAGTTGGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077310.1
CDS	143..1345
Translation	MAANYSSTSTRREHVKVKTSSQPGFLERLSETSGGMFVGLMAFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWALLIAGLALVPILVARTRVPAKKLE

Target ORF information:

RefSeq Version	NM_024334.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 43 (TMEM43), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024334.3

ORF Insert Sequence:

ATGGCCGCGA ATTATTCCAG TACCAGTACC CGGAGAGAAC ATGTCAAAGT TAAAACCAGC 
TCCCAGCCAG GCTTCCTGGA ACGGCTGAGC GAGACCTCGG GTGGGATGTT TGTGGGGCTC 
ATGGCCTTCC TGCTCTCCTT CTACCTAATT TTCACCAATG AGGGCCGCGC ATTGAAGACG 
GCAACCTCAT TGGCTGAGGG GCTCTCGCTT GTGGTGTCTC CCGACAGCAT CCACAGTGTG 
GCTCCGGAGA ATGAAGGAAG GCTGGTGCAC ATCATTGGCG CCTTACGGAC ATCCAAGCTT 
TTGTCTGATC CAAACTATGG GGTCCATCTT CCGGCTGTGA AACTGCGGAG GCACGTGGAG 
ATGTACCAAT GGGTAGAAAC TGAGGAGTCC AGGGAGTACA CCGAGGATGG GCAGGTGAAG 
AAGGAGACGA GGTATTCCTA CAACACTGAA TGGAGGTCAG AAATCATCAA CAGCAAAAAC 
TTCGACCGAG AGATTGGCCA CAAAAACCCC AGTGCCATGG CAGTGGAGTC ATTCATGGCA 
ACAGCCCCCT TTGTCCAAAT TGGCAGGTTT TTCCTCTCGT CAGGCCTCAT CGACAAAGTC 
GACAACTTCA AGTCCCTGAG CCTATCCAAG CTGGAGGACC CTCATGTGGA CATCATTCGC 
CGTGGAGACT TTTTCTACCA CAGCGAAAAT CCCAAGTATC CAGAGGTGGG AGACTTGCGT 
GTCTCCTTTT CCTATGCTGG ACTGAGCGGC GATGACCCTG ACCTGGGCCC AGCTCACGTG 
GTCACTGTGA TTGCCCGGCA GCGGGGTGAC CAGCTAGTCC CATTCTCCAC CAAGTCTGGG 
GATACCTTAC TGCTCCTGCA CCACGGGGAC TTCTCAGCAG AGGAGGTGTT TCATAGAGAA 
CTAAGGAGCA ACTCCATGAA GACCTGGGGC CTGCGGGCAG CTGGCTGGAT GGCCATGTTC 
ATGGGCCTCA ACCTTATGAC ACGGATCCTC TACACCTTGG TGGACTGGTT TCCTGTTTTC 
CGAGACCTGG TCAACATTGG CCTGAAAGCC TTTGCCTTCT GTGTGGCCAC CTCGCTGACC 
CTGCTGACCG TGGCGGCTGG CTGGCTCTTC TACCGACCCC TGTGGGCCCT CCTCATTGCC 
GGCCTGGCCC TTGTGCCCAT CCTTGTTGCT CGGACACGGG TGCCAGCCAA AAAGTTGGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM43 ( XM_017007176.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862665.1 Homo sapiens transmembrane protein 43 (TMEM43), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu71826
Clone ID Related Accession (Same CDS sequence)	XM_017007176.1 , XM_017007176.2
Accession Version	XM_017007176.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	transmembrane protein 43 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTGTGG GGCTCATGGC CTTCCTGCTC TCCTTCTACC TAATTTTCAC CAATGAGGGC 
CGCGCATTGA AGACGGCAAC CTCATTGGCT GAGGGGCTCT CGCTTGTGGT GTCTCCCGAC 
AGCATCCACA GTGTGGCTCC GGAGAATGAA GGAAGGCTGG TGCACATCAT TGGCGCCTTA 
CGGACATCCA AGCTTTTGTC TGATCCAAAC TATGGGGTCC ATCTTCCGGC TGTGAAACTG 
CGGAGGCACG TGGAGATGTA CCAATGGGTA GAAACTGAGG AGTCCAGGGA GTACACCGAG 
GATGGGCAGG TGAAGAAGGA GACGAGGTAT TCCTACAACA CTGAATGGAG GTCAGAAATC 
ATCAACAGCA AAAACTTCGA CCGAGAGATT GGCCACAAAA ACCCCAGTGC CATGGCAGTG 
GAGTCATTCA TGGCAACAGC CCCCTTTGTC CAAATTGGCA GGTTTTTCCT CTCGTCAGGC 
CTCATCGACA AAGTCGACAA CTTCAAGTCC CTGAGCCTAT CCAAGCTGGA GGACCCTCAT 
GTGGACATCA TTCGCCGTGG AGACTTTTTC TACCACAGCG AAAATCCCAA GTATCCAGAG 
GTGGGAGACT TGCGTGTCTC CTTTTCCTAT GCTGGACTGA GCGGCGATGA CCCTGACCTG 
GGCCCAGCTC ACGTGGTCAC TGTGATTGCC CGGCAGCGGG GTGACCAGCT AGTCCCATTC 
TCCACCAAGT CTGGGGATAC CTTACTGCTC CTGCACCACG GGGACTTCTC AGCAGAGGAG 
GTGTTTCATA GAGAACTAAG GAGCAACTCC ATGAAGACCT GGGGCCTGCG GGCAGCTGGC 
TGGATGGCCA TGTTCATGGG CCTCAACCTT ATGACACGGA TCCTCTACAC CTTGGTGGAC 
TGGTTTCCTG TTTTCCGAGA CCTGGTCAAC ATTGGCCTGA AAGCCTTTGC CTTCTGTGTG 
GCCACCTCGC TGACCCTGCT GACCGTGGCG GCTGGCTGGC TCTTCTACCG ACCCCTGTGG 
GCCCTCCTCA TTGCCGGCCT GGCCCTTGTG CCCATCCTTG TTGCTCGGAC ACGGGTGCCA 
GCCAAAAAGT TGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862665.1
CDS	482..1579
Translation	MFVGLMAFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWALLIAGLALVPILVARTRVPAKKLE

Target ORF information:

RefSeq Version	XM_017007176.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 43 (TMEM43), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017007176.1

ORF Insert Sequence:

ATGTTTGTGG GGCTCATGGC CTTCCTGCTC TCCTTCTACC TAATTTTCAC CAATGAGGGC 
CGCGCATTGA AGACGGCAAC CTCATTGGCT GAGGGGCTCT CGCTTGTGGT GTCTCCCGAC 
AGCATCCACA GTGTGGCTCC GGAGAATGAA GGAAGGCTGG TGCACATCAT TGGCGCCTTA 
CGGACATCCA AGCTTTTGTC TGATCCAAAC TATGGGGTCC ATCTTCCGGC TGTGAAACTG 
CGGAGGCACG TGGAGATGTA CCAATGGGTA GAAACTGAGG AGTCCAGGGA GTACACCGAG 
GATGGGCAGG TGAAGAAGGA GACGAGGTAT TCCTACAACA CTGAATGGAG GTCAGAAATC 
ATCAACAGCA AAAACTTCGA CCGAGAGATT GGCCACAAAA ACCCCAGTGC CATGGCAGTG 
GAGTCATTCA TGGCAACAGC CCCCTTTGTC CAAATTGGCA GGTTTTTCCT CTCGTCAGGC 
CTCATCGACA AAGTCGACAA CTTCAAGTCC CTGAGCCTAT CCAAGCTGGA GGACCCTCAT 
GTGGACATCA TTCGCCGTGG AGACTTTTTC TACCACAGCG AAAATCCCAA GTATCCAGAG 
GTGGGAGACT TGCGTGTCTC CTTTTCCTAT GCTGGACTGA GCGGCGATGA CCCTGACCTG 
GGCCCAGCTC ACGTGGTCAC TGTGATTGCC CGGCAGCGGG GTGACCAGCT AGTCCCATTC 
TCCACCAAGT CTGGGGATAC CTTACTGCTC CTGCACCACG GGGACTTCTC AGCAGAGGAG 
GTGTTTCATA GAGAACTAAG GAGCAACTCC ATGAAGACCT GGGGCCTGCG GGCAGCTGGC 
TGGATGGCCA TGTTCATGGG CCTCAACCTT ATGACACGGA TCCTCTACAC CTTGGTGGAC 
TGGTTTCCTG TTTTCCGAGA CCTGGTCAAC ATTGGCCTGA AAGCCTTTGC CTTCTGTGTG 
GCCACCTCGC TGACCCTGCT GACCGTGGCG GCTGGCTGGC TCTTCTACCG ACCCCTGTGG 
GCCCTCCTCA TTGCCGGCCT GGCCCTTGTG CCCATCCTTG TTGCTCGGAC ACGGGTGCCA 
GCCAAAAAGT TGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM43 ( XM_017007176.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862665.1 Homo sapiens transmembrane protein 43 (TMEM43), transcript variant X1, mRNA.

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CloneID	OHu71826
Clone ID Related Accession (Same CDS sequence)	XM_017007176.1 , XM_017007176.2
Accession Version	XM_017007176.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transmembrane protein 43 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017007176.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTGTGG GGCTCATGGC CTTCCTGCTC TCCTTCTACC TAATTTTCAC CAATGAGGGC 
CGCGCATTGA AGACGGCAAC CTCATTGGCT GAGGGGCTCT CGCTTGTGGT GTCTCCCGAC 
AGCATCCACA GTGTGGCTCC GGAGAATGAA GGAAGGCTGG TGCACATCAT TGGCGCCTTA 
CGGACATCCA AGCTTTTGTC TGATCCAAAC TATGGGGTCC ATCTTCCGGC TGTGAAACTG 
CGGAGGCACG TGGAGATGTA CCAATGGGTA GAAACTGAGG AGTCCAGGGA GTACACCGAG 
GATGGGCAGG TGAAGAAGGA GACGAGGTAT TCCTACAACA CTGAATGGAG GTCAGAAATC 
ATCAACAGCA AAAACTTCGA CCGAGAGATT GGCCACAAAA ACCCCAGTGC CATGGCAGTG 
GAGTCATTCA TGGCAACAGC CCCCTTTGTC CAAATTGGCA GGTTTTTCCT CTCGTCAGGC 
CTCATCGACA AAGTCGACAA CTTCAAGTCC CTGAGCCTAT CCAAGCTGGA GGACCCTCAT 
GTGGACATCA TTCGCCGTGG AGACTTTTTC TACCACAGCG AAAATCCCAA GTATCCAGAG 
GTGGGAGACT TGCGTGTCTC CTTTTCCTAT GCTGGACTGA GCGGCGATGA CCCTGACCTG 
GGCCCAGCTC ACGTGGTCAC TGTGATTGCC CGGCAGCGGG GTGACCAGCT AGTCCCATTC 
TCCACCAAGT CTGGGGATAC CTTACTGCTC CTGCACCACG GGGACTTCTC AGCAGAGGAG 
GTGTTTCATA GAGAACTAAG GAGCAACTCC ATGAAGACCT GGGGCCTGCG GGCAGCTGGC 
TGGATGGCCA TGTTCATGGG CCTCAACCTT ATGACACGGA TCCTCTACAC CTTGGTGGAC 
TGGTTTCCTG TTTTCCGAGA CCTGGTCAAC ATTGGCCTGA AAGCCTTTGC CTTCTGTGTG 
GCCACCTCGC TGACCCTGCT GACCGTGGCG GCTGGCTGGC TCTTCTACCG ACCCCTGTGG 
GCCCTCCTCA TTGCCGGCCT GGCCCTTGTG CCCATCCTTG TTGCTCGGAC ACGGGTGCCA 
GCCAAAAAGT TGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862665.1
CDS	525..1622
Translation	MFVGLMAFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWALLIAGLALVPILVARTRVPAKKLE

Target ORF information:

RefSeq Version	XM_017007176.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 43 (TMEM43), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017007176.2

ORF Insert Sequence:

ATGTTTGTGG GGCTCATGGC CTTCCTGCTC TCCTTCTACC TAATTTTCAC CAATGAGGGC 
CGCGCATTGA AGACGGCAAC CTCATTGGCT GAGGGGCTCT CGCTTGTGGT GTCTCCCGAC 
AGCATCCACA GTGTGGCTCC GGAGAATGAA GGAAGGCTGG TGCACATCAT TGGCGCCTTA 
CGGACATCCA AGCTTTTGTC TGATCCAAAC TATGGGGTCC ATCTTCCGGC TGTGAAACTG 
CGGAGGCACG TGGAGATGTA CCAATGGGTA GAAACTGAGG AGTCCAGGGA GTACACCGAG 
GATGGGCAGG TGAAGAAGGA GACGAGGTAT TCCTACAACA CTGAATGGAG GTCAGAAATC 
ATCAACAGCA AAAACTTCGA CCGAGAGATT GGCCACAAAA ACCCCAGTGC CATGGCAGTG 
GAGTCATTCA TGGCAACAGC CCCCTTTGTC CAAATTGGCA GGTTTTTCCT CTCGTCAGGC 
CTCATCGACA AAGTCGACAA CTTCAAGTCC CTGAGCCTAT CCAAGCTGGA GGACCCTCAT 
GTGGACATCA TTCGCCGTGG AGACTTTTTC TACCACAGCG AAAATCCCAA GTATCCAGAG 
GTGGGAGACT TGCGTGTCTC CTTTTCCTAT GCTGGACTGA GCGGCGATGA CCCTGACCTG 
GGCCCAGCTC ACGTGGTCAC TGTGATTGCC CGGCAGCGGG GTGACCAGCT AGTCCCATTC 
TCCACCAAGT CTGGGGATAC CTTACTGCTC CTGCACCACG GGGACTTCTC AGCAGAGGAG 
GTGTTTCATA GAGAACTAAG GAGCAACTCC ATGAAGACCT GGGGCCTGCG GGCAGCTGGC 
TGGATGGCCA TGTTCATGGG CCTCAACCTT ATGACACGGA TCCTCTACAC CTTGGTGGAC 
TGGTTTCCTG TTTTCCGAGA CCTGGTCAAC ATTGGCCTGA AAGCCTTTGC CTTCTGTGTG 
GCCACCTCGC TGACCCTGCT GACCGTGGCG GCTGGCTGGC TCTTCTACCG ACCCCTGTGG 
GCCCTCCTCA TTGCCGGCCT GGCCCTTGTG CCCATCCTTG TTGCTCGGAC ACGGGTGCCA 
GCCAAAAAGT TGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ventricular tachycardia ablation in arrhythmogenic right ventricular cardiomyopathy patients with TMEM43 gene mutations.
Journal of cardiovascular electrophysiology29(1)90-97(2018 Jan)
AbdelWahab A,Gardner M,Parkash R,Gray C,Sapp J

TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-?B activation and tumor progression.
Oncogene36(20)2813-2823(2017 May)
Jiang C,Zhu Y,Zhou Z,Gumin J,Bengtsson L,Wu W,Songyang Z,Lang FF,Lin X

Early and late manifestation of Brugada syndrome ECG in arrhythmogenic cardiomyopathy.
International journal of cardiology220260-1(2016 Oct)
Peters S

Long-Term Clinical Outcome of Arrhythmogenic Right Ventricular Cardiomyopathy in Individuals With a p.S358L Mutation in TMEM43 Following Implantable Cardioverter Defibrillator Therapy.
Circulation. Arrhythmia and electrophysiology9(3)(2016 Mar)
Hodgkinson KA,Howes AJ,Boland P,Shen XS,Stuckless S,Young TL,Curtis F,Collier A,Parfrey PS,Connors SP

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

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TMEM43 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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