UQCC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UQCC3
Entrez Gene ID	790955
Full Name	ubiquinol-cytochrome c reductase complex assembly factor 3
Synonyms	C11orf83,CCDS41658.1,MC3DN9,UNQ655
General protein information	Preferred Names ubiquinol-cytochrome c reductase complex assembly factor 3 Names ubiquinol-cytochrome-c reductase complex assembly factor 3 UPF0723 protein C11orf83 assembly factor CBP4 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.3
Summary	Complex III is a mitochondrial inner membrane protein complex that transfers electrons from ubiquinol to cytochrome c. This gene encodes a protein that functions in complex III assembly. Mutations in this gene result in Mitochondrial complex III deficiency, nuclear type 9. [provided by RefSeq, Dec 2014].
Disorder MIM:	616097
Disorder Html:	?Mitochondrial complex III deficiency, nuclear type 9, 616111 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001085372.3	NP_001078841.1	ubiquinol-cytochrome-c reductase complex assembly factor 3
NM_001085372.2	NP_001078841.1	ubiquinol-cytochrome-c reductase complex assembly factor 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	C11orf83	NP_001078841.1
	C14H11orf83	XP_001116443.1
Pan troglodytes (chimpanzee)	C11H11orf83	XP_001155585.1
Canis lupus familiaris (dog)	C18H11orf83	XP_855039.3
Mus musculus (house mouse)	AI462493	NP_001153828.1
Bos taurus (cattle)	C29H11orf83	NP_001069182.1
Rattus norvegicus (Norway rat)	LOC690344	NP_001162132.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial C11orf83 is a potent Antiviral Protein Independent of interferon production.
Yang Y, Xiong S, Cai B, Luo H, Dong E, Li Q, Ji G, Zhao C, Wen Y, Wei Y, Yang H
Scientific reports744303(2017 Apr)

C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.
Desmurs M, Foti M, Raemy E, Vaz FM, Martinou JC, Bairoch A, Lane L
Molecular and cellular biology35(7)1139-56(2015 Apr)

A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability.
Wanschers BF, Szklarczyk R, van den Brand MA, Jonckheere A, Suijskens J, Smeets R, Rodenburg RJ, Stephan K, Helland IB, Elkamil A, Rootwelt T, Ott M, van den Heuvel L, Nijtmans LG, Huynen MA
Human molecular genetics23(23)6356-65(2014 Dec)

[Bioinformatics analysis and function prediction of the novel gene AY358935].
Xiong SQ, Yang HS, Long QD
Nan fang yi ke da xue xue bao = Journal of Southern Medical University30(2)232-5(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

C11orf83 depletion in HeLa cells caused abnormal crista morphology, higher sensitivity to apoptosis, a decreased ATP level due to impaired respiration and subtle, but significant, changes in cardiolipin composition.
Title: C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.

UQCC3 functions in complex III assembly and that the c.59T>A mutation has a causal role in complex III deficiency.
Title: A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability.

AY358935 is a predicted secretary protein with a small molecular weight that might have important functions in cellular proliferation and anti-viral innate immune regulation.
Title: [Bioinformatics analysis and function prediction of the novel gene AY358935].

The following UQCC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UQCC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01166	NM_001085372.3 Latest version!	Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu01166	NM_001085372.2	Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UQCC3 ( NM_001085372.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001078841.1 Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3), mRNA.

Price & Availability↑

CloneID	OHu01166
Clone ID Related Accession (Same CDS sequence)	NM_001085372.3 , NM_001085372.2
Accession Version	NM_001085372.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	ubiquinol-cytochrome-c reductase complex assembly factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358935.1, CA422425.1, AP001458.6, BC090057.1, BF055120.1 and AI972746.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001085372.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS representation uses a downstream start codon, which is more consistent with the presence of an N-terminal signal peptide, and with experimental evidence for cleavage of this signal peptide in PMID:15340161. It should be noted that an alternative upstream start codon, which would result in a protein that is 38 aa longer at the N-terminus, also exists. However, the use of the upstream start codon would eliminate the signal peptide, and it has a weak Kozak signal, so it is likely that leaky scanning by ribosomes will allow the use of the downstream start codon. ##Evidence-Data-START## Transcript exon combination :: DA538472.1, SRR1803613.7345.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000377953.4/ ENSP00000367189.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATTCCT TGCGGAAAAT GCTGATCTCA GTCGCAATGC TGGGCGCAGG GGCTGGCGTG 
GGCTACGCGC TCCTCGTTAT CGTGACCCCG GGAGAGCGGC GGAAGCAGGA AATGCTAAAG 
GAGATGCCAC TGCAGGACCC AAGGAGCAGG GAGGAGGCGG CCAGGACCCA GCAGCTATTG 
CTGGCCACTC TGCAGGAGGC AGCGACCACG CAGGAGAACG TGGCCTGGAG GAAGAACTGG 
ATGGTTGGCG GCGAAGGCGG CGCCGGCGGG AGGTCACCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001078841.1
CDS	74..355
Translation	MDSLRKMLISVAMLGAGAGVGYALLVIVTPGERRKQEMLKEMPLQDPRSREEAARTQQLLLATLQEAATTQENVAWRKNWMVGGEGGAGGRSP

Target ORF information:

RefSeq Version	NM_001085372.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001085372.3

ORF Insert Sequence:

ATGGATTCCT TGCGGAAAAT GCTGATCTCA GTCGCAATGC TGGGCGCAGG GGCTGGCGTG 
GGCTACGCGC TCCTCGTTAT CGTGACCCCG GGAGAGCGGC GGAAGCAGGA AATGCTAAAG 
GAGATGCCAC TGCAGGACCC AAGGAGCAGG GAGGAGGCGG CCAGGACCCA GCAGCTATTG 
CTGGCCACTC TGCAGGAGGC AGCGACCACG CAGGAGAACG TGGCCTGGAG GAAGAACTGG 
ATGGTTGGCG GCGAAGGCGG CGCCGGCGGG AGGTCACCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UQCC3 ( NM_001085372.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001078841.1 Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3), mRNA.

Price & Availability↑

CloneID	OHu01166
Clone ID Related Accession (Same CDS sequence)	NM_001085372.3 , NM_001085372.2
Accession Version	NM_001085372.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ubiquinol-cytochrome-c reductase complex assembly factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358935.1, CA422425.1, AP001458.6, BC090057.1, BF055120.1 and AI972746.1. This sequence is a reference standard in the RefSeqGene project. On Sep 2, 2010 this sequence version replaced NM_001085372.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS representation uses a downstream start codon, which is more consistent with the presence of an N-terminal signal peptide, and with experimental evidence for cleavage of this signal peptide in PMID:15340161. It should be noted that an alternative upstream start codon, which would result in a protein that is 38 aa longer at the N-terminus, also exists. However, the use of the upstream start codon would eliminate the signal peptide, and it has a weak Kozak signal, so it is likely that leaky scanning by ribosomes will allow the use of the downstream start codon. ##Evidence-Data-START## Transcript exon combination :: AY358935.1, SRR1803613.7345.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTCCT TGCGGAAAAT GCTGATCTCA GTCGCAATGC TGGGCGCAGG GGCTGGCGTG 
GGCTACGCGC TCCTCGTTAT CGTGACCCCG GGAGAGCGGC GGAAGCAGGA AATGCTAAAG 
GAGATGCCAC TGCAGGACCC AAGGAGCAGG GAGGAGGCGG CCAGGACCCA GCAGCTATTG 
CTGGCCACTC TGCAGGAGGC AGCGACCACG CAGGAGAACG TGGCCTGGAG GAAGAACTGG 
ATGGTTGGCG GCGAAGGCGG CGCCGGCGGG AGGTCACCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001078841.1
CDS	93..374
Translation	MDSLRKMLISVAMLGAGAGVGYALLVIVTPGERRKQEMLKEMPLQDPRSREEAARTQQLLLATLQEAATTQENVAWRKNWMVGGEGGAGGRSP

Target ORF information:

RefSeq Version	NM_001085372.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001085372.2

ORF Insert Sequence:

ATGGATTCCT TGCGGAAAAT GCTGATCTCA GTCGCAATGC TGGGCGCAGG GGCTGGCGTG 
GGCTACGCGC TCCTCGTTAT CGTGACCCCG GGAGAGCGGC GGAAGCAGGA AATGCTAAAG 
GAGATGCCAC TGCAGGACCC AAGGAGCAGG GAGGAGGCGG CCAGGACCCA GCAGCTATTG 
CTGGCCACTC TGCAGGAGGC AGCGACCACG CAGGAGAACG TGGCCTGGAG GAAGAACTGG 
ATGGTTGGCG GCGAAGGCGG CGCCGGCGGG AGGTCACCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial C11orf83 is a potent Antiviral Protein Independent of interferon production.
Scientific reports744303(2017 Apr)
Yang Y,Xiong S,Cai B,Luo H,Dong E,Li Q,Ji G,Zhao C,Wen Y,Wei Y,Yang H

C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.
Molecular and cellular biology35(7)1139-56(2015 Apr)
Desmurs M,Foti M,Raemy E,Vaz FM,Martinou JC,Bairoch A,Lane L

A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability.
Human molecular genetics23(23)6356-65(2014 Dec)
Wanschers BF,Szklarczyk R,van den Brand MA,Jonckheere A,Suijskens J,Smeets R,Rodenburg RJ,Stephan K,Helland IB,Elkamil A,Rootwelt T,Ott M,van den Heuvel L,Nijtmans LG,Huynen MA

[Bioinformatics analysis and function prediction of the novel gene AY358935].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University30(2)232-5(2010 Feb)
Xiong SQ,Yang HS,Long QD

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UQCC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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