SCG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCG2
Entrez Gene ID	7857
Full Name	secretogranin II
Synonyms	CHGC,EM66,SN,SgII
General protein information	Preferred Names secretogranin II Names secretogranin-2 chromogranin-C secretoneurin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q36.1
Summary	The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008].
Disorder MIM:	118930

mRNA and Protein(s)

mRNA	Protein	Name
NM_003469.5	NP_003460.2	secretogranin-2 precursor
NM_003469.4	NP_003460.2	secretogranin-2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Scg2	NP_073160.1
Danio rerio (zebrafish)	scg2b	NP_001071216.1
Xenopus tropicalis (tropical clawed frog)	scg2	NP_001072311.1
Homo sapiens (human)	SCG2	NP_003460.2
Pan troglodytes (chimpanzee)	SCG2	XP_001166617.1
Canis lupus familiaris (dog)	SCG2	XP_545669.1
Bos taurus (cattle)	SCG2	NP_776601.1
Mus musculus (house mouse)	Scg2	NP_033155.1
	SCG2	XP_001108599.1
Gallus gallus (chicken)	SCG2	XP_422624.3

Gene Ontology
Bibliography

Related articles in PubMed

Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.
Berard AR, Severini A, Coombs KM
Journal of virology89(23)11954-64(2015 Dec)

Secretogranin II is overexpressed in advanced prostate cancer and promotes the neuroendocrine differentiation of prostate cancer cells.
Courel M, El Yamani FZ, Alexandre D, El Fatemi H, Delestre C, Montero-Hadjadje M, Tazi F, Amarti A, Magoul R, Chartrel N, Anouar Y
European journal of cancer (Oxford, England : 1990)50(17)3039-49(2014 Nov)

Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.
Albrecht-Schgoer K, Schgoer W, Theurl M, Stanzl U, Lener D, Dejaco D, Zelger B, Franz WM, Kirchmair R
Angiogenesis17(1)27-36(2014 Jan)

Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1.
Xu R, Li Q, Zhou J, Zhou X, Perelman JM, Kolosov VP
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology33(2)446-56(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.
Title: Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.

present data show that SgII is highly expressed in advanced prostate cancer and may contribute to the neuroendocrine differentiation by promoting the formation of secretory granules and the proliferation of PCa cells.
Title: Secretogranin II is overexpressed in advanced prostate cancer and promotes the neuroendocrine differentiation of prostate cancer cells.

Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.
Title: Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.

SN induces MUC5AC hypersecretion in a dose- and time-dependent manner; moreover, the MUC5AC over synthesis induced by SN is strongly associated with the enhanced binding of EGF to NRP1
Title: Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1.

CgA, CgB, and secretoneurin are detectable in feces, and collagenous colitis patients express higher values than patients with inflammatory bowel disease and controls. In treatment, fecal secretoneurin decreased to control levels in collagenous colitis.
Title: Increased fecal levels of chromogranin A, chromogranin B, and secretoneurin in collagenous colitis.

The following SCG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19599	NM_003469.5 Latest version!	Homo sapiens secretogranin II (SCG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu19599	NM_003469.4	Homo sapiens secretogranin II (SCG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCG2 ( NM_003469.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003460.2 Homo sapiens secretogranin II (SCG2), mRNA.

Price & Availability↑

CloneID	OHu19599
Clone ID Related Accession (Same CDS sequence)	NM_003469.5 , NM_003469.4
Accession Version	NM_003469.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	secretogranin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA271642.1, AK312452.1 and BC022509.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_003469.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022509.1, SRR1660807.201113.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305409.3/ ENSP00000304133.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGAAG CAAAGACCCA CTGGCTTGGA GCAGCCCTGT CTCTTATCCC TTTAATTTTC 
CTCATCTCTG GGGCTGAAGC AGCTTCATTT CAGAGAAACC AGCTGCTTCA GAAAGAACCA 
GACCTCAGGT TGGAAAATGT CCAAAAGTTT CCCAGTCCTG AAATGATCAG GGCTTTGGAG 
TACATAGAAA ACCTCCGACA ACAAGCTCAT AAGGAAGAAA GCAGCCCAGA TTATAATCCC 
TACCAAGGTG TCTCTGTCCC CCTTCAGCAA AAAGAAAATG GCGATGAAAG CCACTTGCCC 
GAGAGGGATT CACTGAGTGA AGAAGACTGG ATGAGAATAA TACTCGAAGC TTTGAGACAG 
GCTGAAAATG AGCCTCAGTC TGCACCAAAA GAAAATAAGC CCTATGCCTT GAATTCAGAA 
AAGAACTTTC CAATGGACAT GAGTGATGAT TATGAGACAC AGCAGTGGCC AGAAAGAAAG 
CTTAAGCACA TGCAATTCCC TCCTATGTAT GAAGAGAATT CCAGGGATAA CCCCTTTAAA 
CGCACAAATG AAATAGTGGA GGAACAATAT ACTCCTCAAA GCCTTGCTAC ATTGGAATCT 
GTCTTCCAAG AGCTGGGGAA ACTGACAGGA CCAAACAACC AGAAACGTGA GAGGATGGAT 
GAGGAGCAAA AACTTTATAC GGATGATGAA GATGATATCT ACAAGGCTAA TAACATTGCC 
TATGAAGATG TGGTCGGGGG AGAAGACTGG AACCCAGTAG AGGAGAAAAT AGAGAGTCAA 
ACCCAGGAAG AGGTGAGAGA CAGCAAAGAG AATATAGAAA AAAATGAACA AATCAACGAT 
GAGATGAAAC GCTCAGGGCA GCTTGGCATC CAGGAAGAAG ATCTTCGGAA AGAGAGTAAA 
GACCAACTCT CAGATGATGT CTCCAAAGTA ATTGCCTATT TGAAAAGGTT AGTAAATGCT 
GCAGGAAGTG GGAGGTTACA GAATGGGCAA AATGGGGAAA GGGCCACCAG GCTTTTTGAG 
AAACCTCTTG ATTCTCAGTC TATTTATCAG CTGATTGAAA TCTCAAGGAA TTTACAGATA 
CCCCCAGAAG ACTTAATTGA GATGCTCAAA ACTGGGGAGA AGCCGAATGG ATCAGTGGAA 
CCGGAGCGGG AGCTTGACCT TCCTGTTGAC CTAGATGACA TCTCAGAGGC TGACTTAGAC 
CATCCAGACC TGTTCCAAAA TAGGATGCTC TCCAAGAGTG GCTACCCTAA AACACCTGGT 
CGTGCTGGGA CTGAGGCCCT ACCAGACGGG CTCAGTGTTG AGGATATTTT AAATCTTTTA 
GGGATGGAGA GTGCAGCAAA TCAGAAAACG TCGTATTTTC CCAATCCATA TAACCAGGAG 
AAAGTTCTGC CAAGGCTCCC TTATGGTGCT GGAAGATCTA GATCGAACCA GCTTCCCAAA 
GCTGCCTGGA TTCCACATGT TGAAAACAGA CAGATGGCAT ATGAAAACCT GAACGACAAG 
GATCAAGAAT TAGGTGAGTA CTTGGCCAGG ATGCTAGTTA AATACCCTGA GATCATTAAT 
TCAAACCAAG TGAAGCGAGT TCCTGGTCAA GGCTCATCTG AAGATGACCT GCAGGAAGAG 
GAACAAATTG AGCAGGCCAT CAAAGAGCAT TTGAATCAAG GCAGCTCTCA GGAGACTGAC 
AAGCTGGCCC CGGTGAGCAA AAGGTTCCCT GTGGGGCCCC CGAAGAATGA TGATACCCCA 
AATAGGCAGT ACTGGGATGA AGATCTGTTA ATGAAAGTGC TGGAATACCT CAACCAAGAA 
AAGGCAGAAA AGGGAAGGGA GCATATTGCT AAGAGAGCAA TGGAAAATAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003460.2
CDS	92..1945
Translation	MAEAKTHWLGAALSLIPLIFLISGAEAASFQRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLFQNRMLSKSGYPKTPGRAGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLPYGAGRSRSNQLPKAAWIPHVENRQMAYENLNDKDQELGEYLARMLVKYPEIINSNQVKRVPGQGSSEDDLQEEEQIEQAIKEHLNQGSSQETDKLAPVSKRFPVGPPKNDDTPNRQYWDEDLLMKVLEYLNQEKAEKGREHIAKRAMENM

Target ORF information:

RefSeq Version	NM_003469.5
Organism	Homo sapiens(human)
Definition	Homo sapiens secretogranin II (SCG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003469.5

ORF Insert Sequence:

ATGGCTGAAG CAAAGACCCA CTGGCTTGGA GCAGCCCTGT CTCTTATCCC TTTAATTTTC 
CTCATCTCTG GGGCTGAAGC AGCTTCATTT CAGAGAAACC AGCTGCTTCA GAAAGAACCA 
GACCTCAGGT TGGAAAATGT CCAAAAGTTT CCCAGTCCTG AAATGATCAG GGCTTTGGAG 
TACATAGAAA ACCTCCGACA ACAAGCTCAT AAGGAAGAAA GCAGCCCAGA TTATAATCCC 
TACCAAGGTG TCTCTGTCCC CCTTCAGCAA AAAGAAAATG GCGATGAAAG CCACTTGCCC 
GAGAGGGATT CACTGAGTGA AGAAGACTGG ATGAGAATAA TACTCGAAGC TTTGAGACAG 
GCTGAAAATG AGCCTCAGTC TGCACCAAAA GAAAATAAGC CCTATGCCTT GAATTCAGAA 
AAGAACTTTC CAATGGACAT GAGTGATGAT TATGAGACAC AGCAGTGGCC AGAAAGAAAG 
CTTAAGCACA TGCAATTCCC TCCTATGTAT GAAGAGAATT CCAGGGATAA CCCCTTTAAA 
CGCACAAATG AAATAGTGGA GGAACAATAT ACTCCTCAAA GCCTTGCTAC ATTGGAATCT 
GTCTTCCAAG AGCTGGGGAA ACTGACAGGA CCAAACAACC AGAAACGTGA GAGGATGGAT 
GAGGAGCAAA AACTTTATAC GGATGATGAA GATGATATCT ACAAGGCTAA TAACATTGCC 
TATGAAGATG TGGTCGGGGG AGAAGACTGG AACCCAGTAG AGGAGAAAAT AGAGAGTCAA 
ACCCAGGAAG AGGTGAGAGA CAGCAAAGAG AATATAGAAA AAAATGAACA AATCAACGAT 
GAGATGAAAC GCTCAGGGCA GCTTGGCATC CAGGAAGAAG ATCTTCGGAA AGAGAGTAAA 
GACCAACTCT CAGATGATGT CTCCAAAGTA ATTGCCTATT TGAAAAGGTT AGTAAATGCT 
GCAGGAAGTG GGAGGTTACA GAATGGGCAA AATGGGGAAA GGGCCACCAG GCTTTTTGAG 
AAACCTCTTG ATTCTCAGTC TATTTATCAG CTGATTGAAA TCTCAAGGAA TTTACAGATA 
CCCCCAGAAG ACTTAATTGA GATGCTCAAA ACTGGGGAGA AGCCGAATGG ATCAGTGGAA 
CCGGAGCGGG AGCTTGACCT TCCTGTTGAC CTAGATGACA TCTCAGAGGC TGACTTAGAC 
CATCCAGACC TGTTCCAAAA TAGGATGCTC TCCAAGAGTG GCTACCCTAA AACACCTGGT 
CGTGCTGGGA CTGAGGCCCT ACCAGACGGG CTCAGTGTTG AGGATATTTT AAATCTTTTA 
GGGATGGAGA GTGCAGCAAA TCAGAAAACG TCGTATTTTC CCAATCCATA TAACCAGGAG 
AAAGTTCTGC CAAGGCTCCC TTATGGTGCT GGAAGATCTA GATCGAACCA GCTTCCCAAA 
GCTGCCTGGA TTCCACATGT TGAAAACAGA CAGATGGCAT ATGAAAACCT GAACGACAAG 
GATCAAGAAT TAGGTGAGTA CTTGGCCAGG ATGCTAGTTA AATACCCTGA GATCATTAAT 
TCAAACCAAG TGAAGCGAGT TCCTGGTCAA GGCTCATCTG AAGATGACCT GCAGGAAGAG 
GAACAAATTG AGCAGGCCAT CAAAGAGCAT TTGAATCAAG GCAGCTCTCA GGAGACTGAC 
AAGCTGGCCC CGGTGAGCAA AAGGTTCCCT GTGGGGCCCC CGAAGAATGA TGATACCCCA 
AATAGGCAGT ACTGGGATGA AGATCTGTTA ATGAAAGTGC TGGAATACCT CAACCAAGAA 
AAGGCAGAAA AGGGAAGGGA GCATATTGCT AAGAGAGCAA TGGAAAATAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCG2 ( NM_003469.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003460.2 Homo sapiens secretogranin II (SCG2), mRNA.

Price & Availability↑

CloneID	OHu19599
Clone ID Related Accession (Same CDS sequence)	NM_003469.5 , NM_003469.4
Accession Version	NM_003469.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	secretogranin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA271642.1, AK312452.1 and BC022509.1. This sequence is a reference standard in the RefSeqGene project. On Sep 2, 2010 this sequence version replaced NM_003469.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022509.1, SRR1803613.133581.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTGAAG CAAAGACCCA CTGGCTTGGA GCAGCCCTGT CTCTTATCCC TTTAATTTTC 
CTCATCTCTG GGGCTGAAGC AGCTTCATTT CAGAGAAACC AGCTGCTTCA GAAAGAACCA 
GACCTCAGGT TGGAAAATGT CCAAAAGTTT CCCAGTCCTG AAATGATCAG GGCTTTGGAG 
TACATAGAAA ACCTCCGACA ACAAGCTCAT AAGGAAGAAA GCAGCCCAGA TTATAATCCC 
TACCAAGGTG TCTCTGTCCC CCTTCAGCAA AAAGAAAATG GCGATGAAAG CCACTTGCCC 
GAGAGGGATT CACTGAGTGA AGAAGACTGG ATGAGAATAA TACTCGAAGC TTTGAGACAG 
GCTGAAAATG AGCCTCAGTC TGCACCAAAA GAAAATAAGC CCTATGCCTT GAATTCAGAA 
AAGAACTTTC CAATGGACAT GAGTGATGAT TATGAGACAC AGCAGTGGCC AGAAAGAAAG 
CTTAAGCACA TGCAATTCCC TCCTATGTAT GAAGAGAATT CCAGGGATAA CCCCTTTAAA 
CGCACAAATG AAATAGTGGA GGAACAATAT ACTCCTCAAA GCCTTGCTAC ATTGGAATCT 
GTCTTCCAAG AGCTGGGGAA ACTGACAGGA CCAAACAACC AGAAACGTGA GAGGATGGAT 
GAGGAGCAAA AACTTTATAC GGATGATGAA GATGATATCT ACAAGGCTAA TAACATTGCC 
TATGAAGATG TGGTCGGGGG AGAAGACTGG AACCCAGTAG AGGAGAAAAT AGAGAGTCAA 
ACCCAGGAAG AGGTGAGAGA CAGCAAAGAG AATATAGAAA AAAATGAACA AATCAACGAT 
GAGATGAAAC GCTCAGGGCA GCTTGGCATC CAGGAAGAAG ATCTTCGGAA AGAGAGTAAA 
GACCAACTCT CAGATGATGT CTCCAAAGTA ATTGCCTATT TGAAAAGGTT AGTAAATGCT 
GCAGGAAGTG GGAGGTTACA GAATGGGCAA AATGGGGAAA GGGCCACCAG GCTTTTTGAG 
AAACCTCTTG ATTCTCAGTC TATTTATCAG CTGATTGAAA TCTCAAGGAA TTTACAGATA 
CCCCCAGAAG ACTTAATTGA GATGCTCAAA ACTGGGGAGA AGCCGAATGG ATCAGTGGAA 
CCGGAGCGGG AGCTTGACCT TCCTGTTGAC CTAGATGACA TCTCAGAGGC TGACTTAGAC 
CATCCAGACC TGTTCCAAAA TAGGATGCTC TCCAAGAGTG GCTACCCTAA AACACCTGGT 
CGTGCTGGGA CTGAGGCCCT ACCAGACGGG CTCAGTGTTG AGGATATTTT AAATCTTTTA 
GGGATGGAGA GTGCAGCAAA TCAGAAAACG TCGTATTTTC CCAATCCATA TAACCAGGAG 
AAAGTTCTGC CAAGGCTCCC TTATGGTGCT GGAAGATCTA GATCGAACCA GCTTCCCAAA 
GCTGCCTGGA TTCCACATGT TGAAAACAGA CAGATGGCAT ATGAAAACCT GAACGACAAG 
GATCAAGAAT TAGGTGAGTA CTTGGCCAGG ATGCTAGTTA AATACCCTGA GATCATTAAT 
TCAAACCAAG TGAAGCGAGT TCCTGGTCAA GGCTCATCTG AAGATGACCT GCAGGAAGAG 
GAACAAATTG AGCAGGCCAT CAAAGAGCAT TTGAATCAAG GCAGCTCTCA GGAGACTGAC 
AAGCTGGCCC CGGTGAGCAA AAGGTTCCCT GTGGGGCCCC CGAAGAATGA TGATACCCCA 
AATAGGCAGT ACTGGGATGA AGATCTGTTA ATGAAAGTGC TGGAATACCT CAACCAAGAA 
AAGGCAGAAA AGGGAAGGGA GCATATTGCT AAGAGAGCAA TGGAAAATAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003460.2
CDS	230..2083
Translation	MAEAKTHWLGAALSLIPLIFLISGAEAASFQRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLFQNRMLSKSGYPKTPGRAGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLPYGAGRSRSNQLPKAAWIPHVENRQMAYENLNDKDQELGEYLARMLVKYPEIINSNQVKRVPGQGSSEDDLQEEEQIEQAIKEHLNQGSSQETDKLAPVSKRFPVGPPKNDDTPNRQYWDEDLLMKVLEYLNQEKAEKGREHIAKRAMENM

Target ORF information:

RefSeq Version	NM_003469.4
Organism	Homo sapiens(human)
Definition	Homo sapiens secretogranin II (SCG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003469.4

ORF Insert Sequence:

ATGGCTGAAG CAAAGACCCA CTGGCTTGGA GCAGCCCTGT CTCTTATCCC TTTAATTTTC 
CTCATCTCTG GGGCTGAAGC AGCTTCATTT CAGAGAAACC AGCTGCTTCA GAAAGAACCA 
GACCTCAGGT TGGAAAATGT CCAAAAGTTT CCCAGTCCTG AAATGATCAG GGCTTTGGAG 
TACATAGAAA ACCTCCGACA ACAAGCTCAT AAGGAAGAAA GCAGCCCAGA TTATAATCCC 
TACCAAGGTG TCTCTGTCCC CCTTCAGCAA AAAGAAAATG GCGATGAAAG CCACTTGCCC 
GAGAGGGATT CACTGAGTGA AGAAGACTGG ATGAGAATAA TACTCGAAGC TTTGAGACAG 
GCTGAAAATG AGCCTCAGTC TGCACCAAAA GAAAATAAGC CCTATGCCTT GAATTCAGAA 
AAGAACTTTC CAATGGACAT GAGTGATGAT TATGAGACAC AGCAGTGGCC AGAAAGAAAG 
CTTAAGCACA TGCAATTCCC TCCTATGTAT GAAGAGAATT CCAGGGATAA CCCCTTTAAA 
CGCACAAATG AAATAGTGGA GGAACAATAT ACTCCTCAAA GCCTTGCTAC ATTGGAATCT 
GTCTTCCAAG AGCTGGGGAA ACTGACAGGA CCAAACAACC AGAAACGTGA GAGGATGGAT 
GAGGAGCAAA AACTTTATAC GGATGATGAA GATGATATCT ACAAGGCTAA TAACATTGCC 
TATGAAGATG TGGTCGGGGG AGAAGACTGG AACCCAGTAG AGGAGAAAAT AGAGAGTCAA 
ACCCAGGAAG AGGTGAGAGA CAGCAAAGAG AATATAGAAA AAAATGAACA AATCAACGAT 
GAGATGAAAC GCTCAGGGCA GCTTGGCATC CAGGAAGAAG ATCTTCGGAA AGAGAGTAAA 
GACCAACTCT CAGATGATGT CTCCAAAGTA ATTGCCTATT TGAAAAGGTT AGTAAATGCT 
GCAGGAAGTG GGAGGTTACA GAATGGGCAA AATGGGGAAA GGGCCACCAG GCTTTTTGAG 
AAACCTCTTG ATTCTCAGTC TATTTATCAG CTGATTGAAA TCTCAAGGAA TTTACAGATA 
CCCCCAGAAG ACTTAATTGA GATGCTCAAA ACTGGGGAGA AGCCGAATGG ATCAGTGGAA 
CCGGAGCGGG AGCTTGACCT TCCTGTTGAC CTAGATGACA TCTCAGAGGC TGACTTAGAC 
CATCCAGACC TGTTCCAAAA TAGGATGCTC TCCAAGAGTG GCTACCCTAA AACACCTGGT 
CGTGCTGGGA CTGAGGCCCT ACCAGACGGG CTCAGTGTTG AGGATATTTT AAATCTTTTA 
GGGATGGAGA GTGCAGCAAA TCAGAAAACG TCGTATTTTC CCAATCCATA TAACCAGGAG 
AAAGTTCTGC CAAGGCTCCC TTATGGTGCT GGAAGATCTA GATCGAACCA GCTTCCCAAA 
GCTGCCTGGA TTCCACATGT TGAAAACAGA CAGATGGCAT ATGAAAACCT GAACGACAAG 
GATCAAGAAT TAGGTGAGTA CTTGGCCAGG ATGCTAGTTA AATACCCTGA GATCATTAAT 
TCAAACCAAG TGAAGCGAGT TCCTGGTCAA GGCTCATCTG AAGATGACCT GCAGGAAGAG 
GAACAAATTG AGCAGGCCAT CAAAGAGCAT TTGAATCAAG GCAGCTCTCA GGAGACTGAC 
AAGCTGGCCC CGGTGAGCAA AAGGTTCCCT GTGGGGCCCC CGAAGAATGA TGATACCCCA 
AATAGGCAGT ACTGGGATGA AGATCTGTTA ATGAAAGTGC TGGAATACCT CAACCAAGAA 
AAGGCAGAAA AGGGAAGGGA GCATATTGCT AAGAGAGCAA TGGAAAATAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.
Journal of virology89(23)11954-64(2015 Dec)
Berard AR,Severini A,Coombs KM

Secretogranin II is overexpressed in advanced prostate cancer and promotes the neuroendocrine differentiation of prostate cancer cells.
European journal of cancer (Oxford, England : 1990)50(17)3039-49(2014 Nov)
Courel M,El Yamani FZ,Alexandre D,El Fatemi H,Delestre C,Montero-Hadjadje M,Tazi F,Amarti A,Magoul R,Chartrel N,Anouar Y

Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.
Angiogenesis17(1)27-36(2014 Jan)
Albrecht-Schgoer K,Schgoer W,Theurl M,Stanzl U,Lener D,Dejaco D,Zelger B,Franz WM,Kirchmair R

Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology33(2)446-56(2014)
Xu R,Li Q,Zhou J,Zhou X,Perelman JM,Kolosov VP

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

SCG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報