TMSB4X cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMSB4X
Entrez Gene ID	7114
Full Name	thymosin beta 4, X-linked
Synonyms	FX,PTMB4,TB4X,TMSB4
General protein information	Preferred Names thymosin beta 4, X-linked Names thymosin beta-4 prothymosin beta-4 t beta-4 thymosin, beta 4, X chromosome
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.2
Summary	This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008].
Disorder MIM:	300159

mRNA and Protein(s)

mRNA	Protein	Name
NM_021109.3	NP_066932.1	thymosin beta-4
NM_021109.4	NP_066932.1	thymosin beta-4

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Serum thymosin beta4 as a noninvasive biomarker in patients with nonalcoholic steatohepatitis.
Jiang Y, Han T, Zhang ZG, Zhang Y, Qi FX
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva110(1)19-24(2018 Jan)

Thymosin beta-4 overexpression correlates with high-risk groups in gastric gastrointestinal stromal tumors: A retrospective analysis by immunohistochemistry.
?ahin S, Ekinci O, Se?kin S, Dursun A
Pathology, research and practice213(9)1139-1143(2017 Sep)

Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Chi LH, Chang WM, Chang YC, Chan YC, Tai CC, Leung KW, Chen CL, Wu AT, Lai TC, Li YJ, Hsiao M
Scientific reports7(1)9031(2017 Aug)

Recombinant adeno-associated virus carrying thymosin ?
Zheng XY, Lv YF, Li S, Li Q, Zhang QN, Zhang XT, Hao ZM
World journal of gastroenterology23(2)242-255(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tbeta4 exerts a protective effect on murine colitis, indicating that recombinant adeno-associated virus carrying thymosin beta4 could potentially be developed into a promising agent for the therapy of inflammatory bowel diseases.
Title: Recombinant adeno-associated virus carrying thymosin ?

Results showed that the TMSB4 pseudogene, lncRNA-MSR, was upregulated in the damaged cartilage and was activated in chondrocytes in response to mechanical stress. Furthermore, lncRNA-MSR regulated the expression of TMSB4 by competing with miRNA-152 in chondrocytes.
Title: The TMSB4 Pseudogene LncRNA Functions as a Competing Endogenous RNA to Promote Cartilage Degradation in Human Osteoarthritis.

Serum thymosin beta4 concentrations were correlated with the occurrence and severity of obstructive sleep apnea syndrome.
Title: Serum Thymosin ?4 Concentrations in Obstructive Sleep Apnea Syndrome Patients.

Tbeta4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro and decreased tumor growth in vivo. Mechanistic investigations revealed a significant decrease in Notch1 activation in Tbeta4 gene-silenced cells.
Title: Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation.

Developed an innovative biotechnological method for thymosin beta4 production that employs the peptide acetylation in vivo.
Title: Development of the intein-mediated method for production of recombinant thymosin ?4 from the acetylated in vivo fusion protein.

The following TMSB4X gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMSB4X cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17656	NM_021109.4 Latest version!	Homo sapiens thymosin beta 4 X-linked (TMSB4X), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17656	NM_021109.3	Homo sapiens thymosin beta 4, X-linked (TMSB4X), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMSB4X ( NM_021109.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066932.1 Homo sapiens thymosin beta 4, X-linked (TMSB4X), mRNA.

Price & Availability↑

CloneID	OHu17656
Clone ID Related Accession (Same CDS sequence)	NM_021109.3 , NM_021109.4
Accession Version	NM_021109.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 135bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	thymosin beta-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV715954.1 and BC001631.1. On Mar 4, 2008 this sequence version replaced NM_021109.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB470271.2, BU954015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGTCTGACA AACCCGATAT GGCTGAGATC GAGAAATTCG ATAAGTCGAA ACTGAAGAAG 
ACAGAGACGC AAGAGAAAAA TCCACTGCCT TCCAAAGAAA CGATTGAACA GGAGAAGCAA 
GCAGGCGAAT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066932.1
CDS	79..213
Translation	MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES

Target ORF information:

RefSeq Version	NM_021109.3
Organism	Homo sapiens(human)
Definition	Homo sapiens thymosin beta 4, X-linked (TMSB4X), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021109.3

ORF Insert Sequence:

1
61
121

ATGTCTGACA AACCCGATAT GGCTGAGATC GAGAAATTCG ATAAGTCGAA ACTGAAGAAG 
ACAGAGACGC AAGAGAAAAA TCCACTGCCT TCCAAAGAAA CGATTGAACA GGAGAAGCAA 
GCAGGCGAAT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMSB4X ( NM_021109.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066932.1 Homo sapiens thymosin beta 4 X-linked (TMSB4X), mRNA.

Price & Availability↑

CloneID	OHu17656
Clone ID Related Accession (Same CDS sequence)	NM_021109.3 , NM_021109.4
Accession Version	NM_021109.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 135bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	thymosin beta-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV715954.1 and BC001631.1. On Nov 22, 2018 this sequence version replaced NM_021109.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC083509.1, AW162675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000451311.7/ ENSP00000414376.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121

ATGTCTGACA AACCCGATAT GGCTGAGATC GAGAAATTCG ATAAGTCGAA ACTGAAGAAG 
ACAGAGACGC AAGAGAAAAA TCCACTGCCT TCCAAAGAAA CGATTGAACA GGAGAAGCAA 
GCAGGCGAAT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066932.1
CDS	76..210
Translation	MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES

Target ORF information:

RefSeq Version	NM_021109.4
Organism	Homo sapiens(human)
Definition	Homo sapiens thymosin beta 4 X-linked (TMSB4X), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021109.4

ORF Insert Sequence:

1
61
121

ATGTCTGACA AACCCGATAT GGCTGAGATC GAGAAATTCG ATAAGTCGAA ACTGAAGAAG 
ACAGAGACGC AAGAGAAAAA TCCACTGCCT TCCAAAGAAA CGATTGAACA GGAGAAGCAA 
GCAGGCGAAT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum thymosin beta4 as a noninvasive biomarker in patients with nonalcoholic steatohepatitis.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva110(1)19-24(2018 Jan)
Jiang Y,Han T,Zhang ZG,Zhang Y,Qi FX

Thymosin beta-4 overexpression correlates with high-risk groups in gastric gastrointestinal stromal tumors: A retrospective analysis by immunohistochemistry.
Pathology, research and practice213(9)1139-1143(2017 Sep)
?ahin S,Ekinci O,Se?kin S,Dursun A

Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Scientific reports7(1)9031(2017 Aug)
Chi LH,Chang WM,Chang YC,Chan YC,Tai CC,Leung KW,Chen CL,Wu AT,Lai TC,Li YJ,Hsiao M

Recombinant adeno-associated virus carrying thymosin ?
World journal of gastroenterology23(2)242-255(2017 Jan)
Zheng XY,Lv YF,Li S,Li Q,Zhang QN,Zhang XT,Hao ZM

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TMSB4X cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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