TCHH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TCHH
Entrez Gene ID	7062
Full Name	trichohyalin
Synonyms	THH,THL,TRHY,UHS3
General protein information	Preferred Names trichohyalin Names trichohyalin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. [provided by RefSeq, Feb 2017].
Disorder MIM:	190370
Disorder Html:	?Uncombable hair syndrome 3, 617252 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_007113.3	NP_009044.2	trichohyalin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.
? Basmanav FB, Cau L, Tafazzoli A, M?chin MC, Wolf S, Romano MT, Valentin F, Wiegmann H, Huchenq A, Kandil R, Garcia Bartels N, Kilic A, George S, Ralser DJ, Bergner S, Ferguson DJP, Oprisoreanu AM, Wehner M, Thiele H, Altm?ller J, N?rnberg P, Swan D, Houniet D, B?chner A, Weibel L, Wagner N, Grimalt R, Bygum A, Serre G, Blume-Peytavi U, Sprecher E, Schoch S, Oji V, Hamm H, Farrant P, Simon M, Betz RC
American journal of human genetics99(6)1292-1304(2016 Dec)

Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.
Wu S, Tan J, Yang Y, Peng Q, Zhang M, Li J, Lu D, Liu Y, Lou H, Feng Q, Lu Y, Guan Y, Zhang Z, Jiao Y, Sabeti P, Krutmann J, Tang K, Jin L, Xu S, Wang S
Human genetics135(11)1279-1286(2016 Nov)

Induced Pluripotent Stem Cell Differentiation and Three-Dimensional Tissue Formation Attenuate Clonal Epigenetic Differences in Trichohyalin.
Petrova A, Capalbo A, Jacquet L, Hazelwood-Smith S, Dafou D, Hobbs C, Arno M, Farcomeni A, Devito L, Badraiq H, Simpson M, McGrath JA, Di WL, Cheng JB, Mauro TM, Ilic D
Stem cells and development25(18)1366-75(2016 09)

Evaluation of the predictive capacity of DNA variants associated with straight hair in Europeans.
Po?piech E, Kar?owska-Pik J, Marci?ska M, Abidi S, Andersen JD, Berge MVD, Carracedo ?, Eduardoff M, Freire-Aradas A, Morling N, Sijen T, Skowron M, S?chtig J, Syndercombe-Court D, Weiler N, Schneider PM, Ballard D, B?rsting C, Parson W, Phillips C, Branicki W,
Forensic science international. Genetics19280-288(2015 Nov)

Trichohyalin is a potential major autoantigen in human alopecia areata.
Leung MC, Sutton CW, Fenton DA, Tobin DJ
Journal of proteome research9(10)5153-63(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation.
Title: Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.

To evaluate the relative contribution of these variants, we performed a second genome-wide scan in 709 samples from the Uyghur, an admixed population with both eastern and western Eurasian ancestries. In Uyghurs, both EDAR (rs3827760: P = 1.92 x 10(-12)) and TCHH (rs11803731: P = 1.46 x 10(-3)) are associated with hair straightness, but EDAR (OR 0.415) has a greater effect than TCHH (OR 0.575).
Title: Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.

The difference between the twoinduced pluripotent stem cell(IPSC) clones in TCHH methylation did not have an obvious effect on its expression in 3D human epidermal equivalent, suggesting that differentiation and tissue formation may mitigate variations in the iPSC methylome.
Title: Induced Pluripotent Stem Cell Differentiation and Three-Dimensional Tissue Formation Attenuate Clonal Epigenetic Differences in Trichohyalin.

Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder.
Title: Trichohyalin is a potential major autoantigen in human alopecia areata.

Observational study of gene-disease association. (HuGE Navigator)
Title: Web-based, participant-driven studies yield novel genetic associations for common traits.

The following TCHH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TCHH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu11573	NM_007113.3 Latest version!	Homo sapiens trichohyalin (TCHH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$923.30 $1319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TCHH ( NM_007113.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009044.2 Homo sapiens trichohyalin (TCHH), mRNA.

Price & Availability↑

CloneID	OHu11573
Clone ID Related Accession (Same CDS sequence)	NM_007113.3
Accession Version	NM_007113.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5832bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	trichohyalin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL589986.15. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced XM_005245468.1, NM_007113.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA2146236 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTCCAC TTCTGAGAAG CATCTGTGAC ATCACTGAAA TTTTCAATCA GTATGTCTCT 
CATGATTGTG ATGGAGCAGC ATTAACTAAG AAAGACCTGA AGAACCTCCT TGAAAGGGAA 
TTTGGAGCTG TGCTTCGGAG ACCACATGAC CCTAAGACGG TAGATCTGAT CCTGGAACTT 
CTGGATCTTG ACAGTAATGG GCGTGTCGAT TTCAACGAAT TCCTCCTATT TATTTTCAAA 
GTGGCTCAAG CTTGTTACTA TGCTCTCGGC CAGGCCACGG GACTGGATGA GGAGAAGCGA 
GCCCGGTGTG ACGGAAAGGA GAGCCTGTTA CAAGATCGCA GGCAAGAAGA AGACCAAAGG 
AGATTCGAGC CCCGGGACAG ACAACTGGAA GAAGAACCTG GGCAACGACG CAGGCAGAAG 
AGGCAGGAAC AGGAGAGGGA GCTAGCTGAG GGAGAGGAGC AAAGTGAGAA ACAAGAGCGA 
CTTGAACAGC GCGACAGGCA GCGCCGCGAC GAGGAGCTGT GGCGGCAAAG GCAAGAATGG 
CAAGAACGGG AAGAGCGCCG TGCAGAGGAA GAGCAGCTGC AGAGTTGCAA AGGTCACGAA 
ACTGAGGAGT TTCCAGACGA AGAGCAACTG CGAAGGCGGG AGCTGCTGGA GCTGAGGAGG 
AAGGGCCGCG AGGAGAAACA GCAGCAAAGG CGAGAGCGGC AAGACAGAGT GTTCCAGGAG 
GAAGAAGAGA AAGAGTGGAG GAAGCGCGAG ACAGTGCTCC GGAAGGAAGA AGAGAAGTTG 
CAGGAAGAGG AGCCGCAGCG GCAAAGAGAG CTCCAGGAGG AAGAAGAGCA GCTACGGAAG 
CTGGAGCGGC AAGAGCTGAG GAGGGAGCGC CAGGAGGAAG AGCAGCAGCA GCAAAGGCTG 
AGGCGCGAGC AGCAACTAAG GCGCAAGCAG GAGGAGGAGA GGCGCGAGCA GCAGGAGGAG 
AGGCGCGAGC AGCAGGAGAG GCGCGAGCAG CAGGAGGAGA GGCGCGAGCA GCAGCTGAGG 
CGCGAGCAGG AGGAGAGGCG CGAGCAGCAG CTGAGGCGCG AGCAGGAGGA GGAGAGGCGC 
GAGCAGCAGC TGAGGCGCGA GCAGGAGGAG GAGAGGCGCG AGCAGCAGCT GAGGCGCGAG 
CAGCAGCTGA GGCGCGAGCA GCAGCTGAGG CGCGAGCAGC AGCTGAGGCG CGAGCAGCAG 
CTGAGGCGCG AGCAGCAGCT GAGGCGCGAG CAGCAGCTGA GGCGCGAGCA GCAGCTGAGG 
CGCGAGCAGC AGCTGAGGCG CGAGCAGGAG GAGGAGAGGC ACGAGCAGAA GCACGAGCAG 
GAGAGGCGCG AGCAGCGGCT GAAGCGCGAG CAGGAGGAGA GGCGCGATTG GCTGAAGCGC 
GAGGAGGAGA CGGAGAGGCA CGAGCAGGAG AGGCGCAAGC AGCAGCTGAA GCGCGACCAG 
GAGGAGGAGA GGCGCGAACG TTGGCTGAAG CTCGAGGAGG AGGAGAGGCG CGAGCAGCAG 
GAGAGGCGCG AGCAGCAACT AAGGCGGGAG CAAGAGGAGA GGCGCGAGCA GCGGCTGAAG 
CGCCAGGAGG AGGAAGAGAG GCTCCAGCAG CGGTTGAGGA GCGAGCAACA ACTAAGACGC 
GAGCAGGAGG AGAGGCGCGA GCAGCTGCTG AAGCGCGAGG AGGAGAAGAG GCTCGAGCAG 
GAGAGGCGAG AGCAGCGGCT GAAGCGCGAG CAGGAGGAGA GGCGCGATCA GCTGCTGAAG 
CGCGAGGAGG AGAGGCGCCA GCAGCGGCTG AAGCGCGAGC AGGAAGAGAG GCTCGAGCAG 
CGACTGAAGC GCGAGGAGGT GGAGAGACTC GAGCAGGAGG AGAGGCGCGA GCAGCGGCTG 
AAGCGCGAGG AGCCGGAGGA AGAGAGGCGC CAGCAGCTGC TGAAGAGCGA GGAGCAGGAG 
GAGAGGCGCC AGCAGCAACT AAGGCGCGAG CAGCAGGAAA GGCGCGAGCA GCGGCTGAAG 
CGCGAGGAGG AGGAAGAGAG GCTCGAGCAG CGGCTGAAGC GCGAGCATGA GGAAGAGAGG 
CGCGAGCAGG AGCTAGCTGA GGAGGAGCAG GAACAGGCCC GGGAGCGGAT TAAGAGCCGC 
ATCCCGAAGT GGCAGTGGCA GCTAGAAAGC GAGGCCGACG CACGGCAAAG CAAAGTCTAC 
TCGAGGCCCC GCAAGCAGGA AGGGCAGAGG CGCCGCCAAG AGCAGGAGGA AAAGAGGCGG 
CGCCGGGAGA GTGAGCTGCA ATGGCAGGAG GAGGAACGGG CTCACCGGCA GCAGCAGGAA 
GAGGAGCAGC GCCGGGACTT CACATGGCAG TGGCAGGCGG AGGAAAAGAG CGAGAGGGGC 
CGTCAGAGGC TGTCGGCCAG GCCCCCATTG CGGGAGCAGC GGGAGAGGCA GCTGAGGGCC 
GAGGAGCGCC AGCAGCGGGA ACAACGGTTT CTCCCGGAGG AGGAGGAGAA GGAGCAGCGG 
CGCCGCCAGC GACGCGAGAG GGAGAAAGAG CTGCAGTTCC TGGAGGAAGA GGAGCAGCTC 
CAGCGGCGGG AGCGTGCCCA ACAGCTCCAG GAGGAGGAGG ACGGCCTCCA GGAGGATCAG 
GAGAGGAGGC GAAGCCAGGA GCAGCGCCGC GACCAAAAAT GGAGGTGGCA ACTAGAAGAA 
GAAAGGAAGA GACGCCGCCA CACGCTGTAC GCCAAGCCAG CCCTACAAGA GCAGCTGAGG 
AAGGAACAGC AGCTGCTGCA GGAGGAGGAG GAGGAGCTAC AGAGAGAGGA GCGCGAGAAG 
AGAAGGCGCC AAGAACAGGA GAGACAATAC CGCGAGGAAG AGCAGCTGCA GCAGGAGGAA 
GAGCAGCTGC TGAGAGAGGA ACGGGAGAAA AGAAGACGCC AGGAGCGGGA AAGGCAATAT 
CGGAAGGATA AGAAGCTGCA GCAGAAGGAA GAGCAGCTGC TGGGAGAGGA ACCGGAGAAG 
AGAAGGCGCC AGGAGCGGGA GAAAAAATAC CGCGAGGAAG AGGAGTTGCA GCAGGAGGAA 
GAGCAGCTGC TGAGAGAGGA ACGGGAGAAG AGAAGGCGCC AGGAGTGGGA GAGGCAGTAC 
CGCAAAAAAG ACGAGCTGCA GCAGGAAGAA GAGCAGCTGC TGAGAGAGGA ACGGGAGAAA 
AGAAGACTCC AGGAGCGGGA GAGGCAATAT CGGGAGGAAG AGGAGCTGCA GCAGGAGGAA 
GAGCAGCTGC TGGGAGAGGA ACGGGAGACG AGAAGGCGCC AGGAGCTGGA GAGGCAATAT 
CGGAAGGAAG AGGAGCTGCA GCAGGAGGAA GAGCAGCTGC TGAGAGAGGA ACCGGAGAAG 
AGAAGGCGCC AGGAGCGGGA GAGGCAATGT CGGGAGGAAG AGGAGCTGCA GCAGGAGGAA 
GAGCAGCTGC TGAGAGAGGA ACGGGAGAAG AGAAGGCGCC AGGAGCTGGA GAGGCAATAT 
CGGGAGGAAG AGGAGGTGCA GCAGGAGGAA GAGCAGCTGC TGAGAGAGGA ACCGGAGAAG 
AGAAGGCGCC AGGAGCTGGA GAGGCAATAC CGCGAGGAAG AGGAGCTGCA GCAGGAGGAA 
GAGCAGCTGC TGAGAGAGGA ACAGGAGAAA AGGCGCCAGG AGCGGGAGAG GCAGTATCGG 
GAGGAGGAAG AGCTTCAGCG CCAGAAAAGG AAGCAGCGAT ACCGGGATGA GGATCAGCGC 
AGTGATCTGA AATGGCAGTG GGAACCAGAA AAAGAAAATG CAGTTCGTGA TAACAAGGTT 
TACTGCAAAG GCAGAGAGAA TGAACAGTTC CGGCAGTTGG AAGATTCCCA GCTGCGCGAC 
AGACAATCCC AGCAAGATCT GCAGCACCTG CTGGGTGAAC AGCAAGAGCG AGATCGTGAG 
CAAGAGAGGA GGCGCTGGCA GCAGCGCGAC AGGCATTTCC CAGAGGAAGA ACAGCTGGAG 
CGAGAAGAGC AAAAGGAAGC CAAAAGGCGC GACAGGAAGT CCCAAGAGGA AAAGCAGTTG 
CTGAGAGAGG AAAGAGAAGA GAAGAGACGC CGTCAAGAGA CAGACAGAAA ATTCCGCGAG 
GAGGAACAGC TGCTCCAGGA AAGGGAGGAA CAGCCGCTGC GCCGCCAAGA GCGTGACAGA 
AAATTCCGCG AAGAGGAACT GCGCCATCAG GAACAAGGGA GAAAATTCCT CGAGGAGGAA 
CAGCGGCTGC GCCGCCAGGA ACGGGAGAGA AAATTCCTTA AGGAGGAACA GCAGCTGCGC 
TGCCAGGAGC GCGAGCAACA GCTGCGTCAG GACCGCGACA GAAAATTCCG CGAGGAGGAA 
CAGCAGCTGA GCCGCCAAGA GCGTGACAGA AAATTCCGTG AAGAGGAACA GCAGGTGCGC 
CGCCAGGAAC GAGAGAGAAA ATTCCTGGAG GAGGAACAGC AGCTGCGCCA GGAGCGTCAC 
AGAAAATTCC GCGAAGAGGA ACAGCTGCTC CAGGAAAGGG AAGAACAGCA GCTGCACCGC 
CAAGAGCGTG ACAGAAAATT CCTGGAGGAG GAACAACAGC TGCGCCGCCA AGAGCGTGAC 
AGAAAATTCC GCGAACAGGA ACTGCGCAGT CAGGAACCAG AGAGAAAATT CCTCGAGGAG 
GAACAGCAGC TGCACCGCCA GCAACGGCAG AGAAAATTCC TCCAGGAGGA ACAGCAGCTG 
CGCCGCCAGG AGCGCGGGCA ACAGCGGCGT CAGGACCGTG ACAGAAAATT CCGCGAGGAG 
GAACAGCTGC GCCAGGAGAG GGAGGAACAG CAGCTGAGCC GCCAAGAGCG TGACAGAAAA 
TTCCGTTTAG AGGAACAGAA AGTGCGCCGC CAGGAACAAG AGAGAAAATT CATGGAGGAC 
GAACAGCAGC TGCGCCGCCA GGAGGGCCAA CAACAGCTGC GCCAGGAGCG CGACAGAAAA 
TTCCGCGAAG ACGAACAGCT GCTCCAGGAA AGGGAAGAAC AGCAGCTGCA CCGCCAAGAG 
CGTGACAGAA AATTCCTCGA GGAGGAACCG CAGCTGCGCC GCCAGGAGCG CGAACAACAG 
CTGCGTCACG ACCGCGACAG AAAATTCCGT GAAGAGGAAC AGCTGCTCCA GGAAGGGGAG 
GAACAGCAGC TGCGCCGCCA AGAGCGTGAC AGAAAATTCC GCGAAGAGGA ACAGCAGCTC 
CGCCGTCAGG AACGAGAGAG AAAATTCCTC CAGGAGGAAC AGCAGCTGCG CCGCCAGGAA 
CTGGAGAGAA AATTCCGTGA GGAGGAACAG CTGCGCCAAG AAACGGAGCA AGAGCAGCTG 
CGCCGCCAAG AACGCTACAG AAAAATCCTA GAGGAAGAGC AGCTCCGTCC GGAAAGGGAA 
GAACAGCAGC TGCGCCGCCA GGAGCGCGAC AGAAAATTCC GCGAGGAGGA ACAGCTCCGC 
CAGGAGAGGG AGGAACAGCA GCTGCGCAGC CAAGAGTCTG ACAGAAAATT CCGCGAGGAG 
GAACAGCTAC GCCAGGAGAG GGAAGAACAG CAGCTGCGCC CCCAACAGCG TGACGGAAAG 
TATCGCTGGG AAGAAGAGCA GCTCCAACTT GAGGAACAAG AGCAGAGGCT GCGGCAGGAG 
CGAGACCGGC AGTACCGGGC GGAGGAGCAG TTTGCCACGC AGGAGAAGAG TCGTCGTGAG 
GAACAAGAAC TATGGCAAGA AGAGGAGCAG AAACGTCGCC AGGAACGGGA AAGGAAATTA 
CGGGAAGAAC ACATCCGCCG CCAGCAGAAG GAGGAACAGA GGCACCGCCA AGTCGGGGAG 
ATAAAATCCC AAGAAGGGAA GGGCCATGGG CGGCTTCTGG AGCCCGGCAC TCATCAGTTT 
GCCAGTGTCC CAGTGCGCTC CAGCCCTCTC TATGAGTACA TCCAAGAGCA GAGATCTCAA 
TACCGCCCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009044.2
CDS	96..5927
Translation	MSPLLRSICDITEIFNQYVSHDCDGAALTKKDLKNLLEREFGAVLRRPHDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQYRP

Target ORF information:

RefSeq Version	NM_007113.3
Organism	Homo sapiens(human)
Definition	Homo sapiens trichohyalin (TCHH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007113.3

ORF Insert Sequence:

ATGTCTCCAC TTCTGAGAAG CATCTGTGAC ATCACTGAAA TTTTCAATCA GTATGTCTCT 
CATGATTGTG ATGGAGCAGC ATTAACTAAG AAAGACCTGA AGAACCTCCT TGAAAGGGAA 
TTTGGAGCTG TGCTTCGGAG ACCACATGAC CCTAAGACGG TAGATCTGAT CCTGGAACTT 
CTGGATCTTG ACAGTAATGG GCGTGTCGAT TTCAACGAAT TCCTCCTATT TATTTTCAAA 
GTGGCTCAAG CTTGTTACTA TGCTCTCGGC CAGGCCACGG GACTGGATGA GGAGAAGCGA 
GCCCGGTGTG ACGGAAAGGA GAGCCTGTTA CAAGATCGCA GGCAAGAAGA AGACCAAAGG 
AGATTCGAGC CCCGGGACAG ACAACTGGAA GAAGAACCTG GGCAACGACG CAGGCAGAAG 
AGGCAGGAAC AGGAGAGGGA GCTAGCTGAG GGAGAGGAGC AAAGTGAGAA ACAAGAGCGA 
CTTGAACAGC GCGACAGGCA GCGCCGCGAC GAGGAGCTGT GGCGGCAAAG GCAAGAATGG 
CAAGAACGGG AAGAGCGCCG TGCAGAGGAA GAGCAGCTGC AGAGTTGCAA AGGTCACGAA 
ACTGAGGAGT TTCCAGACGA AGAGCAACTG CGAAGGCGGG AGCTGCTGGA GCTGAGGAGG 
AAGGGCCGCG AGGAGAAACA GCAGCAAAGG CGAGAGCGGC AAGACAGAGT GTTCCAGGAG 
GAAGAAGAGA AAGAGTGGAG GAAGCGCGAG ACAGTGCTCC GGAAGGAAGA AGAGAAGTTG 
CAGGAAGAGG AGCCGCAGCG GCAAAGAGAG CTCCAGGAGG AAGAAGAGCA GCTACGGAAG 
CTGGAGCGGC AAGAGCTGAG GAGGGAGCGC CAGGAGGAAG AGCAGCAGCA GCAAAGGCTG 
AGGCGCGAGC AGCAACTAAG GCGCAAGCAG GAGGAGGAGA GGCGCGAGCA GCAGGAGGAG 
AGGCGCGAGC AGCAGGAGAG GCGCGAGCAG CAGGAGGAGA GGCGCGAGCA GCAGCTGAGG 
CGCGAGCAGG AGGAGAGGCG CGAGCAGCAG CTGAGGCGCG AGCAGGAGGA GGAGAGGCGC 
GAGCAGCAGC TGAGGCGCGA GCAGGAGGAG GAGAGGCGCG AGCAGCAGCT GAGGCGCGAG 
CAGCAGCTGA GGCGCGAGCA GCAGCTGAGG CGCGAGCAGC AGCTGAGGCG CGAGCAGCAG 
CTGAGGCGCG AGCAGCAGCT GAGGCGCGAG CAGCAGCTGA GGCGCGAGCA GCAGCTGAGG 
CGCGAGCAGC AGCTGAGGCG CGAGCAGGAG GAGGAGAGGC ACGAGCAGAA GCACGAGCAG 
GAGAGGCGCG AGCAGCGGCT GAAGCGCGAG CAGGAGGAGA GGCGCGATTG GCTGAAGCGC 
GAGGAGGAGA CGGAGAGGCA CGAGCAGGAG AGGCGCAAGC AGCAGCTGAA GCGCGACCAG 
GAGGAGGAGA GGCGCGAACG TTGGCTGAAG CTCGAGGAGG AGGAGAGGCG CGAGCAGCAG 
GAGAGGCGCG AGCAGCAACT AAGGCGGGAG CAAGAGGAGA GGCGCGAGCA GCGGCTGAAG 
CGCCAGGAGG AGGAAGAGAG GCTCCAGCAG CGGTTGAGGA GCGAGCAACA ACTAAGACGC 
GAGCAGGAGG AGAGGCGCGA GCAGCTGCTG AAGCGCGAGG AGGAGAAGAG GCTCGAGCAG 
GAGAGGCGAG AGCAGCGGCT GAAGCGCGAG CAGGAGGAGA GGCGCGATCA GCTGCTGAAG 
CGCGAGGAGG AGAGGCGCCA GCAGCGGCTG AAGCGCGAGC AGGAAGAGAG GCTCGAGCAG 
CGACTGAAGC GCGAGGAGGT GGAGAGACTC GAGCAGGAGG AGAGGCGCGA GCAGCGGCTG 
AAGCGCGAGG AGCCGGAGGA AGAGAGGCGC CAGCAGCTGC TGAAGAGCGA GGAGCAGGAG 
GAGAGGCGCC AGCAGCAACT AAGGCGCGAG CAGCAGGAAA GGCGCGAGCA GCGGCTGAAG 
CGCGAGGAGG AGGAAGAGAG GCTCGAGCAG CGGCTGAAGC GCGAGCATGA GGAAGAGAGG 
CGCGAGCAGG AGCTAGCTGA GGAGGAGCAG GAACAGGCCC GGGAGCGGAT TAAGAGCCGC 
ATCCCGAAGT GGCAGTGGCA GCTAGAAAGC GAGGCCGACG CACGGCAAAG CAAAGTCTAC 
TCGAGGCCCC GCAAGCAGGA AGGGCAGAGG CGCCGCCAAG AGCAGGAGGA AAAGAGGCGG 
CGCCGGGAGA GTGAGCTGCA ATGGCAGGAG GAGGAACGGG CTCACCGGCA GCAGCAGGAA 
GAGGAGCAGC GCCGGGACTT CACATGGCAG TGGCAGGCGG AGGAAAAGAG CGAGAGGGGC 
CGTCAGAGGC TGTCGGCCAG GCCCCCATTG CGGGAGCAGC GGGAGAGGCA GCTGAGGGCC 
GAGGAGCGCC AGCAGCGGGA ACAACGGTTT CTCCCGGAGG AGGAGGAGAA GGAGCAGCGG 
CGCCGCCAGC GACGCGAGAG GGAGAAAGAG CTGCAGTTCC TGGAGGAAGA GGAGCAGCTC 
CAGCGGCGGG AGCGTGCCCA ACAGCTCCAG GAGGAGGAGG ACGGCCTCCA GGAGGATCAG 
GAGAGGAGGC GAAGCCAGGA GCAGCGCCGC GACCAAAAAT GGAGGTGGCA ACTAGAAGAA 
GAAAGGAAGA GACGCCGCCA CACGCTGTAC GCCAAGCCAG CCCTACAAGA GCAGCTGAGG 
AAGGAACAGC AGCTGCTGCA GGAGGAGGAG GAGGAGCTAC AGAGAGAGGA GCGCGAGAAG 
AGAAGGCGCC AAGAACAGGA GAGACAATAC CGCGAGGAAG AGCAGCTGCA GCAGGAGGAA 
GAGCAGCTGC TGAGAGAGGA ACGGGAGAAA AGAAGACGCC AGGAGCGGGA AAGGCAATAT 
CGGAAGGATA AGAAGCTGCA GCAGAAGGAA GAGCAGCTGC TGGGAGAGGA ACCGGAGAAG 
AGAAGGCGCC AGGAGCGGGA GAAAAAATAC CGCGAGGAAG AGGAGTTGCA GCAGGAGGAA 
GAGCAGCTGC TGAGAGAGGA ACGGGAGAAG AGAAGGCGCC AGGAGTGGGA GAGGCAGTAC 
CGCAAAAAAG ACGAGCTGCA GCAGGAAGAA GAGCAGCTGC TGAGAGAGGA ACGGGAGAAA 
AGAAGACTCC AGGAGCGGGA GAGGCAATAT CGGGAGGAAG AGGAGCTGCA GCAGGAGGAA 
GAGCAGCTGC TGGGAGAGGA ACGGGAGACG AGAAGGCGCC AGGAGCTGGA GAGGCAATAT 
CGGAAGGAAG AGGAGCTGCA GCAGGAGGAA GAGCAGCTGC TGAGAGAGGA ACCGGAGAAG 
AGAAGGCGCC AGGAGCGGGA GAGGCAATGT CGGGAGGAAG AGGAGCTGCA GCAGGAGGAA 
GAGCAGCTGC TGAGAGAGGA ACGGGAGAAG AGAAGGCGCC AGGAGCTGGA GAGGCAATAT 
CGGGAGGAAG AGGAGGTGCA GCAGGAGGAA GAGCAGCTGC TGAGAGAGGA ACCGGAGAAG 
AGAAGGCGCC AGGAGCTGGA GAGGCAATAC CGCGAGGAAG AGGAGCTGCA GCAGGAGGAA 
GAGCAGCTGC TGAGAGAGGA ACAGGAGAAA AGGCGCCAGG AGCGGGAGAG GCAGTATCGG 
GAGGAGGAAG AGCTTCAGCG CCAGAAAAGG AAGCAGCGAT ACCGGGATGA GGATCAGCGC 
AGTGATCTGA AATGGCAGTG GGAACCAGAA AAAGAAAATG CAGTTCGTGA TAACAAGGTT 
TACTGCAAAG GCAGAGAGAA TGAACAGTTC CGGCAGTTGG AAGATTCCCA GCTGCGCGAC 
AGACAATCCC AGCAAGATCT GCAGCACCTG CTGGGTGAAC AGCAAGAGCG AGATCGTGAG 
CAAGAGAGGA GGCGCTGGCA GCAGCGCGAC AGGCATTTCC CAGAGGAAGA ACAGCTGGAG 
CGAGAAGAGC AAAAGGAAGC CAAAAGGCGC GACAGGAAGT CCCAAGAGGA AAAGCAGTTG 
CTGAGAGAGG AAAGAGAAGA GAAGAGACGC CGTCAAGAGA CAGACAGAAA ATTCCGCGAG 
GAGGAACAGC TGCTCCAGGA AAGGGAGGAA CAGCCGCTGC GCCGCCAAGA GCGTGACAGA 
AAATTCCGCG AAGAGGAACT GCGCCATCAG GAACAAGGGA GAAAATTCCT CGAGGAGGAA 
CAGCGGCTGC GCCGCCAGGA ACGGGAGAGA AAATTCCTTA AGGAGGAACA GCAGCTGCGC 
TGCCAGGAGC GCGAGCAACA GCTGCGTCAG GACCGCGACA GAAAATTCCG CGAGGAGGAA 
CAGCAGCTGA GCCGCCAAGA GCGTGACAGA AAATTCCGTG AAGAGGAACA GCAGGTGCGC 
CGCCAGGAAC GAGAGAGAAA ATTCCTGGAG GAGGAACAGC AGCTGCGCCA GGAGCGTCAC 
AGAAAATTCC GCGAAGAGGA ACAGCTGCTC CAGGAAAGGG AAGAACAGCA GCTGCACCGC 
CAAGAGCGTG ACAGAAAATT CCTGGAGGAG GAACAACAGC TGCGCCGCCA AGAGCGTGAC 
AGAAAATTCC GCGAACAGGA ACTGCGCAGT CAGGAACCAG AGAGAAAATT CCTCGAGGAG 
GAACAGCAGC TGCACCGCCA GCAACGGCAG AGAAAATTCC TCCAGGAGGA ACAGCAGCTG 
CGCCGCCAGG AGCGCGGGCA ACAGCGGCGT CAGGACCGTG ACAGAAAATT CCGCGAGGAG 
GAACAGCTGC GCCAGGAGAG GGAGGAACAG CAGCTGAGCC GCCAAGAGCG TGACAGAAAA 
TTCCGTTTAG AGGAACAGAA AGTGCGCCGC CAGGAACAAG AGAGAAAATT CATGGAGGAC 
GAACAGCAGC TGCGCCGCCA GGAGGGCCAA CAACAGCTGC GCCAGGAGCG CGACAGAAAA 
TTCCGCGAAG ACGAACAGCT GCTCCAGGAA AGGGAAGAAC AGCAGCTGCA CCGCCAAGAG 
CGTGACAGAA AATTCCTCGA GGAGGAACCG CAGCTGCGCC GCCAGGAGCG CGAACAACAG 
CTGCGTCACG ACCGCGACAG AAAATTCCGT GAAGAGGAAC AGCTGCTCCA GGAAGGGGAG 
GAACAGCAGC TGCGCCGCCA AGAGCGTGAC AGAAAATTCC GCGAAGAGGA ACAGCAGCTC 
CGCCGTCAGG AACGAGAGAG AAAATTCCTC CAGGAGGAAC AGCAGCTGCG CCGCCAGGAA 
CTGGAGAGAA AATTCCGTGA GGAGGAACAG CTGCGCCAAG AAACGGAGCA AGAGCAGCTG 
CGCCGCCAAG AACGCTACAG AAAAATCCTA GAGGAAGAGC AGCTCCGTCC GGAAAGGGAA 
GAACAGCAGC TGCGCCGCCA GGAGCGCGAC AGAAAATTCC GCGAGGAGGA ACAGCTCCGC 
CAGGAGAGGG AGGAACAGCA GCTGCGCAGC CAAGAGTCTG ACAGAAAATT CCGCGAGGAG 
GAACAGCTAC GCCAGGAGAG GGAAGAACAG CAGCTGCGCC CCCAACAGCG TGACGGAAAG 
TATCGCTGGG AAGAAGAGCA GCTCCAACTT GAGGAACAAG AGCAGAGGCT GCGGCAGGAG 
CGAGACCGGC AGTACCGGGC GGAGGAGCAG TTTGCCACGC AGGAGAAGAG TCGTCGTGAG 
GAACAAGAAC TATGGCAAGA AGAGGAGCAG AAACGTCGCC AGGAACGGGA AAGGAAATTA 
CGGGAAGAAC ACATCCGCCG CCAGCAGAAG GAGGAACAGA GGCACCGCCA AGTCGGGGAG 
ATAAAATCCC AAGAAGGGAA GGGCCATGGG CGGCTTCTGG AGCCCGGCAC TCATCAGTTT 
GCCAGTGTCC CAGTGCGCTC CAGCCCTCTC TATGAGTACA TCCAAGAGCA GAGATCTCAA 
TACCGCCCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.
American journal of human genetics99(6)1292-1304(2016 Dec)
? Basmanav FB,Cau L,Tafazzoli A,M?chin MC,Wolf S,Romano MT,Valentin F,Wiegmann H,Huchenq A,Kandil R,Garcia Bartels N,Kilic A,George S,Ralser DJ,Bergner S,Ferguson DJP,Oprisoreanu AM,Wehner M,Thiele H,Altm?ller J,N?rnberg P,Swan D,Houniet D,B?chner A,Weibel L,Wagner N,Grimalt R,Bygum A,Serre G,Blume-Peytavi U,Sprecher E,Schoch S,Oji V,Hamm H,Farrant P,Simon M,Betz RC

Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.
Human genetics135(11)1279-1286(2016 Nov)
Wu S,Tan J,Yang Y,Peng Q,Zhang M,Li J,Lu D,Liu Y,Lou H,Feng Q,Lu Y,Guan Y,Zhang Z,Jiao Y,Sabeti P,Krutmann J,Tang K,Jin L,Xu S,Wang S

Induced Pluripotent Stem Cell Differentiation and Three-Dimensional Tissue Formation Attenuate Clonal Epigenetic Differences in Trichohyalin.
Stem cells and development25(18)1366-75(2016 09)
Petrova A,Capalbo A,Jacquet L,Hazelwood-Smith S,Dafou D,Hobbs C,Arno M,Farcomeni A,Devito L,Badraiq H,Simpson M,McGrath JA,Di WL,Cheng JB,Mauro TM,Ilic D

Evaluation of the predictive capacity of DNA variants associated with straight hair in Europeans.
Forensic science international. Genetics19280-288(2015 Nov)
Po?piech E,Kar?owska-Pik J,Marci?ska M,Abidi S,Andersen JD,Berge MVD,Carracedo ?,Eduardoff M,Freire-Aradas A,Morling N,Sijen T,Skowron M,S?chtig J,Syndercombe-Court D,Weiler N,Schneider PM,Ballard D,B?rsting C,Parson W,Phillips C,Branicki W,

Trichohyalin is a potential major autoantigen in human alopecia areata.
Journal of proteome research9(10)5153-63(2010 Oct)
Leung MC,Sutton CW,Fenton DA,Tobin DJ

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TCHH cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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