SRY cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SRY
Entrez Gene ID	6736
Full Name	sex determining region Y
Synonyms	SRXX1,SRXY1,TDF,TDY
General protein information	Preferred Names sex determining region Y Names sex-determining region Y protein essential protein for sex determination in human males sex-determining region on Y testis-determining factor on Y truncated sex-determining region Y protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yp11.2
Summary	This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008].
Disorder MIM:	480000
Disorder Html:	46XY sex reversal 1, 400044 (3); 46XX sex reversal 1, 400045 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003140.2	NP_003131.1	sex-determining region Y protein
NM_003140.3	NP_003131.1	sex-determining region Y protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SRY	NP_001014407.1
Pan troglodytes (chimpanzee)	SRY	NP_001008988.1
Homo sapiens (human)	SRY	NP_003131.1

Gene Ontology
Bibliography

Related articles in PubMed

Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.
Liu C, Ren YF, Dong J, Ke MY, Ma F, Monga SPS, Wu R, Lv Y, Zhang XF
Cancer letters41020-31(2017 Dec)

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Calvo SE, Pagliarini DJ, Mootha VK
Proceedings of the National Academy of Sciences of the United States of America106(18)7507-12(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Activation of SRY and its downstream Sox9 and PDGFRalpha pathways are commonly involved in male hepatocarcinogenesis, which provides novel insights into gender disparity and sex-specific therapeutic strategies of hepatocellular carcinoma.
Title: Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.

a single-nucleotide polymorphism in the amelogenin gene using amplified product-length polymorphisms in combination with sex-determining region Y analysis, is reported.
Title: Sex Determination from Fragmented and Degenerated DNA by Amplified Product-Length Polymorphism Bidirectional SNP Analysis of Amelogenin and SRY Genes.

Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9, demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis.
Title: Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.

Missense Mutation 224G>T (R75M) in SRY Coding Region is associated with 46, XY Gonadal Dysgenesis.
Title: A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis.

The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender
Title: Noninvasive Diagnosis of Fetal Gender: Utility of Combining DYS14 and SRY.

The following SRY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28314	NM_003140.3 Latest version!	Homo sapiens sex determining region Y (SRY), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu28314	NM_003140.2	Homo sapiens sex determining region Y (SRY), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SRY ( NM_003140.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003131.1 Homo sapiens sex determining region Y (SRY), mRNA.

Price & Availability↑

CloneID	OHu28314
Clone ID Related Accession (Same CDS sequence)	NM_003140.2 , NM_003140.3
Accession Version	NM_003140.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	sex-determining region Y protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006040.3 and L10101.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2013 this sequence version replaced NM_003140.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: full length.

ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT 
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT 
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG 
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA 
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG 
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC 
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG 
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC 
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA 
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC 
TGGACAAAGC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003131.1
CDS	139..753
Translation	MQSYASAMLSVFNSDDYSPAVQENIPALRRSSSFLCTESCNSKYQCETGENSKGNVQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL

Target ORF information:

RefSeq Version	NM_003140.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sex determining region Y (SRY), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003140.2

ORF Insert Sequence:

ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT 
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT 
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG 
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA 
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG 
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC 
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG 
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC 
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA 
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC 
TGGACAAAGC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SRY ( NM_003140.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003131.1 Homo sapiens sex determining region Y (SRY), mRNA.

Price & Availability↑

CloneID	OHu28314
Clone ID Related Accession (Same CDS sequence)	NM_003140.2 , NM_003140.3
Accession Version	NM_003140.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	sex-determining region Y protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L10101.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_003140.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: L10101.1, BC074923.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000383070.2/ ENSP00000372547.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT 
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT 
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG 
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA 
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG 
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC 
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG 
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC 
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA 
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC 
TGGACAAAGC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003131.1
CDS	80..694
Translation	MQSYASAMLSVFNSDDYSPAVQENIPALRRSSSFLCTESCNSKYQCETGENSKGNVQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL

Target ORF information:

RefSeq Version	NM_003140.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sex determining region Y (SRY), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003140.3

ORF Insert Sequence:

ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT 
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT 
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG 
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA 
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG 
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC 
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG 
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC 
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA 
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC 
TGGACAAAGC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.
Cancer letters41020-31(2017 Dec)
Liu C,Ren YF,Dong J,Ke MY,Ma F,Monga SPS,Wu R,Lv Y,Zhang XF

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Proceedings of the National Academy of Sciences of the United States of America106(18)7507-12(2009 May)
Calvo SE,Pagliarini DJ,Mootha VK

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SRY cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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