SPRR2E cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPRR2E
Entrez Gene ID	6704
Full Name	small proline rich protein 2E
General protein information	Preferred Names small proline rich protein 2E Names small proline-rich protein 2E SPR-2E SPR-II small proline-rich protein II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014].
Disorder MIM:	617588

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024209.4	NP_001019380.2	small proline-rich protein 2E
NM_001024209.3	NP_001019380.2	small proline-rich protein 2E

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Kainu K, Kivinen K, Zucchelli M, Suomela S, Kere J, Inerot A, Baker BS, Powles AV, Fry L, Samuelsson L, Saarialho-Kere U
Experimental dermatology18(2)109-15(2009 Feb)

Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus.
Hong SH, Nah HY, Lee JY, Lee YJ, Lee JW, Gye MC, Kim CH, Kang BM, Kim MK
Molecules and cells17(3)477-84(2004 Jun)

Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.
Cabral A, Voskamp P, Cleton-Jansen AM, South A, Nizetic D, Backendorf C
The Journal of biological chemistry276(22)19231-7(2001 Jun)

Creation of genome-wide protein expression libraries using random activation of gene expression.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M
Nature biotechnology19(5)440-5(2001 May)

Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.
Song HJ, Poy G, Darwiche N, Lichti U, Kuroki T, Steinert PM, Kartasova T
Genomics55(1)28-42(1999 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Title: Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.

The following SPRR2E gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPRR2E cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22904	NM_001024209.4 Latest version!	Homo sapiens small proline rich protein 2E (SPRR2E), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu22904	NM_001024209.3	Homo sapiens small proline rich protein 2E (SPRR2E), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPRR2E ( NM_001024209.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001019380.2 Homo sapiens small proline rich protein 2E (SPRR2E), mRNA.

Price & Availability↑

CloneID	OHu22904
Clone ID Related Accession (Same CDS sequence)	NM_001024209.4 , NM_001024209.3
Accession Version	NM_001024209.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	small proline-rich protein 2E
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE714447.1, DA761769.1, DA761491.1 and BG185829.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001024209.3. ##Evidence-Data-START## Transcript exon combination :: M20030.1, DA761491.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368750.8/ ENSP00000357739.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAAAAAT GTCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTG TCCACCCAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019380.2
CDS	63..281
Translation	MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKCPPVTPSPPCQPKCPPKSK

Target ORF information:

RefSeq Version	NM_001024209.4
Organism	Homo sapiens(human)
Definition	Homo sapiens small proline rich protein 2E (SPRR2E), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024209.4

ORF Insert Sequence:

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAAAAAT GTCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTG TCCACCCAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPRR2E ( NM_001024209.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001019380.2 Homo sapiens small proline rich protein 2E (SPRR2E), mRNA.

Price & Availability↑

CloneID	OHu22904
Clone ID Related Accession (Same CDS sequence)	NM_001024209.4 , NM_001024209.3
Accession Version	NM_001024209.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	small proline-rich protein 2E
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE714447.1, DA761769.1, DA761491.1 and BG185829.1. This sequence is a reference standard in the RefSeqGene project. On Feb 20, 2014 this sequence version replaced NM_001024209.2. ##Evidence-Data-START## Transcript exon combination :: M20030.1, ERR279831.7248.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAAAAAT GTCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTG TCCACCCAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019380.2
CDS	65..283
Translation	MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKCPPVTPSPPCQPKCPPKSK

Target ORF information:

RefSeq Version	NM_001024209.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small proline rich protein 2E (SPRR2E), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024209.3

ORF Insert Sequence:

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAAAAAT GTCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTG TCCACCCAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Experimental dermatology18(2)109-15(2009 Feb)
Kainu K,Kivinen K,Zucchelli M,Suomela S,Kere J,Inerot A,Baker BS,Powles AV,Fry L,Samuelsson L,Saarialho-Kere U

Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus.
Molecules and cells17(3)477-84(2004 Jun)
Hong SH,Nah HY,Lee JY,Lee YJ,Lee JW,Gye MC,Kim CH,Kang BM,Kim MK

Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.
The Journal of biological chemistry276(22)19231-7(2001 Jun)
Cabral A,Voskamp P,Cleton-Jansen AM,South A,Nizetic D,Backendorf C

Creation of genome-wide protein expression libraries using random activation of gene expression.
Nature biotechnology19(5)440-5(2001 May)
Harrington JJ,Sherf B,Rundlett S,Jackson PD,Perry R,Cain S,Leventhal C,Thornton M,Ramachandran R,Whittington J,Lerner L,Costanzo D,McElligott K,Boozer S,Mays R,Smith E,Veloso N,Klika A,Hess J,Cothren K,Lo K,Offenbacher J,Danzig J,Ducar M

Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.
Genomics55(1)28-42(1999 Jan)
Song HJ,Poy G,Darwiche N,Lichti U,Kuroki T,Steinert PM,Kartasova T

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

SPRR2E cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報