ISL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ISL2
Entrez Gene ID	64843
Full Name	ISL LIM homeobox 2
General protein information	Preferred Names ISL LIM homeobox 2 Names insulin gene enhancer protein ISL-2 ISL2 transcription factor, LIM/homeodomain, (islet-2) islet-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q24.3
Disorder MIM:	609481

mRNA and Protein(s)

mRNA	Protein	Name
NM_145805.3	NP_665804.1	insulin gene enhancer protein ISL-2
XM_017022505.1	XP_016877994.1	insulin gene enhancer protein ISL-2 isoform X1
NM_145805.2	NP_665804.1	insulin gene enhancer protein ISL-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ISL2	NP_665804.1
Mus musculus (house mouse)	Isl2	NP_081673.2
Rattus norvegicus (Norway rat)	Isl2	NP_065204.1
Danio rerio (zebrafish)	isl2a	NP_571045.1
Pan troglodytes (chimpanzee)	ISL2	XP_003314842.1
	ISL2	XP_001105068.1
Bos taurus (cattle)	ISL2	NP_001178166.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Contribution of LHX4 Mutations to Pituitary Deficits in a Cohort of 417 Unrelated Patients.
Cohen E, Maghnie M, Collot N, Leger J, Dastot F, Polak M, Rose S, Touraine P, Duquesnoy P, Tauber M, Copin B, Bertrand AM, Brioude F, Larizza D, Edouard T, Gonz?lez Brice?o L, Netchine I, Oliver-Petit I, Sobrier ML, Amselem S, Legendre M
The Journal of clinical endocrinology and metabolism102(1)290-301(2017 Jan)

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Oshikawa M, Tsutsui C, Ikegami T, Fuchida Y, Matsubara M, Toyama S, Usami R, Ohtoko K, Kato S
Investigative ophthalmology & visual science52(9)6662-70(2011 Aug)

Sperry versus Hebb: topographic mapping in Isl2/EphA3 mutant mice.
Tsigankov D, Koulakov AA
BMC neuroscience11155(2010 Dec)

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.
Dykes IM, Lanier J, Eng SR, Turner EE
Neural development53(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Experiments in Isl2/EphA3 knock-in mice test the interactions between effects of molecular labels and correlated activity during the development of neural connectivity.
Title: Sperry versus Hebb: topographic mapping in Isl2/EphA3 mutant mice.

The broad expression of Isl-2 gene in tissues during embryogenesis and adult development suggests that it may be involved in both differentiation and maintenance of these tissues and might play an important role.
Title: Cloning and expression of a novel human gene, Isl-2, encoded a LIM-homeodomain protein.

The following ISL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ISL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu71522	NM_145805.3 Latest version!	Homo sapiens ISL LIM homeobox 2 (ISL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
OHu85623	XM_017022505.1 Latest version!	Homo sapiens ISL LIM homeobox 2 (ISL2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu71522	NM_145805.2	Homo sapiens ISL LIM homeobox 2 (ISL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ISL2 ( NM_145805.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_665804.1 Homo sapiens ISL LIM homeobox 2 (ISL2), mRNA.

Price & Availability↑

CloneID	OHu71522
Clone ID Related Accession (Same CDS sequence)	NM_145805.3 , NM_145805.2
Accession Version	NM_145805.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	insulin gene enhancer protein ISL-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB055557.1, BC012136.1 and AC027243.20. On Nov 22, 2018 this sequence version replaced NM_145805.2. ##Evidence-Data-START## Transcript exon combination :: BC012136.1, SRR1163657.507285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMN01820689 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000290759.9/ ENSP00000290759.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGTGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTG 
CGGGTGTCGC CCGACCTCGA GTGGCACGCG GCCTGCCTCA AGTGTGCCGA GTGCAGCCAG 
TACCTGGACG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AGACCTACTG CAAGCGGGAC 
TATGTCAGGC TGTTCGGCAT CAAGTGCGCC AAGTGCCAGG TGGGCTTCAG CAGCAGCGAC 
CTGGTGATGA GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTGCCTGG GGACGAGTTC TCGCTGCGGG AGCACGAGCT GCTCTGCCGC 
GCCGACCACG GCCTCCTGCT CGAGCGCGCC GCGGCCGGCA GCCCGCGCAG CCCCGGCCCG 
CTTCCCGGCG CCCGCGGCCT GCATCTGCCC GACGCTGGGT CGGGCCGGCA GCCCGCGTTG 
CGCCCGCACG TGCACAAGCA GACGGAGAAG ACGACCCGCG TGCGGACTGT GCTGAACGAG 
AAGCAGCTGC ACACTCTGCG GACCTGCTAC GCCGCCAACC CGCGGCCCGA CGCTCTCATG 
AAGGAGCAGC TGGTGGAGAT GACCGGCCTG AGCCCGCGGG TCATCCGCGT CTGGTTCCAG 
AACAAGCGCT GCAAGGACAA GAAGAAATCC ATTCTCATGA AGCAGCTGCA GCAGCAGCAG 
CACAGCGACA AGACGAGCCT TCAGGGACTG ACTGGGACGC CCCTGGTGGC GGGCAGTCCC 
ATCCGCCATG AGAACGCCGT GCAGGGCAGC GCAGTGGAGG TGCAGACGTA CCAGCCGCCG 
TGGAAGGCGC TCAGCGAGTT TGCCCTCCAG AGCGACCTGG ACCAACCCGC CTTCCAACAG 
CTGGTCTCCT TCTCCGAGTC CGGCTCCCTA GGCAACTCCT CCGGCAGCGA CGTGACCTCC 
CTGTCCTCGC AGCTCCCGGA CACCCCCAAC AGTATGGTGC CGAGTCCCGT GGAGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665804.1
CDS	112..1191
Translation	MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET

Target ORF information:

RefSeq Version	NM_145805.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ISL LIM homeobox 2 (ISL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145805.3

ORF Insert Sequence:

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGTGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTG 
CGGGTGTCGC CCGACCTCGA GTGGCACGCG GCCTGCCTCA AGTGTGCCGA GTGCAGCCAG 
TACCTGGACG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AGACCTACTG CAAGCGGGAC 
TATGTCAGGC TGTTCGGCAT CAAGTGCGCC AAGTGCCAGG TGGGCTTCAG CAGCAGCGAC 
CTGGTGATGA GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTGCCTGG GGACGAGTTC TCGCTGCGGG AGCACGAGCT GCTCTGCCGC 
GCCGACCACG GCCTCCTGCT CGAGCGCGCC GCGGCCGGCA GCCCGCGCAG CCCCGGCCCG 
CTTCCCGGCG CCCGCGGCCT GCATCTGCCC GACGCTGGGT CGGGCCGGCA GCCCGCGTTG 
CGCCCGCACG TGCACAAGCA GACGGAGAAG ACGACCCGCG TGCGGACTGT GCTGAACGAG 
AAGCAGCTGC ACACTCTGCG GACCTGCTAC GCCGCCAACC CGCGGCCCGA CGCTCTCATG 
AAGGAGCAGC TGGTGGAGAT GACCGGCCTG AGCCCGCGGG TCATCCGCGT CTGGTTCCAG 
AACAAGCGCT GCAAGGACAA GAAGAAATCC ATTCTCATGA AGCAGCTGCA GCAGCAGCAG 
CACAGCGACA AGACGAGCCT TCAGGGACTG ACTGGGACGC CCCTGGTGGC GGGCAGTCCC 
ATCCGCCATG AGAACGCCGT GCAGGGCAGC GCAGTGGAGG TGCAGACGTA CCAGCCGCCG 
TGGAAGGCGC TCAGCGAGTT TGCCCTCCAG AGCGACCTGG ACCAACCCGC CTTCCAACAG 
CTGGTCTCCT TCTCCGAGTC CGGCTCCCTA GGCAACTCCT CCGGCAGCGA CGTGACCTCC 
CTGTCCTCGC AGCTCCCGGA CACCCCCAAC AGTATGGTGC CGAGTCCCGT GGAGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ISL2 ( NM_145805.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_665804.1 Homo sapiens ISL LIM homeobox 2 (ISL2), mRNA.

Price & Availability↑

CloneID	OHu71522
Clone ID Related Accession (Same CDS sequence)	NM_145805.3 , NM_145805.2
Accession Version	NM_145805.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	insulin gene enhancer protein ISL-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB055557.1, BC012136.1 and AC027243.20. On Dec 21, 2014 this sequence version replaced NM_145805.1. ##Evidence-Data-START## Transcript exon combination :: BC012136.1, SRR1163657.507285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMN01820689 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGTGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTG 
CGGGTGTCGC CCGACCTCGA GTGGCACGCG GCCTGCCTCA AGTGTGCCGA GTGCAGCCAG 
TACCTGGACG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AGACCTACTG CAAGCGGGAC 
TATGTCAGGC TGTTCGGCAT CAAGTGCGCC AAGTGCCAGG TGGGCTTCAG CAGCAGCGAC 
CTGGTGATGA GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTGCCTGG GGACGAGTTC TCGCTGCGGG AGCACGAGCT GCTCTGCCGC 
GCCGACCACG GCCTCCTGCT CGAGCGCGCC GCGGCCGGCA GCCCGCGCAG CCCCGGCCCG 
CTTCCCGGCG CCCGCGGCCT GCATCTGCCC GACGCTGGGT CGGGCCGGCA GCCCGCGTTG 
CGCCCGCACG TGCACAAGCA GACGGAGAAG ACGACCCGCG TGCGGACTGT GCTGAACGAG 
AAGCAGCTGC ACACTCTGCG GACCTGCTAC GCCGCCAACC CGCGGCCCGA CGCTCTCATG 
AAGGAGCAGC TGGTGGAGAT GACCGGCCTG AGCCCGCGGG TCATCCGCGT CTGGTTCCAG 
AACAAGCGCT GCAAGGACAA GAAGAAATCC ATTCTCATGA AGCAGCTGCA GCAGCAGCAG 
CACAGCGACA AGACGAGCCT TCAGGGACTG ACTGGGACGC CCCTGGTGGC GGGCAGTCCC 
ATCCGCCATG AGAACGCCGT GCAGGGCAGC GCAGTGGAGG TGCAGACGTA CCAGCCGCCG 
TGGAAGGCGC TCAGCGAGTT TGCCCTCCAG AGCGACCTGG ACCAACCCGC CTTCCAACAG 
CTGGTCTCCT TCTCCGAGTC CGGCTCCCTA GGCAACTCCT CCGGCAGCGA CGTGACCTCC 
CTGTCCTCGC AGCTCCCGGA CACCCCCAAC AGTATGGTGC CGAGTCCCGT GGAGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665804.1
CDS	161..1240
Translation	MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET

Target ORF information:

RefSeq Version	NM_145805.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ISL LIM homeobox 2 (ISL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145805.2

ORF Insert Sequence:

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGTGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTG 
CGGGTGTCGC CCGACCTCGA GTGGCACGCG GCCTGCCTCA AGTGTGCCGA GTGCAGCCAG 
TACCTGGACG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AGACCTACTG CAAGCGGGAC 
TATGTCAGGC TGTTCGGCAT CAAGTGCGCC AAGTGCCAGG TGGGCTTCAG CAGCAGCGAC 
CTGGTGATGA GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTGCCTGG GGACGAGTTC TCGCTGCGGG AGCACGAGCT GCTCTGCCGC 
GCCGACCACG GCCTCCTGCT CGAGCGCGCC GCGGCCGGCA GCCCGCGCAG CCCCGGCCCG 
CTTCCCGGCG CCCGCGGCCT GCATCTGCCC GACGCTGGGT CGGGCCGGCA GCCCGCGTTG 
CGCCCGCACG TGCACAAGCA GACGGAGAAG ACGACCCGCG TGCGGACTGT GCTGAACGAG 
AAGCAGCTGC ACACTCTGCG GACCTGCTAC GCCGCCAACC CGCGGCCCGA CGCTCTCATG 
AAGGAGCAGC TGGTGGAGAT GACCGGCCTG AGCCCGCGGG TCATCCGCGT CTGGTTCCAG 
AACAAGCGCT GCAAGGACAA GAAGAAATCC ATTCTCATGA AGCAGCTGCA GCAGCAGCAG 
CACAGCGACA AGACGAGCCT TCAGGGACTG ACTGGGACGC CCCTGGTGGC GGGCAGTCCC 
ATCCGCCATG AGAACGCCGT GCAGGGCAGC GCAGTGGAGG TGCAGACGTA CCAGCCGCCG 
TGGAAGGCGC TCAGCGAGTT TGCCCTCCAG AGCGACCTGG ACCAACCCGC CTTCCAACAG 
CTGGTCTCCT TCTCCGAGTC CGGCTCCCTA GGCAACTCCT CCGGCAGCGA CGTGACCTCC 
CTGTCCTCGC AGCTCCCGGA CACCCCCAAC AGTATGGTGC CGAGTCCCGT GGAGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ISL2 ( XM_017022505.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877994.1 Homo sapiens ISL LIM homeobox 2 (ISL2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu85623
Clone ID Related Accession (Same CDS sequence)	XM_017022505.1
Accession Version	XM_017022505.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	insulin gene enhancer protein ISL-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGTGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTG 
CGGGTGTCGC CCGACCTCGA GTGGCACGCG GCCTGCCTCA AGTGTGCCGA GTGCAGCCAG 
TACCTGGACG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AGACCTACTG CAAGCGGGAC 
TATGTCAGGC TGTTCGGCAT CAAGTGCGCC AAGTGCCAGG TGGGCTTCAG CAGCAGCGAC 
CTGGTGATGA GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTGCCTGG GGACGAGTTC TCGCTGCGGG AGCACGAGCT GCTCTGCCGC 
GCCGACCACG GCCTCCTGCT CGAGCGCGCC GCGGCCGGCA GCCCGCGCAG CCCCGGCCCG 
CTTCCCGGCG CCCGCGGCCT GCATCTGCCC GACGCTGGGT CGGGCCGGCA GCCCGCGTTG 
CGCCCGCACG TGCACAAGCA GACGGAGAAG ACGACCCGCG TGCGGACTGT GCTGAACGAG 
AAGCAGCTGC ACACTCTGCG GACCTGCTAC GCCGCCAACC CGCGGCCCGA CGCTCTCATG 
AAGGAGCAGC TGGTGGAGAT GACCGGCCTG AGCCCGCGGG TCATCCGCGT CTGGTTCCAG 
AACAAGCGCT GCAAGGACAA GAAGAAATCC ATTCTCATGA AGCAGCTGCA GCAGCAGCAG 
CACAGCGACA AGACGAGCCT TCAGGGACTG ACTGGGACGC CCCTGGTGGC GGGCAGTCCC 
ATCCGCCATG AGAACGCCGT GCAGGGCAGC GCAGTGGAGG TGCAGACGTA CCAGCCGCCG 
TGGAAGGCGC TCAGCGAGTT TGCCCTCCAG AGCGACCTGG ACCAACCCGC CTTCCAACAG 
CTGGGCTTGC TCTCAGCTGG CGGCCGGTCC CCAAGGGACA CTTTCCGACT CGGAGCACGC 
GGCCCTGGAG CACCAGCTCG CGTGCCTCTT CACCTGCCTC TTCCCGGTGT TTCCGCCGCC 
CCAGGTCTCC TTCTCCGAGT CCGGCTCCCT AGGCAACTCC TCCGGCAGCG ACGTGACCTC 
CCTGTCCTCG CAGCTCCCGG ACACCCCCAA CAGTATGGTG CCGAGTCCCG TGGAGACGTG 
AGGGGGACCC CTCCCTGCCA GCCCGCGGAC CTCGCATGCT CCCTGCATGA GACTCACCCA 
TGCTCAGGCC ATTCCAGTTC CGAAAGCTCT CTCGCCTTCG TAATTATTCT ATTGTTATTT 
ATGAGAGAGT ACCGAGAGAC ACGGTCTGGA CAGCCCAAGG CGCCAGGATG CAACCTGCTT 
TCACCAGACT GCAGACCCCT GCTCCGAGGA CTCTTAGTTT TTCAAAACCA GAATCTGGGA 
CTTACCAGGG TTAGCTCTGC CCTCTCCTCT CCTCTCTACG TGGCCGCCGC TCTGTCTCTC 
CACGCCCCAC CTGTGTCCCC ATCTCGGCCG GCCCGGAGCT CGCCCACGCG GACCCCCGCC 
CTGCCCCAGC TCAGCGCTCC CTGGCGGCTT CGCCCGGGCT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877994.1
CDS	161..1765
Translation	MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLGLLSAGGRSPRDTFRLGARGPGAPARVPLHLPLPGVSAAPGLLLRVRLPRQLLRQRRDLPVLAAPGHPQQYGAESRGDVRGTPPCQPADLACSLHETHPCSGHSSSESSLAFVIILLLFMREYRETRSGQPKAPGCNLLSPDCRPLLRGLLVFQNQNLGLTRVSSALSSPLYVAAALSLHAPPVSPSRPARSSPTRTPALPQLSAPWRLRPGS

Target ORF information:

RefSeq Version	XM_017022505.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ISL LIM homeobox 2 (ISL2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022505.1

ORF Insert Sequence:

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGTGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTG 
CGGGTGTCGC CCGACCTCGA GTGGCACGCG GCCTGCCTCA AGTGTGCCGA GTGCAGCCAG 
TACCTGGACG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AGACCTACTG CAAGCGGGAC 
TATGTCAGGC TGTTCGGCAT CAAGTGCGCC AAGTGCCAGG TGGGCTTCAG CAGCAGCGAC 
CTGGTGATGA GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTGCCTGG GGACGAGTTC TCGCTGCGGG AGCACGAGCT GCTCTGCCGC 
GCCGACCACG GCCTCCTGCT CGAGCGCGCC GCGGCCGGCA GCCCGCGCAG CCCCGGCCCG 
CTTCCCGGCG CCCGCGGCCT GCATCTGCCC GACGCTGGGT CGGGCCGGCA GCCCGCGTTG 
CGCCCGCACG TGCACAAGCA GACGGAGAAG ACGACCCGCG TGCGGACTGT GCTGAACGAG 
AAGCAGCTGC ACACTCTGCG GACCTGCTAC GCCGCCAACC CGCGGCCCGA CGCTCTCATG 
AAGGAGCAGC TGGTGGAGAT GACCGGCCTG AGCCCGCGGG TCATCCGCGT CTGGTTCCAG 
AACAAGCGCT GCAAGGACAA GAAGAAATCC ATTCTCATGA AGCAGCTGCA GCAGCAGCAG 
CACAGCGACA AGACGAGCCT TCAGGGACTG ACTGGGACGC CCCTGGTGGC GGGCAGTCCC 
ATCCGCCATG AGAACGCCGT GCAGGGCAGC GCAGTGGAGG TGCAGACGTA CCAGCCGCCG 
TGGAAGGCGC TCAGCGAGTT TGCCCTCCAG AGCGACCTGG ACCAACCCGC CTTCCAACAG 
CTGGGCTTGC TCTCAGCTGG CGGCCGGTCC CCAAGGGACA CTTTCCGACT CGGAGCACGC 
GGCCCTGGAG CACCAGCTCG CGTGCCTCTT CACCTGCCTC TTCCCGGTGT TTCCGCCGCC 
CCAGGTCTCC TTCTCCGAGT CCGGCTCCCT AGGCAACTCC TCCGGCAGCG ACGTGACCTC 
CCTGTCCTCG CAGCTCCCGG ACACCCCCAA CAGTATGGTG CCGAGTCCCG TGGAGACGTG 
AGGGGGACCC CTCCCTGCCA GCCCGCGGAC CTCGCATGCT CCCTGCATGA GACTCACCCA 
TGCTCAGGCC ATTCCAGTTC CGAAAGCTCT CTCGCCTTCG TAATTATTCT ATTGTTATTT 
ATGAGAGAGT ACCGAGAGAC ACGGTCTGGA CAGCCCAAGG CGCCAGGATG CAACCTGCTT 
TCACCAGACT GCAGACCCCT GCTCCGAGGA CTCTTAGTTT TTCAAAACCA GAATCTGGGA 
CTTACCAGGG TTAGCTCTGC CCTCTCCTCT CCTCTCTACG TGGCCGCCGC TCTGTCTCTC 
CACGCCCCAC CTGTGTCCCC ATCTCGGCCG GCCCGGAGCT CGCCCACGCG GACCCCCGCC 
CTGCCCCAGC TCAGCGCTCC CTGGCGGCTT CGCCCGGGCT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Contribution of LHX4 Mutations to Pituitary Deficits in a Cohort of 417 Unrelated Patients.
The Journal of clinical endocrinology and metabolism102(1)290-301(2017 Jan)
Cohen E,Maghnie M,Collot N,Leger J,Dastot F,Polak M,Rose S,Touraine P,Duquesnoy P,Tauber M,Copin B,Bertrand AM,Brioude F,Larizza D,Edouard T,Gonz?lez Brice?o L,Netchine I,Oliver-Petit I,Sobrier ML,Amselem S,Legendre M

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Investigative ophthalmology & visual science52(9)6662-70(2011 Aug)
Oshikawa M,Tsutsui C,Ikegami T,Fuchida Y,Matsubara M,Toyama S,Usami R,Ohtoko K,Kato S

Sperry versus Hebb: topographic mapping in Isl2/EphA3 mutant mice.
BMC neuroscience11155(2010 Dec)
Tsigankov D,Koulakov AA

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.
Neural development53(2010 Jan)
Dykes IM,Lanier J,Eng SR,Turner EE

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ISL2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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